%PDF-1.4 % 238 0 obj <> endobj xref 238 565 0000000016 00000 n 0000013021 00000 n 0000013194 00000 n 0000013220 00000 n 0000013291 00000 n 0000013348 00000 n 0000013717 00000 n 0000013899 00000 n 0000014081 00000 n 0000014262 00000 n 0000014444 00000 n 0000014626 00000 n 0000014808 00000 n 0000014992 00000 n 0000015132 00000 n 0000015326 00000 n 0000015482 00000 n 0000015618 00000 n 0000015759 00000 n 0000015911 00000 n 0000016113 00000 n 0000016315 00000 n 0000016471 00000 n 0000016657 00000 n 0000016870 00000 n 0000016949 00000 n 0000017027 00000 n 0000017107 00000 n 0000017186 00000 n 0000017264 00000 n 0000017341 00000 n 0000017420 00000 n 0000017499 00000 n 0000017578 00000 n 0000017657 00000 n 0000017736 00000 n 0000017815 00000 n 0000017893 00000 n 0000017971 00000 n 0000018048 00000 n 0000018126 00000 n 0000018205 00000 n 0000018284 00000 n 0000018363 00000 n 0000018442 00000 n 0000018521 00000 n 0000018600 00000 n 0000018679 00000 n 0000018758 00000 n 0000018837 00000 n 0000018916 00000 n 0000018995 00000 n 0000019074 00000 n 0000019153 00000 n 0000019232 00000 n 0000019311 00000 n 0000019390 00000 n 0000019469 00000 n 0000019548 00000 n 0000019627 00000 n 0000019706 00000 n 0000019785 00000 n 0000019864 00000 n 0000019943 00000 n 0000020022 00000 n 0000020101 00000 n 0000020180 00000 n 0000020259 00000 n 0000020338 00000 n 0000020417 00000 n 0000020496 00000 n 0000020575 00000 n 0000020654 00000 n 0000020733 00000 n 0000020812 00000 n 0000020891 00000 n 0000020970 00000 n 0000021049 00000 n 0000021128 00000 n 0000021207 00000 n 0000021286 00000 n 0000021365 00000 n 0000021444 00000 n 0000021523 00000 n 0000021602 00000 n 0000021681 00000 n 0000021760 00000 n 0000021839 00000 n 0000021918 00000 n 0000021997 00000 n 0000022076 00000 n 0000022153 00000 n 0000022231 00000 n 0000022309 00000 n 0000022387 00000 n 0000022465 00000 n 0000022541 00000 n 0000022619 00000 n 0000022697 00000 n 0000022775 00000 n 0000022853 00000 n 0000022931 00000 n 0000023009 00000 n 0000023087 00000 n 0000023165 00000 n 0000023244 00000 n 0000023323 00000 n 0000023402 00000 n 0000023481 00000 n 0000023560 00000 n 0000023639 00000 n 0000023718 00000 n 0000023797 00000 n 0000023876 00000 n 0000023955 00000 n 0000024034 00000 n 0000024113 00000 n 0000024192 00000 n 0000024271 00000 n 0000024350 00000 n 0000024429 00000 n 0000024508 00000 n 0000024587 00000 n 0000024666 00000 n 0000024745 00000 n 0000024824 00000 n 0000024903 00000 n 0000024982 00000 n 0000025061 00000 n 0000025140 00000 n 0000025219 00000 n 0000025298 00000 n 0000025377 00000 n 0000025456 00000 n 0000025535 00000 n 0000025614 00000 n 0000025693 00000 n 0000025772 00000 n 0000025851 00000 n 0000025930 00000 n 0000026009 00000 n 0000026088 00000 n 0000026167 00000 n 0000026246 00000 n 0000026325 00000 n 0000026404 00000 n 0000026483 00000 n 0000026562 00000 n 0000026641 00000 n 0000026720 00000 n 0000026799 00000 n 0000026878 00000 n 0000026957 00000 n 0000027036 00000 n 0000027115 00000 n 0000027194 00000 n 0000027273 00000 n 0000027352 00000 n 0000027431 00000 n 0000027510 00000 n 0000027589 00000 n 0000027668 00000 n 0000027747 00000 n 0000027826 00000 n 0000027905 00000 n 0000027984 00000 n 0000028063 00000 n 0000028142 00000 n 0000028221 00000 n 0000028300 00000 n 0000028379 00000 n 0000028458 00000 n 0000028535 00000 n 0000028614 00000 n 0000028693 00000 n 0000028772 00000 n 0000028851 00000 n 0000028930 00000 n 0000029009 00000 n 0000029088 00000 n 0000029167 00000 n 0000029246 00000 n 0000029325 00000 n 0000029404 00000 n 0000029483 00000 n 0000029562 00000 n 0000029641 00000 n 0000029720 00000 n 0000029799 00000 n 0000029878 00000 n 0000029957 00000 n 0000030036 00000 n 0000030115 00000 n 0000030194 00000 n 0000030273 00000 n 0000030352 00000 n 0000030431 00000 n 0000030510 00000 n 0000030589 00000 n 0000030668 00000 n 0000030747 00000 n 0000030826 00000 n 0000030905 00000 n 0000030984 00000 n 0000031063 00000 n 0000031142 00000 n 0000031221 00000 n 0000031300 00000 n 0000031379 00000 n 0000031458 00000 n 0000031537 00000 n 0000031616 00000 n 0000031695 00000 n 0000031774 00000 n 0000031853 00000 n 0000031932 00000 n 0000032011 00000 n 0000032090 00000 n 0000032169 00000 n 0000032248 00000 n 0000032327 00000 n 0000032406 00000 n 0000032485 00000 n 0000032564 00000 n 0000032643 00000 n 0000032722 00000 n 0000032801 00000 n 0000032880 00000 n 0000032959 00000 n 0000033038 00000 n 0000033117 00000 n 0000033196 00000 n 0000033275 00000 n 0000033354 00000 n 0000033433 00000 n 0000033512 00000 n 0000033591 00000 n 0000033670 00000 n 0000033749 00000 n 0000033828 00000 n 0000033907 00000 n 0000033986 00000 n 0000034065 00000 n 0000034144 00000 n 0000034223 00000 n 0000034302 00000 n 0000034381 00000 n 0000034460 00000 n 0000034539 00000 n 0000034618 00000 n 0000034697 00000 n 0000034776 00000 n 0000034855 00000 n 0000034934 00000 n 0000035013 00000 n 0000035092 00000 n 0000035171 00000 n 0000035250 00000 n 0000035329 00000 n 0000035408 00000 n 0000035487 00000 n 0000035566 00000 n 0000035645 00000 n 0000035724 00000 n 0000035803 00000 n 0000035882 00000 n 0000035961 00000 n 0000036040 00000 n 0000036119 00000 n 0000036198 00000 n 0000036277 00000 n 0000036356 00000 n 0000036435 00000 n 0000036514 00000 n 0000036593 00000 n 0000036672 00000 n 0000036751 00000 n 0000036830 00000 n 0000036909 00000 n 0000036988 00000 n 0000037067 00000 n 0000037144 00000 n 0000037223 00000 n 0000037302 00000 n 0000037381 00000 n 0000037460 00000 n 0000037539 00000 n 0000037618 00000 n 0000037697 00000 n 0000037776 00000 n 0000037855 00000 n 0000037934 00000 n 0000038013 00000 n 0000038092 00000 n 0000038171 00000 n 0000038250 00000 n 0000038329 00000 n 0000038408 00000 n 0000038487 00000 n 0000038566 00000 n 0000038645 00000 n 0000038724 00000 n 0000038803 00000 n 0000038882 00000 n 0000038961 00000 n 0000039040 00000 n 0000039119 00000 n 0000039198 00000 n 0000039277 00000 n 0000039356 00000 n 0000039435 00000 n 0000039514 00000 n 0000039593 00000 n 0000039672 00000 n 0000039751 00000 n 0000039830 00000 n 0000039909 00000 n 0000039988 00000 n 0000040067 00000 n 0000040146 00000 n 0000040225 00000 n 0000040304 00000 n 0000040383 00000 n 0000040462 00000 n 0000040541 00000 n 0000040618 00000 n 0000040697 00000 n 0000040776 00000 n 0000040855 00000 n 0000040934 00000 n 0000041013 00000 n 0000041092 00000 n 0000041171 00000 n 0000041250 00000 n 0000041329 00000 n 0000041408 00000 n 0000041487 00000 n 0000041564 00000 n 0000041643 00000 n 0000041722 00000 n 0000041801 00000 n 0000041880 00000 n 0000041959 00000 n 0000042038 00000 n 0000042115 00000 n 0000042192 00000 n 0000042271 00000 n 0000042350 00000 n 0000042429 00000 n 0000042508 00000 n 0000042587 00000 n 0000042666 00000 n 0000042745 00000 n 0000042824 00000 n 0000042903 00000 n 0000042982 00000 n 0000043061 00000 n 0000043140 00000 n 0000043219 00000 n 0000043298 00000 n 0000043377 00000 n 0000043456 00000 n 0000043535 00000 n 0000043614 00000 n 0000043693 00000 n 0000043772 00000 n 0000043851 00000 n 0000043930 00000 n 0000044009 00000 n 0000044088 00000 n 0000044167 00000 n 0000044246 00000 n 0000044325 00000 n 0000044404 00000 n 0000044483 00000 n 0000044562 00000 n 0000044641 00000 n 0000044720 00000 n 0000044799 00000 n 0000044878 00000 n 0000044957 00000 n 0000045036 00000 n 0000045115 00000 n 0000045194 00000 n 0000045273 00000 n 0000045352 00000 n 0000045431 00000 n 0000045510 00000 n 0000045589 00000 n 0000045668 00000 n 0000045747 00000 n 0000045826 00000 n 0000045905 00000 n 0000045984 00000 n 0000046063 00000 n 0000046142 00000 n 0000046221 00000 n 0000046300 00000 n 0000046379 00000 n 0000046458 00000 n 0000046537 00000 n 0000046616 00000 n 0000046695 00000 n 0000046774 00000 n 0000046853 00000 n 0000046932 00000 n 0000047011 00000 n 0000047090 00000 n 0000047169 00000 n 0000047248 00000 n 0000047327 00000 n 0000047406 00000 n 0000047485 00000 n 0000047564 00000 n 0000047643 00000 n 0000047722 00000 n 0000047801 00000 n 0000047880 00000 n 0000047959 00000 n 0000048038 00000 n 0000048117 00000 n 0000048196 00000 n 0000048275 00000 n 0000048354 00000 n 0000048433 00000 n 0000048512 00000 n 0000048591 00000 n 0000048670 00000 n 0000048749 00000 n 0000048828 00000 n 0000048907 00000 n 0000048986 00000 n 0000049065 00000 n 0000049144 00000 n 0000049223 00000 n 0000049302 00000 n 0000049381 00000 n 0000049460 00000 n 0000049539 00000 n 0000049618 00000 n 0000049697 00000 n 0000049776 00000 n 0000049855 00000 n 0000049934 00000 n 0000050013 00000 n 0000050092 00000 n 0000050171 00000 n 0000050250 00000 n 0000050329 00000 n 0000050408 00000 n 0000050487 00000 n 0000050566 00000 n 0000050645 00000 n 0000050724 00000 n 0000050803 00000 n 0000050882 00000 n 0000050961 00000 n 0000051040 00000 n 0000051119 00000 n 0000051198 00000 n 0000051277 00000 n 0000051356 00000 n 0000051435 00000 n 0000051514 00000 n 0000051593 00000 n 0000051672 00000 n 0000051751 00000 n 0000051830 00000 n 0000051909 00000 n 0000051988 00000 n 0000052067 00000 n 0000052146 00000 n 0000052225 00000 n 0000052304 00000 n 0000052383 00000 n 0000052462 00000 n 0000052541 00000 n 0000052620 00000 n 0000052699 00000 n 0000052778 00000 n 0000052857 00000 n 0000052936 00000 n 0000053014 00000 n 0000053091 00000 n 0000053169 00000 n 0000053247 00000 n 0000053324 00000 n 0000053401 00000 n 0000053477 00000 n 0000053554 00000 n 0000053632 00000 n 0000053710 00000 n 0000053996 00000 n 0000054448 00000 n 0000054826 00000 n 0000055211 00000 n 0000055378 00000 n 0000055841 00000 n 0000056316 00000 n 0000056487 00000 n 0000056755 00000 n 0000056813 00000 n 0000057237 00000 n 0000057339 00000 n 0000057796 00000 n 0000058168 00000 n 0000058361 00000 n 0000058737 00000 n 0000059021 00000 n 0000062266 00000 n 0000062459 00000 n 0000065427 00000 n 0000068455 00000 n 0000070817 00000 n 0000073294 00000 n 0000076126 00000 n 0000078727 00000 n 0000081249 00000 n 0000084139 00000 n 0000086054 00000 n 0000090017 00000 n 0000093354 00000 n 0000093854 00000 n 0000093962 00000 n 0000096094 00000 n 0000096389 00000 n 0000096733 00000 n 0000096935 00000 n 0000097316 00000 n 0000097529 00000 n 0000098015 00000 n 0000098139 00000 n 0000109183 00000 n 0000109221 00000 n 0000109723 00000 n 0000109867 00000 n 0000153139 00000 n 0000153177 00000 n 0000153651 00000 n 0000153763 00000 n 0000208087 00000 n 0000208125 00000 n 0000208226 00000 n 0000208282 00000 n 0000208768 00000 n 0000208864 00000 n 0000208984 00000 n 0000209083 00000 n 0000209208 00000 n 0000209325 00000 n 0000209464 00000 n 0000209569 00000 n 0000209674 00000 n 0000209809 00000 n 0000209939 00000 n 0000210089 00000 n 0000210252 00000 n 0000210388 00000 n 0000210508 00000 n 0000210623 00000 n 0000210800 00000 n 0000210939 00000 n 0000211086 00000 n 0000211243 00000 n 0000011596 00000 n trailer <<0823A7ABE06BB64E9007C6F932E14208>]>> startxref 0 %%EOF 802 0 obj<>stream xb```c`೘A8,  XTץfᓼAb ", F(!`XyϾS2JmJ}I4x>WI{BBkd{4w'Xرb⏪{?W3| BJ{K]$;Q$סhGwEs+/.x`8>Λ=a7;>{ֵfM[ayЋ1EGO1;jԅ#6ƇOZ6ujbxwMpwzK ѫ 龗cŝ#\N-l.L~ο7[3l;敕_g~=,kιes璉/9c:|e82aOЛ]zMwz;٤ʹgס5,rYT3OP,5ϦiN>TBl=t)y4ɴ)z84)x0w?JνN"O=yndI5ItsIpcO0 i5b nI=@)6p0m/EŁ/6|<0m`,p@_m 9&艳n̈rmcmyWevJzG2 _RR3&Jx,@aca30bL`Lgexa"'>Q x&3,ũ9?nDD8y60&3f<Ðxl; }!7qML挿c62r3h1Lg`ghg}a&q!RZY"!W2p=Ҷ L@w3Pv@;TT2p1P ,l`8, endstream endobj 239 0 obj<> endobj 240 0 obj[241 0 R] endobj 241 0 obj<>>> endobj 242 0 obj<> endobj 243 0 obj<> endobj 244 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 245 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 246 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 247 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 248 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 249 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 250 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 251 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 252 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 253 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 254 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 255 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 256 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 257 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 258 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 259 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 260 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 261 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 262 0 obj<> endobj 263 0 obj<> endobj 264 0 obj<> endobj 265 0 obj<> endobj 266 0 obj<> endobj 267 0 obj<> endobj 268 0 obj<> endobj 269 0 obj<> endobj 270 0 obj<> endobj 271 0 obj<> endobj 272 0 obj<> endobj 273 0 obj<> endobj 274 0 obj<> endobj 275 0 obj<> endobj 276 0 obj<> endobj 277 0 obj<> endobj 278 0 obj<> endobj 279 0 obj<> endobj 280 0 obj<> endobj 281 0 obj<> endobj 282 0 obj<> endobj 283 0 obj<> endobj 284 0 obj<> endobj 285 0 obj<> endobj 286 0 obj<> endobj 287 0 obj<> endobj 288 0 obj<> endobj 289 0 obj<> endobj 290 0 obj<> endobj 291 0 obj<> endobj 292 0 obj<> endobj 293 0 obj<> endobj 294 0 obj<> endobj 295 0 obj<> endobj 296 0 obj<> endobj 297 0 obj<> endobj 298 0 obj<> endobj 299 0 obj<> endobj 300 0 obj<> endobj 301 0 obj<> endobj 302 0 obj<> endobj 303 0 obj<> endobj 304 0 obj<> endobj 305 0 obj<> endobj 306 0 obj<> endobj 307 0 obj<> endobj 308 0 obj<> endobj 309 0 obj<> endobj 310 0 obj<> endobj 311 0 obj<> endobj 312 0 obj<> endobj 313 0 obj<> endobj 314 0 obj<> endobj 315 0 obj<> endobj 316 0 obj<> endobj 317 0 obj<> endobj 318 0 obj<> endobj 319 0 obj<> endobj 320 0 obj<> endobj 321 0 obj<> endobj 322 0 obj<> endobj 323 0 obj<> endobj 324 0 obj<> endobj 325 0 obj<> endobj 326 0 obj<> endobj 327 0 obj<> endobj 328 0 obj<> endobj 329 0 obj<> endobj 330 0 obj<> endobj 331 0 obj<> endobj 332 0 obj<> endobj 333 0 obj<> endobj 334 0 obj<> endobj 335 0 obj<> endobj 336 0 obj<> endobj 337 0 obj<> endobj 338 0 obj<> endobj 339 0 obj<> endobj 340 0 obj<> endobj 341 0 obj<> endobj 342 0 obj<> endobj 343 0 obj<> endobj 344 0 obj<> endobj 345 0 obj<> endobj 346 0 obj<> endobj 347 0 obj<> endobj 348 0 obj<> endobj 349 0 obj<> endobj 350 0 obj<> endobj 351 0 obj<> endobj 352 0 obj<> endobj 353 0 obj<> endobj 354 0 obj<> endobj 355 0 obj<> endobj 356 0 obj<> endobj 357 0 obj<> endobj 358 0 obj<> endobj 359 0 obj<> endobj 360 0 obj<> endobj 361 0 obj<> endobj 362 0 obj<> endobj 363 0 obj<> endobj 364 0 obj<> endobj 365 0 obj<> endobj 366 0 obj<> endobj 367 0 obj<> endobj 368 0 obj<> endobj 369 0 obj<> endobj 370 0 obj<> endobj 371 0 obj<> endobj 372 0 obj<> endobj 373 0 obj<> endobj 374 0 obj<> endobj 375 0 obj<> endobj 376 0 obj<> endobj 377 0 obj<> endobj 378 0 obj<> endobj 379 0 obj<> endobj 380 0 obj<> endobj 381 0 obj<> endobj 382 0 obj<> endobj 383 0 obj<> endobj 384 0 obj<> endobj 385 0 obj<> endobj 386 0 obj<> endobj 387 0 obj<> endobj 388 0 obj<> endobj 389 0 obj<> endobj 390 0 obj<> endobj 391 0 obj<> endobj 392 0 obj<> endobj 393 0 obj<> endobj 394 0 obj<> endobj 395 0 obj<> endobj 396 0 obj<> endobj 397 0 obj<> endobj 398 0 obj<> endobj 399 0 obj<> endobj 400 0 obj<> endobj 401 0 obj<> endobj 402 0 obj<> endobj 403 0 obj<> endobj 404 0 obj<> endobj 405 0 obj<> endobj 406 0 obj<> endobj 407 0 obj<> endobj 408 0 obj<> endobj 409 0 obj<> endobj 410 0 obj<> endobj 411 0 obj<> endobj 412 0 obj<> endobj 413 0 obj<> endobj 414 0 obj<> endobj 415 0 obj<> endobj 416 0 obj<> endobj 417 0 obj<> endobj 418 0 obj<> endobj 419 0 obj<> endobj 420 0 obj<> endobj 421 0 obj<> endobj 422 0 obj<> endobj 423 0 obj<> endobj 424 0 obj<> endobj 425 0 obj<> endobj 426 0 obj<> endobj 427 0 obj<> endobj 428 0 obj<> endobj 429 0 obj<> endobj 430 0 obj<> endobj 431 0 obj<> endobj 432 0 obj<> endobj 433 0 obj<> endobj 434 0 obj<> endobj 435 0 obj<> endobj 436 0 obj<> endobj 437 0 obj<> endobj 438 0 obj<> endobj 439 0 obj<> endobj 440 0 obj<> endobj 441 0 obj<> endobj 442 0 obj<> endobj 443 0 obj<> endobj 444 0 obj<> endobj 445 0 obj<> endobj 446 0 obj<> endobj 447 0 obj<> endobj 448 0 obj<> endobj 449 0 obj<> endobj 450 0 obj<> endobj 451 0 obj<> endobj 452 0 obj<> endobj 453 0 obj<> endobj 454 0 obj<> endobj 455 0 obj<> endobj 456 0 obj<> endobj 457 0 obj<> endobj 458 0 obj<> endobj 459 0 obj<> endobj 460 0 obj<> endobj 461 0 obj<> endobj 462 0 obj<> endobj 463 0 obj<> endobj 464 0 obj<> endobj 465 0 obj<> endobj 466 0 obj<> endobj 467 0 obj<> endobj 468 0 obj<> endobj 469 0 obj<> endobj 470 0 obj<> endobj 471 0 obj<> endobj 472 0 obj<> endobj 473 0 obj<> endobj 474 0 obj<> endobj 475 0 obj<> endobj 476 0 obj<> endobj 477 0 obj<> endobj 478 0 obj<> endobj 479 0 obj<> endobj 480 0 obj<> endobj 481 0 obj<> endobj 482 0 obj<> endobj 483 0 obj<> endobj 484 0 obj<> endobj 485 0 obj<> endobj 486 0 obj<> endobj 487 0 obj<> endobj 488 0 obj<> endobj 489 0 obj<> endobj 490 0 obj<> endobj 491 0 obj<> endobj 492 0 obj<> endobj 493 0 obj<> endobj 494 0 obj<> endobj 495 0 obj<> endobj 496 0 obj<> endobj 497 0 obj<> endobj 498 0 obj<> endobj 499 0 obj<> endobj 500 0 obj<> endobj 501 0 obj<> endobj 502 0 obj<> endobj 503 0 obj<> endobj 504 0 obj<> endobj 505 0 obj<> endobj 506 0 obj<> endobj 507 0 obj<> endobj 508 0 obj<> endobj 509 0 obj<> endobj 510 0 obj<> endobj 511 0 obj<> endobj 512 0 obj<> endobj 513 0 obj<> endobj 514 0 obj<> endobj 515 0 obj<> endobj 516 0 obj<> endobj 517 0 obj<> endobj 518 0 obj<> endobj 519 0 obj<> endobj 520 0 obj<> endobj 521 0 obj<> endobj 522 0 obj<> endobj 523 0 obj<> endobj 524 0 obj<> endobj 525 0 obj<> endobj 526 0 obj<> endobj 527 0 obj<> endobj 528 0 obj<> endobj 529 0 obj<> endobj 530 0 obj<> endobj 531 0 obj<> endobj 532 0 obj<> endobj 533 0 obj<> endobj 534 0 obj<> endobj 535 0 obj<> endobj 536 0 obj<> endobj 537 0 obj<> endobj 538 0 obj<> endobj 539 0 obj<> endobj 540 0 obj<> endobj 541 0 obj<> endobj 542 0 obj<> endobj 543 0 obj<> endobj 544 0 obj<> endobj 545 0 obj<> endobj 546 0 obj<> endobj 547 0 obj<> endobj 548 0 obj<> endobj 549 0 obj<> endobj 550 0 obj<> endobj 551 0 obj<> endobj 552 0 obj<> endobj 553 0 obj<> endobj 554 0 obj<> endobj 555 0 obj<> endobj 556 0 obj<> endobj 557 0 obj<> endobj 558 0 obj<> endobj 559 0 obj<> endobj 560 0 obj<> endobj 561 0 obj<> endobj 562 0 obj<> endobj 563 0 obj<> endobj 564 0 obj<> endobj 565 0 obj<> endobj 566 0 obj<> endobj 567 0 obj<> endobj 568 0 obj<> endobj 569 0 obj<> endobj 570 0 obj<> endobj 571 0 obj<> endobj 572 0 obj<> endobj 573 0 obj<> endobj 574 0 obj<> endobj 575 0 obj<> endobj 576 0 obj<> endobj 577 0 obj<> endobj 578 0 obj<> endobj 579 0 obj<> endobj 580 0 obj<> endobj 581 0 obj<> endobj 582 0 obj<> endobj 583 0 obj<> endobj 584 0 obj<> endobj 585 0 obj<> endobj 586 0 obj<> endobj 587 0 obj<> endobj 588 0 obj<> endobj 589 0 obj<> endobj 590 0 obj<> endobj 591 0 obj<> endobj 592 0 obj<> endobj 593 0 obj<> endobj 594 0 obj<> endobj 595 0 obj<> endobj 596 0 obj<> endobj 597 0 obj<> endobj 598 0 obj<> endobj 599 0 obj<> endobj 600 0 obj<> endobj 601 0 obj<> endobj 602 0 obj<> endobj 603 0 obj<> endobj 604 0 obj<> endobj 605 0 obj<> endobj 606 0 obj<> endobj 607 0 obj<> endobj 608 0 obj<> endobj 609 0 obj<> endobj 610 0 obj<> endobj 611 0 obj<> endobj 612 0 obj<> endobj 613 0 obj<> endobj 614 0 obj<> endobj 615 0 obj<> endobj 616 0 obj<> endobj 617 0 obj<> endobj 618 0 obj<> endobj 619 0 obj<> endobj 620 0 obj<> endobj 621 0 obj<> endobj 622 0 obj<> endobj 623 0 obj<> endobj 624 0 obj<> endobj 625 0 obj<> endobj 626 0 obj<> endobj 627 0 obj<> endobj 628 0 obj<> endobj 629 0 obj<> endobj 630 0 obj<> endobj 631 0 obj<> endobj 632 0 obj<> endobj 633 0 obj<> endobj 634 0 obj<> endobj 635 0 obj<> endobj 636 0 obj<> endobj 637 0 obj<> endobj 638 0 obj<> endobj 639 0 obj<> endobj 640 0 obj<> endobj 641 0 obj<> endobj 642 0 obj<> endobj 643 0 obj<> endobj 644 0 obj<> endobj 645 0 obj<> endobj 646 0 obj<> endobj 647 0 obj<> endobj 648 0 obj<> endobj 649 0 obj<> endobj 650 0 obj<> endobj 651 0 obj<> endobj 652 0 obj<> endobj 653 0 obj<> endobj 654 0 obj<> endobj 655 0 obj<> endobj 656 0 obj<> endobj 657 0 obj<> endobj 658 0 obj<> endobj 659 0 obj<> endobj 660 0 obj<> endobj 661 0 obj<> endobj 662 0 obj<> endobj 663 0 obj<> endobj 664 0 obj<> endobj 665 0 obj<> endobj 666 0 obj<> endobj 667 0 obj<> endobj 668 0 obj<> endobj 669 0 obj<> endobj 670 0 obj<> endobj 671 0 obj<> endobj 672 0 obj<> endobj 673 0 obj<> endobj 674 0 obj<> endobj 675 0 obj<> endobj 676 0 obj<> endobj 677 0 obj<> endobj 678 0 obj<> endobj 679 0 obj<> endobj 680 0 obj<> endobj 681 0 obj<> endobj 682 0 obj<> endobj 683 0 obj<> endobj 684 0 obj<> endobj 685 0 obj<> endobj 686 0 obj<> endobj 687 0 obj<> endobj 688 0 obj<> endobj 689 0 obj<> endobj 690 0 obj<> endobj 691 0 obj<> endobj 692 0 obj<> endobj 693 0 obj<> endobj 694 0 obj<> endobj 695 0 obj<> endobj 696 0 obj<> endobj 697 0 obj<> endobj 698 0 obj<> endobj 699 0 obj<> endobj 700 0 obj<> endobj 701 0 obj<> endobj 702 0 obj<> endobj 703 0 obj<> endobj 704 0 obj<> endobj 705 0 obj<> endobj 706 0 obj<> endobj 707 0 obj<> endobj 708 0 obj<> endobj 709 0 obj<> endobj 710 0 obj<> endobj 711 0 obj<> endobj 712 0 obj<> endobj 713 0 obj<> endobj 714 0 obj<> endobj 715 0 obj<> endobj 716 0 obj<> endobj 717 0 obj<> endobj 718 0 obj<> endobj 719 0 obj<> endobj 720 0 obj<> endobj 721 0 obj<> endobj 722 0 obj<> endobj 723 0 obj<> endobj 724 0 obj<> endobj 725 0 obj<> endobj 726 0 obj<> endobj 727 0 obj<> endobj 728 0 obj<> endobj 729 0 obj<>/Font<>/ProcSet[/PDF/Text]/Properties<>/ExtGState<>>> endobj 730 0 obj<> endobj 731 0 obj<> endobj 732 0 obj<> endobj 733 0 obj<> endobj 734 0 obj<> endobj 735 0 obj<> endobj 736 0 obj<> endobj 737 0 obj<> endobj 738 0 obj<> endobj 739 0 obj<> endobj 740 0 obj<> endobj 741 0 obj<> endobj 742 0 obj<>stream Hbd`ab`ddpqvvL)1K5M1JM6NKIa!#gv]/ 1032r[Wd`_PYQRBHZIc##ǔTbϼĒ=ǜ bԢ2((Cv̔ԜԢ"̼<Gw= E`&`xɉ+b~a]g`;ӹsTJ=f^]K6>l endstream endobj 743 0 obj<> endobj 744 0 obj<> endobj 745 0 obj<>stream HTP=0 +<ҲT!uC/ҫOR@ OwUlyak X2X#<a;AFr=E!5#,Uyfl-D)@e !wGOCnGXO}> ;WYQPdyJH{x4Wxm;Nys6;YH|J! ht endstream endobj 746 0 obj<>stream HWr+l0憋dmzVJ;c$iweQ٤",3ӧ{^g/<]PI\,Yf6L~,g!ϾvNݿ$Vu4SE-ztb\|zWMg݊uKEFo!vzF87wd\MA[L#!:z<:+cvqݶYTÖ8:Rtys-k6*HD^""yOexga 6Kh~rvV۲_-^4$6C/ۦf^T25B9mF7C{W$t$ò~h^y)F[PZW>w گfυX܅\j#N ;I1 H+ЗƩ)XiNGH֒Xi#+"d<2|*Cq#ՑI2YfI'MRE ;~\=[,R VidR<QVE\X`WNS݊;a#9E~%^f+7'+PT6sʭlK&O*4LuYDYD*Dž*$Rk5\tLBzg4k2qg0$gÞvoz=u?0Wݬj֕5pN&~Oj@8噯]ȟ[\ZdB?YĖ5/66 L{#Xii#xpbʀ;e1MSAeU02ESp[KCVJv;+]_CIfQwڵj@UW9š_ⲬeIJiin<eSm@1I0- J yJmВ6_Cd:a1ҵ蜓ǷiY?/Mm7Q M3z+^WͦY=gVƍf*my( 2Gb}#?2&w2s.D-,bC9[EIY522 J [@FQBf3f|a32t~}ίz:4yhTV d`2#t)SCքP6?]A%?ׇrQa=G xǙ$P1DsN))v84.F# aq!£ ʿڮaFpap⏞r1wrV<'WD%^9IFTBђgok5r$o`M4$$/~B):n-.m3t=l?t4dIka8zi4(\>M 3[%~vP5  VE `@ *TJTWTK|҄"Q7@֢-v[֋r8XEȄnGx E$.۵ #$!zA$ XFV+)*bQtJ($O8a戀66jؒե̫k(%l~]s r :dxj VjGes7'D$wsѕG6Udb\B'#g赨Y6Gʤbx(>Ə3Ѽ4TQuѐna5uj#[$egU4](p LQPI*jQnhZZ UJhnp,ĶٔaZ ݺ+%=aļT ]Ya cDѻEKkGvcyY뇅j A@d3?<jAo0ߔMWx?(^wd)\sȡ0?ƕt' %:>X3*FRx ZGXTT4XRRD{>@,$l-VF@ N#&' ܶ3v}nxXOW~ǣ}(0eXr/2eЉ.j Sߏ8f!A?<Ҭq\ԺelwqY)V˒ Not_ 0Al endstream endobj 747 0 obj<> endobj 748 0 obj<>stream HWɎ ^ 3݄|P@jElR= EnU, F:4eFd˗Y˟'˿N>U֌ͥ65?O|:l|7l_8.j國㟪F֦:5f}~kᵭ4kWOcېr^}}uW׻YrWq[s%=)eu~KZW9V,j9,3F׊1IQn\#f1@ Q5OH|:*gx䫻YMnqPa% f 9؛ӜAj!P_#b!gs>b>2q<_ +Yn:7ۻ_qu WDi3Vc0,6='YMa)cQrF SDq"b͉aǻĤ%m-yS` |ۂ ]mYS>Ӣ" j@* XV9㌨D)Y-\`Dz(2#HK;Ks:= l6P$&m"|Ir ejc/UXjJ%!cIIPP^U_}C%z4}騧Сd0c2eF܇WϬtdtl7FO;L6\e=H6:Í@4 R$-.YX>9QBT\ӇԆt]ۯ,<OLz'.DtAIi{9aP,=aB[+|)x8ZSCK&Z!(tچ$,]_/1mhcRtϽf)5kJ7UqrS30o,Ƅ0VOOLa =gSf.w JlNaS0죬6m{iW'GJ<=z^wUv}:|Ww>==y>BA>7aj N~MH?ˎf+ 8@>Xɽ XkXsi6kDޟo~y˧?{;yӇDNV^M?3pָ綆j8Q~! c$3M<,6"t?)g;N'`k393!?͡[/ų9r95L{]`D@+6ŜНY V8',Mq"};{zN _s>S T dP-.cךyЦ$NƅrF/alk B] MAb!}܄҂H)h4x)(l)7i]bbit tc.diPޠ;J)YG%ᒉSzVX;Ӗ|!:$%%g;VC7P"$! X#݅Y ZfD۞ i@RAT.*@ Ɖn<^*E.*(HR} Spǃ -3ftcERWwE[La̛QŔ,%Rb̥EJ/,^WH#/S7bw7BaD %_Bqɶ<qy|b5u8qU֋MCDpD6KYg \>à W&Q*/}P \$?0 ѫ;DUW~ M$==_'%Fb遱m!9 >.?YnO.LZd3{Ox5,=뮙ƬV;F#mWW"@ܬDDWS<~#P:%3}WPeR <neAQmXɲ!YEwNѹ\<-e2p2 m,#fyt}|M[;D:SO__n5 endstream endobj 749 0 obj<>stream HWv}W2a.~B˱+u%u5qE8$@?_}f(s0s=g5^1nrMVM4"nTYﵞm'̟?'GWˢΗd<ٿAb$r%˻WrW푮hw/9RH蟻s^1[](l\@6e)cIr./J\lm5<6F"_Һ(wM^mq8૗'QͅsWνDMчo'h"v I`§v ~$ Mff]Qf v[/wMPFDy&|츩U Yq: yhj0rT&?e:Wz܇lL$ĊY2p)duZai_[eU}[,9H~y!\ ᴒ|P ϖ\8+$fq]MuMRAV]_l75HPW֘sCH%o4\}:9`ZL)E(=:x2Z}e宮#%$f4E|\겭z]B$L%1r24C@>I95xa+LDiU٦qAF_C0FvX*x%!R"U[VћP=@D747sAM}*M,/HЫPU&Q F,I+rc_bQݭNP_^YU|x%jX7yiÎv„|u~_W Db\2}=֑0*ѻ.ogNA} |X?U I[2f{Wm>ՂTl8EZf93,AG#s[T-pV9Pvo4[3T@tR/XFjp9s1;}z=wCPyi;J4'?9j~sL}R?YCB*ƴfkLkXϥP|sFQ%o+׌{V{ 5` B|{6ɨ?;<}Vǵ>ߝM2etҬD;)kX?~% [/{;RVUH\Xv~8bl,:2Z+Ϩ%Ѓ.F/n az5WfY@ M?s OzS<3X!}Q1CAlGj^U-^mz?+z &=leq6A4OnMV 'TOݍG|im@k=ZܬeWb![%`rbVGEU۰GCd9o{&#aGxX=}XxHѱ@UNXeֲ.Wxvqx=Y:ƙQv32u JЛdFpԁ̀86'IeNӉ^Pлi%A{69#/ j%MEaY舳e6 2f8'q*gƒwٌ6 |БӨWZ:6Yf8بiRH=pŸ'@iیS߼/CfAR{ik}q<'K8CTb iYR 4Xe>kXHl+].2;n]=^鏯>KyVF0bC2H%vTsv`.Dl1/-csb?a@S2ll@ YF'] ;7=t+dA؝t Fk k:i=wiGfu H#qcyR;c$. [ӞNg!;Ep]%.'KNw"78Ql՜',ck&Xw4"$9h~&dBXLzd^qSWnkP!”YValH7mP0)-+Mg:+EղTy'&o^Te pF}dRO `l^n7b,mx->'>0"4K ʸxqC53pAtP#C(No*+hss)K[ġy 0 endstream endobj 750 0 obj<>stream HtWInC;@?HΦr.lgeTY"S(kKW0Zc~>>9_sALX#&n=/L!'4X*ut:0cۊUb*Iv/]}(QtKMѨq9}8Dԯ^8i^ƳO9gM ]}D7ٙEu ny)KwLsuz/~eZ5j2S1=WZ|ӸBx-VVjrBz+7f)ҁ?bƢkks"flČG`YKr+s@ mqcv.ԔL'_R7<Yl \kD0 B-ks#^n=,BVfdk3JUMix< Nϐf|}fTs<1sr,Pf1.;{؛G3>uЍ!r1,0NE>"r36Sh螦 螑WV>&rKV|oCۊlErf೦_=/8Dڔ[Xʩ-)b4UgN`:?+Bܢ5e7}uSS7wu_M_F7)n+% WgL_3壞wTq]kQ]xmDye+F+*Dtu˫3&tzk-# )K4GW#WR|.̴L 0Dڤr]@uuZ>h+uV*[rƵ50RgdT_z)3|3HR3|9L[ n]4.SFfSuՐ2NҊ# tnw E\c3 o| q1/'H@ &1|]_,n>ޣΏ|\0N2.u+ MXS<71jsPĭ1+aZ iA у)m$Cˌûn23eײTe࿎F'W3-e;cJ ft,lBhQ##5ʳ%qxR"9J =D*s")ҺylKjzÜx.مn]oW?n3&BzNu:T3vvǺ3cphnt~O`L0o)B^3g;xW4qzjp8I>;Hclohzfx*{0#ld|6"]>w {r Q<GXUY+*MOhܔiiz__X_xEɗ0USUz)-b#G>!j▐o1taq%]w yo?Xd m{q{wGdA>{̉` _o2dzwL))ɘñ(Qr0<EdAdK +U>a}aԊsIw5kP]N;<8~2F< &~j60o*ᄍϷmƚ`:#%ADãLq<=~D"k9 R/O0ۧ3U|!r0 l!{CDU-më5({M w{;]FzY1EMh"9n^z|_^ endstream endobj 751 0 obj<>stream HWI3 )| cd ɢ}IR@6JQ)3S{ԔP:Rg)@.@=c)' Aٹ;G>s ڤ"+FJQ d x~Aϑb:{A|y)|pro'g|A+xPdׅ]J'p=]xzrGJ,vΖqmЙq 2b ~C&W:) ϖ$ &"hυqT78̦Y i& +\T \fvBm:{'b+g!#[~"ƅFId _JB 8jRi/G*4ZCKJ4vE0 =$z5,D)AVm "x[IϒShL1YQP x`wvU:WEO8뜓rQ$I3bх'ژf5DZţD>)Ѫ} ѭ$,2E{Ewu5:i>H; Pc!HS$_IFUF'^FԳ4iLDȟ'Sދ/i/܁~y!,K3"G N G S46ݦw "k6oYcDƨs h]5,C $8|Ȱ%L+~,deP@qGmw,no:4OXWkN\ؑQ@(6M:v8O \ ia9`~n$S(pһ^_dlh?}\.*Y*ZgQ+iϣ#]¨r}PٙNo4UVL ʫ" Ŭ tz6Q.aT>eVgH[&|ȴbJV^>h1kCIóiOBaOBSu6([PA1:<:c66`6n"ecIcjQR'!Ւh{==!hTmҍ?n Cd ;w8 hN[xZDp7mtw!R1o-bS_abV,4mܹu4hsɿK7(6uCh{ ]9-:Hem7#~σwA*rhdL6 4"f؉z~*U2J2]W7=RȕW-Uv&&FKs*@.p6S"YPÍx%J)" $!@jr8F_Z=Gxdt*@>3-tbEUdc ѴYeoG(IcG2&]2ԚlJv P- )(Gx:&ȂY_ HSuP230dq&CQ@*H9kh ~VE  _6}Hq^ ,hӓ$hXc,-o",R<OCu`*Ə(|}Jnw/UvخAd95iVjCeQ4(ž[i=B s٦&Q^ B L c.&KLĸz"G:lvYN'1tTJ5'̣pʲMF)OT=m<6`[l>g#>m:Q4[JtA"bUE pwA3e޿A'+N oxܼ&Yx\ o"s?.H endstream endobj 752 0 obj<>stream H|Wˎd W;"lR3 v8A~?骻YLאW|T/gKENjqf~[zFYxQ&`|r6;'I>^n#lZ1L%gI|0 m1S 8k>3>e5U/J'9*/(gEjI^L)1R2$됓{;Iҋ\#OwTHX,Uo1N3JAHtit"ͤIb,FXpx(VIq]P8'3CD҂G]}y\'p`l⇝^#O Cs,]a;g- Q*1@6.NtY>1@sC - ^__nGHL+!cfl<1myf,'47VЏHחم ctxҭ7JHf :QN|*MYC>ʢ@ G :҃q@N/iޅQ;I0̑cѮ6h^:(Ȧf#[/ /ɤgFe};lAU^4 nJGUCr+ó)S JgkS6Vktm!Dh`xq0x2J~hñ8ITQ@4'+{"M3rv Qj Tœb[.z gvg<#Ylw92._t?!u l%׎Z )I} Ph*vvQuG1q8\LgtfS&nWvH 6N5";leejkxhȨAkT+]=*y\3&eNm_1w/3M}^8t )Tg{BrpS;9[ЩQ'Z{Llڢiݟ?}ێoçJgo R,`YRrk(wS1y^Ӄ u[C t?(&@QYY31'?#eׄc]wlb "㓶`0s!b48>)' UBZE,nh5zw2bWX)o,V%ܢ7 mvL0UNYܾW:~z|퇨YэQ&05UCHaM99#,t2_L񗿦~oR{AT_i$Vf^3%ǫrʖ`>stream HlWAd; )% ii4ߎ!UQ*A3 6񰯸mί1!_\?4vL%7dm7>Y\-fD vy^βpM(\m@O< V _ ږL禃j/+ Sp %BЈc /yꦼK^ƗbΒ +,5'x/~jOZ:Xܿ ʺ*3Зy :!MuDy+R!2oZJ4 6PGa()0<];qGCW߫h Õ@J!})%P-eռ,*'1f+^!7mޢfJp%!+ײXK u`1QA`^IA܈ -Ov8$ nv4 BEK zdu&xق|~BS*L}7b˟wLX8~74'Bqd'M[LZ|(Iw#/=+'5p!窡dIDqUD)jUT뚐<"YpИɐ4p*Cy~o\MsƍRd"A~) z+ԕ4#͘ʎ1\o31SA7a*kc1֓gd!es!>|W1(G>A.뤨Oi4oy]Z%Qk=Cnč]qh~~h$}8Qh^^xO=M~n: ě&t=~Urv|sEa7jߕ ut(DGMW_'7m+' `+$6|!e)n,3M3pֈIMm@F*!1;'69B}dҊ15zg=Uk7􋳕/g9ƭkY/s^lՒ]⋫ܐ#?9WwnzSGHi96N&jHqM:ClNR+K;$^e=Pˋ TC+><ӻZqwQ|Do {oyIE*KF^]7;>Qj="i? "JPy?`l0%v "*~E'|w!$j r ˝K.ɩ%Q)gyB?Nȷî+]5|eb5I:ԋJJ`}?|m}87gY{TݸaYy_ū0WdaP? 2@넾;Зw /xt .B 5V>@w3=?T!"kM}UI[[g=7 _aѸUo{=Egq߭/uV_nz܅dj?4GLMYsr'\Nrv`lG{OEYK&;_F,JT3Zqc Fpy*5)6w 4,W\.ɛ-k^/X՘As2^W6|` Q[L5[젤d$b-qf^|VŮ BjLK3nr% QR֍г=* U욚݌mw}Y|\ RC " Q ٮbHԺ|؟J6~kh1wO\Es):^+ہ|A^dxX,*G΅}5J肅l|AWYϡ c31B3 1 =W䵵*1y#w #/)@z.#"a3;:sd37S<>Dq4}V22W\C#e6Rzɶ6,_[(>ZoR~yh?4I ` '}u G$aL/`Vz#@p&Q޸gm%{zY3CF ԪMm 5z$Y8Rb$Dd׮&&g19&@*AԀpEjN v ᷺ݷ∹qxAfE ދ}Oija*.s?Yᅟd*~eK?`5 endstream endobj 754 0 obj<>stream HtW;C s)K2v9)`ItIG| ̿5W.6Y_?ě&#K#,J=Wmub 9Ȗ.THА]Xe'W^oNH Zfj։|avZ`FqGlcR=۫@Ϸ'lxgYՉ~kJV9ivOW!HAԪ eK|2]K-h/d9sj1') /p| Ri6+L :;0vdbhp@fuC߮?5h5;Q2?Q@:0%wĀl(#륹LV#WI!V:{F]&APMK0ZLB{⋓*qOfJHv*CƉ;b,f۔QMN N tby;!/ :2ʭt),|O/ܗ< u!Oy-œUiˠ1 ?G5ۼp~$J'nqw(VḞOal W󡱡Th=;kƢ9*Wv&9TAUBDკ7Q;C.`~uaj;}<-l?74o:Pjk(}c}K͟0U'm\Wh;rWv 0Dg0~ׇFk92 qxFf2z'c,\g~๐58I s\<5HUYΧUsmw-:=p0={ۅ 4?CmZ>JJ0 4F'L x-LƓ:$h- Pv )pOsw[Ŵ$9{ƈ;ޑ9[kmAWߊ4H̘3x% 'B6M< X2MC,}T962/UO1D DXb _*p9q?q&o8zj>L軨5wvEϒ L W ʘwe# y qv}/Sc`mƐ` 0d%^;ia?>" '8Џ!sY,K׋7|H{T8nDAKR ^gJ . ̵ם\JT|2؋4U&̨.!r .|d"5|skVˀE>stream HdUiTWn^7[uK#B/,aёEn(*,-H306KD5* j+*ģBAP0 12z[x3??uw}UQTM0qLt檤Y6sp)0F9dA%履oƽB*1jo:rW+>pS`Lct=f6mY11/H[a 4ss >ߘl˷9V)P>L[n͑es+3.Kɳ{#8.o;aT aw_ R3L)^`4kyGSeΫZՌ:IS}IݩXn9n5DhjNNc?&JQLkզjhou#uZ~]>}GGGyszɃ[2An)Tϋӟ_583mSi>!P^ă^D([A(蚌D6|̆aJ h:{8\ ~9`>I0$$h%E -8[ŀAhF#uZo&΅6b?ݬ6@ fB6ua-=ML%M9N\WMh9oxQ2-Q, [45 Ǘ`N o5\ިC0ʄ^\*k&'qᶫ7K( j,0m%F ^A@|i.9V$\83=Z8T|*^h@\٠+V:"TCHN҅_8pwa4{鼘٫JEh'x #.!t,CPqE.^SBRcVLx_C,rc8fc:P ! ]Rq;%Q^A d(i]JʡdTs7YmAzY_!~n:XZN8W]4mFjGwOۼv9%n)tϜ1>- _=3p؟ 48Ik+n />$ t7yr~JT eKd/|>dqTXm8,g:rFAO   z)EDve/!qH./KN0`:%ro&EgGH\GNi8*)7iaǤL7>rT}.sKh4Gᙽtf{PJQ#DJ^]C3!DZ}0EFNMDЮ"i 2 ?fW ,/;?oy9{ɀgb!0'0 H 卤 ]_w:^֧~˛">!1C).37P' gQ_O%WujWPZ hA FFԉuX ߭ZH7agBY=6HD: Q^2OPhq( gf:fhtQBF֗h%XiئM1a :}鎈 -; 1X[}\sC?iå>>;ʼBw5, ^`BtUzriSЀ)}!9=Cp{L)GyPngr-m:,2#J?ut]ilSZc5 |5v^X2AdO_:zņ8@jfT\e!‘6<\"ġG2!!ɪ9an9Ymf'H 怨4: -C!uFE3GXXO89- ]v+>stream HT{PT { ƻ{ !JEQF%<|@( (DRGK"1> >($:S&դo,ڙtG9;Sq*iupЊА9)yo'{0gET)S4)+#iX~DH9O&#tps,N//)>s~wUOE}Ss &sB v"Cfa|"+~)f%PGo ΧVxO5 =p B}q2Sy}斶smյeߪ?;-H .`9{,غDƷ)T{\bހ0#,8捆%oJvⴑLi8k]mpж}H OC]WLtԍK+egKOOŠ.W?vI<ٽ{mxoP[(4ӲHw }ϝւ˄UU:K[EtRHe[EQ-Lc\']2jeCM}urѳ{GAM,x3`{O$L@A/WZ3tW0< WЎ̞-ܜ!_`n,50X(L+6CtzHy#1]^IvH~4^B=EN&l$ nI]](x,g^k!g'<׼lC?![$M;̢M1Mb5Yc tS \R:t{t j \_ F abE;-!lLzM?GG]Ȗ 7/_uGyrRFn!zzKp"VDo͖gmg_ĺfTTjk )Sv)vֆDμ+*۳Yni}\L7Oa2 3Yuri@k 'J;_7%  & endstream endobj 757 0 obj<>stream H\TyTT} 0<@}{0&))ژژK4w7@/u7ɑForǓ~CڞcyrR!c3g)ҚQ/r_g&%I_Ŵ`]4`E$Y8fj(QY1HETF6l<3s T|8xT'u( Ev&q(Sx ;|OD:(:{k5MQS%t/tMCUX$2KCufbY)TKl&sq \"42]3@ &;iձ>. >$!{}iXG@5dmR*4rHסgh쇾@d|a=5!) kl"pm9&,ȂI>$6:Ao 0YS'-Aqݠʡ'4`\|4pLKH0x ]+M"Ʈ` @yP*fw\uS\hj ,]?Wz#7(SnLrdl="SGJdP> <51 x DpzsB=Aץsф|L9%C(-ȏ1bpD>xmX~7gKc:l-q|}CH8fuzRR%IA0˨a ڻ$>k|iFEA0dPp *u{l`v$^%6nFW2dkWO: ~I!K[:T/ЋL,!r޹&;?ԀGAi\5$pb˩$*:$0:ԡ/~ g@.15b1?B.MF:i3Pn L@nI#>%<rHJE""F>r 2ĩz|LNA3#sn+GegJ@VSx5WyU0\ya'6: t`)ݹtIЭ{? =(_?ӗaH22}hS G.j#.6VretY.6QXĭ\2=ORK|D?V8ܙ?b%gˆ1ħ!:`GoZT/)UIk/5L/pNO/9ts8(֗+"iR_H)Ng9F]+W/UG VC*C꤈l37ŕ#mAF>Lq}P # 8,Brr"+/"B@  oc"EPbMtuSְgɟ}oݪUET~Huj*#kh@-n⺜u]F<)ӝ.o(xQy3!LefߝoB^-#&u\_zVO1yMz-ZQ-)$4v/E4+Ĺ_#TYg`^dL38̩qJ\xE(_=1(:pA 27eBR.&9Wҳ8Ca0Ԋ,r5րPtpK *cEQjPZ#Cm{1VFy-2 s& ou!D/ [;I,,y? N0 {~QRԇ~ŒPvSͺ'am?y2Ԣd֏Qu QԊsq x[kӆ'>5)-҆{0K_Pǚʌ%F~w%[ܡRV R)vK% Re7-Ր*xoZ0S\r+NmM JJ`/9CHamp7h4ϷT*;ͥ/iS@Ѿƙ Z%i=R8R[/;۹01x?[Cٖ).GCzj7is2dIi-Ҫ9Uo~gYCv^Dp %Ҷ@0e6a8$N7IZAj ڎ[۞ &ll2ub0ӿnV6){㛧FLzv}X ]Q?ao_Ȓ|^i)o4%.ȣ.;>]w%)Ã>Yt'b<~ZJr0Km۩\V}hThb[u[\jQF WȦr_GQ2E&{W,/(<$v#Y^L'wַ}C 8ckz[YQ/0MJO8,iêi_[aoFHZ"C2!f2@C[2[{5To;r(&Ak]JdpZ֟%e&}A03$]/| endstream endobj 758 0 obj<>stream H|U{TT*..6.,I!V1r04 k&&Mc51V($4c}">.ѦgΝoo~3WȥD"δ̳ΝXPz4۫|{@#h$jS* F\+T"Ik֗(\?=1Ƒ:j>h'iJsV痖)-]g+'ZOu/קme>VT`[g+[a+,/.-/,Zm[ONa({Po#axHW 1f0Q,+a,l)d4)e3ĈNPBrH*JWKei}FY%%'?_*m`?e$GU(RVRf*?TyLH83YyW;^{;;{~6 >>E WqqfsEO˥{tf'bϳ#,C\ODXe0:b X 3?"&,HLP P-Eou8 `g`|$i"@ K&G|r±jʍ} NܖB0GH[VtU ^b9ȃi&rԘT jL&9cF ̂ 9:n@aXZՎJNxɋI}?^l={f;xA5 r8y4lӶ!{l47zR B.B9ᛞDAxwBoc:0ZߌR7ḭ#22%CMιwuЉ'X6 %D{m_!0,qPi@ GA4,ZXW;C 8Dm&Myo$-: P2z]R7\U;? }8`@}|_ GamHإN|xa, \Io&e+#tlXu)f(⚞]?weqôP(l%_O0$WhW7,JY0Uϸ2AP|N5OO?үirnԤp/x#b'ŠT#QW2=|2!&vbcpw_kAЯ-f-VmQbpS!OB܎"6tbmPK h)fzrj'?@ #m'xеN>,"s 5I=TYpGz(Vr+bߣ.p=nUrW;[$A(q +*+ esVaA.lu6{ t$48h'Iŝw>fL_}DxsUJZM// W:&ܠ{ve;B%Rr[N\siJ^C;j'EO-p$ϤL33u= y k'8濆ӡW~8|N:JtN `r; e]}:*`[$oC6-WVc2)!uӒ'iꏩEJѻuDí<=Ň$ | S#LQY8Bl.AF &T033~޹v-Vn{=~9Ze9PEǎ]98`;|?IXq}XpPJ:SZ2΍E >zn71 NBoSr`2d ]aݥsB;w˓N71tiқ[ |Mw9J<9V=sRnZrT{zT/!MB~)\ca(5B,t֫?`i&+)'4N1 ;aJ.(\^ڙr\F~j!?p;D|0<36&V!"X򉎫-,|E%4?2s cQ-7k>Z"w< 4bOs(N xGDo_P_Õ3}\0zdh vC-[0y-,]a%yh;I k1&3 ry\4a=[Ad%SlaQ bpp?A" pȢWHE@ ҶUºKK]>stream H\@@$9OWs,]՚Vӡ+L4B0URQ5 !rĺ eۆM[һr[vi JGLGc2'ʹhM\&^oMoqF)e3,ٜDN}xcѓWGO^P\Y5 w0}u8Q+\)+Ɇ:)9nrvܲp=ٓ|`pW=^B~;R|?\<h.N8_%| 0RSD endstream endobj 760 0 obj<> endobj 761 0 obj<>stream HUiTWn=`FBҮfqHEQQ *44(͢l+4bEA8 :sj&sfqf~Su{}]{ID2*<`VhPD̰/&{ikhI1hqG ZU17fɾgi4Fdoo6rwssWǭ[V-JKWMSĮӮ_]sUUiuZi8uj6AUh3b֮J$STACO o(0%qb 02&PK2 Y0KA #c\Pf˴K%tK*^24dcͤA6QAA\H*ёCt]@C z9jPςh$nDٸkIQWV|cy]tLMvྦྷ&33TQRXhlr VlMްp ?7qB;?:p{`PN&%0twmi+jE aYhf&dsEǀ]ҭleZ_[r`R YL~(|##lzcEŶL! (( h1)J4Jc)D~ýG|(4F7Bah3(r ԰PHOl3P!Ԋ"@B6`w]zNqfGĕh5 o7-ۘ/+P!#nmjRRqw=#śvnvTVUU*6.W)m,?xPWd?MUKBF=cEsئ'`#adEAJX.س#[p8 }q*.5wx]QN )x9.<[n/b0=FRl+ 8Qy ꚸ켂l>_*Q-ksS BM2.k^@>ɛSωp|qV^h8]o5H$oIؙR4ߑ{_rb͡a'vSftgiۄ˕w7/:< D́DL^@Hbje#">i5yb/:@8y8spໄl8ͽosm.+"u8,NY_we> ;X :omTncڰ FSa3_ K5rZN:2^ɌkHEe!G)Ű^&q@,zgOsUz΋Q%bKFQO9a^S8ꪲj5HAV 𣏕ul?F*fWx5y\^NYYBvzl bA.8R[FKa endstream endobj 762 0 obj<> endobj 763 0 obj<>stream Hbd`ab`dd pqvvL)100341562Jf!#I[wv'8}s~AeQfzFJCK  ii&u SR+KRs< KRSsr@RS@` =R3SRsRS\Js32R&AL(3@Pr2!ߏ=k~Xs;w@:m+!l[GfcK uX &`r endstream endobj 764 0 obj<> endobj 765 0 obj<>stream Hbd`ab`dd pqvL)1LIML21162Jf!#ꯚI[w v+8}s~AeQfzFJCK  ii&u SR+KRs< KRSsr@RS@` =R3SRsRS\Js32R&AL(3@PȤ}w٢g\8 lŊ[cj9~~(iXG^w [}߂b0Mn endstream endobj 766 0 obj<> endobj 767 0 obj<>stream Hώ0<%M+5YUD)]ސLVSqx-j7|sBրd;e OJTU/;VjUwy׸P&]AEe7Gݧ9%C ]/?V ɔeIlh&){Cgs_m뫷GZ zr۶eYie|2i+poPt Om&jS6AWW5'{0/L|Y#ο;&LJ!* ۸."A}@ߧ_\$ME%&a䠡!I/V2rQhU. Yym(:;jTal_h> endobj 769 0 obj<>stream application/postscript Adobe Illustrator CS3 2018-09-24T14:18:04+08:00 2018-09-24T14:18:04+08:00 2018-09-24T14:18:04+08:00 256 28 JPEG /9j/4AAQSkZJRgABAgEASABIAAD/7QAsUGhvdG9zaG9wIDMuMAA4QklNA+0AAAAAABAASAAAAAEA AQBIAAAAAQAB/+4ADkFkb2JlAGTAAAAAAf/bAIQABgQEBAUEBgUFBgkGBQYJCwgGBggLDAoKCwoK DBAMDAwMDAwQDA4PEA8ODBMTFBQTExwbGxscHx8fHx8fHx8fHwEHBwcNDA0YEBAYGhURFRofHx8f Hx8fHx8fHx8fHx8fHx8fHx8fHx8fHx8fHx8fHx8fHx8fHx8fHx8fHx8fHx8f/8AAEQgAHAEAAwER AAIRAQMRAf/EAaIAAAAHAQEBAQEAAAAAAAAAAAQFAwIGAQAHCAkKCwEAAgIDAQEBAQEAAAAAAAAA AQACAwQFBgcICQoLEAACAQMDAgQCBgcDBAIGAnMBAgMRBAAFIRIxQVEGE2EicYEUMpGhBxWxQiPB UtHhMxZi8CRygvElQzRTkqKyY3PCNUQnk6OzNhdUZHTD0uIIJoMJChgZhJRFRqS0VtNVKBry4/PE 1OT0ZXWFlaW1xdXl9WZ2hpamtsbW5vY3R1dnd4eXp7fH1+f3OEhYaHiImKi4yNjo+Ck5SVlpeYmZ qbnJ2en5KjpKWmp6ipqqusra6voRAAICAQIDBQUEBQYECAMDbQEAAhEDBCESMUEFURNhIgZxgZEy obHwFMHR4SNCFVJicvEzJDRDghaSUyWiY7LCB3PSNeJEgxdUkwgJChgZJjZFGidkdFU38qOzwygp 0+PzhJSktMTU5PRldYWVpbXF1eX1RlZmdoaWprbG1ub2R1dnd4eXp7fH1+f3OEhYaHiImKi4yNjo +DlJWWl5iZmpucnZ6fkqOkpaanqKmqq6ytrq+v/aAAwDAQACEQMRAD8A6n5287+YdW8xHyh5SJSZ WMd3eIaNyX7YV/8Adap+03Wu3zKtQ/kNBNCZNS1maW/cVeREBXl3+2SzfOoxtUskvfOn5ZapAl7c Pqvl2duK1JIoOoXkWMUgG/GvE/qUPTNb0jT/ADf5diiS6kis7r07iK4gIDFacl6g+O+BLxvyd5IX zB5i1jS5NSuIItNZxHIp5MwWUxjlUgdBkkJ35m/L3XvJ+nPr2ha5cP8AVCrTxGqtwJA5bMVcAndW XpgtWYWUcP5i+RLF7ueS0lZw1w1uQG9WHkjdQdmrypil5p5F8kL5l1XVrObUri3TTmAjZDyLAuy7 1P8Ak4UJn5v/ACl1fS7e3fQ7i81WWRys0ew4KBUHY9zgtXoH5k+U7fXNKN5LdT276VBczRLCQA5K BqPUH/feIS8q/K7zxcaDq6w6hIx0fUX9KWRySscq0pICfDkA/sa9sSh7R5t8rWvmfTIrGe5lto45 lnWW3IDEqjLTcHb48CXkf5V+U4te1S+nub25jOjz27wqjCj1eQ0fkD/vodMJQ94wJdirxn83r7Ud Z81Wvl3SyzSWNvJPKiEishjMrA08I4xT3OEIZh+UOvnVvJ0EUr8rnTmNrKSakqu8Z/4AhfoxKWUa 5rFno2k3Op3hpb2qF2A6seiqPdmIAwK8k02x86/mZNLe3l82meX1cpHDHXg1OqqgK8yO7Mfl4YUJ pcfkTbwRerpGs3FvfIKo8gHEkbgVj4Mu/ffG0o/8mvNGtavZ6lY6rObmTTXiEVw55SES8wVZurUM exO++JVL/OPnPzHrvmVvKPlFzE0ZZLy9Q8W5J/eUkG6InQkbk7D3VXRfkNZSxc9Q1i4nvXFXlRVC 8v8AZ82b78bVLdOTzP5H8/aZoJ1R7/S9RaMCOTlx4SOUrwYtwdWX9k7/AIYoTz85fLEM2k3HmYXc 8dzYwwwR26MBEwa4pVtq1/fHviEsf8l/lZD5g8tWerzavcwSXPqcokoVHpyvHsSf8jG0Jj5W8i63 5f8AzIh4fWbrRoY3/wBOk2Qs8J2IB7MaYqs/MjVtb1nzrZ+TNPu2sraQILhlJHNpF5ktShKqnRa7 nEKpaz+SY0vSZ9R0jVLhtQs4mmVOFDIUHIqnpnkrEDbrvjasw8i61rQ8htf64krXlks7P6ylJXSE Fl5cgCTTauKXnnlXyzqn5k3F7q2uapKlvDKESGPejEcuKKx4oqqfDfFCIu/KvmXyJ5m0xtBurq9s Lpx68axuUCh1DrMF5IahtjtiqK/IWOO4v9dv5jzvaQryP2qStIzn/ZMgxKvYsCWIfm1bW0/kLUmn ArB6UsLH9mQSqop8wxX6cIVR/J2eaXyFZCXcRPNHGSa1QSEj7iSMSrzzyj5y0jyv5y8xXGpLK0dx NLHH6KhjUTsd6suKE187fmvY+YNHk0LQLO5mudQKxuzoK8eQPGNELlmalMaVn/5eeXp9A8p2Vhci l2Q01yvXi8h5cf8AYigwFLyPyXr/AJk0jXtdbRNJbVXmlInVQ54BZH4n4PGpySHpnlDzZ5z1XVja 6xoD6ZaCJnFyyyAcwRRfiFN6nAlkXmf/AJRvVv8AmDuP+TTYFeOeQ/J0Pmj8v9UtRRb+C8MtjMe0 npJVSf5XGx+/thQy38ovOE91byeWNWrHqumApEJNmeKM8Shr+1Edvl8jiUpZ+Q/+9fmX/jJbf8Sn xKvW8Cqd1cw2ttLcztwhgRpJXPQKg5MfuGKvFfy38yaCfNGteZtevorS5uWK2schNQJW5NSgOyqq qMKFb8ttX03SvzH1PSbC4SbSNTLfU3Q/DyWssQ38EZk+eJVkf57TSJ5Nt1RiFlvokkHioilan/BK DiEsq8j29vB5O0WOAD0zZwPttVpEDufpZicCp3iqkYkgikaCJQ/EkKoA5EA0BpiryT8g0jmuddvZ TzvD6Clz9rjIZGY1/wAplH3YSr2DAqxoYWcOyKzr9liASPkcVYl+bv8A5LzVv+jf/qJixCsD8kec fPWneWLKz0vy29/Yxer6N2FlIflK7NuopsxIwoen+TdZ13VtMluda006XdJO0aW7BgWjCKQ/x77l iPowJY3+Y35c32t30GuaJcC31i2VRxLFA/pnkjK4+y499unTCFSK2/NLzn5bmSz846S8iV4i7RRG 7eJBFYZP9jTGkPTtL1TStf0hLuzcXFjdoymoI2NVdGHUEdDgS8sl8k+fvJOoz3vlOT6/pspq9qaM 5UbgSRHjyIrQNHv8sKE+8p/nDZ6jfJpWuWjaZqTuIlbf0mkO3Fg3xxknoDX540li959e/LTz7LqA geXy/qRb7A29N25lBWi+pE3QHqPnih6bafmD5KurUXKazaohFSk0qxSDatPTcq/4YEvOPzB86N5x ubfyr5XR7qKSUNPOAVWRl+yBXpGh+Jmb9Q3KHpuj2ml+VPLVlY3N1Fb21ogje4mdYkaRyWc1YgfE 5JAwJeWflvfeXV85+YpdTuLMW80khtXuXi4OWnJHplzQ1HhhKHs1vYWNsxa3tooWOxMaKhP3AYEt X2o6fp8Pr391DaQFgolnkWJOR6Dk5Artirx/8o9a0aw1/wAxS31/b2sU7qYXnlSNX/eSH4SxAbY9 sJQzXzf+Zui6NpS3emXVnqtyZVjNrFcxlgrAkv8AAXO1PDGkph5k13TY/KU8l7dQWk2oWErW8Msq IXZoalYwxBYguBtgVhP5FappkGkXllPeQRXk93WC2eRFlf8AdqPgQnk3TsMJVU/NfyzeadfQedtD Hp3do6m+CDw2WUgdR+y/t9OIVDfkDIZJfMUhFC7WrEfMznEq9ewK88/OLzZZWXlq50m2uo21K7dI JrdHUyxxMPUYugPJQygDfrywhVvkLyH5Ju/KtjLNb2up3hSt5OjiTjK/7wxMUagZFcCmKsW/NLSd D8satpGpeX/q9reWsgaeyjceoCpEkUjR1LcTRgTSnTEIZ/5ht9K8+eTZ7fTLqKaZkjng4urGKYDm qScSeBIJU16YpYj+W/5i22jW3+GPM3KxnsnMdvPKpAVSa+nL3UqTselPCm6UPQLzz55NtLczy6za MlOQWKVJXI9kjLMfuwJY1+V/nLXPMuoay94/PToGX6l+7VOIdnIUso3PEDCVYpOb78s/Pk14YGl8 v6mWpw6emzcuIJ29SI9j1HzxQ9PsvPvk28thcRazaKlKlZpUicV/mSQqw+7AlhXmD8z7q584aTpX la8FxaSyxxXpSJXVi8gBCMwrsnUjbDSp1+cGp6bH5K1LT5LuFL+ZYHitGkUTOouU+JYyeRHwncDs cQqG/K7zN5bsvImmW15qtnbXMfr+pBNcRRuvK4kYVVmBFQa4lUY/5lWsnnex8vaesF9aXagtfwTi QK3F2K0QMtRwHfvjSpTc/mLfaP8AmVdaTrdwINC4gW5Ma0UvGrIxdRyK1qPbv0xVM/PnnLyRL5Vv 7eW/tdQe4hdLe2gkSZzKV/dtRCeHFqHkemKpD+Wi63pv5W6vf2wZZ2a4udOUryr6cSryCmtash29 sVTb8vvzO0zUtGC69qkEGrRu4l9cpbqyE1QqTxQ7beONKw782tU0XzBr+lWvl5kvNUBaKW5t9wxd lESB1+1xNTUdMQh7Hrv6E/Rc36b9D9G0/ffWePp+32u/h38MCXk1x/yoH124+rSu/p/XOH0ct8KG feRP+Vf/AFaT/CfodP3/AB5fWKf5fq/vaV8dsCUZ52/wr+g2/wAUf8cr1E5f3395+x/cfHirAIf+ hffWT0/7zkOH/HS+1XbrhV67gVj3nn/CP6FX/FX/ABzPWTj/AH397RuP9x8fSvtirAP+sef8/wBJ YVd/1jz/AJ/pLFWVedf+VZ/U9I/xP/vN6b/or/er+74x8v7jfpw+3/XFUn8uf8qS/Tll+hf+Or6g +p/73/3nb+8+D/gsVekXv1T6nP8AXOP1T03+sep9j0+J58q9uPXArFfy+/5V5XUP8H/8VfXv96f8 v0v96P8AZ/Z+ntirMMVeb+bv+VN/4hu/8Rf8dn939a/3u/30vD+5/d/3fHp+vCrJPIX+Df0PN/hL /jnfWG9X+/8A7/gnL/ej4/scem2BUh86/wDKo/06/wDif/jq+mnP/e37FPg/uPg6YVTjyB/gT6pd /wCEP95/UX61/vR9vj8P+9G/TwwKhfPv/Ks+Sf4q9D61T93x5/WePb+4/ecfDlthVhdt/wAqB9Ve Xq07er9c4/TxxQ9V8uf4e/RUX+H/AEP0bU8Pq3Hhy71p+1413wJVNd/Qf6Mm/Tnofo6n7361x9P2 +138Kb+GKvJbj/lQXrNx9alf91/XOH0ct8KGZ+RP+VX+q3+Fvq/1yhrz9T6zx78fX/ecfHjtilR8 +/8AKq/0xD/i3/jo/V19L/ez+45vx/3n+D7fLrvirG/+sef8/wBJYqmvlb/lS36fs/0D/wAdfkfq n+9/2uJr/e/B9mvXFU98/f8AKu/Sh/xZ6PqU/wBH/vPrHGv7Po/vONfoxVhGnf8AKhPrcf2+VRx+ sfWvTr/lfs0/1tsUPYLX6r9Wi+qcPqvBfQ9Knp8KfDw47cadKYEvLPMn/Kjf0lL9b4/XOR9b6l6/ Dl3/ALr91WvWmFCc+Qf+VU/Xj/hr0/0nxNPX9X1+Pf0/X9uvDFL/AP/Z uuid:A7354AFB96C1E81186C0E1ACBCA73DB7 uuid:A8354AFB96C1E81186C0E1ACBCA73DB7 uuid:fe3e98a7-5223-e141-97d2-3629640fb861 uuid:46322547-5fae-1945-9ee0-dc108487ccca 595.276001 779.528015 Points 1 False False Black Default Swatch Group 0 endstream endobj 770 0 obj<> endobj 771 0 obj<>stream Hn0 } =hf)N 6bAvh ,AT,i~H}vEn$E~IP2^G+HI棹l,ڛ{<,4iSc%(&q~4qbޝтmJi]פ>%mh$ xzԞ5N.e" MIdDΡNZ/FVf3_aC΄a}rx`3wviVuw'(BFBu_}݈| %5CV> ^P> endobj 773 0 obj<>stream application/postscript LOGO_frontiers_journals 2015-01-21T16:42:48+01:00 2015-01-21T16:42:48+01:00 2015-01-21T16:42:48+01:00 Adobe Illustrator CC (Windows) 256 36 JPEG /9j/4AAQSkZJRgABAgEBLAEsAAD/7QAsUGhvdG9zaG9wIDMuMAA4QklNA+0AAAAAABABLAAAAAEA AQEsAAAAAQAB/+4ADkFkb2JlAGTAAAAAAf/bAIQABgQEBAUEBgUFBgkGBQYJCwgGBggLDAoKCwoK DBAMDAwMDAwQDA4PEA8ODBMTFBQTExwbGxscHx8fHx8fHx8fHwEHBwcNDA0YEBAYGhURFRofHx8f Hx8fHx8fHx8fHx8fHx8fHx8fHx8fHx8fHx8fHx8fHx8fHx8fHx8fHx8fHx8f/8AAEQgAJAEAAwER AAIRAQMRAf/EAaIAAAAHAQEBAQEAAAAAAAAAAAQFAwIGAQAHCAkKCwEAAgIDAQEBAQEAAAAAAAAA AQACAwQFBgcICQoLEAACAQMDAgQCBgcDBAIGAnMBAgMRBAAFIRIxQVEGE2EicYEUMpGhBxWxQiPB UtHhMxZi8CRygvElQzRTkqKyY3PCNUQnk6OzNhdUZHTD0uIIJoMJChgZhJRFRqS0VtNVKBry4/PE 1OT0ZXWFlaW1xdXl9WZ2hpamtsbW5vY3R1dnd4eXp7fH1+f3OEhYaHiImKi4yNjo+Ck5SVlpeYmZ qbnJ2en5KjpKWmp6ipqqusra6voRAAICAQIDBQUEBQYECAMDbQEAAhEDBCESMUEFURNhIgZxgZEy obHwFMHR4SNCFVJicvEzJDRDghaSUyWiY7LCB3PSNeJEgxdUkwgJChgZJjZFGidkdFU38qOzwygp 0+PzhJSktMTU5PRldYWVpbXF1eX1RlZmdoaWprbG1ub2R1dnd4eXp7fH1+f3OEhYaHiImKi4yNjo +DlJWWl5iZmpucnZ6fkqOkpaanqKmqq6ytrq+v/aAAwDAQACEQMRAD8Al35l/mDrWneeL/SZYlaO 39MWEoLLwEsSuDSnxfE1D0ys55RsCnPzdgQzaX8yJy4oxka2r038uSYeVvzO15fL1vbo0U0kRkWS 5k5SSFjIzbnlTavhmtz6vLA8NOR2R2bDLgjOd3v9717RNTj1PSra+Tb1kBdR2cbOPoYHNjhyccRJ 12ownHkMT0RuWtLsVdirsVdirsVdirsVdirsVdirsVdirsVdirsVdirsVdirsVdirsVdirsVdirs VdirsVdirx7VtWvddKwamwmgY8fSChVAbY0oK5ymbXZZb3yaNPmmckRexIYT5R/LzzkoutP0xQ0S yu5lkaNQV5cFYcjy+JVB2GdjpNfoNWBKdSycIsb7eXdzaO1T2rDKYacnHh7/AE7n7Zfc9C88Wete V/yztLG0m4szKNUukkZZDJIQxVCOqlqr2+EZHIYmR4QIx6AbN+njkGMDJIznW5JJ3+P2LNG85ebN LuP8MW+mw3B0q3juLy7knZysLIs0jszcORpJsMg3Im1/NfXfTs9ZvNKii8tX10bSKZJC1wh3oWFa H7J7DpjSUFH+cnmVtKi1h9FhXSluha3Fx6jEszLz4xjqCFB+LcdMaVKbnX/NTWvncak7TW1rNbC4 hW6lH1d2uSFS1JBohNeWw2AxQj5vzou7NYrTTrOB7awt4Uma6lb1ZXCqrrHSm6mvWvSvtjSp1Zfm d5h1nXG0/QdIiuIlht7p5JZOLJFJHG8oIJQMytJxFDjSULoH5t6zqWv29jPY2lvDPc/V3tnlaK5i UkAMTLxRyK/ZX4jTp0xpXqeBXYq7FXYq7FXYq7FXYq7FXYq7FXYq7FXYq7FXYq7FXYq7FXYq7FXY q+ZvzA/J385H1wW2lXr6vpM5Jgmikjs/SHXjOnJBUdiK19jtmXpMWkxixEA/P7S6vLpsvF6TYesf lL5O87+XbGRfNOoW17MyKsPoc3kUVrSSVggcj/V+k5rvyWnx5Tkwjh4uY6fAdHawz5ZYxHIeKuvV knnXQNO1zQZLLUbh7W1DpK80dOQ4HbqG8cuQssfJmn2nmG/1v1ZJZdQt0tZrd+Jj4IiJtQV3Ee+K pDD+U2iWc8UlxqVy+i2MzXcOmzOogjbqSzH9kU/qetTaoGy8qeR77QF8oW2syuJLn69ExAWRyE40 QsgVloK/DiqK8xflxoKzavqV3q1zZWOrFTfQrQx8xIJQ3Q9GXao2qcVdb/lxpM8ty+ha5eWEbGO1 1OO2YLzlt1HUkAqxDVPbfG1TfT/LGg6H5me++uTG81W3SzjgmYtyEMaLXnTkXKxVNW8cVS2H8otN XU7W6uNTu7u2spvXtrWUq1DyDBTJTkVqoxtWe4FdirsVQ8mo2Ud7FYvKFup1LQxGtWCgk0PTamKr H1fTk1BNOeYC9kHJIaNUgbk1pTFUXiqGt9Ssbi6uLWCYST2pAuFWpCltwCelfEV2xVE4qsaeFXMZ kUSKvqMlRyCdOVOtMVatriG5gjuIHDwyqGjcdCD0O+KqmKrJ54oIXmlbjHGCztQmgHsMVQyaxpj6 YdUS5Q6eEMhua/BxWoJr9GKr7fU7G5EBhlDi6RpINiOSoQGIqO3IYqicVdiqHt9Rsri5uLWGUPcW vH6xHuCvOvGtR34nFV63Vu1y9srgzxqrvHvUKxIU/TxOKrLvUbKzaFbmURG4kWGGtfidiAq7DuTi qIxV2KuxV2KuxVIvO1z9V8u3Fwty1rLGVMMiSGMl6/ZqCK7V2xCpNKyahqeurBrFwbe0gS5tYra5 IAkdGZm5IeRUFVoteI8N8KozVJ31HyVZXhP1yE/VJ9QSIBzLFG6NcLRevQ8l9iMVV9V8waDNb272 UkOoaiebaXHCVldZfSchuIPILtRsVYjc3V9P5fuJf0jDKJ9OuGvIDfy3Msh9OvIW7xRrCUb7QWgA 2xQmsep20Osy3Md76UT6yjTgS8YmtrjT1MbuK8SrOi8WOKVM63ZyaqJFvTcWVtrcZhZ5DIFR7GQH gWP2DMWC9vDFVmka9DcarZsb9obHUbe4adHv5JpEpRkZwwRLdxRqBD2PhiqeeULmRPKSavd3k2oT y2/r3BL86empPCNfsqwGx7k9cVSLSNajkvWibUjHaXmmSXFDfyXDrKroUJdwgik4s1UTb7sVV47u 9stP0XVItTmvLrUYpVmEkvOF5fqkkiIkQ+AMJkVBQVPQ7nFWtPudLOueWpotXkvZrhJnnWaf1P3j w0B4EkREsSvAU+W2Kp/ql3p48zWkE90kJ/R98sn70RugZ7Y1rUFTxViD7V7YFSPTLieHTtC1eTV5 ria6uo7e6Lz1g9N0ccDH9jkKL8X2q98KoCO5EDRw2N/zs7rULsXkkl/JCpKOxgUzosrR+qORqKF6 dcUI2zup5Z4bHVtZ9LTuE7Wt1a3bfvJFkoInu+MLO0S9u/U1xSqWkGmR+YYnuNZmmhm00+jfNcmM S+nKytRlKqeK0Jp3+LFVLSdUt9Ritxq+sS2scenWslu0dyYBI7R/6RKzqRzdJBxKkkDuN8Vdok1x q2qQWt5q1wglslmeCKYwSSOsjLE9FKvHygCyMq0rWpxVO9E1lT5LS/ubpXkhgZZp3cV9RKqodv5z t174qxm00i5Pl+DTQy/4cmtYr+e7LgIsiQgPATX9q4VZD/shihXudfmhstIn0295XM+jSsbYSBx6 sawhGENePqLWTam5FO2KVbVJ9OtNHvb3TfMk9xMtm00cTXfq1kVl4S7n4ak8Sn2TXptiquv1NNQn tNT1y5itoreKexn+tNCJxICZZw6kB6NQBPsqO2+KpZpl3b3WoTy61q02nyPp8EiSpKbVpVSScJM1 OJLcCrcenxdMUKkWvXvoBZ9ReJ7i30x9Qf1PjgWV5lnkRDX0iyiPnt8PKuKVTVby3t7xYbXUJLzR 7ebT7i6mmlNwkEgvI/8Ad7Fj8SVYqW2p2riq4amx00agNVmPmQ3PAaYJjw5+rx+r/Va8ePD9qlf2 uWKtHUVljt0k1e4j1i71IW97ZLMyssfrlfTWKv7pQlKOtCfE1xVFTJfjWj5cF3dc5bpL6O69aTkL ARnmnKv+/V4fSD1xVmuBXYqpz/V+H7/hwr+3SlfpxVZF9Rq3pelWnxcOP2fenbFVSL0fTHo8fT/Z 4U49e1MVUbb9GevL9W9H6x/u70+HPr+1x3+/FXRfo31p/S9H1v8Aj548OX+zpv8AfirT/ov0X9T0 PR4Jz5cOPp/sVrtx8MVX/wCgcB/dcKJx+zSlfgp7fy4qsT9F8ZPT9DjzPq8eFOdN+VP2qYqrw+j6 Y9Hj6fbhSn4Yqh4v0V6R9L0PS5NXjw48qfF02rTriqqPqfCOnp8OX7qnGnKv7PvXwxVZD+jeT+j6 PL1P3nDjX1P8qn7X44qvk+peofV9L1Kb8uPKlPftTFXD6l6Qp6Xpcvhpx48vbtXFVM/oz0JK+h9X 29avDhTty7ffirpf0X9TT1fQ+pbcOfD0v8mlfh+WKr5fqPCP1fS4f7p58adP2a/5PhiqnN+ifTi9 b0PT5fuefDjz/wAmvf5Yqrf6J9Y/3X9Y79OfT7+mKtD6l6LU9P0K/F9nhX37YquH1b0NuHoU9uFP 1Yqpp+j+acPS5/7rpxr1PSnviqyL9EUm9L6vTl/pHHh9qp+3TvXxxVdc/o3hF9Z9H06j0PU4Ur24 cv4Yq3dfo6o+tejXktPV4/a34/a79aYqu/0P1X/u/VofU+zyp3r3piqyD9GfVG9D0fqe/Lhw9P3r T4cVbH6P+ubel9c47fZ9Xh/xKmKsbuuP+IIP0j9e+q/Wh9V5/VPR9bkfS5ej/pHp8vsc+/XthVH6 N9X/AE1e/WPrP6V4/D9b9P8A3l5nj6Po/u+HLr+105dsCv8A/9k= xmp.iid:176be94b-be34-f848-8427-d41f97d925a9 xmp.did:176be94b-be34-f848-8427-d41f97d925a9 uuid:5D20892493BFDB11914A8590D31508C8 default uuid:85fe236e-144d-4a8b-b3aa-2bb8326d68c3 xmp.did:593dd6ce-0483-f240-babe-b146ed48ec5f uuid:5D20892493BFDB11914A8590D31508C8 default saved xmp.iid:3fe272f3-c268-46ee-a2e2-08382aa440b3 2014-10-14T14:13:53+02:00 Adobe Illustrator CC 2014 (Macintosh) / saved xmp.iid:176be94b-be34-f848-8427-d41f97d925a9 2015-01-21T16:42:48+01:00 Adobe Illustrator CC (Windows) / Print False False 1 159.998833 49.999194 Millimeters Cyan Magenta Yellow Black Default Swatch Group 0 Blanc CMYK PROCESS 0.000000 0.000000 0.000000 0.000000 Noir CMYK PROCESS 0.000000 0.000000 0.000000 100.000000 Rouge CMJN CMYK PROCESS 0.000000 100.000000 100.000000 0.000000 Jaune CMJN CMYK PROCESS 0.000000 0.000000 100.000000 0.000000 Vert CMJN CMYK PROCESS 100.000000 0.000000 100.000000 0.000000 Cyan CMJN CMYK PROCESS 100.000000 0.000000 0.000000 0.000000 Bleu CMJN CMYK PROCESS 100.000000 100.000000 0.000000 0.000000 Magenta CMJN CMYK PROCESS 0.000000 100.000000 0.000000 0.000000 C=15 M=100 J=90 N=10 CMYK PROCESS 15.000000 100.000000 90.000000 10.000000 C=0 M=90 J=85 N=0 CMYK PROCESS 0.000000 90.000000 85.000000 0.000000 C=0 M=80 J=95 N=0 CMYK PROCESS 0.000000 80.000000 95.000000 0.000000 C=0 M=50 J=100 N=0 CMYK PROCESS 0.000000 50.000000 100.000000 0.000000 C=0 M=35 J=85 N=0 CMYK PROCESS 0.000000 35.000000 85.000000 0.000000 C=5 M=0 J=90 N=0 CMYK PROCESS 5.000000 0.000000 90.000000 0.000000 C=20 M=0 J=100 N=0 CMYK PROCESS 20.000000 0.000000 100.000000 0.000000 C=50 M=0 J=100 N=0 CMYK PROCESS 50.000000 0.000000 100.000000 0.000000 C=75 M=0 J=100 N=0 CMYK PROCESS 75.000000 0.000000 100.000000 0.000000 C=85 M=10 J=100 N=10 CMYK PROCESS 85.000000 10.000000 100.000000 10.000000 C=90 M=30 J=95 N=30 CMYK PROCESS 90.000000 30.000000 95.000000 30.000000 C=75 M=0 J=75 N=0 CMYK PROCESS 75.000000 0.000000 75.000000 0.000000 C=80 M=10 J=45 N=0 CMYK PROCESS 80.000000 10.000000 45.000000 0.000000 C=70 M=15 J=0 N=0 CMYK PROCESS 70.000000 15.000000 0.000000 0.000000 C=85 M=50 J=0 N=0 CMYK PROCESS 85.000000 50.000000 0.000000 0.000000 C=100 M=95 J=5 N=0 CMYK PROCESS 100.000000 95.000000 5.000000 0.000000 C=100 M=100 J=25 N=25 CMYK PROCESS 100.000000 100.000000 25.000000 25.000000 C=75 M=100 J=0 N=0 CMYK PROCESS 75.000000 100.000000 0.000000 0.000000 C=50 M=100 J=0 N=0 CMYK PROCESS 50.000000 100.000000 0.000000 0.000000 C=35 M=100 J=35 N=10 CMYK PROCESS 35.000000 100.000000 35.000000 10.000000 C=10 M=100 J=50 N=0 CMYK PROCESS 10.000000 100.000000 50.000000 0.000000 C=0 M=95 J=20 N=0 CMYK PROCESS 0.000000 95.000000 20.000000 0.000000 C=25 M=25 J=40 N=0 CMYK PROCESS 25.000000 25.000000 40.000000 0.000000 C=40 M=45 J=50 N=5 CMYK PROCESS 40.000000 45.000000 50.000000 5.000000 C=50 M=50 J=60 N=25 CMYK PROCESS 50.000000 50.000000 60.000000 25.000000 C=55 M=60 J=65 N=40 CMYK PROCESS 55.000000 60.000000 65.000000 40.000000 C=25 M=40 J=65 N=0 CMYK PROCESS 25.000000 40.000000 65.000000 0.000000 C=30 M=50 J=75 N=10 CMYK PROCESS 30.000000 50.000000 75.000000 10.000000 C=35 M=60 J=80 N=25 CMYK PROCESS 35.000000 60.000000 80.000000 25.000000 C=40 M=65 J=90 N=35 CMYK PROCESS 40.000000 65.000000 90.000000 35.000000 C=40 M=70 J=100 N=50 CMYK PROCESS 40.000000 70.000000 100.000000 50.000000 C=50 M=70 J=80 N=70 CMYK PROCESS 50.000000 70.000000 80.000000 70.000000 Gris 1 C=0 M=0 J=0 N=100 CMYK PROCESS 0.000000 0.000000 0.000000 100.000000 C=0 M=0 J=0 N=90 CMYK PROCESS 0.000000 0.000000 0.000000 89.999400 C=0 M=0 J=0 N=80 CMYK PROCESS 0.000000 0.000000 0.000000 79.998800 C=0 M=0 J=0 N=70 CMYK PROCESS 0.000000 0.000000 0.000000 69.999700 C=0 M=0 J=0 N=60 CMYK PROCESS 0.000000 0.000000 0.000000 59.999100 C=0 M=0 J=0 N=50 CMYK PROCESS 0.000000 0.000000 0.000000 50.000000 C=0 M=0 J=0 N=40 CMYK PROCESS 0.000000 0.000000 0.000000 39.999400 C=0 M=0 J=0 N=30 CMYK PROCESS 0.000000 0.000000 0.000000 29.998800 C=0 M=0 J=0 N=20 CMYK PROCESS 0.000000 0.000000 0.000000 19.999700 C=0 M=0 J=0 N=10 CMYK PROCESS 0.000000 0.000000 0.000000 9.999100 C=0 M=0 J=0 N=5 CMYK PROCESS 0.000000 0.000000 0.000000 4.998800 Couleurs vives 1 C=0 M=100 J=100 N=0 CMYK PROCESS 0.000000 100.000000 100.000000 0.000000 C=0 M=75 J=100 N=0 CMYK PROCESS 0.000000 75.000000 100.000000 0.000000 C=0 M=10 J=95 N=0 CMYK PROCESS 0.000000 10.000000 95.000000 0.000000 C=85 M=10 J=100 N=0 CMYK PROCESS 85.000000 10.000000 100.000000 0.000000 C=100 M=90 J=0 N=0 CMYK PROCESS 100.000000 90.000000 0.000000 0.000000 C=60 M=90 J=0 N=0 CMYK PROCESS 60.000000 90.000000 0.003100 0.003100 Adobe PDF library 10.01 endstream endobj 774 0 obj<> endobj 775 0 obj<>stream HMn0=.i9H A.IxKcEԸR|.z^d;?" Gbf$KXk[RUAO瓹mv{}'=/g]վmB%QǜUA3F2eYU5.T$eg4 j\}bUDs޶-kO kfY'S>&ё4E3š6lĤ^M~42hYb6X=?/"$rf}NbLH/t.YA/zn̦|!|8~Jr0P&I'*1H9Po(."vQ -jh`0Ir#캠]`%6in |>t'o-aAcqpqC endstream endobj 776 0 obj<> endobj 777 0 obj<>stream application/postscript Print 2018-04-03T19:09:44+08:00 2018-04-03T19:09:44+08:00 2018-04-03T19:09:44+08:00 Adobe Illustrator CS6 (Windows) 256 256 JPEG /9j/4AAQSkZJRgABAgEASABIAAD/7QAsUGhvdG9zaG9wIDMuMAA4QklNA+0AAAAAABAASAAAAAEA AQBIAAAAAQAB/+4ADkFkb2JlAGTAAAAAAf/bAIQABgQEBAUEBgUFBgkGBQYJCwgGBggLDAoKCwoK DBAMDAwMDAwQDA4PEA8ODBMTFBQTExwbGxscHx8fHx8fHx8fHwEHBwcNDA0YEBAYGhURFRofHx8f Hx8fHx8fHx8fHx8fHx8fHx8fHx8fHx8fHx8fHx8fHx8fHx8fHx8fHx8fHx8f/8AAEQgBAAEAAwER AAIRAQMRAf/EAaIAAAAHAQEBAQEAAAAAAAAAAAQFAwIGAQAHCAkKCwEAAgIDAQEBAQEAAAAAAAAA AQACAwQFBgcICQoLEAACAQMDAgQCBgcDBAIGAnMBAgMRBAAFIRIxQVEGE2EicYEUMpGhBxWxQiPB UtHhMxZi8CRygvElQzRTkqKyY3PCNUQnk6OzNhdUZHTD0uIIJoMJChgZhJRFRqS0VtNVKBry4/PE 1OT0ZXWFlaW1xdXl9WZ2hpamtsbW5vY3R1dnd4eXp7fH1+f3OEhYaHiImKi4yNjo+Ck5SVlpeYmZ qbnJ2en5KjpKWmp6ipqqusra6voRAAICAQIDBQUEBQYECAMDbQEAAhEDBCESMUEFURNhIgZxgZEy obHwFMHR4SNCFVJicvEzJDRDghaSUyWiY7LCB3PSNeJEgxdUkwgJChgZJjZFGidkdFU38qOzwygp 0+PzhJSktMTU5PRldYWVpbXF1eX1RlZmdoaWprbG1ub2R1dnd4eXp7fH1+f3OEhYaHiImKi4yNjo +DlJWWl5iZmpucnZ6fkqOkpaanqKmqq6ytrq+v/aAAwDAQACEQMRAD8A7ZoWhQ+cI5Ne115bi2nl kWwsBI6QxwoxQGilTyquKpt/yrLyR/1bf+S9x/1UxV3/ACrLyR/1bf8Akvcf9VMVd/yrLyR/1bf+ S9x/1UxV3/KsvJH/AFbf+S9x/wBVMVd/yrLyR/1bf+S9x/1UxV3/ACrLyR/1bf8Akvcf9VMVd/yr LyR/1bf+S9x/1UxV3/KsvJH/AFbf+S9x/wBVMVd/yrLyR/1bf+S9x/1UxV3/ACrLyR/1bf8Akvcf 9VMVd/yrLyR/1bf+S9x/1UxV3/KsvJH/AFbf+S9x/wBVMVd/yrLyR/1bf+S9x/1UxV3/ACrLyR/1 bf8Akvcf9VMVd/yrLyR/1bf+S9x/1UxV3/KsvJH/AFbf+S9x/wBVMVd/yrLyR/1bf+S9x/1UxV3/ ACrLyR/1bf8Akvcf9VMVd/yrLyR/1bf+S9x/1UxV3/KsvJH/AFbf+S9x/wBVMVd/yrLyR/1bf+S9 x/1UxV3/ACrLyR/1bf8Akvcf9VMVd/yrLyR/1bf+S9x/1UxV3/KsvJH/AFbf+S9x/wBVMVd/yrLy R/1bf+S9x/1UxV3/ACrLyR/1bf8Akvcf9VMVd/yrLyR/1bf+S9x/1UxV3/KsvJH/AFbf+S9x/wBV MVd/yrLyR/1bf+S9x/1UxV3/ACrLyR/1bf8Akvcf9VMVSrXdCg8nwpr2gvJb29vLGL+wMjPDJC7B Ds5Y8qt1xVNfyy/5QjTf+e//AFESYqyfFXYq7FXYq7FXYq7FXYq7FXYq7FXYqtkkjjRpJGCIoqzs QAAO5JxVjWpfmf8Al/prFLrXrTmOqwv65G9KEQiSh9sVSOf8/Py0jZgl/NMF6MlvMA21duaofvxp bdB+fn5aSMoe/mhDdWe3mIXau/BXP3Y0tp3pn5n/AJfak/C11205nosz+gT2oBMI6nFWTRyRyxrJ E4eNwGR1IKkHoQRiq7FXYq7FXYq7FXYq7FXYq7FXYq7FXYqxj8zf+UI1L/nh/wBREeKu/LL/AJQj Tf8Anv8A9REmKsnxV2KuxV2KuxV2KuxV2KuxV2KpdrvmHRdBsGvtXvI7O2XYNId2P8qKKsx9lGKv EvN//OSF5Kz23la0FvH0F/dgNIfdIgSi/wCy5fIYaRbyXXPNPmPXZjLq+oz3rVqFlclF/wBVBRF+ gYUJVirsVdirsVTXRPNPmPQpRLpGoz2TVBKxOQjU3+JD8Df7IYq9a8of85IXkTJbearQXEXT6/aA LIPd4iQjf7Hj8jgpNvbdB8xaJr9gt/pF5HeWzftId1P8rqaMjezDAlMcVdirsVdirsVdirsVdirs VdirGPzN/wCUI1L/AJ4f9REeKu/LL/lCNN/57/8AURJirJ8VdirsVdirsVdirsVdirsVYJ+Zf5r6 R5NtzbxhbzXJVrBZA/CgPSSYjovt1P44q+Y/MnmnXfMmotqGsXTXM5qEU7JGpNeEadFX5ZJilOKu xVekUshoiM3yBOKqy6det0iP00H6zirm069XrEfoof1HFVF4pYzR0ZfmCMVWYq7FU28t+aNd8t6i uoaPdvbTigcDdJFBrwkQ7MvzxV9N/ln+bGk+crf6tKFs9diWs9lU8XA6yQk9V/yeo/HIsmeYq7FX Yq7FXYq7FXYq7FXYqxj8zf8AlCNS/wCeH/URHiq38sz/AM6Rpv8Az2/6iJMVZRXFXVxV1cVdXFXV xV1cVdXFXVxVgn5rfmXb+TtIEdsVl1y8UiygO4RehmkH8o7Dufpwq+Vr+/vNQvJr29ma4u7hjJNN IaszHqScLFD4qiLWynuT8Aoo6uegxVNrfSrWKhYeo/i3T7sVRgAAoBQDoBireKuxVogEUIqD1BxV B3GlW0tSo9N/Fen3YqlN1ZT2zfGKr2cdMVQ+Koiwv7zT7yG9spmt7u3YSQzRmjKw6EHFX1R+VH5m QectKMVzxi1yzUfXIV2Dr0E0Y/lP7Q7H6MDJnlcCurirq4q6uKurirq4q6uKurirF/zMP/Okal/z x/6iI8VW/lqf+dJ07/nt/wAn5MVZPXFXVxV1cVdXFXVxV1cVdXFUu8w67Y6Dot3q983G2s4zIw7s eiovuzEKMVfHvmjzJqPmTXLrV9Qas9y1VQElY0H2I0r+yo2yTFKcVej/AJT/AJT3Pmy5XUtSVofL 8DUZhVWuGU7xxnsv8zfQN+gSA356srSx826lZ2cSwWtvKI4YUFFVVUAAYUFIsVdirsVdirsVdiqe +RbK0vvNum2d5Es9rcSmOaFxVWVlIIOKhd+bP5TTeVJv0npfOfQZ3I3BLWzE7I57of2W+g79Qmnm uFCa+V/Meo+XNctdYsGpPbPUoSQsiHZ43p+yw2xV9h+XtesNe0W01exblbXkYkUHqp6Mjf5SMCpy LJMa4q6uKurirq4q6uKurirq4qxj8yj/AM6TqP8Azx/5Px4qt/LY/wDOl6d/z2/5PyYqyWuKurir q4q6uKurirq4q6uKvFvz/wBQ1PUUt9D0795b2hFxfxqTzaQr+7UCm/FG5dd+Q8MIQXgjKVJVgQRs QeowoZN+Xnky482+ZYNNUlLRP31/OP2IVI5UO/xN9lffAr630+xs9PsoLGyiWC0tkEcMKCiqq7AY GT5v/Mb/AJTjWP8AjOf+IjCGJY5hV2KuxV2KuxV2Ksj/AC5/5TjR/wDjOP8AiJwFQ+kL+xs9Qspr K9iWe0uEMc0LiqsrdQcDJ8k/mL5LuPKPmWbTmLPZyD1rCdv24WO1f8pT8Lff3woYvhQ9r/5x083m K8u/K9y/7u4BurCvaRQBKg/1kHL/AGJ8cBSHvVcCXVxV1cVdXFXVxV1cVdXFWNfmSf8AnS9R/wCe P/J+PFVn5cH/AJ0zTv8Ant/yfkxVkvLFXcsVdyxV3LFXcsVdyxVZLNHFG8sjBY41LOxOwAFSTirw bUL2W+vri8l2kuJGkZa148jXiK9l6DChItY8u2Gpgs6+lcdp0G/+yH7WKvWPyW8nr5e8rmeUA32p yGWWShH7pCVhAr241f8A2WKvQeWBL5r/ADF/5TfWP+M5/wCIjJMSxzFXYq7FXYq7FXYqyP8ALr/l N9H/AOM4/wCInFQ+lOWRZPOvzx8qprfk6W+iSt9o9bmIjcmHb11+XEc/9jhQ+YsKEz8s61LonmDT 9Wirysp0lZRtyQH41/2S1GKvsyKaOWJJY2DRyKGRh0KkVBGRZL+WKu5Yq7liruWKu5Yq7lirGvzH P/Omaj/zx/5Px4qs/Lo/86bp/wDz2/5PvirJK4q6uKurirq4q6uKuriqS+c7trbyvqEijkWj9Eg+ EzCIn6A+KvGcKFS2t5bm4it4RWWZ1jjHizGg/E4q94t4Ybe3it4V4Qwosca+CqKAb+wwJVK4q+bv zE/5TbV/+M//ABqMkxLHcVdirsVdirsVdirIvy7/AOU20j/jP/xqcVD6RrkWSyeKKeGSCZQ8MqlJ EPRlYUIPzGKvjHWtNk0zWL7TZPt2VxLbsfExuVr+GSYoLFX1v+WWpNqPkHQ7ljVhbLCx61MBMJP0 +ngSyeuBLq4q6uKurirq4q6uKsb/ADFP/Om6h/zx/wCT6Yqt/Ls/86dp/wDz2/5PvirI+WKu5Yq7 liruWKu5Yq7lirFvzIndPLnBWoJp40YeIAL0+9a4oeV4VTPyxCZfMWnKBWlxG/8AwDc/+NcVe1cs CXcsVeG/mFpsFz5o1FqcJeYo4/1F6jvhYlg91Zz2z8ZF2P2WHQ4VUcVdirsVdirsVZJ+W/8Aym+k /wDGVv8Ak22AqH0ZywMncsVfKX5tWv1b8xdbjoBymWXb/i6JJP8AjfCgsRwofTX5FXJk/Lu0jqT6 E88YB7VkL7f8HgKXoPLAl3LFXcsVdyxV3LFXcsVY5+Yh/wCdO1D/AJ4/8n0xVZ+Xp/50/T/+e3/J 98VZHyxV3LFXcsVdyxV3LFXcsVYt+Y8bP5dDAVEc6Mx8BRl/42xQ8uwqmfliYw+YdOcGhNxGn0O3 D/jbFXs/LAl3LFXjfnT/AJSjUP8AXH/EFwsSkUkaSIUdQynqDiqT3ujOlXtqsvePuPl44VSsgg0O xHUYq7FXYq7FWSflx/ym2lf8ZW/5NtgKh9E8sDJ3LFXyr+bN19a/MTW5ag8Zli2/4qiSP/jTCgsR wofTH5GQmL8vLV6EevPPICe9JCm3/AYEvQOWBLuWKu5Yq7liruWKu5Yqxz8wj/zp+of88f8Ak+mK rfy+P/OoWH/Pb/k8+FWRcsCHcsVdyxV3LFXcsVdyxVJvOFu9z5av40IBWMSmvhEwkb8FxV5DhVUg nkgnjniPGWJldG8GU1B+/FXt9vcxXEEc8R5RSoskbeKsKg/dgVU5Yq8d85/8pPf/AOuP+ILhQUlx V2Kq1l5Ou/MExS0i4sNnuTtGv+ue/wAuuKpF5j8q6z5fuvR1CGiMSIblPiikp/K38DvhVKMVdirI /wAuf+U10r/jK3/JtsBUPoflgSpzXEUEMk0rhIolLyOegVRUk/IYq+O9a1F9T1i+1F/tXlxLOQe3 qOWp+OSQgsVfWH5bWDaf5E0S2bZjbLMw6UM5MxH/AA+BLJeWBXcsVdyxV3LFXcsVdyxVjv5gn/nU L/8A54/8nkwpWeQD/wA6lYf89f8Ak8+KshrgQ6uKurirq4q6uKuriqyaOOaJ4pAGjkUo6noVYUIx V4re2slpdzWsn95A7RsexKmlRXscKqOKvS/IGr/WtJNnI1Z7I8RXcmNqlDv4br92KsorgV5D5y/5 Sa//ANcf8QXCgpMqszBVBLE0AG5JOKsz8u/l9NPxudWrDD1W1G0jf6x/ZHt1+WK0z+2tre1gWC2j WKFBRUQUAwJW3tlZ31s9reQpPbyCjxyAEH+33xV5P5v/AClubXneaByubfq1kd5U/wBQ/tj2+188 Nop5yysrFWBVlNGU7EEdjhVkX5d/8pppX/GRv+TbYCofQdcCWA/nP5oXR/KEtpE9L3Vq20ag7iIj 983y4/D/ALLCr5swoTLy5o8us69YaXHUNeTJEzDfipPxt/sVqcVfXsaJFGkcYCxoAqKOgAFAMild XFXVxV1cVdXFXVxV1cVY95/P/OpX/wDzy/5PJhSs8hH/AJ1Ox/56/wDJ58VZBXFDq4q6uKurirq4 q6uKurirz78wtKMV9HqSD93cgJKfCRRt/wAEo/DFWI4qj9E1abStRju4/iA+GWPpzQ/aX+I98Vet Wl5Bd20dzbuHhlHJGHh/Ud8VedaxoWo6t5rvo7SOqCRfUmbZE+Bep/h1xQy7QPKenaQokp695T4r hx0/1B+z+vFKe1xV1cVdXFXVxVi/mzyDo/mBWm4/VdRp8N3GPtH/AIsXbl+v3xV575e8r6xoHnzS 4b+GiNKwhuE3ikpG32W/gd8UPZLy+trK0mu7uRYbaBDJNK3RVUVJOKXy55/84T+afMM1+apZx/ur GE9ViU7E/wCUx+I/dihjeFXr35B+WGlvbrzHOn7u3BtrInvI4/eMP9VPh/2RwJe31xV1cVdXFXVx V1cVdXFXVxVj/n0/86nff88v+TyYpW+RD/zqlj/z1/5PPiqfVwIdXFXVxV1cVdXFXVxV1cVQmq6f DqNhNZy7LIPhburDdWHyOKvJb2zns7qW1nXjLExVh2+Y9j1GFVHFU98seZ5dIlMUoMljIayRjqp/ mX+IxV6RaXdrdQLcWrrJDJuHXv8AP3+eBVauKurirq4q6uKurirq4qpXdza28DXF06xwxfEXfoD0 FPfwxV5b571j/E1u+nq0kGnAhlCmjOy9GfsR/k/x6FXkWseXb/TWLOvq23adBt/sh+zhQs8vaFfa 7rFtpdivKe4anI/ZRRuzt7KN8VfVGg6PZaJpFrpdmtLe1QIp7serOfdmJJyKUfXFXVxV1cVdXFXV xV1cVdXFUh89n/nVL7/nl/yeTClZ5FP/ADqtj/z1/wCTz4qn1cUOrirq4q6uKurirq4q6uKurirH /NnlwapALi3AF9CKL2Ei9eJPj4Yq84dGRijgq6khlIoQR1BGKtYqjtK1rUNLl9S0kop+3E26N81/ iN8VZtpfnrTLkBLsG0m6VPxRk+zDp9I+nFWQw3EE8YkgkWWM9HQhlP0jFV9cVdXFVk1xDBGZJpFi jXq7kKo+k4qx7VPPWl2oZLSt3MNqr8MYPux6/wCxBxVhWq63qOqS87uSqj7EK7Rr8l/id8VQGKuE ZlIiCGQyHgIwORYttxA718MVZ/5H8kaf5djmulgSPUbynrld+CdfTU7gCu7U2r8hirKa4q6uKuri rq4q6uKurirq4q6uKpD56P8Azqt9/wA8v+TyYpWeRz/zq9l/z1/5PPiqe1xQ6uKurirq4q6uKuri rq4q6uKuriqQeY/K0Gp1uLciG9A3b9mT2anf3xVgF1aXNpO0FzGYpV6q36x4j3xVRxV2Kr4ppoXE kLtG46MhKn7xiqNi8wa5GarfTE/5Tl/+JVxV0vmHXJTVr6Yf6jlP+I0xVBSzTTOZJpGkkPV3JYn6 TiqzFXYqrWlndXk6wW0Zllboq/rJOwHucVegeXPK8GlgXExE18RTmPspXqEr+vFU+rirq4q6uKur irq4q6uKurirq4q6uKpF54P/ADq97/zy/wCTyYpW+ST/AM6xZf8APX/k6+KE85Yq7liruWKu5Yq7 liruWKu5Yq7liruWKu5YqhNQ02x1CH0ruISAfZboy/6rDcYqxDU/I97CS9i4uI+0bUWQff8ACfw+ WKscuLa4t39O4ieJ/wCV1Kn8cVU8VdirsVdiqrb2tzcyenbxPM/XiiljTx2xVkWm+RryUh7+QW8f eNCGkP07qPx+WKsw0/TrHT4fStIhGp+0erMfFmO564qiuWKu5Yq7liruWKu5Yq7liruWKu5Yq7li ruWKpH52P/OsXv8Azy/5OpiqzyUf+dZs/wDnp/ydfFU85DFXchiruQxV3IYq7kMVdyGKu5DFXchi ruQxV3IYq7kMVdyGKrJY4ZkMcyLIh6o4DA/QcVS2fyxoMzFmtFVj/vssg/4FSF/DFUE/kfRmNRJO nsrL/FTirk8j6MpBZ53HgzLT/hVGKo2DyzoMLBltFZv+LCzj7mJH4YqmUUcMSCOJFjjXoigKB9Ax VfyGKu5DFXchiruQxV3IYq7kMVdyGKu5DFXchiruQxV3IYq7kMVSPzqf+dZvP+ef/J1MVW+TD/zr Vn/z0/5OviqdcsCu5Yq7liruWKu5Yq7liruWKu5Yq7liruWKu5Yq7liruWKu5Yq7liruWKu5Yq7l iruWKu5Yq7liruWKu5Yq7liruWKu5Yq7liruWKu5Yq7liqS+cz/zrV5/zz/5OphVZ5OP/Ot2f/PT /k62Kp1XArq4q6uKurirD/Pn5jWXlhVtooxdapKvJIK0RFOwaQj8FHX2wqwuHzF+dWpw/X7KF47V xyRUggVSp6FBMC7D78VRGgfm/rFlqQ07zXbcAGCS3AjMUsRPeSPoR/qgfTirLvzI8z6honluLUdK lT1JJ40WQgSKUdGao7b0G+Ko7yHrV9rPlSx1K+ZWup/V9RlUKPgmdBsP8lRirIK4FdXFXVxV1cVd XFXVxVSupWjtZpF+0iMy/MAnFXnH5X+fPMPmHWbq11OSN4YrcyoEjCHlzVeo9mwq9MrgV1cVdXFX lXnL8z/MMHmWTQ/L8CF4nWHk0ZklklNKhVrSm9OmFWceTLzzHc6KsnmCH0NREjqU4hPgFOJoCRiq e1wK6uKurirq4q6uKurirq4q6uKpL5xP/Ot3n/PP/k6uFVvk8/8AOuWn/PT/AJOtgVOeWKu5Yq7l iruWKvCPKMC+bvzHkvL9fWg5yXkkZ3UpGQsSGv7IJQUPbbCr3flgViHnf8u7LzTcW1ybn6ncQKyP IsYcyKSCoPxL9nenzxVIfzO01tL/AC40/TmnNz9UuIYhMw4llWOQLtU0oNsIVj3lPWPzBv8AQbbR /LEQgtrAOLm8PD4nllaSnKTYUDjZRXviqO0D8wvN2j+Zo9F80N6sbyLDN6ioHiMlOLh46Bl3B77d MVZ356862/lfTFm4Ca+uCUtIDsCQPidv8laj/PfArALbVfzo1W2/S9nzW1I5woqW6Bl6/BG45uPD rXtXCrJvy7/MebXJ30nVo1h1aMExuo4iUJ9oFT9l16n+FMVUfzC/Mq60m+Gi6IiyakePrTFefpl6 FURP2nII/wA+iqRXN7+dWm2batcuzW6DnNGVtnKpsatGoqo8abjvTFWY+TvO6eaPL940qLDqFrGy 3US14HkrcXSpJoafRirAvyRkSLzBqEkjBI0smZ3Y0AAkQkknEqnGrfmR5k1vzCmleTFHpISDcMit 6m9DIeYISNe3f9WKvStLhvoLCKO/uvrl4B++nCLGCx68VUAADtgVDeZzrv6Duf0Dx/SvwfVuXCn9 4vP+8+H7HLrirweL/Fv+Ojw4/wCJfXav93x9XieXX930woet3fm3UvLXkyC+8xqJdcdnjECFAHkL sU3j+EKI6EkfrxSw2w1n83vM0T6hpsggswSIwgiiQkdQhkq7fMmmKo7yt+Z+uWuufoPzZGBK0gh+ sFFjeOQmg9QLRCh/mA99xiqa/mv5u13y/wDov9FTrD9Z9f1qoj19P0+P2wafbOIVix88/mV5kkP6 BhkjtoQqO0MaGrAbl5HHEE9eIpir2W3aT6vF6v8Ae8F9T/Wpv098CqnLFXcsVdyxVJvOB/51y7/5 5/8AJ1cVW+UD/wA67af89P8Ak62KU4rirq4q6uKurirwz8sp/wBCef5LC6ojyiaxYttRwwYD/ZNF QfPCh7nXAliXnr8wYfKslpELQXs1yHdo/V9IoqkAE/A9eRJp8sKLSH8zNSk1P8udP1CSD6s13PDN 6HLnxDxyFfiotdvbFU3/AChVV8k25UAF5pmY+J50r9wGJUMI/NKn/Kw7Q+MdtX/kYcQrf53SSHzN ZRk/u1slZQenJpZA3/ERiFLII7/86o41jj0i0REAVFDQAADYAD1sVSfSPKHn4+drXXr7Tlt+Vyst 28UsAUK20hCiRm3UmuKoXy+I5/zln+tUfjfXhjD7/FGJPT6/y8RTFXtMwieF1mAMTKRIG+zxI3rX tTAlj2l6f5OtIL5tAFqJngYTfVpBIeIBpUBm74oeF+XbDX9SuZtO0ZXaS6jKXIU8VMQIYh27LUD5 9MkhnH5N65a2Oo3eh3cKwXdy3KKZhxkLx7NC1fChKjxrgKQ9grgS6uKvFLX/AMnS3/MbJ/ybbChM Pz1eU3Gjoa+kEnKjtyJSv8MQpemeX4raHQtPjtafVltovSK9CvAEH6euBLyb87ordPMFjKlBcSW3 72ncK5CH9eEIKI/OWSWTTvLMk3968MzSf6xWAn8cQpejeTLK3svKulw26BVNtFI9O7yIHdj82bAq dVxS6uKurirq4qk/m8/867d/88/+Tq4qt8pH/nXrT/np/wAnGxVN64odXFXVxV1cVea/mN+XV7f3 p1zQx/puzXNup4MzJ0kjO3xbbj+OFUjh/M38wNPhFld2Cy3K/CJLiCVZdv5gpQE/Riqlo/k3zV5v 1sap5gWWC0JBmklUxsyDcRwoaUHvSg67nFWafmtpl3deU4LTTbSSdo7mLjBbxs5VFRx9lAdhtiqM /LCzvLLyhbW95BJbTrJKWimRo3ALkiqsAcVYd+Y+ia1d+ebW5tLC5uLdUtw00UMjoCrkmrKCNsVZ L+ZvkmfzDZw3dgAdSswwWMkD1Y2341OwIO4+nFWLaf8AmH570m0TTLvR2nuIEEcLzRSrJQbLyC/b 27ilfHFUx8i+VfMl75hbzP5iDwNyaSK3kqrPIw4gmP8AYVB0B36Yqh/zA8l65Z+YB5m8vxvKS6zS RxDnJHMvVgm/JWpU/T2xVB6j+YnnbV9Ok0qDSGiublTFLLDHKzFW2YKprxr474qyr8vvJlzoGgXs l4v+5K/T44lo3BFU8EqP2qsSafwxVIvyd0bWNP1W/e/sbi0R4FVGnieME8waAsBXEq1+Z3kvUo9X h1/QreWSaZwbiO2RmkSdN1lUICfipufH54q9B8ratfanosFxf2ktnfAencwzRtEea9WUMB8LdR93 bAqbVxV5Nb6Bri/mwdRNhOLD63I/1r029PiUIB5UpTCrMPzC8oN5l0dY7cquoWjGS1Ztg1RR4ye3 Kg38QMVYFpPnHz55WsxpF3pLTJDUW5mjkqq+Cunwug7U+/FW9F8peZvN3mP9M+YYWtrPkryCRDHz RD8MMaH4uPav4k4qnX5zaTquofof6hZT3fpfWfU9CJ5ePL0qcuANK0NMQrPPL6SRaDpsUqGOSO1h V0YEMrCNQQQehGBUfXFXVxV1cVdXFUo82n/nXrv/AJ5/8nFxSs8pn/cBa/8APT/k42FU3rih1cVd XFXVxV1cVdXFXVxV1cVdXFXVxV1cVdXFXVxVD3eo2FmqteXMVsrmiGZ1QEjw5EYqqQ3EM8SzQSLL E4qkiEMpHsRscVVK4q6uKurirq4q6uKurirq4q6uKurirq4q6uKurirq4q6uKuriqUebD/uAuv8A nn/ycXFK3yqf9wNr/wA9P+TjYoTauKurirq4q6uKuriqyaeKGJ5pWCRRqXkdtgFUVJPyGKoTTdc0 jVPU/R93Fdejx9X0mDceVeNaePE4qu1LWdL0xEfULqO1SQkRtKwUEjcgVxV0utaVDp66jLdRpYuF K3JYBCG2Xf3xVCzebfLcNml7JqUAtpCRHJzB5FTQ8QNzT2xVvSvNXl7VpPT0+/inl6+kDxcgdSEb ix+7FU1riqS3/nTytp9wba71KGOcGjRglyp8G4BuP04qwf8AN7UrDUNG0q4sbiO5gM0gEkTBhXgN jTofbFWY/l+f+dN0r/jD/wAbHFUffeZvL9hL6N5qNvBMOsTyKGHzWtRiqIsNV03UIzJY3UV0g6tC 6vSvY8SaYqwn81/MNvDo/wBRs7/0tTiuIzLDFIVlCFGO/Eg0+IYqjfy28x6fP5d06wnv1l1ZvW5Q vJymNJZHFamv2N/lirK77UrGwgNxe3EdtCNvUlYKK+Ar3xVL7Dzj5Yv5xb2mpQSTN9mPlxLHwXlS p9hiqcVxVJtQ85eWNOlMN3qUMcq15RhubKR2ITkQfniqL0zXdI1RC+nXcVyF+0I2BYfNeo+nFUdX FXVxV1cVdXFXVxV1cVSnzUf9wN1/zz/5OLiq3ysf9wVr/s/+TjYqU1rgV1cVdXFXVxV1cVS/zEf+ df1P/mEn/wCTbYVeffkif+O1/wBG3/M3EoRH51n/AHHaZ/xmk/4iMQrXmA/8gfsv+MVr/wASGKUp /LfyNYa3aSajq/Oa1icwW1sGZQafEzEqQaVbYA9a4oW/mF5Jt/LottY0V5IIfVCMnIlopN2Rkcnl T4cVZDrHna8P5aW+qxv6d/fUtTKhoVkBYSOKdCRGxHhXFKTeQfy40/VtLGrau0jpOzfV4EbiCqkq Wcjfdht/bihKPzE8nReXbiB7GR2067qVjc1KSJ1HauzbfTirO9JGtv8AljZx6IP9yMkASJuSoVBk PNgW2rxrTFKQaB+WFjFbS3Pmyf6vMzH0ohOijiNy7PvUk++KEjjfT/L/AOYFougXjXFiZoo3ZXDA rIwWSPkvwuP8+2Ksj/Nvy3pkVo+vIH+v3M8UUhLfBxEZXZaeEYxVF/lj5S0f9F6b5ipJ+kf3+/L4 PtyQ/Zp/JirFLm8HnTzk66hfLZ6VCX9JndUVYUNAE5Hjzk2r/QUxVMPNfkvydbaRJd6LqkZu7Ycz A1xHJ6ijrQDflTcUxVMtB806vqH5caqEmc6ppyGMTgnmYiAQ3Ib8gnIV9q4pYn5JXyLKbhPMxcTu R9XdmkWMDvvFvyr/ADbYoZVpfkCa31+LWPK+q276dHIjBfUZ2KbF4mMYIIPvir06uBLq4q6uKuri rq4q6uKpV5pP+4K6/wBh/wAnFwqFvlc/7grb/Z/8nGxVNa4FdXFXVxV1cVdXFUBr4Z9C1JFFWa1m CgdyY2xV5v8Akte28d5qdo7hZ7hIXhU/tCIvyp7jmMJQrfnPqNq/6PsEcNcxs8sqA7orABeX+tiE ojzAf+QQWX/GK2/4kMVXfk/r1mdNm0eSRUu45WlhRiBzRwK8fEqRviVVPzg1m0TSIdKV1a7mlWVo walY0B3PhUkUxCpPqmj3SflFp5KnlFOLyVSNxHIZFU/dIpxQyn8rdas7vyzBYo4F3Y8kmi2B4s5Z XA8CGpXxxSxv85NZs55LLS4ZBJPbs8twFNQhYAKp9+pxCou+1zUNI/KrS5bFzFPccbczD7SK3qMS p7H4KVxVDeS/y/0XW9Ij1jU7qa6nnZucavQIVYijndi1BXqOuKsd1qDQ7Pz1bW+jlRY289spZXLr zDKXPMk1364oZ9+b9T5Ujp2uo6/8A+ISjfywljbyTYKrBmjMyuAalSZnah+gg4q8u8t6Nox80y6R 5gZoY1MkKOG9MCZG+Hkx7MAQPemKGc635A8g6Np8t9fG4WKMbKJRzduyoCBVjilU8o6n5U0ny7qe s6VaXwsY3RbhZRGzsVoPgAelF9SrVOKqeneX/wAvfOUE13Y2stjLG/GVIysTioBDemDJGFPYgYqw 3zFp0vkrzHD+idQMkioJQdg61JHpygbEED6fDFD3KKQvEjkcSyglT1FRWmBK+uKurirq4q6uKuri qVeaD/uCuf8AYf8AJxcKrPLJ/wBwlt/s/wDk42KlNOWKu5Yq7liruWKu5Yq6uKvO9Y/KG1nvHuNM vTZo7Fvq7pzVSd/gYMpA8B+OKr1/J7ShYiFr6RrouGe5CAVABHFUqaDevU4qiPPenppv5dfo9HMi W3oRq52JCuBWgxVjPlDyDp/mLy2bozvaXsdxJGJlHNSoVSAyEr0J7EYoT3S/yf063u1n1C+e+iU8 vQEfpBj/AJZ5uSPlTFLPpYIJbdreSNWgdTG0RA4lCKFaeFMVef335O2T3TS6fqUlnExqImj9UrXs GDxmnzxVePye0r6mInvpWui4Z7niNwARxCVNKk16nFWSHyjpsvliLy/ds01vEtEmFFcMCSrr1AIr irEv+VNRrIeGsOsJO6ej8RHgWEgH4YoRN9+T2kyQQJZXsltLGCJpZFEvqEmoNAY+NPbFLI28pWk/ lWPy9eTNNHGgUXIHF+atyDgEtTFUk8ufljFomu2+qJqJnFvz4wmIKTzRk+1zPTl4Yqj/ADX+Xuk6 /N9b5tZ35ADToAwcAUHNDSpHjUYqx+1/JtPVU3uqtLAh2jjj4kr/AKzM3H7sUM/tNK06001dNggV bJUMfo0qCrfa5V68q71xSwa+/KGAXLT6TqclmrV4xOpegPYOrIafMHFUXoP5V6XYXiXmoXLajOjc 1RlCR8vFlJctv7/RirOeWKu5Yq7liruWKu5Yq7liqV+Zj/uEuf8AYf8AJxcVC3y2f9wtt/s/+TjY qUzrirq4q6uKurirq4q6uKurirq4qlnmLRLfXNLk06eR4o5GVi6U5fAa964qs8s+Xrby/pzWNvK8 0bSNKWkpWrACmwH8uKptXFXVxV1cVdXFXVxV1cVdXFXVxV1cVdXFXVxV1cVdXFXVxV1cVdXFXVxV 1cVdXFXVxVLPMh/3C3P+w/5OLioW+XD/ALhrf/Z/8TbFSmVcVdXFXVxV1cVdXFXVxV1cVdXFXVxV 1cVdXFXVxV1cVdXFXVxV1cVdXFXVxV1cVdXFXVxV1cVdXFXVxV1cVdXFXVxV1cVdXFXVxVLfMZ/3 DXH+w/4muKhfc21x5anl07UYnS2R2NpdhS0bxs1RuK0O+4xSQpf4j0f/AJaP+Ef/AJpxRTv8R6P/ AMtH/CP/AM04rTv8R6P/AMtH/CP/AM04rTv8R6P/AMtH/CP/AM04rTv8R6P/AMtH/CP/AM04rTv8 R6P/AMtH/CP/AM04rTv8R6P/AMtH/CP/AM04rTv8R6P/AMtH/CP/AM04rTv8R6P/AMtH/CP/AM04 rTv8R6P/AMtH/CP/AM04rTv8R6P/AMtH/CP/AM04rTv8R6P/AMtH/CP/AM04rTv8R6P/AMtH/CP/ AM04rTv8R6P/AMtH/CP/AM04rTv8R6P/AMtH/CP/AM04rTv8R6P/AMtH/CP/AM04rTv8R6P/AMtH /CP/AM04rTv8R6P/AMtH/CP/AM04rTv8R6P/AMtH/CP/AM04rTv8R6P/AMtH/CP/AM04rTv8R6P/ AMtH/CP/AM04rTv8R6P/AMtH/CP/AM04rTv8R6P/AMtH/CP/AM04rTv8R6P/AMtH/CP/AM04rTv8 R6P/AMtH/CP/AM04rTv8R6P/AMtH/CP/AM04rTv8R6P/AMtH/CP/AM04rTv8R6P/AMtH/CP/AM04 rTv8R6P/AMtH/CP/AM04rTv8R6P/AMtH/CP/AM04rSrb29x5lmj07Tone3kdTd3ZQrHHGrVO5pvt sMU0/wD/2Q== xmp.iid:5B0DF43F2F37E811B301980F8332B901 xmp.did:5B0DF43F2F37E811B301980F8332B901 uuid:5D20892493BFDB11914A8590D31508C8 proof:pdf uuid:e4605c3c-53b1-4c1c-b17e-d25e6ce6c450 xmp.did:0980117407206811822A897E387FE54C uuid:5D20892493BFDB11914A8590D31508C8 proof:pdf saved xmp.iid:5B0DF43F2F37E811B301980F8332B901 2018-04-03T19:09:44+08:00 Adobe Illustrator CS6 (Windows) / Print False False 1 210.001652 296.999959 Millimeters Cyan Magenta Yellow Black Default Swatch Group 0 White CMYK PROCESS 0.000000 0.000000 0.000000 0.000000 Black CMYK PROCESS 0.000000 0.000000 0.000000 100.000000 CMYK Red CMYK PROCESS 0.000000 100.000000 100.000000 0.000000 CMYK Yellow CMYK PROCESS 0.000000 0.000000 100.000000 0.000000 CMYK Green CMYK PROCESS 100.000000 0.000000 100.000000 0.000000 CMYK Cyan CMYK PROCESS 100.000000 0.000000 0.000000 0.000000 CMYK Blue CMYK PROCESS 100.000000 100.000000 0.000000 0.000000 CMYK Magenta CMYK PROCESS 0.000000 100.000000 0.000000 0.000000 C=15 M=100 Y=90 K=10 CMYK PROCESS 14.999998 100.000000 90.000004 10.000002 C=0 M=90 Y=85 K=0 CMYK PROCESS 0.000000 90.000004 84.999996 0.000000 C=0 M=80 Y=95 K=0 CMYK PROCESS 0.000000 80.000001 94.999999 0.000000 C=0 M=50 Y=100 K=0 CMYK PROCESS 0.000000 50.000000 100.000000 0.000000 C=0 M=35 Y=85 K=0 CMYK PROCESS 0.000000 35.000002 84.999996 0.000000 C=5 M=0 Y=90 K=0 CMYK PROCESS 5.000001 0.000000 90.000004 0.000000 C=20 M=0 Y=100 K=0 CMYK PROCESS 19.999999 0.000000 100.000000 0.000000 C=50 M=0 Y=100 K=0 CMYK PROCESS 50.000000 0.000000 100.000000 0.000000 C=75 M=0 Y=100 K=0 CMYK PROCESS 75.000000 0.000000 100.000000 0.000000 C=85 M=10 Y=100 K=10 CMYK PROCESS 84.999996 10.000002 100.000000 10.000002 C=90 M=30 Y=95 K=30 CMYK PROCESS 90.000004 30.000001 94.999999 30.000001 C=75 M=0 Y=75 K=0 CMYK PROCESS 75.000000 0.000000 75.000000 0.000000 C=80 M=10 Y=45 K=0 CMYK PROCESS 80.000001 10.000002 44.999999 0.000000 C=70 M=15 Y=0 K=0 CMYK PROCESS 69.999999 14.999998 0.000000 0.000000 C=85 M=50 Y=0 K=0 CMYK PROCESS 84.999996 50.000000 0.000000 0.000000 C=100 M=95 Y=5 K=0 CMYK PROCESS 100.000000 94.999999 5.000001 0.000000 C=100 M=100 Y=25 K=25 CMYK PROCESS 100.000000 100.000000 25.000000 25.000000 C=75 M=100 Y=0 K=0 CMYK PROCESS 75.000000 100.000000 0.000000 0.000000 C=50 M=100 Y=0 K=0 CMYK PROCESS 50.000000 100.000000 0.000000 0.000000 C=35 M=100 Y=35 K=10 CMYK PROCESS 35.000002 100.000000 35.000002 10.000002 C=10 M=100 Y=50 K=0 CMYK PROCESS 10.000002 100.000000 50.000000 0.000000 C=0 M=95 Y=20 K=0 CMYK PROCESS 0.000000 94.999999 19.999999 0.000000 C=25 M=25 Y=40 K=0 CMYK PROCESS 25.000000 25.000000 39.999998 0.000000 C=40 M=45 Y=50 K=5 CMYK PROCESS 39.999998 44.999999 50.000000 5.000001 C=50 M=50 Y=60 K=25 CMYK PROCESS 50.000000 50.000000 60.000002 25.000000 C=55 M=60 Y=65 K=40 CMYK PROCESS 55.000001 60.000002 64.999998 39.999998 C=25 M=40 Y=65 K=0 CMYK PROCESS 25.000000 39.999998 64.999998 0.000000 C=30 M=50 Y=75 K=10 CMYK PROCESS 30.000001 50.000000 75.000000 10.000002 C=35 M=60 Y=80 K=25 CMYK PROCESS 35.000002 60.000002 80.000001 25.000000 C=40 M=65 Y=90 K=35 CMYK PROCESS 39.999998 64.999998 90.000004 35.000002 C=40 M=70 Y=100 K=50 CMYK PROCESS 39.999998 69.999999 100.000000 50.000000 C=50 M=70 Y=80 K=70 CMYK PROCESS 50.000000 69.999999 80.000001 69.999999 Grays 1 C=0 M=0 Y=0 K=100 CMYK PROCESS 0.000000 0.000000 0.000000 100.000000 C=0 M=0 Y=0 K=90 CMYK PROCESS 0.000000 0.000000 0.000000 89.999402 C=0 M=0 Y=0 K=80 CMYK PROCESS 0.000000 0.000000 0.000000 79.998797 C=0 M=0 Y=0 K=70 CMYK PROCESS 0.000000 0.000000 0.000000 69.999701 C=0 M=0 Y=0 K=60 CMYK PROCESS 0.000000 0.000000 0.000000 59.999102 C=0 M=0 Y=0 K=50 CMYK PROCESS 0.000000 0.000000 0.000000 50.000000 C=0 M=0 Y=0 K=40 CMYK PROCESS 0.000000 0.000000 0.000000 39.999402 C=0 M=0 Y=0 K=30 CMYK PROCESS 0.000000 0.000000 0.000000 29.998803 C=0 M=0 Y=0 K=20 CMYK PROCESS 0.000000 0.000000 0.000000 19.999701 C=0 M=0 Y=0 K=10 CMYK PROCESS 0.000000 0.000000 0.000000 9.999102 C=0 M=0 Y=0 K=5 CMYK PROCESS 0.000000 0.000000 0.000000 4.998803 Brights 1 C=0 M=100 Y=100 K=0 CMYK PROCESS 0.000000 100.000000 100.000000 0.000000 C=0 M=75 Y=100 K=0 CMYK PROCESS 0.000000 75.000000 100.000000 0.000000 C=0 M=10 Y=95 K=0 CMYK PROCESS 0.000000 10.000002 94.999999 0.000000 C=85 M=10 Y=100 K=0 CMYK PROCESS 84.999996 10.000002 100.000000 0.000000 C=100 M=90 Y=0 K=0 CMYK PROCESS 100.000000 90.000004 0.000000 0.000000 C=60 M=90 Y=0 K=0 CMYK PROCESS 60.000002 90.000004 0.003099 0.003099 Adobe PDF library 10.01 endstream endobj 778 0 obj<> endobj 779 0 obj<> endobj 780 0 obj<> endobj 781 0 obj<> endobj 782 0 obj<> endobj 783 0 obj<> endobj 784 0 obj<> endobj 785 0 obj<> endobj 786 0 obj<> endobj 787 0 obj<> endobj 788 0 obj<> endobj 789 0 obj<> endobj 790 0 obj<> endobj 791 0 obj<> endobj 792 0 obj<> endobj 793 0 obj<> endobj 794 0 obj<> endobj 795 0 obj<> endobj 796 0 obj<> endobj 797 0 obj<> endobj 798 0 obj<> endobj 799 0 obj<> endobj 800 0 obj<> endobj 801 0 obj<> endobj 1 0 obj<> endobj 2 0 obj<> endobj 3 0 obj<> endobj 4 0 obj<> endobj 5 0 obj<> endobj 6 0 obj<> endobj 7 0 obj<> endobj 8 0 obj<> endobj 9 0 obj<> endobj 10 0 obj<> endobj 11 0 obj<> endobj 12 0 obj<> endobj 13 0 obj<> endobj 14 0 obj<> endobj 15 0 obj<> endobj 16 0 obj<> endobj 17 0 obj<> endobj 18 0 obj<> endobj 19 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 20 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 21 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 22 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 23 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 24 0 obj<>/ProcSet[/PDF/Text]/ExtGState<>>> endobj 25 0 obj<>stream /GS1 gs BT /F1 1 Tf 10.0001 0 0 10.0001 175.748 710.0786 Tm 0 0 0 1 k 0 Tc 0 Tw (Conclusion:)Tj /F6 1 Tf 5.879 0 TD [(A)-310.4(high)-306.7(prevalence)-309.7(of)-309.2(point)-309.1(mutations)-311.8(in)-306.8(the)]TJ /F5 1 Tf 18.6348 0 TD (pfdhfr)Tj /F6 1 Tf 2.8006 0 TD (and)Tj /F5 1 Tf 1.9219 0 TD (pfdhps)Tj /F6 1 Tf 3.2825 0 TD [(genes)-309.4(of)]TJ /F5 1 Tf 4.0025 0 TD (P.)Tj -36.5213 -1.4003 TD (falciparum)Tj /F6 1 Tf 4.6771 0 TD [(isolates)-300.3(was)-301.6(detected)-310.3(among)-298.5(Chinese)-306.8(migrant)-303(workers)-303.8(returning)-306.6(from)-297.7(Africa.)]TJ -4.6771 -1.4003 TD 0.0187 Tc [(Therefore,)-516.3(continuous)]TJ /F5 1 Tf 10.4031 0 TD 0.0172 Tc [(in)-523.3(vitro)]TJ /F6 1 Tf 3.6623 0 TD 0.018 Tc [(m)-4.7(o)3.1(l)-3.4(ecul)-3.4(a)0.8(r)-520.4(m)0.9(onitoring)-518.5(o)-2.6(f)-520(S)2.4(ul)-3.4(fadoxine)-4.9(-P)-3.3(yrim)-4.7(ethemi)-3.4(ne)]TJ -14.0654 -1.4003 TD 0.0122 Tc [(combine)-5(d)]TJ /F5 1 Tf 4.8586 0 TD 0.0136 Tc [(in)-509.9(vi)3.5(vo)]TJ /F6 1 Tf 3.4526 0 TD 0.012 Tc [(therap)-5.6(eutic)-509.8(m)0.6(onitor)-4.8(ing)-513.2(o)2.7(f)-514.7(a)0.4(r)-4.8(t)2.5(em)-5(is)]TJ 15.0632 0 TD 0.0117 Tc [(inin)-517.5(com)-5.4(b)-0.2(ination)-511.8(t)-3.4(herap)-5.9(y)-511.1(\(A)-3.9(CT\))]TJ -23.3743 -1.4003 TD 0 Tc (ef)Tj /F7 1 Tf 0.7597 0 TD ()Tj /F6 1 Tf 0.4365 0 TD [(cacy)-302.4(and)-303.2(additional)-302.1(control)-300.9(ef)62.7(forts)-304.4(among)-298.5(migrant)-303(workers)-303.8(are)-300.8(urgently)-306.1(needed.)]TJ /F1 1 Tf 6.9999 0 0 6.9999 175.748 635.1306 Tm 0.0274 Tc [(Ke)-8(ywo)-8.4(r)-0.7(ds)-8.5(:)]TJ /F2 1 Tf 5.8071 0 TD 0.0286 Tc [(Pl)-4.9(asmodi)-4.9(um)-531.3(fa)-6.8(lci)-4.9(p)0.9(ar)-7.6(um)]TJ /F1 1 Tf 12.0191 0 TD 0.0322 Tc [(,)-532(s)4.4(ul)6.8(fa)4.9(doxin)7.8(e)-3.2(-pyrime)4.9(t)2.6(ha)4.9(mi)6.8(ne)4.9(,)-532(d)4.5(ihy)7.7(d)]TJ 17.9396 0 TD 0.0278 Tc [(r)-8.4(opte)-7.6(r)-0.3(oa)-7.6(te)-534.1(synt)-9.9(ha)-7.6(se,)-536.4(d)0.1(i)-5.7(h)3.4(ydr)-8.4(o)0.1(f)-6.6(o)0.1(la)-7.6(te)]TJ -35.7658 -1.4255 TD 0 Tc [(reductase,)-309.2(migrants)-299.7(from)-304.8(Africa)]TJ 11.9999 0 0 11.9999 45.3543 585.1274 Tm (INTRODUCTION)Tj /F9 1 Tf 9.5 0 0 9.5 45.3543 565.1148 Tm [(Im)23.1(po)17.4(r)11.9(t)0(e)19.8(d)]TJ /F10 1 Tf 3.8551 0 TD [(Pl)21.2(as)16.4(mo)19.7(di)24(u)11.8(m)-161.9(fa)19(l)12.2(c)0(i)18.4(p)0(a)19.1(r)11.9(u)11.8(m)]TJ /F9 1 Tf 9.3692 0 TD [(in)19.2(fe)20.7(ct)19.8(io)20(ns)-145.3(ar)19.2(e)-162.9(o)0(f)-145.9(g)0(r)16.4(e)0(a)23.5(t)-163.5(co)20.8(nc)20.1(er)22.1(n)-157.2(i)0(n)]TJ -13.2243 -1.2114 TD [(Chi)20.7(na)-430.4(dur)13.5(in)13.3(g)-437.1(m)0(a)13.7(l)0(a)12.7(r)0(i)15.3(a)-440.2(el)15.5(imi)19.1(na)11.2(ti)13(on)-433(an)11.2(d)-434.8(p)0(o)11.5(s)0(t)15.5(-)0(e)12.1(lim)15.1(in)13.3(at)16.9(io)14(n)-437.7(sta)16.9(ge)14.7(s,)]TJ 0 -1.2055 TD [(be)20.8(ca)17.5(u)12.7(s)0(e)-413.5(C)0(h)23.3(i)0(n)19.2(a)-416.4(ac)17.5(h)11.8(i)0(e)19.6(v)0(e)20.6(d)-422.9(ze)20.4(r)11.9(o)-419(in)19.2(di)16.1(ge)20.6(no)20.5(u)12.8(s)-423.7(m)12.3(a)0(l)18.6(a)13.3(ri)21.3(a)-422.3(c)0(a)17.5(s)11.9(es)-407.6(in)-410.4(20)21.1(17)]TJ 0 -1.2114 TD (\()Tj 0 0 0 0.7 k 0.3521 0 TD [(Fe)-12.9(n)-8(g)-467(e)-7.7(t)-467.8(al)-11.2(.)-8.8(,)-468.3(20)-14.7(18)]TJ 0 0 0 1 k 7.1731 0 TD [(\))-9.1(.)-462.3(A)-11.2(p)0(p)-16.3(r)0(o)-13.2(p)-11.1(ri)-14.5(at)-12.9(e)-467.2(t)-8.3(re)-13.7(a)-10.6(t)-8.3(me)-13.3(n)-8(t)-461.9(f)-13.3(o)-7.3(r)]TJ /F10 1 Tf 12.5261 0 TD [(P.)-472.2(fa)-16.8(lc)-12.6(i)-10.5(p)0(a)-10.7(r)-12(um)]TJ /F9 1 Tf -20.0513 -1.2114 TD [(a)-10.6(c)-7.7(c)-7.7(o)-13.2(rd)-17.1(i)-8.5(n)-8(g)-473(t)-8.3(o)-466.8(t)-8.3(h)-12.1(e)-467.2(n)-8(a)-10.6(t)-8.3(i)-8.5(o)-7.2(n)-14(al)-476.7(p)-11.1(l)-6.6(a)-10.6(n)-467.5(i)-8.5(s)-471.5(i)-8.5(m)0(p)-16.7(o)-7.2(r)-12(t)-8.3(a)-10.6(n)-8(t)-8.3(;)-468.3(h)-12.1(o)-7.3(w)-9.3(e)-7.7(v)-13.4(e)-7.7(r)-12(,)-468.3(so)-19.2(me)]TJ T* 0.0161 Tc [(stu)5(d)-1(ies)-467.3(h)4(ave)-463(d)-1(emonstra)5.5(ted)-460.5(m)-1.4(uta)5.5(t)1.8(ions)-461.3(in)-463.4(m)4.6(o)2.9(lecul)3.5(a)-0.4(r)-467.3(m)4.6(ar)4.1(kers)]TJ T* 0 Tc [(re)-7.7(l)-6.6(a)0(t)-7(e)-7.7(d)-458.7(t)0(o)-463.1(a)0(r)-10.6(t)0(e)-10.1(m)0(i)-8.2(s)0(i)-8.6(n)-8(in)-464.1(co)-9(mb)-6.9(i)-8.5(nat)-9(i)-8.5(o)0(n)-462.9(t)0(h)-8.4(e)-7.7(rap)-9.8(y)-461(\()-9.1(ACT)-12.3(\))-456.7(r)0(e)-13.7(s)0(i)-8.6(s)0(t)-8.3(a)0(n)-12.6(c)0(e)]TJ T* [(am)19.7(on)20.5(g)-246.2(i)0(s)15.3(o)0(l)21.9(a)13.3(te)19.8(s)-250.7(f)0(r)22.4(o)0(m)-239.6(A)0(f)17.2(r)11.9(ic)19.6(a,)-240.2(s)11.9(u)0(g)17.2(g)0(e)20.6(s)11.9(ti)18.9(ng)-242.3(t)15.6(h)0(a)19.1(t)-247(ca)17.5(r)11.9(e)0(f)14.7(u)12.8(l)-251.3(s)11.9(u)12.7(r)0(v)16.4(e)0(i)19.6(l)0(l)22.6(a)0(n)17.2(c)0(e)-236.2(o)0(f)]TJ 0 -1.2055 TD [(A)12.7(f)0(r)16.5(i)0(c)19.6(a)13.3(n)-282.5(p)0(a)20.1(r)0(a)19.2(s)0(i)15.3(t)15.6(e)-288.2(p)12.7(op)17.4(u)12.7(l)0(a)18.6(t)0(i)18.9(o)0(n)20.5(s)-280.5(is)-271.2(st)21.5(il)20.7(l)-287.1(w)14.6(ar)19.2(ra)19.2(nt)19.5(ed)-275.4(\()]TJ 0 0 0 0.7 k 18.5833 0 TD [(Fe)17(ng)-272.1(et)-272.6(al)18.6(.,)-274.2(2)13.5(0)0(1)21.1(5)0(a)]TJ 0 0 0 1 k 6.8568 0 TD (;)Tj 0 0 0 0.7 k -25.4401 -1.2114 TD [(Fe)17(ng)-218.4(et)-218.9(a)13.3(l)0(.)14.5(,)-229.6(2)13.5(0)0(1)21.1(9)]TJ 0 0 0 1 k 6.272 0 TD (,)Tj 0 0 0 0.7 k 0.4476 0 TD [(Ya)23.6(n)-234.8(e)0(t)-218.9(a)13.3(l.)20.4(,)-229.6(2)0(0)21.1(2)0(0)]TJ 0 0 0 1 k 5.9438 0 TD (\).)Tj -11.3982 -1.2114 TD -0.0206 Tc [(Sulfadoxine)-4.4(-)5.2(pyrimethamine)-189.4(\()0.1(SP\))-184.8(i)]TJ 12.8842 0 TD -0.0209 Tc [(s)-188(a)-186.6(secon)-5.1(d)3.8(-line)-189.7(a)4.3(n)-5.1(t)0.6(imalarial)-182.7(f)-4.4(or)]TJ -14.1493 -1.2114 TD -0.0194 Tc [(uncom)4.9(p)-0.7(lica)5.8(ted)]TJ /F10 1 Tf 5.8185 0 TD -0.0211 Tc [(P.)-180(falciparum)]TJ /F9 1 Tf 5.174 0 TD -0.023 Tc [(m)-4.7(a)-3.7(laria)-182.8(t)-1.5(re)-6.8(at)-7.4(men)-7.2(t)-1.5(,)-175(a)-3.7(s)-178.2(r)-5.1(ec)-6.8(omm)-4.7(e)-0.9(n)-7.2(d)1.7(e)-6.8(d)-177.3(by)]TJ -10.9924 -1.2114 TD 0 Tc [(the)-439.9(Wo)11.9(rld)-441.5(He)12.3(al)12.7(th)-444.1(Or)10.9(ga)11.8(niz)11.5(ati)20.3(on)-444.9(\(WH)18.1(O\),)-442.6(wh)14.5(ich)-440.1(is)-444.2(use)11(d)-446.8(a)0(s)-446.2(a)0(n)]TJ T* -0.0212 Tc [(inte)-5(rmitten)-5.4(t)-369.7(pre)-5(v)1.2(enti)-5.9(ve)-369.1(treatment)-369.7(i)0.1(n)-375.3(p)-2.5(reg)-4.8(n)0.6(ancy)-374.8(\(IPTp\))-370.4(and)-372.5(a)-1.9(s)-373.3(a)4(n)]TJ 0 -1.2055 TD 0 Tc [(in)19.2(te)19.8(rm)18.3(it)18.9(te)13.8(nt)-428.1(pr)12.7(ev)20.6(en)20.1(ti)18.9(ve)-432.9(tr)15.5(ea)17.5(tm)21.9(en)14.1(t)-438(i)0(n)-434.3(i)0(n)19.2(f)0(a)17.8(n)0(t)19.5(s)-447.6(\(I)19.6(P)13(T)0(i)14.7(\))-438.8(in)-434.3(ma)19.7(la)18.6(ri)15.3(a-)]TJ 0 -1.2114 TD 0.0125 Tc [(en)4.5(demi)4(c)-472.6(r)0.5(e)4.8(g)-0.9(i)4(o)-0.7(n)4.5(s)-470.9(\()]TJ 0 0 0 0.7 k 7.74 0 TD 0 Tc [(G)-8.1(o)-13.2(sl)-18.6(i)-14.5(n)-8(g)-484.9(e)-7.7(t)-485.7(a)-10.6(l)-6.6(.)-14.7(,)-480.2(2)-10.3(0)-16.3(1)-10.3(0)]TJ 0 0 0 1 k 8.4383 0 TD (;)Tj 0 0 0 0.7 k 0.6982 0 TD 0.01 Tc [(Konate)-475.1(et)-475.7(al.,)-470.2(2)-6.3(011)]TJ 0 0 0 1 k 8.2115 0 TD 0.0091 Tc (\).)Tj -25.088 -1.2114 TD -0.0214 Tc [(Re)-5.2(sistance)-440.9(to)-440.4(SP)-438.1(is)-439.2(cause)-5.2(d)-438.3(main)-5.6(ly)-440.6(by)-440.6(point)-441.5(m)2.9(utations)-439.2(i)-6.1(n)]TJ /F10 1 Tf 23.3693 0 TD -0.0202 Tc (pfdhfr)Tj /F9 1 Tf -23.3693 -1.2114 TD 0.0331 Tc [(\(e)-4.4(nc)-4.4(odin)-4.8(g)-493.6(d)-1.9(ihydrofolate)-499.8(reduct)-5.1(a)-1.3(se)-4.4(\))-495.2(a)-1.3(nd)]TJ /F10 1 Tf 18.1178 0 TD 0.0345 Tc (pfdhps)Tj /F9 1 Tf 3.2703 0 TD 0.0387 Tc [(\(e)7.1(n)6.8(c)1.2(o)7.6(d)3.7(in)6.8(g)]TJ -21.3881 -1.2114 TD -0.0191 Tc [(dihydr)4.7(opteroate)-438.6(s)-1.2(yn)]TJ 7.8713 0 TD -0.0195 Tc [(thase\).)-440(M)0.2(utations)-443.2(in)]TJ /F10 1 Tf 8.5039 0 TD -0.0192 Tc (pfdhfr)Tj /F9 1 Tf 2.7213 0 TD -0.0206 Tc (and)Tj /F10 1 Tf 1.8798 0 TD -0.0192 Tc (pfdhps)Tj /F9 1 Tf 2.9003 0 TD -0.0216 Tc [(hav)-5.2(e)]TJ -23.8766 -1.2114 TD 0 Tc [(been)-466.3(associated)-471.7(with)-461.9(dec)-8.6(reased)-466.8(parasite)-468.7(sensiti)-11.4(vity)-461.5(to)-463.1(the)-463.7(SP,)]TJ T* -0.0213 Tc [(be)-5.1(cause)-387.1(t)0.2(he)-387.1(products)-385.4(of)-386.7(the)-5.1(s)2.5(e)-387.1(g)1.1(en)-5.5(es)-385.4(could)-384.5(i)0(ncrementally)-380.9(i)-6(n)0.5(crease)]TJ 0 -1.2055 TD -0.0203 Tc [(the)-362.2(p)-1.6(arasite)]TJ /F11 1 Tf 4.4877 0 TD 0 Tc ()Tj /F9 1 Tf 0.1969 0 TD -0.0208 Tc [(s)-367(t)0.7(o)-4.2(l)2.4(erance)-368.7(to)-362.2(t)-5.2(h)2.9(e)-368.7(d)3.9(rugs)]TJ /F10 1 Tf 9.7034 0 TD -0.0196 Tc [(in)-365.8(v)5.6(i)-0.2(tro)]TJ /F9 1 Tf 3.2285 0 TD 0 Tc (\()Tj 0 0 0 0.7 k 0.3223 0 TD -0.0203 Tc [(Chulay)-367.9(et)-368.8(a)4.9(l)-3(.)-363.3(1984)]TJ 0 0 0 1 k 7.1791 0 TD -0.0207 Tc (\).)Tj -25.1179 -1.2114 TD -0.0211 Tc [(Studies)-259.8(have)-261.5(identi)]TJ /F12 1 Tf 7.1552 0 TD 0 Tc ()Tj /F9 1 Tf 0.5132 0 TD -0.021 Tc [(ed)-258.9(point)-262.1(m)3.3(utation)-5.2(s)-253.8(in)-261.8(codon)-5.2(s)-253.8(N51I,)-256.5(C)2.4(59R,)-262.5(a)-1.7(nd)]TJ -7.6684 -1.2114 TD -0.0199 Tc [(S108)5.6(N,)-177.9(I164L)-181.1(of)]TJ /F10 1 Tf 6.2243 0 TD -0.0202 Tc (pfdhfr)Tj /F9 1 Tf 2.4527 0 TD -0.0219 Tc [(lo)-5.3(cated)-182.2(o)0.7(n)-185.1(c)0.2(hro)-5.3(m)2.4(o)-5.3(s)1.9(ome)-184.8(4)-181.4(an)-6.1(d)-182.2(c)0.2(odons)-183.1(I)-5.2(431V,)]TJ -8.677 -1.2114 TD -0.0195 Tc [(S436)6(A,)-392.3(A)5.1(437G,)-392.3(K)2(54)6(0E,)-392.3(A)5.1(581G,)-392.3(a)5.7(nd)-388.7(A6)6(13S)-392.9(of)]TJ /F10 1 Tf 18.7146 0 TD -0.0202 Tc (pfdhps)Tj /F9 1 Tf 2.8406 0 TD -0.0217 Tc [(locate)-5.5(d)-390.9(o)0.9(n)]TJ -21.5552 -1.2114 TD -0.0212 Tc [(chro)-4.6(mosome)-297.4(8,)-298.5(all)-296.4(o)1.4(f)-297.1(w)5.3(hich)-295.8(were)-297.4(associated)-294.9(wit)-5.6(h)]TJ /F10 1 Tf 19.2397 0 TD [(P.)-299.3(falciparum)]TJ /F9 1 Tf 5.4127 0 TD -0.0204 Tc (SP)Tj -24.6524 -1.2114 TD [(treatme)-4.2(n)1.4(t)-189.8(f)2.1(ailure)-183.3(\()]TJ 0 0 0 0.7 k 6.7972 0 TD -0.02 Tc [(Triglia)-191.7(e)2.1(t)-189.4(a)5.2(l.,)-189.9(1)5.5(997)]TJ 0 0 0 1 k 6.6181 0 TD 0 Tc (;)Tj 0 0 0 0.7 k 0.3819 0 TD -0.0223 Tc [(Be)-6.1(rg)-5.9(lez)-191.1(e)-0.2(t)-191.7(a)-3(l.,)-192.2(2004)]TJ 0 0 0 1 k 6.8747 0 TD 0 Tc (;)Tj 0 0 0 0.7 k 0.3879 0 TD -0.0204 Tc [(P)4.5(e)-4.2(arce)-189.2(et)-183.9(al.,)]TJ -21.0599 -1.2055 TD -0.0195 Tc [(200)6(9)]TJ 0 0 0 1 k 1.8321 0 TD -0.02 Tc [(\).)-321.2(Monitor)3.8(i)1.3(ng)-319.9(d)4.7(r)-2.1(ug)-319.9(r)3.8(e)2.1(sistance)-320.1(and)-317.6(t)-4.4(he)-320.1(pa)5.2(ttern)-314.5(o)-3.4(f)-319.8(m)4.3(utations)-318.4(is)]TJ -1.8321 -1.2114 TD -0.0212 Tc [(esse)-5(ntial)-206.8(f)1.3(or)-206.2(early)-207.7(d)3.5(e)-5(t)0.3(ecti)-5.9(o)1.4(n)-202.3(a)-1.9(nd)-205.4(subse)-5(q)-0.5(uent)-202.6(preve)-5(n)0.6(tion)-208.3(of)-207.6(the)-207.9(s)2.6(pread)]TJ T* -0.0203 Tc [(of)-153(dru)4.4(g)-153.1(resista)4.9(n)-4.5(ce.)-154.4(Th)3.4(e)-153.3(p)-1.6(r)3.5(e)-4.1(s)3.5(e)-4.1(nt)-153.9(s)3.5(t)1.2(udy)-153.1(identi)]TJ /F12 1 Tf 15.8382 0 TD 0 Tc ()Tj /F9 1 Tf 0.5132 0 TD -0.0213 Tc [(ed)-157.7(the)-154.3(p)-2.6(ol)-4(ymorphisms)-152.6(in)]TJ /F10 1 Tf -16.3514 -1.2114 TD -0.0202 Tc (pfdhfr)Tj /F9 1 Tf 2.4825 0 TD -0.0206 Tc (and)Tj /F10 1 Tf 1.653 0 TD -0.0255 Tc [(pf)-6.1(d)-8.9(h)-4.8(ps)]TJ /F9 1 Tf 2.6556 0 TD -0.0153 Tc (in)Tj /F10 1 Tf 0.9787 0 TD -0.0201 Tc [(P.)-208.8(falciparum)]TJ /F9 1 Tf 5.2456 0 TD [(am)4.3(ong)-212.5(r)-2.1(etur)3.8(ned)-210.2(m)-1.7(igrant)-213.3(work)3.5(ers)]TJ -13.0155 -1.2114 TD -0.0207 Tc [(from)-372.4(Africa)-377.4(in)-374.8(2)4.8(017)]TJ /F11 1 Tf 7.931 0 TD 0 Tc ()Tj /F9 1 Tf 0.4893 0 TD -0.0194 Tc [(2)6.1(019)-369.9(reported)-370.7(in)-367.6(ea)5.8(stern)-373.5(C)4(hina.)-374.3(T)3.8(h)4.3(e)-373.2(resul)3.8(t)2.1(s)]TJ -8.4204 -1.2114 TD -0.0204 Tc [(pr)3.4(ovide)-362.3(a)-371.1(d)4.3(e)-4.2(eper)-366.6(under)3.4(s)-2.5(tanding)-368(o)2.2(f)-367.9(t)1.1(he)-368.3(diseas)3.4(e)-368.3(a)-1.1(s)-366.6(w)6.1(ell)-367.2(a)-1.1(s)-366.5(b)2.2(as)3.4(eline)]TJ T* 0 Tc [(informa)-11.6(tion)-461.8(on)-468.8(antimalari)-11.7(al)-464.8(drug)-465.4(re)-7.7(sistance)-468.7(among)-468.6(impo)-8.6(rted)]TJ /F10 1 Tf 0 -1.2055 TD -0.0201 Tc [(P.)-238.7(falciparum)]TJ /F9 1 Tf 5.2993 0 TD -0.0207 Tc [(in)-243.6(China.)]TJ /F1 1 Tf 11.9999 0 0 11.9999 45.3543 134.8157 Tm 0 Tc [(MATERIALS)-306.1(AND)-297(METHODS)]TJ 0 -1.748 TD [(Sample)-303(Sites)]TJ /F13 1 Tf 10.0001 0 0 10.0001 45.3543 101.8204 Tm [(Sample)-302.8(Collection)-305(and)-301.6(DNA)-301.8(Extraction)]TJ /F9 1 Tf 9.5 0 0 9.5 45.3543 90.3118 Tm [(Th)17.1(e)-497.1(s)0(t)15.5(u)12.7(dy)-490(wa)15.9(s)-501.3(c)0(o)20.9(n)0(d)16.7(u)12.8(ct)19.8(ed)-496.2(i)15.3(n)-503.3(An)16.6(h)11.8(u)0(i)16.1(,)-498.1(Sh)20.3(an)17.2(d)12.7(o)0(n)14.6(g)0(,)-487.7(a)0(n)17.2(d)-500.5(Gu)16.6(a)13.3(n)0(g)20.3(x)0(i)]TJ 0 -1.2055 TD [(P)-10.9(r)0(o)-13.2(v)-7.5(i)-8.5(n)-14(c)-7.7(e)-7.7(s)-537.1(i)-8.5(n)-539.1(Ea)-15.5(s)-12(t)-8.3(e)-7.7(r)0(n)-545.1(a)-10.6(n)-8(d)-536.3(S)-9.4(o)-7.2(u)-11.1(t)-8.3(he)-13.8(r)-12(n)-539.1(C)-6.4(h)0(i)-14.6(n)-14(a,)-544.5(w)-9.3(h)0(e)-13.8(r)-12(e)-538.8(i)-8.5(mp)-16.7(o)-7.3(r)0(t)-14.3(e)-13.7(d)]TJ /F10 1 Tf 0 -1.2114 TD -0.0201 Tc [(P.)-441.6(falciparum)]TJ /F9 1 Tf 5.7051 0 TD -0.0212 Tc [(cases)-444.9(w)-0.6(ere)-440.7(p)-2.5(re)-5(domi)-5.9(nantly.)-447.7(A)-2.6(nhui)-441.5(Provinc)-5(e)-440.7(c)-5(o)1.4(vers)]TJ 21.7461 54.7652 TD -0.0219 Tc [(105)-378.4(c)-5.7(ounties)-380(w)-1.3(ith)-380.1(7)-2.4(0.)-6.8(6)-372.4(m)-3.6(illion)-382(pe)-5.7(ople)-381.7(an)-6.1(d)-373.2(e)-5.7(xperie)-5.7(nce)-5.7(d)-379.1(a)-372.6(m)-3.6(alaria)]TJ 0 -1.2114 TD 0.0254 Tc [(re)-6.2(su)-3.6(rg)-5.9(ence)-549.2(in)-549.6(2005)]TJ /F11 1 Tf 8.5158 0 TD 0 Tc ()Tj /F9 1 Tf 0.5371 0 TD 0.0248 Tc [(20)-3.5(0)-3.5(8)-546.5(th)-5.2(at)-550.4(wa)-3.7(s)-548.1(m)-4.6(ainl)-5.7(y)-549.6(c)-0.8(a)-3.7(u)1.7(s)-5.1(e)-0.8(d)-547.3(b)-6.3(y)-549.6(t)-1.4(he)]TJ -9.0529 -1.2055 TD -0.0181 Tc [(accumulation)-503.5(of)-502.9(residual)-502.1(f)-1.6(oci)-498.1(o)-1.5(f)]TJ /F10 1 Tf 13.6003 0 TD -0.0201 Tc [(P.)-507.2(viv)-6.8(a)-2.5(x)]TJ /F9 1 Tf 3.7596 0 TD 0 Tc (\()Tj 0 0 0 0.7 k 0.3282 0 TD -0.0191 Tc [(Feng)-504(et)-504.8(al.,)-505.3(20)-5.6(15b)]TJ 0 0 0 1 k 7.4297 0 TD -0.0207 Tc (\).)Tj -25.1179 -1.2114 TD -0.0215 Tc [(Shandon)-5.7(g)-327.4(Provi)-6.2(n)0.3(ce,)-328.7(lo)-4.9(cated)-331(i)-0.2(n)-327.9(e)0.6(as)]TJ 13.2959 0 TD -0.0205 Tc [(tern)-326.9(China,)-327.7(has)-324.9(a)-329.5(long)-320.4(coastline)]TJ -13.2959 -1.2114 TD -0.0197 Tc [(measuring)-373.3(3)5.8(,0)5.8(24.4)-370.2(k)-2.1(il)]TJ 8.3547 0 TD -0.0214 Tc [(o)-4.8(m)2.9(e)-5.2(t)0.1(ers.)-376.3(It)-375.8(con)-5.6(t)0.1(ain)-5.6(s)-373.5(137)-377.9(c)0.7(ountie)-5.2(s)-373.5(a)-2.1(nd)-372.7(has)-373.5(a)]TJ -8.3547 -1.2114 TD -0.0212 Tc [(popul)-3.9(a)-1.9(tion)-417.1(of)-422.4(97.9)-419.4(mill)-3.9(ion.)-417.9(Eco)-4.6(n)0.6(omic)-416.8(trade)-422.8(o)1.4(verseas)-415.1(is)-421.1(frequent.)]TJ T* -0.0219 Tc [(Another)-487.4(p)-3.2(ro)-5.3(vinc)-5.7(e,)-490.2(Guang)-5.5(x)-1.5(i,)-490.2(is)-487.4(kn)-6(own)-489.4(f)0.6(or)-487.4(its)-493.4(g)0.5(old)-492.5(m)2.4(i)-6.6(n)-0.1(ers)-487.4(w)-1.3(ho)]TJ T* -0.0164 Tc [(returned)-510.9(from)-505.4(Ghana)-510.4(i)4.9(n)-507.8(2)-2.9(013,)-508.6(which)-505.9(w)-1.8(as)-505.8(mainl)-16.4(y)-490(repo)-16.4(r)12.1(t)-0.8(ed)-504.9(in)]TJ T* -0.0208 Tc [(Shanglin)-327.2(County)-326.7(\()]TJ 0 0 0 0.7 k 7.1493 0 TD [(F)3.8(e)-4.7(ng)-326.8(et)-327.6(al.,)-328.1(2)4.6(015a)]TJ 0 0 0 1 k 6.7972 0 TD [(\).)-322.1(T)-3.7(h)2.8(e)-327(n)0.9(umber)-325.3(o)-4.3(f)-326.7(i)0.4(mported)]TJ /F10 1 Tf 10.9566 0 TD (P.)Tj -24.903 -1.2055 TD 0 Tc [(falcip)9.4(arum)]TJ /F9 1 Tf 4.792 0 TD [(case)9.8(s,)-516.1(especial)11.6(ly)-515.4(those)-512.8(from)-509.6(Africa,)-513.7(has)-512(incre)9.8(ased)]TJ -4.792 -1.2114 TD -0.023 Tc [(si)-7.7(gni)]TJ /F12 1 Tf 1.7784 0 TD 0 Tc ()Tj /F9 1 Tf 0.5132 0 TD -0.0208 Tc [(cantly)-344.6(in)-339.1(t)-5.2(h)2.9(ese)-338.8(t)0.7(hre)-4.6(e)-338.8(pro)-4.2(v)1.6(inc)-4.6(e)1.3(s,)-339.9(and)-342.2(3)4.7(60)-341.5(P)]TJ /F10 1 Tf 16.4827 0 TD 0.32 Tc [(.f)339.4(a)343.5(l)338.2(c)342.9(i)339.4(p)339.5(a)343.5(r)337.9(u)343.8(m)]TJ /F9 1 Tf 4.9711 0 TD -0.0204 Tc (cases)Tj -23.7453 -1.2114 TD [(were)-380.3(rep)4.2(o)-3.9(rted)-383.7(in)-380.6(20)5(19,)-381.4(a)4.7(c)-4.3(counting)-380.1(for)-378.6(18.5%)-380.5(of)-380(all)]TJ /F10 1 Tf 20.4392 0 TD -0.0211 Tc [(P.)-382.9(falciparum)]TJ /F9 1 Tf -20.4392 -1.2114 TD -0.0207 Tc [(cases)-301.2(n)1.1(ationwide)-302.9(\()]TJ 0 0 0 0.7 k 7.0657 0 TD -0.02 Tc [(Zhang)-302(L)-300.6(et)-296.9(al.,)-297.3(20)5.5(20)]TJ 0 0 0 1 k 7.7162 0 TD -0.0207 Tc (\).)Tj -13.5167 -1.2114 TD 0 Tc [(A)-506.5(t)0(o)14.3(t)0(a)16.9(l)-507.9(of)-504(20)15.1(6)]TJ /F10 1 Tf 6.6838 0 TD [(P.)-502.1(fa)13(lci)18.7(pa)13.2(ru)11.8(m)]TJ /F9 1 Tf 5.5022 0 TD [(-in)15.2(fe)14.7(ct)13.8(ed)-502.2(bl)16(oo)15.3(d)-512.4(s)0(a)13.3(m)0(p)13.1(l)0(e)15.5(s)-507.3(we)12.8(re)]TJ -13.4511 -1.2114 TD -0.0215 Tc [(collec)-5.3(ted)-426.5(f)1(rom)-426.9(t)0(he)-423.1(travelers)-421.4(r)-3.6(eturni)-6.2(ng)-422.8(from)-426.9(Af)-5(ric)-5.3(a)-420(f)-5(r)2.3(o)-4.9(m)-420.9(2017)-425.7(t)0(o)]TJ 0 -1.2055 TD 0.0234 Tc [(2019.)-546.3(The)-545.3(s)5.5(a)-5.1(m)-0.1(ples)-543.6(distribution)-539.6(were)-545.3(shown)-545.6(a)0.9(s)]TJ /F14 1 Tf 0 0 0 rg 21.5313 0 TD 0.0228 Tc [(Figure)-546.8(1)]TJ /F9 1 Tf 0 0 0 1 k 3.9088 0 TD 0 Tc (.)Tj -25.4401 -1.2114 TD -0.0202 Tc [(Ap)4.5(proxima)5(t)-4.7(ely)-451.4(1)-0.7(0)5.3(0)]TJ /F15 1 Tf 7.9967 0 TD 0 Tc (m)Tj /F9 1 Tf 0.555 0 TD 0.4303 Tc [(lo)452.9(f)]TJ /F12 1 Tf 1.8142 0 TD 0 Tc ()Tj /F9 1 Tf 0.5132 0 TD 0.4296 Tc [(n)451.4(g)452(e)451.7(r)447.5(-)449.4(p)448.3(r)453.4(i)450.9(c)445.8(k)5.5(b)446.2(l)452.8(o)452.2(o)446.2(dw)450.2(a)454.8(s)-0.1(s)447.5(p)448.3(o)452.2(t)451.1(t)451.1(e)451.7(do)446.2(n)451.4(t)451.1(oa)]TJ -10.879 -1.2114 TD -0.0208 Tc [(piece)-285.1(of)-278.8(3MM)-275.6(W)-1.7(hatman)]TJ /F12 1 Tf 9.8645 0 TD 0 Tc ()Tj /F9 1 Tf 0.5073 0 TD -0.021 Tc [(lter)-283.6(paper)-283.6(\()-0.3(GE)-276.6(He)-4.8(althc)-4.8(a)4.2(re,)-280.4(B)1(oston,)-280.4(MA,)]TJ -10.3718 -1.2114 TD -0.0187 Tc [(USA)5.9(\))-302.3(a)6.5(n)-2.9(d)-298.4(a)6.5(ir)-293.2(dried.)]TJ 1.2651 -1.2114 TD 0.0365 Tc [(Th)-5.4(e)]TJ /F10 1 Tf 2.2259 0 TD 0.0394 Tc [(Plasmodium)-546.2(falciparum)]TJ /F9 1 Tf 11.1177 0 TD 0.0387 Tc [(ge)-4.8(nomic)-547.9(D)-2.1(N)-4.1(A)-545.4(f)-4.5(r)2.9(o)-4.4(m)-545.7(the)]TJ -14.6088 -1.2114 TD -0.0146 Tc [(ap)-14.6(p)4.9(r)-14.6(ox)-14.6(imat)-14.6(e)5.2(l)-14.6(y)-458.4(1)-14.6(0)6.5(0)]TJ /F15 1 Tf 7.943 0 TD 0 Tc (m)Tj /F9 1 Tf 0.5669 0 TD [(l)-454.2(o)0(f)-438.3(c)0(o)20.9(l)0(l)16.6(e)0(c)20.4(t)0(e)19.8(d)-452.7(bl)21.9(oo)21.3(d)-452.7(s)0(a)19.2(m)0(p)19.1(l)0(e)-444(w)0(a)21.9(s)-453.6(ex)18.7(tr)21.5(ac)17.5(te)19.8(d)]TJ -8.5099 -1.2114 TD [(u)12.7(s)0(i)15.3(n)0(g)-284.1(a)-297(QI)21.7(A)12.7(a)0(m)19.7(p)-297.6(D)12.9(N)0(A)-286.7(b)0(l)21.9(o)0(o)21.3(d)-297.6(k)11.6(i)0(t)-285.4(\()0(Q)19.8(I)0(A)17.4(G)0(E)22.8(N)0(,)-290.2(V)0(a)24(l)0(e)21.5(n)0(c)20.1(i)0(a)16.7(,)-295.2(CA)18.2(,)-295.2(U)12.9(SA)21.1(\))]TJ 0 -1.2055 TD [(a)13.3(s)-232.8(d)12.7(e)0(s)16.1(c)0(r)22.1(i)0(b)20(e)0(d)-221.7(p)12.7(re)16.1(vi)19.8(ou)23.4(sl)17.2(y)-228.3(\()]TJ 0 0 0 0.7 k 9.5303 0 TD [(Ya)23.6(n)-228.8(e)0(t)-218.9(a)0(l)18.6(.)0(,)-220.4(2)0(0)21.1(2)0(0)]TJ 0 0 0 1 k 5.9438 0 TD [(\).)-220.8(Ea)20.3(ch)-222.7(of)-217.5(th)21.4(e)-228.5(s)0(a)19.2(m)12.3(pl)18.1(es)-222.6(w)14.6(a)0(s)]TJ -15.4741 -1.2114 TD [(la)18.6(be)20.8(le)21.5(d)-291.6(w)0(i)18(t)0(h)-283(a)-297(s)11.9(t)0(u)22.3(d)0(y)-287.1(n)0(u)22.6(m)0(b)17(e)0(r)-282.2(a)0(n)17.2(d)-291.6(s)11.9(t)0(o)20.2(r)0(e)16.1(d)-291.6(at)]TJ /F16 1 Tf 17.1093 0 TD ()Tj /F9 1 Tf 0.561 0 TD [(4)13.5()0(C)-288.1(u)12.7(nt)19.5(il)-283.7(ex)18.7(tr)21.5(ac)17.5(t)15.6(i)0(o)20(n)0(.)]TJ -17.6702 -1.2114 TD [(In)20.6(di)22.1(vi)19.8(du)19.5(al)-261.9(ep)22.9(id)16.1(em)22.5(io)20(lo)21.9(gi)19.8(ca)17.5(l)-269.2(i)0(n)19.2(f)0(o)21.2(r)11.9(ma)19.7(ti)18.9(on)-259.9(wa)21.9(s)-268.6(a)0(l)18.6(s)11.9(o)-269.8(c)0(o)20.8(l)0(l)16.6(e)0(c)20.4(t)0(e)19.8(d)-267.7(us)18.7(in)19.2(g)-270.1(a)]TJ T* [(we)-11(b)-7.3(-)0(b)-11.3(a)0(s)-10.6(e)-7.7(d)-524.3(r)0(e)-13.7(p)0(o)-12.4(r)0(t)-14.3(i)0(n)-10.6(g)-526.7(sy)-7.5(st)-14.3(e)-7.7(m)-524.8(\(C)-9.5(hi)-14.6(n)-8(a)-517.8(I)-7.2(n)-8(f)-7.4(o)-7.3(rm)-11.6(at)-12.9(io)-9.8(n)-527.2(S)0(y)-10.9(s)0(t)-14.3(e)0(m)-526.5(f)-7.4(o)-7.3(r)]TJ T* [(D)12.9(i)0(s)15.3(e)0(a)23.5(s)11.9(es)-282.2(Co)22.1(nt)19.5(ro)16.6(l)-287.1(a)0(n)17.2(d)-285.6(Pr)18.9(ev)20.6(en)20.1(ti)18.9(on)20.5(\))-289.6(a)0(n)17.2(d)-285.6(an)17.2(al)18.6(yz)20.6(ed)22.9(.)]TJ /F1 1 Tf 11.9999 0 0 11.9999 306.1417 264.1322 Tm -0.0494 Tc [(Detection)-241.2(o)1.8(f)]TJ /F2 1 Tf 5.4378 0 TD -0.05 Tc [(pfdhf)-4.6(r)]TJ /F1 1 Tf 2.8252 0 TD -0.0484 Tc (and)Tj /F2 1 Tf 1.852 0 TD -0.0512 Tc [(pf)-5.8(dhps)]TJ /F1 1 Tf 3.2126 0 TD -0.0498 Tc (Polymorphisms)Tj /F9 1 Tf 9.5 0 0 9.5 306.1417 252.6236 Tm 0 Tc [(P)13(o)0(i)20(n)0(t)-302.8(m)12.3(ut)16.4(a)13.3(t)0(i)18.9(o)0(n)20.5(s)-310.3(a)13.3(t)-312.7(co)20.8(do)17.4(ns)-300.5(1)13.5(6)0(,)-299.6(5)0(1)21.1(,)-313.1(5)13.5(9)0(,)-299.6(1)0(0)15.1(8)13.5(,)-313.1(a)13.3(nd)-299.6(16)21.1(4)-314.7(o)0(f)-295.1(t)0(h)15.4(e)]TJ /F10 1 Tf 23.3156 0 TD [(pf)20.9(dh)19.4(fr)]TJ /F9 1 Tf -23.3156 -1.2114 TD [(ge)20.6(ne)-326(an)17.2(d)-339.3(c)0(o)20.9(d)12.7(on)20.5(s)-340.2(4)13.5(31)21.1(,)-337(4)0(3)21.1(6)0(,)-329.4(4)13.5(37)15.1(,)-337(5)13.5(40)21.1(,)-337(5)0(8)21.1(1)0(,)-329.4(a)13.3(nd)-329.5(61)21.1(3)-338.6(o)0(f)-325(t)0(h)21.4(e)]TJ /F10 1 Tf 23.1426 0 TD -0.0158 Tc [(pf)-15.8(dh)-15.8(p)6.4(s)]TJ /F9 1 Tf -23.1426 -1.2055 TD 0.0199 Tc [(gene)-530.9(were)-530.9(evaluated)-528.3(u)2.8(sing)-524.7(ne)-5.7(sted)-528.3(PCR)-529.8(a)3.4(mpli)]TJ /F12 1 Tf 20.1647 0 TD 0 Tc ()Tj /F9 1 Tf 0.555 0 TD 0.019 Tc [(cation.)-532.8(T)0.4(he)]TJ -20.7197 -1.2114 TD 0 Tc [(s)11.9(e)0(q)18.9(u)0(e)17(n)0(c)20.1(e)0(s)-330(o)0(f)-336.9(t)0(h)21.4(e)-341.9(pr)18.7(im)15.7(er)22.1(s)-346.2(u)12.7(s)11.9(e)0(d)-335.1(f)0(o)15.2(r)]TJ /F10 1 Tf 13.9225 0 TD [(pf)20.9(dh)19.4(fr)]TJ /F9 1 Tf 2.6854 0 TD [(an)17.2(d)]TJ /F10 1 Tf 1.8261 0 TD -0.0158 Tc [(pf)-15.8(dh)-15.8(p)6.4(s)]TJ /F9 1 Tf 2.8645 0 TD 0 Tc [(ge)20.6(no)20.5(ty)20(p)12.7(i)0(n)19.2(g)]TJ -21.2986 -1.2114 TD -0.0195 Tc [(w)-19.5(e)-0.7(r)-7.6(e)-415.1(a)-6.2(s)-413.4(d)-6.8(e)-19.5(sc)-19.5(ri)-19.5(be)-19.5(d)-402.4(p)-19.5(re)-19.5(vi)-19.5(ou)-19.5(sl)-19.5(y)-403.6(\()]TJ 0 0 0 0.7 k 12.2516 0 TD 0 Tc [(Zh)20(an)17.2(g)-389.4(e)0(t)-386(a)13.3(l.)20.4(,)-396.7(2)13.5(01)21.1(4)]TJ 0 0 0 1 k 7.376 0 TD [(\).)-381.9(Th)17.1(e)-389.6(p)0(r)18.7(i)0(m)21.7(a)0(r)19.2(y)]TJ -19.6276 -1.2114 TD -0.0133 Tc [(am)-13.3(p)5.8(l)-13.3(i)]TJ /F12 1 Tf 2.2259 0 TD 0 Tc ()Tj /F9 1 Tf 0.5252 0 TD [(ca)23.5(ti)18.9(on)-409.1(w)14.6(a)0(s)-410.4(p)12.7(er)16.1(fo)21.2(r)11.9(m)12.3(ed)-412.7(u)12.7(s)11.9(in)19.2(g)-419.2(t)0(h)21.4(e)-419.5(fo)21.2(ll)22.6(ow)19.3(in)19.2(g)-413.3(p)0(a)20.1(r)0(a)19.2(m)0(e)16.6(t)15.5(er)16.1(s)11.9(:)-420.5(1)]TJ -2.7511 -1.2114 TD [(cy)20.6(cl)21.5(e)-282.2(o)0(f)-271.2(9)13.5(5)18.3(C)-280.9(f)0(o)21.2(r)-280.5(3)-284.9(m)12.3(in)19.2(;)-283.3(3)13.5(5)-278.9(c)0(y)20.6(c)0(l)15.5(e)0(s)-270.3(o)0(f)-271.2(9)13.5(5)18.3(C)-280.9(f)0(o)21.2(r)-280.5(30)-271.3(s)11.9(,)-283.3(5)13.5(5)0()18.3(C)-280.9(fo)21.2(r)-280.5(3)0(0)-271.3(s)11.9(,)]TJ T* [(a)13.3(n)0(d)-204.1(6)13.5(5)18.3(C)-209.3(f)0(o)21.2(r)-208.9(6)-207.3(f)0(o)21.2(r)-214.9(3)13.5(0)-207.3(s,)-199.8(an)17.2(d)-208.1(1)-207.3(cy)14.7(cl)21.5(e)-210.6(o)0(f)-193.7(6)0(5)15.1()0(C)-198.6(f)0(o)21.2(r)-208.9(6)13.5(0)-213.2(s)11.9(;)-211.7(a)13.3(n)0(d)-198.2(6)0(5)21.1()0(C)-204.5(f)0(o)21.2(r)-208.9(5)]TJ T* [(m)12.3(i)0(n)19.2(.)-271.4(Th)23.1(e)-270.3(s)11.9(ec)20.4(on)20.5(d)-267.7(a)0(m)19.7(p)0(l)18.1(i)0(f)19.9(c)0(a)23.5(t)0(i)18.9(o)0(n)-254(w)0(a)15.9(s)-268.6(p)12.7(e)0(r)22.1(f)0(o)15.2(r)11.9(m)12.3(e)0(d)-257.5(u)0(s)18.7(i)0(n)19.2(g)-270.1(t)15.5(h)0(e)-258.5(f)0(o)21.2(l)0(l)16.6(o)0(w)25.2(i)0(n)19.2(g)]TJ 0 -1.2055 TD [(p)12.7(a)0(r)19.2(a)0(m)19.7(e)0(t)19.8(e)0(r)16.1(s)11.9(:)-289.2(1)-284.9(cy)20.6(cl)15.5(e)-288.2(o)0(f)-277.2(9)13.5(5)18.3(C)-286.9(f)0(o)21.2(r)-292.4(3)-284.9(m)0(i)21.7(n)0(;)-279.4(3)0(5)-277.3(c)0(y)20.6(c)0(l)15.5(e)0(s)-276.3(o)0(f)-277.2(9)0(5)21.1()0(C)-282.1(f)0(o)21.2(r)-286.5(30)-277.3(s)11.9(,)]TJ 0 -1.2114 TD [(5)13.5(2)0()18.3(C)-191.4(fo)15.2(r)-191(3)0(0)-181.8(s)0(,)-187.8(a)13.3(nd)-186.2(65)21.1(C)-186.6(fo)21.2(r)-191(6)0(0)-187.8(s)11.9(;)-193.8(a)0(n)17.2(d)-190.2(1)-195.3(c)0(y)20.6(c)0(l)21.5(e)-192.7(of)-187.7(6)13.5(5)0()18.3(C)-191.4(fo)15.2(r)-191(5)-195.3(m)12.3(i)0(n)19.2(.)-193.8(75)21.1(0-)]TJ T* [(bp)-298.9(pr)18.7(od)23.4(uc)17(t)-306.7(o)0(f)]TJ /F10 1 Tf 5.8006 0 TD [(pf)20.9(dh)19.4(p)13.5(s)]TJ /F9 1 Tf 2.8287 0 TD [(we)18.8(r)11.9(e)-312.1(s)11.9(e)0(n)20.1(t)-312.7(fo)21.2(r)-310.3(S)14.5(an)17.2(ge)20.6(r)-310.3(s)11.9(eq)18.9(ue)17(nc)20.1(i)15.3(n)0(g)-302(\()0(S)17.3(h)11.8(a)13.3(n)0(g)14.3(h)11.8(a)13.3(i)]TJ -8.6292 -1.2114 TD [(Bu)22.9(na)17.2(n)-288.5(B)0(i)19.5(o)0(l)21.9(o)0(g)21.1(i)0(c)19.6(a)0(l)-279.8(C)0(o)22.1(.)0(,)-280.1(L)0(t)15.4(d)12.7(.,)-280.1(Sh)20.3(an)17.2(gh)22.2(ai)22.7(,)-295.2(C)0(h)23.3(i)0(n)19.2(a)13.3(\).)]TJ /F1 1 Tf 11.9999 0 0 11.9999 306.1417 90.1417 Tm [(Data)-301.6(Analysis)]TJ /F9 1 Tf 9.5 0 0 9.5 306.1417 78.6331 Tm -0.0001 Tc [(Sequences)-361.1(were)-365(analyzed)-362.3(using)-357.6(the)-356.4(Blast)-361.7(program)-364.4(\(http://blast.)]TJ T* 0 Tc [(ncbi.nlm.nih.gov/\).)-212.7(Multiple)-201.5(nucleotide)-203.5(sequence)-208.4(alignments)-208.2(and)]TJ ET 0 0 0 0.7 k 45.354 737.518 504.567 0.28345 re f BT /F6 1 Tf 6.9999 0 0 6.9999 45.3543 744.2644 Tm [(Yan)-298.8(et)-300.5(al.)]TJ /F5 1 Tf 53.0817 0 TD (pfdhfr)Tj /F6 1 Tf 2.4864 0 TD (/)Tj /F5 1 Tf 0.324 0 TD (pfdhps)Tj /F6 1 Tf 3.2802 0 TD [(Mutations)-303(in)-304.4(Chinese)-298.8(Migrants)]TJ ET 45.354 42.803 504.567 0.22675 re f 45.354 42.803 504.567 0.22675 re f BT 6.9999 0 0 6.9999 45.3543 31.2945 Tm [(Frontiers)-306.1(in)-296.3(Cellular)-302.6(and)-306.5(Infection)-301.5(Microbiology)-499.5(|)-502.8(www.frontiersin.org)-22490(September)-305.7(2021)-505.2(|)-494.7(Volume)-307.7(11)-499.6(|)-494.7(Article)-305.6(673194)]TJ 35.7658 0 TD (2)Tj ET endstream endobj 26 0 obj<>stream HTS{PTev-z "pXX@XJma '* eUAQ(:cNj F%!iųAG}|GCtZhTKʔe¨Q5ꤱXjDkJ(-[k-/PN(&M22D1saiUI_[^a]U$Jy0E1\+irr$: o\к2j_n+ l%Ŝ6`A4ğ)Zb yX$:NH&!لL`} :b$U4"4)6}Svvύwmqkqy7c_/a  rpD(6pKó*a8ga.P fOei&b<a2LTRLe!,QU<(d}: S >3!FQs6x=kW uxR83e7w|~Ě L}ZV= ^H: y繃{K۾:x4oB$w.Z:7޴NRكW:*WxewWxb' 29&@'q 1CP3};,#%Ki֧}dgyzt 쿔4"7,pIWF~_p4YDL^17n4uk1X+PaaA9F{\_P$,AEg=9awyU2:ŒlpҾm 0S J3Ixz׆/J_MEY6y]VOEB۝7,@'SlF3[eu0cDNX! q!CFB qj4âmvcwe ,)}0d~ ^ǘKlճV~ 6׬$f(ޭ=E+4q i[WY[~+?LhNo0a"s0b8 4lH CB":86M`/|c endstream endobj 27 0 obj<> endobj 28 0 obj<>stream Hbd`ab`dd pqvL)1N0IM35IHf!#_հ~w,#cLs~AeQfzFF4 L+8'*W+x%%)8()V(J-N-* :@V2pG`9φˤ\}Ap܎cgI%~9wpʌI]E g6l޽t['(gk-.o꫞Q3yR"8kӋJ ꋺsgp$ϭ߲KCv>_r endstream endobj 29 0 obj<> endobj 30 0 obj<>stream Hbd`ad`ddpqpvL)1LM375O662If!#[O_#v/b`bd̯_`d``"SR+KRs< KRSsr23JRS@zz @y% .z :f&z %E `bԼ̼t= '2C~\{?|!C endstream endobj 31 0 obj<> endobj 32 0 obj<> endobj 33 0 obj<> endobj 34 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 35 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 36 0 obj<> endobj 37 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 38 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 39 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 40 0 obj<>/Font<>/ProcSet[/PDF/Text/ImageC]/ExtGState<>>> endobj 41 0 obj<>stream /GS1 gs BT /F9 1 Tf 9.5 0 0 9.5 45.3543 190.6582 Tm 0 0 0 1 k 0 Tc 0 Tw [(analysis)-272.7(were)-275.4(carried)-272.5(out)-271.4(using)-273.9(the)-272.8(MAFFT)-271.1(web-based)-273.9(tool)-268.1(with)]TJ 0 -1.2055 TD 0.0001 Tc [(the)-218.9(Cluster)-219.2(Omega)-223.2(Sequence)-223.6(Alignment)-220.6(Editor)-219.1(\(https://www.ebi.)]TJ 0 -1.2114 TD 0 Tc [(ac.uk/To)-10.9(ols)-7.9(/msa/clu)-12.3(stalo/\).)-510.4(Seque)-9.3(nces)-506.8(with)-503.7(poor)-509(quality)-509.4(after)]TJ T* [(three)-304.4(sequencing)-302.3(attempts)-304.6(or)-305.7(those)-297.9(with)-300.8(more)-307(than)-301.6(one)-297.5(peak)-304.3(at)]TJ T* [(one)-345.2(locus)-343(were)-347(not)-345.9(included)-346.5(in)-344.8(the)-344.4(analysis.)-347.1(The)-342.7(map)-343.6(showing)]TJ T* [(the)-201.1(imported)-208.9(of)-199.6(countries)-207.9(with)-199.3(number)-206.8(of)-199.6(the)-207.1(isolates)-204.2(was)-198.9(created)]TJ T* [(by)-241.5(ArcGIS)-246.5(10.1)-242.7(\(Environmental)-249.4(Systems)-241.5(Research)-249.4(Institute,)-243.4(Inc.,)]TJ T* [(Redlands,)-267.5(CA,)-259.1(USA\).)-264.3(SPSS18.0)-269.9(\(IBM)-261(Corp.,)-263.2(Armonk,)-262(NY,)-268(USA\))]TJ 0 -1.2055 TD [(was)-246.7(used)-250.8(to)-242.3(conduct)-252.2(the)-248.9(statistical)-250.6(analyses,)-244.8(and)-250.5(the)-248.9(Chi-squared)]TJ 0 -1.2114 TD [(test)-227.3(was)-222.8(employed)-225.7(to)-224.4(test)-227.3(the)-225(dif)62.5(ferent)-224.2(constituent)-232.6(ratios)-225.7(of)]TJ /F10 1 Tf 23.2679 0 TD (pfdhfr)Tj /F9 1 Tf -23.2679 -1.2114 TD 0.0392 Tc (and)Tj /F10 1 Tf 2.1543 0 TD 0.0395 Tc (pfdhps)Tj /F9 1 Tf 3.3479 0 TD 0.0403 Tc [(gene)-534.3(pol)3.9(y)3(morph)4.4(i)1.9(sms)4.5(.)-541.4(T)3.8(h)-1.6(e)-540.3(F)5.3(isher)]TJ /F11 1 Tf 15.0027 0 TD 0 Tc ()Tj /F9 1 Tf 0.2566 0 TD 0.5789 Tc [(sp)537.9(r)543.1(e)541.4(c)535.4(i)540.5(s)537.1(i)540.5(o)541.8(n)]TJ 6.6897 12.1024 TD 0 Tc [(probability)-375.4(test)-376.5(was)-372(used)-376.1(as)-374.6(the)-374.2(sample)-375.8(size)-376.1(is)-372.6(less)-372.4(50;)-375.6(For)-376.5(the)]TJ 0 -1.2055 TD [(sample)-238.5(size)-238.8(less)-235.2(than)]TJ /F12 1 Tf 8.4144 0 TD ()Tj /F9 1 Tf 0.5311 0 TD [(ve)-236(would)-236.4(be)-235.8(discarded)-241(when)-240(analyzing)-242.1(the)]TJ -8.9455 -1.2114 TD [(geographical)-485(distribution)-481(dif)62.5(ference.)-484.7(The)-479.9(inter)-480.2(and)-483.3(intragenic)]TJ T* [(SNP)-504.7(Linkage)-508.3(dise)-9.5(quilibriu)-11.3(m)-500.9(\(LD\))-506.7(association)-11.2(s)-501.3(o)0(f)]TJ /F10 1 Tf 21.2568 0 TD [(pfdh)-7.4(fr)]TJ /F9 1 Tf 2.9003 0 TD (and)Tj /F10 1 Tf -24.1571 -1.2114 TD (pfdhps)Tj /F9 1 Tf 2.8704 0 TD [(were)-305.2(analyzed)-302.5(using)-303.7(Haploview)-305.2(15)-295.2(\()]TJ 0 0 0 0.7 k 14.5849 0 TD [(Patel)-300.7(et)-302.5(al.,)-303.3(2017)]TJ 0 0 0 1 k 6.6301 0 TD (\).)Tj /F1 1 Tf 11.9999 0 0 11.9999 306.1417 121.1527 Tm [(Ethical)-304.7(Considerations)]TJ /F9 1 Tf 9.5 0 0 9.5 306.1417 109.7007 Tm [(This)-271.9(study)-270.8(was)-264.6(reviewed)-274.4(and)-268.4(approved)-275.3(by)-265.4(the)-272.8(ethical)-270.4(committee)]TJ 0 -1.2114 TD [(of)-223.5(the)-219.1(National)-228(Institute)-222.7(of)-223.5(Parasitic)-226.3(Diseases,)-227.5(Chinese)-223.5(Centre)-223.2(for)]TJ T* 0.0654 Tc [(Disease)-562.9(C)-0.7(ontr)-6.2(ol)-567.8(and)-566.4(P)0.8(revention)-569.2(\()2.6(NIPD,)-570(C)-0.7(hina)-565.8(CDC,)]TJ T* 0 Tc [(No.)-303.5(2019008\).)]TJ ET 0 0 0 0.7 k 45.354 717.505 m 549.921 717.505 l 549.694 717.222 l 45.581 717.222 l f* 549.921 717.505 m 549.921 217.701 l 549.694 217.984 l 549.694 717.222 l f* 549.921 217.701 m 45.354 217.701 l 45.581 217.984 l 549.694 217.984 l f* 45.354 217.701 m 45.354 717.505 l 45.581 717.222 l 45.581 217.984 l f* q 425.253418 0 0 455.244019 84.982658 244.516434 cm /Im1 Do Q BT /F1 1 Tf 6.9999 0 0 6.9999 50.6268 223.4834 Tm 0 0 0 1 k [(FIGURE)-299.4(1)]TJ /F6 1 Tf 5.0053 0 TD [(|)-429.9(Sample)-307.2(collection)-297.5(and)-306.5(distribution,)-300.2(samples)-306.3(collection)-305.6(sites)-299.4(and)-298.4(sample)-307.4(screening)-302.1(and)-298.4(follow-up)-305.8(analysis)-299.4(of)-299.5(subject)-307.4(patterns.)]TJ ET 0 0 0 0.7 k 45.354 737.518 504.567 0.28345 re f BT 6.9999 0 0 6.9999 45.3543 744.2644 Tm [(Yan)-298.8(et)-300.5(al.)]TJ /F5 1 Tf 53.0817 0 TD (pfdhfr)Tj /F6 1 Tf 2.4864 0 TD (/)Tj /F5 1 Tf 0.324 0 TD (pfdhps)Tj /F6 1 Tf 3.2802 0 TD [(Mutations)-303(in)-304.4(Chinese)-298.8(Migrants)]TJ ET 45.354 42.803 504.567 0.22675 re f 45.354 42.803 504.567 0.22675 re f BT 6.9999 0 0 6.9999 45.3543 31.2945 Tm [(Frontiers)-306.1(in)-296.3(Cellular)-302.6(and)-306.5(Infection)-301.5(Microbiology)-499.5(|)-502.8(www.frontiersin.org)-22490(September)-305.7(2021)-505.2(|)-494.7(Volume)-307.7(11)-499.6(|)-494.7(Article)-305.6(673194)]TJ 35.7658 0 TD (3)Tj ET endstream endobj 42 0 obj<>stream Adobed      ""i  s!1AQa"q2B#R3b$r%C4Scs5D'6Tdt& EFVU(eufv7GWgw8HXhx)9IYiy*:JZjzm!1AQa"q2#BRbr3$4CS%cs5DT &6E'dtU7()󄔤euFVfvGWgw8HXhx9IYiy*:JZjz ?N*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UتV"-ee(#BoLHޘ]4a= <*qT]~X\1Z~OpQ)oү,|ݥs@VL ZPSaኣAb~\ElU /M:lqTP?0XKHZ3@IP׿v!{b |1Vz UثWb]v*UثWb=OHEv4d6aE vb[u8E+>yá#Rλ8͖M>8 Uh?^gY)#q!Q^ZrVCI#eb2hk*UثWb]v*UثT6C[U*3yj^WN|c7DOT)6Y5t]v*]v*UثWM*gߘ5,"0Ktۀ|*ygN\oa|_k"2zUL<Г%ܢ#w,U &&5h~Dv*ƴMv@9ٛWo݊^⬋Nw^Tƀm\U[jq2j:e; (N*~QjgxM"HJ{⬢KH "'UTTN.t{ַB*+Vh+pb1Ua?9ha SO׊_]ӭ=KGuqČUxWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]i *Ŀ0ص"Qc]ُjZ3EDblP^v*UثWb]v*UثWb]/+Im-!~r U&w%]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UJKS$$fcaҴڽ֣=6%+$_1jQO.y"e^v*UثWb]v*Uث7tyYE QkXdǔ)j6P}:5GOLMOpF*U+#iG 1y.< -]RZU%*c?֍Sƿbf6IJ_RX!FI>rlAWk?:~wQzOYy\ qT[҂~޺#G_C-^nk)J;v+M*<_)ڵ4FIY*UثU =9(4Q]v*U X]Rx]4̝mXiZspcޣb.V[wILUثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]c_]qg뵱XHE*ɞzG8/t[ؤ1;FǮ*Nkxt튢1Wb]v*UثWb]v*UثV Bk}BPMEc~V`[ڃgQqH{{.*1Wb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb=gVH(TS*,?=|ikV}튰 G vn6|*yWYԚX#|UCH]ӵV[g"МU/oB]D&դ8u_z/Y'.Q:ѹMwOZmYy3oi/GQƛqHoˏkhԹd)+qTF6e&GԴ}ʓ֘sQ[I#$$o>ثqWb]v*UثWb]v*UثWb]v*UثNqW|:k'↿ 08㶍aBF@T]v*UثWb]v*UB,CEKb"?1<٭[]jK%#"|U,m$V25UMI'e qm +JGU*/|VY_ѥcذS?@VL!EFqTqX-'SVXUdK&T5厅o'+2oLU~ok佼< UX4pΉ Õӯ)\OY@,s*ּG\Uv*UثWb/mn z(XV7v\mHZڵWOi"Ҥ2)ZUlwj1R#dKC"2//(lVb{$v81*gak̟ڮ*1Wb]v*UثWbR}[V2_ Y8V̧a?R7hmd7'QTAѵVxNd}Y^*UثWb]v*UثWb]v*UثWb]v*UثWb]b_m;GиS*'u-y?PQzlUWb]v*UثWb]v*UتS[ i.TD;b--1̿[w1lhQGz *UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*Uتt1Jх"?G׍ n>O|?H#Z3rB׶bq^u9o얁jO}Sv*UثWb]v*UثWb]v*UثWb]v*UثWbXwoIvm1TgZXVo=qVKv*UثWb]v*Uث?{f}gM⫭.5[HRh}V{hEYYQWb]v*Uh_{j}Kv=b_ ~a 얚?/*te*UJjqv*<*uKFT@E婭>dTqc^VEJ}@;⨙?2< ne=*Mf}@j~np~Պ@ l1WlUث )t뷾^p'~Xߒ_#+w5#劤1kqV:z>+5-\$aߊ?64 64Ǩr>튲h{9d2TQ!&I$`WU}{ZI劷v*RTw5a*wUxc[UY850b]]q?d.|k)M/q1WI6v *~gAIf]HSbZ:论 >&=U$j N5PZ9VR{b][i኷v*UثWb]v*UثWb]v*UثWb]v*Uث}[˗Zlz)(ˊWb]v*UثWb]v*Uت#Y*o-VZWޱ;V_Pk[6hsLUZ^kre،Uv*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]AjZ=\ y!~qԕKWlUyϾb]O嬔yFtScͺ<`n*4YL?%aVJb?;w"I)dVH?#]v*UثWb]v*UثWb]v*UثWb]v*~?XX[SzV2@,* $ UztIܽ.T|1Wh|5{uqPySSK=^$a)E]v*Uէ\U#G+ƒCkԜU?ΚEfX.c*:y*yvxע.e,3U`zziD83v*UثWb]7GK6:"|P$ ET+H^U3KEք$, PG*e̾EN֥IlU7G0̲ ߜ$q&2#+PߜRYYC3\:OLUWY Vk9 /&2o𞘫ѴHCj+D(HUn1Wb]v*5km*E'yߞS'OYHBX]V2]NjbKЭm D?*7C9$/dRCzojRtJ*/3.uC -yS@Q5/.пч*iߝ:tI[4I<*a 6uت+ $kYQZ I늳k l![ke  1TF*o?( )֚Lws/I#8|+o1jF\ aGߊTz=W z0p#sپz6SbG1WB_7,zuN*\UثWb]v*UثWb]v*UثWb]v*U wZ2{W b37S&&$Imm'= x UY>; qUg[ޜb S⩏ͬw}bA]v*UثWb]v*UثWb]y痖Ngox HUT$- @TrV:bqi Fhߚ>t, 43 v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*BR=H|)TABjk=~Nh~tcmh6 ث.;)L{¼n}=*?+|fז56N*O?8yPp6u* -&tJ$U4$⬅X0lUZ_̑s4PǩQJ(3UmWb]v*UثWb]v*UثWb]v*?0rn++oO.ڂ[zjeX_^Y^z: ^c/0jIA!v8أm#$1:QF* UثWb]A<fb<61Wb]QPHe=8/7qn}O,Lԑ;I=Wiڍ]Ȳ 1Wb_>6>M-&QPz24O5 ;p;WdثWb]A p$;*UثWb]v*UثWb]v*ƿ1|.ّ{T6*Pkv*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*U3ٵgZ2CVjY6-:C-~"݊ϿN~cw*KJz %ݎ[JcD(M@v*UثT$N߈ۇ|mWWyT?!r{_DWMMͤq򿗼mT oړW U쫊&t?dRqV;~~ZDRw7()Cv*UثWb]v*I%/! rI/Ο>Xb`zb!~hJTLU~*UثWb]v*UثWLU~gg_ʚ#m}vtjz֗[v *銢Wb]v*UثWb]v*tk]fK Ķ2ȭt}OPsi^=c^y\z|HcCj,8 qWMGǗW)6'f>LUثWb^IjGmӨd:wYǐ{ yDqcL?/),䑯&'yw*<qTE7ruR3qz,rMgo%܈ "4^?~~knk8d<;{UZWUJ/5yrxUYywO`"0@LqWb]v*UثWb]v*UثWb]v*UثViHi|Un_2@V+Q=ɨ/S,UkZ_jR՘涿Εk!2o@?X86=X^k8 K+pS5Dt'j N*}cq^'o)_h $S..?5|ͥx nw>XYͻ5m*XFdX#*6۪qTN^=FAlNUy_o 7ZDhA 6SUثWb]v*UثWb]v*UثW~lyN5isG{Uoo24%4 3AgxlUXW1WNSKz}j>~UYy\{VF)'bxuO3k>c勅cqT~u鶑>אc?􌖑\FУ늳?!|YV& *]qWF@ USv*Uت_y~S%#aQScgI ,7aIO7Hw=qW˿3Ьv^IQ:ǜA w`68]C^mM>(ƛn)Do.~RZ( \&qT_#貎/i,U}ĺ?`%Vy9f&&i}q WuX~B~g4g5~`*tW3&;bwݼ1WZEu ⪸Wb]hN* u8s=^KQX?44?KOZrbEܖ=1TO6Rj`EmRC'#*ثӱWb]v*UثWb]v*UثWb:4 ID*|UJ(^j] ʰ $ #]ޙ7 i^ML/T u2˜ֵ/j >apt#^@`6]|TMe{FCU,Q8W~nyqqemGlU+_游 9ңsޣz; xb,¡F#xWb]v*UثWb]v*UثWb]v*UثWbξHdl55VU>ثZSL'Xd U#!$򗤾hӦn&ED_&VKbъM1W3?^gq/[W7엧\U冝o¶֑Q 1TF*UثWb*yBldM~C|o1k7gvmd r4_rPʒy[OKq^qVav*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]Y<"h&⯓?5|^:viv9 yYgGU_$[ܻE:WWXWb]v*UثWb]v*UثVy)^^5u8 Wo,R*Itm&";aH^#yo淔jzRX[*Z6S @*|RC@[I1=Z5N*ֿ8,c6Iq}2AĀ+⩗_Jk˦2L}lUZoq}϶*imNwյ!lzwcP'zlU<>[M׍Yψ*yGc.y 5FU[k B(T]v*UثU8a{k)A_5Y[Me[}m>^,Uxb] |e>v6 aMU={Ν鱈lHvQLUX{+İ(A^5'dkRK:[${5F[hؤīxup #oCj:b~ UgC-^&2*Gҿ;XWYHIomjszC5jGQ?ˉSpN*3hS[_ɶYVO4ʅdT[P%V?21Vwk}"Q4vtz6Wb]v*UثWb]v*UثWb&Wv qz0PI1W~hy8Zk}@:*o,i?4{1FִSJb7767j1~*My=+)dl1W~Xy@Iά=IN*1U;x2F؂**/09yW]krX*Gj3nH4*ɯϺG}<{x1VgiiΖ+t='#KhCSL2| 6Ũ Q384gT7-k 'u8s U$&yP >7vZ }2hE1W~QiW]o< U~H.7#qVwv*UثT&å= bۢO1TF*UثWb]v*UثWb]v*Uث4k;s0S,D&k~}5uxA/9~tjG\(Bw8/ ZLYGMݾU]v*@;5fiZ  !f?F*`y?<V/P[2\Kx℧*'݊Ht{dEbbiHG,(U⿘:W {YZjKb6~CjɨϢLx\2@Nb4-z^QeYVS\Up ]BIv#劼MgLltxYhV*l(pAp1UlUثWb]v*UثWb]v*UثWb]v*Uث?ϭ&w>T$lO~^qk HxO+tt.Pj a}|U]ck7M$7';⯥t}@S-n#lU1t)zЯ`;⩶*UثWb]c@;U⟞? 䙭mhk䢄(۾*ۏ>\ΐCJEi"+X?F>"JSFb]v*UثWb][$*K.եڐ\?*}KiES\U_v*UثWb]v*UثT5֥mhiq*FO0w BSQb&*m.o*H+F*]v*UثWb]v*UثWb]v*UثWb]v*UثWb];mk,Т__?Egim;HA:bwu+־\=*,UثWb]v*UثWb]v*UثWb^i$Ѭl8f*OkbEi4%!หWb]v*UثWb]|9K_,z:~ ;܁A튠,5Kk1ykVqWhHth+X,9@@v<~Z/mV!? |1Vs/sR#tcXƥ-3U}ė4$l⬏D|Z_ٞ<6WlJ21>E~ VbjtS#~UIjMB7յM"s}"O_*oκg(w)؏zb{VZYFb&i^pJ]'_z?mݬ꣺1TQTG& UoCOC\U}k^=9[?.N8#^k~X84;X8ې?*kcY`#*UyȖ~rͅ*GU|U1yŦj{fE劳/+Fx3z2$b]v*UثWb]v*UثWb^OB5]I&-RW*^ҧ7s[k)!`MHVG9#&{6Y7Q*y7呞mDY^6lb۶ i|qWK:n]/}Y>*UثWb^wɧy4~GV_-[SҤ:w9BBI-Nت˿<~jզ,#n+jr;l{MD%\Uv*ÿ5|wM.zru*K;1~OXs½*)|yOLU-_%4?vǓM{boSq!d챒~#^IByVrW7HlUb7ӏ;qTW<:JX hdELU]FOCBk㊦8Wb]v*UثWb]v*UثWb]v*UثWw`\h<(k5ۖ*wߔD7Ŀrun⫟Zy 9;RWߔotnȳIҰW*H-xġE1ULUثWb]똴.ٯ9F<[I_;$ݗKBOR}TipN: N4rZpH;U~p\^u J??lUcL򅤾b- U:?~pV$ h憟F*+?.٩~BԹ?*U(ƇN.UhDx U.cw<@N*OW juYVuU=pD-OP7hlGԞy#z~S ouE1kJ#>Xƕos]8C\OBĝ,Une [ Bت'v*Ul⯝??uM.̺]EpՏ5zb^?T*v*UثWb]v*UثWb]CͦNyK3xX*Ro-oiA4B^siu[Z) Y1T 3[i$I!;MWбB(,Uv*UثWb]c^k|"/:%Ѥhp5*[i,JU1Umոuv4Ss}r%튼ך$RS{E,k!ɸxRC>'Cʸ<ͨCyFUF U9?&4z/ ㊡O.(G0D+v"hƦ+ث']v*UثT6$ZyIb#ĭ0!UWv*UثWb]v*UثWb]CjzZuG cqWy˺G澰z6hC/-YG>^wDv>'EqL=MiWbg#];CLsTb?>yBåW3wiӭDě"SW,F8-1V 8Pv7`7^v*+VzּE~X}تŵ[TP *UثWb;/[D8EST7I{zlGU-&,fcY^+I^M# )]v*ྌu ¸W ˗JTl1m"yO|UhaSIԏSUثWb]v*U]?OrW5l~?iP~*U󮈶NfHR;6*-`rmW󊦾pH⯱qWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb>/1ڧEyGGڕclU]v*UثWb&⯟iKSO7awмO ׯqQAAϗ.lmY۱⬦x#Ya` bWb]5J8NUv]3DաҴ Wܓ*IAWb]v*>;R/0h _qbh󇜬վIEX'bCt+Dx Ѽ1T/'i1[1m*Ek#AA\U3]v*UثWb]yw/*UثWb]v*UثWb]v*UثWb3g*Q?aboM2^C~G|8 P d>U8T5B^ۑ*v*UثWb]v*UثWbZw 1FU&n开 c*ruu"bWb]v*UثWb]v*U`7ZCh8qWb]v*UثWb]v*UثsEG IeF*qWb]v*[-R$"7?*WWu@{5NV~di>Z 4EFA$*#\yU>i<)n?v?קh!CNMV*áEogn R΂Wd_?,EI%ڠ]OqTl&kh2U?0:*E5P^cf{ky(a\Uǚ£^pk6v ƀ U}ռpl6hr*cSq)iMBg]X喣l}$pSRzb\otKVṛeZ枕wj^ IlCwXg4_MQJjL)zGΎ6m/H"T*]v*UثWb]v*UثWb]v*UثWb]mWijDC 6Z҅YԨ~vmbmu 1VAv*UثWb]v*UثWb]v*UPA*?3[w&k Ő>#b^I4= H⯢V늷v*UثWb'W~E4QCXQ8Wb]v*UثWb]W;bU*UثWb]v*UثWb]v*UثWb3dDŽUqWZyX(_*X~L~{]*Wp7c_jb]v*UثWb]v*Bb \ωvӴfqmVXZ'fЏWNX}f\Uu\Uq0(ﳰqT̊x2BjptWr銥֯-̑Lw4_R-E*%ZѱU+ιlC0Z*5SIfyQUN*ȭӦ\DsGT5?:il&0ث MH7↘ϟ/K|]gq%=?TP8>gMX*7טX쟛\=چ&ٯث'm+iRQKUv`h=T]󦛤Zu$0h*/%Wwl%qiثtko-# R8SF]v*UثWb]AzŦTv4^}~n]։a%ݜjJ_8g~qhw##t F74A#ivzG(t A`9RIdzot0RQ8WbV"ĥTTU.ѼgT<[n-.R"K2^^ϊv*UثVC*U :ϗk j>y[ Ierx$[U a;UUثV_͌n.Xox8bcջqTWO$_zYϝbȈe⬛Cԯ_.fYZ{:bU`^|U?Oe,mj\݁^ksK<'n)U1Wb^wozޤ-q-U^ ?7u/1^ Tmǎ*&<Kh5ID`z*UثWb\qWkP]"_^muI %ʹu!5YyGIWݬR/\Uڝ *]v*UثWb]v*UثWb/kW4*#PzUTo巗t+m=ɩ⬟v*UثWb]kտt둳F*.""KKq(*1TF*}e/mpe=8fK-2Yn*UثWb]v*UثWy6]mTu)1T~E˫+?>/1TXk|y,ҫPU5>u,jiUثWb]CF' }Ǔ2ZP1T*45HW6oUNX!.֌j1TZF1}mmR[~1T&du}S(Ť۬F$w*\M2eԖBS.~}SRcnN6'H5O[%]SI.P׌YIb 7bABaF^aZ֒TQXWb]v*UثV?=i^Qnu}5*+DƿI}O*?(y實f:1bH!o*D@A-i6U#`ϖ5G ۗ@*~PHpկHX?Hh%O>YGzc3[ͧ %%OO=wnnQGEqF?!<GiZ>7ẒK`O|U7{{5!g%ݥ߆*zv*UثWb%"ijwv=GOJb?-i WzUrghҿ"XӨYGuִ{E$/|U:]v*UثV=+G]&kr> :b/dմߨ_mXFPz;Y*UثU!%uVsEXW:2c>>Sz⯚3t"$6U튰.irySOi #@^٧~jYj O.ȨX H⬻֞\ vtUh%;z$0qU|Ue1_IEX=銼Zimuއ;qW?ltӮ9XͰ*ta ]KiphyFy|1VW//lftcqjv*UثWb}CNakkXb*1WCQyvZZ;-tt P02u튣Wb]v*UثWbVT6.G#ͦUKpN⩯.Fi[|"E&?.t鯭#&vۓ劲|UثWb]v*UثWb]v*UثWb]v*UثWb]c^l|UH'G7ߊM_B]9dш'LQ6D du>UU?8LobXl}8_w+mjq4(y!f*+25`>qUџFa_֤{ol85;:To^[u*| ?6M~Kє|b*UثWb]v*Uث廊=)m#8)՞z 3kv*UثWb]kV%OqTLTBmo{Wz.*UثWb]v*Uث5dӇ/?^xWb]v*UثWb]v*UثWb]J`Mڋq"تmv*UثWb]v*UثWk/+~fj^WK."b U_|'p> (6v*UثWb]v*UثW~kkW6Z}Z0k߾*()v*UثWb]v*UثWb]v*UثWb]v*UثWb]qSs=*_Kk`-ǻ 劧:O儞=Ĵ0`5**Ug+qnqWkrzu+ LU{#w*j1VQ//Α YXfC[B}K%cLU_~犷s$7HSA֟xbPOVE5R(QP>Ұ*/4ykQ5/~T\_Le[j^8yy6m.ZLVkv*UثWb^}1 *銻v*Uت$XԻu'J<צKzӡKҘS}t$FJn,Ub]v*UثWb]v*U`bt_՗uY ƒ__UثWb]v*UثWb]_.Nf~]+&=]pizwz&ng}O1i`GKjElU8]v*UثWb]v*UثWb]v*U(w։LeASb?3jUJ1[q屡8{yjA,QT(iz-@:m~]򧘥ӢW)Z zU5vOwfX]"gUw1++T{˖P/T>Uyz=^ZH8*x U5ӏZri:ů4bB*|UثWb]v*UثWb]*}:H^ E?qU_iF]ܚy&~(uV*=oJQ#`yxUe5xWbdcRS4RX3MCW5вLU^+XcEU@_[Lգ0"F*j_^XlΟ=F yMۀyWj|K>i[ j|bNo"*çwL1^xZiD}IUI*<*%݇m4zbb?(bټ`MDOQ|G*Sb}[xOw5yQc"IHh^O-txdEGJ8FsQWb]v*UثWbk#T~D*levJ ďNjGɺzkjD|U9]v*UثWb]v*Uث/emNuAiRa/|k=ź!&'@/El3F~W8uRҵ:!Qo]6(#g^0LTn*UثWb]v*UثWb]v*UثWbV<(3($t$bnmb: 8Nk$~F*Yy~\Z#HMOOeHE|Y=3P+m1ciҴ_Eb]v*UثWb]v*UPd_*/!KRE >GRu+}2K˶ jYX'<Z D\UتUc 5 xKڧ|Ui=AF#c`5B6qTF[]۩jP2$}ثϴ6yI,$nV4,?ثZT\H ⨺Wb]~a͏-PdR6$nOlU_ /*21*kk:q^*k[4$t[Է3,%hdPvSQsop Aժ7Umob@M1TN*UثWbV]/YjMQJ~UwCּ;kZ3XZK7 U u-YkNUHvjVb]-`; l#^l)LUͿ7K6cb7*yopYhM>m\VsSKxSX2 _-ώ鑧!JG|UDn~% R*x'b@XN?妳'&OqkzRbA枓̶BH(qVcv*UثWb]IX14aX=$;+YU 9'YGA, Uv*UثWb]v*UK5o3iB/gHxU,ӿ2tB#<IM vQqG3*FPu5QV^b3[NV.1J wN嫕p⬓~rӼno42B +JoxWb]v*UثWb]v*U(zUu1CQiZ%:{⬿Jb$P㊲ K$GsUثWb]v*?/#yYt@k-;=1TnݣʚN ( FSSzYjkd{Uv*Uy .=;7Wa**` ^CAYg *5oQ6v $y~s{/ۯԐVbw^_>c pۉG~OZbȞS\ZrNdocfQ fݤWq5‡NU֙rIOVGa?MWG B݃#uHׯ5.Y ԑdt$wYn*UثWb]v*U/O4k#yO#i4)^_{Wƫo5C^㊻v*UثWb]v*UثWϿyNM\-ޔH銽GӬm;8V(@T-1WyQ1K >Tgxx]~R ήLaNq$P >s~Gi6Y/$<'K<%73iK ^|R1TϖYj_jzB`MAqVWb]v*UثWb]v*UثWb]v*U{AeErXyֳҼޝDj|IQ?eǘuVԮ'E1Wb]v*UثWb]v*5֥І SƘ 󝯘<R.-F*mĜZUPYރg/HG]v*Դ]N3 K4g ,'|<RM;ŚԀ?F* ;um2ະDv*}*Wb]i8* ad%c/b$w+MJS|UmNR|U k?(\K69z}OWO*UثWbZe ;[qԑt׶Va?bL*cMo(j$w^5tE}4cOxFj/Z$p c}LUv*UWc*mZzw$8#nC⬫co1U/*Z:Tb MVWbX?3t% -rxQ]WjZnDbm>Z4 '$4KWhOъ 1)cbr$v~&nCJO Hi.ؚxbQiRxbQ]v*UثWb]~`5nz/j~Cy>`D,Uq@G*]ysZ5AQ?֗jI|zǮ*ނQl z_늠m) iH꜍?^*/&$/j^niI`%0zѱTTRSqF \) # |jqV4Ev^ѭ *s2t[t7*piҤ #*v*UثWb]v*UثWb^_Mfc^t\Be^pP1U(o`E"/P$bثWb]v*U*fR4v/!4qWZEiE1U\UثWb]>v򕏚t4E A"|4yJh $㊾wSkO_v*UثWb]hּq5aQ.=,"huKV:߆*{'0/,N8tTv[/fmTY  z| FSUثWb]v*UثWb]SK QԩxΟY~_]MyI,c,=1V-j_f4 iڴ8 Vv**UثWbZe (wy.~QkVF6IG+w̖ۂB @|qV_/6a +*ŮJq7QT UUثWbZxVƼ={e}bA$AuAثѼy + ~8%V VWb]v*yEΦMT?~-,$@PrǟTUxܰwqC)WU/ɦjaqZ1=slUثWb^Y;DVЕAZSƘ_sYh-\ *1T~p^5Ү>!qU7<#YGI@xWG!Ժ՝Ո;bƖ4n C1VEk )ww\Cn朊Yz֢nD|~\U'?:gCJ*''g,"اY_5 'Ik@v- /ǵ7늩~AjzF˃Rz^*UثWj VTQH?R-OH~apՈUN*tS<"+WO㊧}!0UDz}T£wWbX劳EE 1VWb]v*U ڔF530*~Z6hP H7ɇ\} UAOb?QivWP +JM1Wb]v*UثWb7!gTEܒ@^m~kKJO {ڨfB'qT?^k}̗ZlNGpOqVV<淬|; U*Ѽ$GO2HhfW*;YME-2scOUgjKѠy~e^;Vܚboy < #q Z|*?\^B1VPb2΁ G`>Jߊ?_;O4Z;.n"YqPkxEZWn|g1VIO m[Tmd *Lw37k]V5,==oŀQdž ,nx;W,XSy\i'R|ONgOE ଳ6+~x6yLjK1o#T1D#-C⬫v*UثWb]+1{m%4)Z*;SO)MiZno.9Gw$'*_N;hBbUlt"ylfqq>bwܞݐ-&'-18^&e ^e[\yQmV6IjF?̣dg~DV[.^Z0f*Tb_C&ħDfn>G`_>m~H#ah{ba1$;Q]v*UlOSj5ӯqtY<)_J?ZSѥyr*]v*UثWb {R]2{4Xf*>uHjU/U'zm⦟⯪lnVCUu bثWb]v*UثWb]smM.x.2,+؁^=^Z#?IR2QҴ^JR/Bg({b*UkR3hRTxb)T/m4gw^,yzZi,QܟsWb]v*UثWb]v*UثTY%~AV*X׭4cyvcW2r] N0BU%jS|-F_WWԈ1tQ ez4 8iun~gM1Wb]v*UثWb]v*Uث|uek?'jw1 +E\U: /%H7$ym[tO(';Ky bsVK2X1UGq-vZXF\ )ZbWb]v*UثV R QB޾]/[ڃg |1T 'o|VmvYv*+ov*Uت"YT2K?>ZPj4fYt CՍz7~UV?=CEd/ dѦAUz[jpŜ,l* ⨬UثWb{ P];Ap$,hzV5 / ^೑FPږo%ȥH17o$Bڳ 8ҭ;x0VO>܅xԟwΝRO?\eebkC_L򅃺/t=|qV5 #8i7{yt^\6*i6h=[A*/&Xκ^G[Eߠ튽#q(DU&/.D%~%ʍپCb~w)suoS󆔂ie/UN*1WCAuxB?KWb]v*UثWb]3]i~a..Pk6$xU9Ь!‚0)J UjSi^ag4’ LU,cyǙLeGzP٠E⣧LUKu.XAV!' ֽW>Eo4^iO!dTmfM)^͸b-4_-RK8A_vVSnzb#?~\:mbs@?Y񬱚A8_MR]+O#<)!S~o>j j>Xky;4N`#<{T^S+kMMq^i6M.Qqps(~8e~XZo[,e-k:lh#Kʍ*:f> |2ݒw^kʾC6esIHf>'M@vƈ[QcɲGnupXA'Mnʎkuk[agGHVr_fh*tAY]88䓰e8OxCcFc`sLU:n|\] Qԩ|i3XF"+\U~X:ԩ{5LUxWb]v*UثWb]v*UثWb]LUN;1̡aQWM.%&ujt TM^$k*V8 <*oMe bZ?4 U7SzSv*UثWb]ak QbϗJSycwnSv=Wb] r.iS2[ IA\U_7n8աI(-&-j9l0g^Mm,PIѾ0O1WPyR2<ՀhSzߘ|iuy"A(;7]̺&A/\ȝ*y+rFi,zY*Uثػ"ONyhj|1W8K}R:K4r޴^~sv,ZO4`) (*<|aa6!P@_,Uzoe,OWa܁Gr~֣:n6j}bMޛLW0G$b⩒" R1ijVZZ`E!\v8+r(^uj:fZGAUثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]y熏6DR#@?iGQ?_Kq⯽qVOv*ckpJ=^X<\# 29c⬗d{KZ)>U]v*UثWb{>d[~zB Uế浾4g$}@kR 6vi/jU>A֮mɧcfQ*|3DiXFXB*]yfyE:M]Hi=sfO(+ELUثWb]v*UثWb]v*UثWb]v*UتXci\TO~nmy[nJҰSHbC}Q8KUf*>z[j >_\rUUثWb]v*UثWMLU7ge Z7}^ӊv*UUtѩK7-c'?dƻs^^GHVq|UثWb]v*UثWb]v*U`/nYٗF?W d~U.kGab8bP*]v*UpԜU/P_WG+L⟆*͵hā~wxPb|<%k+ч*lUثWb]v*UثuI}&q4QyKf,^݊yo%cӯtDs1"2QZW**UثWb]v*UثWbK̟F^R vx|qV%[y˅lvҏX#AnB-'T;c'z*WM#M!D+SsMBjvDGp;U[=ȯbM̺ٹ+TU阫WbXGזn1en-JUk4X,Wq3B~0PIVuc$JҲMW̺MEc{" qqqTZ'JO\r!Ob1W/JrMK4{r#}W[ b}ث BRGࣰ^T)/u-FCЬ~y+(>Xѿ2'[cn(bqV"<~S2hfV_McvN*LAS\~$6y0_HơQP Uv*I>چ* t]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*ִ{9't(84/"մ-w.MkW:$A$PF7㊦L{Л-MF,{V*Ώ01}O7jOSMQdYWu劽sv*UثWb]Lj'xc}},ۜU\zmQ,uЦTv4U[+^otn-ݩR;HR8(bثWb]v*UثWb]v*Uث?7ubZ1zxG⬫~SjqQͻN*]v*y]AԥF!RW^/Sm:4RDXǖ?*4O,2dE&TY*UثWb]v*UB-mR"$b{=՞ywFa@ծ*\UثuYj(*UثWb]v*UثWb]v*?7y4ORkGuLUO6 Ee0*6) q'Nت@(uFS'1V}aAZ SQ1Wb/?Z})$5g$⬗A`lxU-e-F1,'zU^u49H|Pˊ CSΞ<րhzgw#SW1Z2?}v*UثWc^[խסV x6db*^-ՌHƝA#EkDV_W@PAN:Dᤏ(;*X'F勧˾ecA#M:wsZኽx; uWvR* *hGosu8גSRmCM9~ߎ*|AǩZWєUkXWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*IV%.QRN*:5q ~Ԃ:TGZƬ<-A줌~X t߾*yWU~k_h÷,UyJ- {; @>;b /\Ar'[.?bAol|`IE F*b~ڄ +Mc+TnE- A][.P~cN_f*Y:EAU~`y?.i^*Jcbߒhj+3C^="Iت+v*UثWbVL9daBUw>XO˛wLbqW`ayLl|}`bjT_|Uߜ~c$fbw lUxWb]v*UثWb]v*UثWb]v*UثW̟>mH<^lUUG*zv_Uq׶n*=w %ލsNkY>zqW8Wb]v*UثT̩$v!HQxT(?nϜ3Oy'"^׊v*U~iXkZc\[oy _|Uߗ?>cS¡g0alU]v*UثWb]v*UثWb^U}Wb]v*UثWb]y痜4BRpcZM(=2 چ̛̯?!Y3ƋK4SS( U!^inm'on8튽v*UثWb]v*UثWb]aPzUQl֖?yesԁSCj:e ZƲDXTb-ގ]Ӛ>^5Ӷ*UثWb]0"4Kפ8!H?kE䛃I|XJ\ýc#Qʾi5zᣐT|SUثWb^QF OIT^aa)WӐ5_^k[G)Ur?K"/o@vSo˟#: Sj׳ J =bOS|U&ռQ_BOcNت\ՓHPY!Bm23QWuc4p{ S":ֱCχҤ,U[϶ڤ ;Ʊ^ޝ\|2S`UVRN"I1W>SՓZ7NZ)ГeZk^ynvYKj>Tj~W[[(-+SbΈo.SKoъ׊{XTɭ[n;E5qUy'ocl-Aw4l\t5k@{i%ѤQ)f>|̫)<:bn^MoYhpy}, j3]v*UثWb^+9jM Dz`S@yDn}zbmPDVP{botqFޙ,dop?^*ϱWb]v*UثWb]v*UثWb]v*UثWM* r_K;o܃늼v*?́=cӽFS]}kuK< 7 n6U|W_4.Yϧop*KWb]v*UثV[;A4$a ҵQp^Zy+bP+xDsJC+z*#x[]q銼Z7y]jոh~ثݠFH`'Wb]v*UثWb]v*UثV/7&`nQR&(\UySeR1cHݻ1T|UƳBaPGB1ULU~t\c/3;qVxMquk|kK?"E;-ew$D @늢Wbu쯮bKuP;*] 䎤x1TM+Yepa#QbsRwHS^WO}w˺uΕ x< Reg"eBNڔpAU ʭnU{*No0ث1_/.YƷSbS&U$*)a֧犰K"ukC%.*R%' 74.1V_̨<߬Is;}F&[M1W/ ,^_#1W]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*Uث<4#`#UgYp@TƤP׶*]ZcSb51Vv*Uث >csgx5*F*Mo3[>rwZqTO%}RLq*kQ_UxWb]v*UثWbq[鯯Js⨌U?K;H,VQSW[[m vT]v*UثWb]v*UثWb]v*UثWb a|:&⯇Tf\qXf ;KI@1W~}IA!{cH`LN61Xs7ޖfLhd4/Mbo9.Zf@{Ӿ*8cyJ8=zGثWb]v*UثWb>=;U."K'*o%hWdd̠-bOd QPNتKâCX˧\w2_|U7?7-5f &lU6W`TQ\U[v*UثWb]v*UثWb]?O𭗣f]Jq_b~i$`Oz*UثWb]v*UثWb]v*UثWb]v*UثWb]v*U銠mbIdX@I$ӧ*E~HIW^Z=V"u.⩇wD_TuSD'vـ^i8I˗ Q[)*v*UثWb]v*Um+:^3sG|qWrxV Q.Ubw"[Oɫ[yu{OfnFlUxWb]v*UثWb]v*UlH9$aC͗cv }cS{Wb]v*UثWb]v*UثWb]v*UثWb]v*UثUu* Wa6Lt2+V䖅ڿ^_(d\O5bV)MfUi_aP%4k=2llXP b;V7Z[>*!Yy+Q2~JXKm0ܷT?? x̬:4*c8.abeSyf~gk2+C@:zF*yZ֙|u_(ȉ/1m<5Ȣ̓^6v*UثWb]v*UdRU "|;lkKXڎU"1VWCT# sbx1VC9i6zkKc0v5nga81P; Uq=d(X(^K8sZM23-ޤ7qWsizUMBkNH|fu?T 2^~mAO-\ZQ5fr+W这plҮ"vqT\մ]:RTwqT?T?ho6#*v**o㊡9FGDu??"k[ۥCPH)ٽVK?;Pn=ms{_*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb^mۣ|sg8i!^*掟GqX H(j<1Wb]v*UثWb]5-VhWwNEj=5؁B1Tv*UثWb]v*Uث<>om@G|9bK]/:y &~BSMw7Xv@͊;V t U y{J'{eNT}M4n*jbu1V ]kWp-ч*ꚇCW*8#y[ CvYžeqnL1UW-S)Ps5aD*UثWb]v*U^-/ƅ1Wz&O4?!HݯHS{h}aኾ UثWb C8?K!j`IJD$+~w^Gkߞm% õN͊n"I5GPA8*UثWb]v*UHb IW*ub>ثȼ/;.C޲{'8Ii][u5b]v*UثWb]v*yvZ^jQ]`;UGd}Ѭi xb7XYc)DZTOkɸv1Wb]v*UثWb]v*UثWb]v*UثWbEumulZ}OUwXZ0K㍏@*YѐH= vW]Wb]v*6v} UBOB)RiتnHnMMiYqWAs‡ qULUثV9m\ÖSO hx-Z^R͹Y*UثWb]v*UثWbXǝ.t:[mZ>ThU|-#GӉЭj|N*_ Q>S0Lw?af~@:z7q1Ic=AdNH_`nZkJ2tM Y}%Hb[@qj|_~*= Jk:ඛW܁ኾ6e<(6#o U]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثVL@\UMA1TZ}tf+Ui> >>+!`{Qf *M_WБ^xqW~u[Yn""XAڿF*+I`F*v*UثWb][,K*V b6vK/k97kF|Tߚ7Ū8:b}Fc42hqV{yOr (v`>Xqv*UثWb]}F@8%Ҽۦ6Qj2_4~vi:$@?BRO.j7ZuxboZz*UثWb]Aj5 [IJ0^|#,ehkr=}*u+gvs78Oqe'p6W*5H\Dd8%]v*UثWb4SyswSDi$_X_ȩp?'`/o0[{EUN*>;tvg,VWJ#VN.0Đި b^;хA⪘Wb]v*UثWb&aFA$ U~\[\z4V)kl;]$BFTtPbWb]v*UثWb]v*⮮*UثWbWWQ#AVc`ע}dC#2@f#'犳KMf9 XV1Duf+ o̝Td[T#UAq‰!`zj1Ui]UG󕂨M1V t/CPSpqTtĒkWS}ޟv*d ,5-^ S׎[9MTN*֣yȶZT~bߚV:HZDr$ I<<ɧc?H%uVqW>yMJ;/i򕯊tرWb]v*UثWb]v*U%.-^b(bZmKABT{/OM۩ij^9w# Us5ciuo*b'϶ZtӔf]ءX8ͣyU3tR D8/'$*.#(ұ%犳r*1TκsG$g4b9կ4;o8Hvѿv;⬳~W0by]3*/EhzzU/g$}\UhZ.7p1 ^|-Vs׶*yB#}P$1W~k~^I_0K5t-튳gM-JR Gӊb]v*UثWb]v*UثWb]uqWb]v*]v*UFgu1Ա*5O->)MF ~*^:tE*e,LiN*bP)AL: F_ΗaJ_qV;o6y@vucm{1YG'Mɪ}VǂO-?&t-[5RK-)aڦN*/<1V +y [[F(jVe=O1Ϧfpy|<ɮ*|ԥ\fuenPGz*UثWb]v*UثU>*C5຿Gݹ!*+=hMMR?8P1:ߛ1B%YVJKF*b]v*UثV<>GxF",4˯,C, ^ش*TBHTw";⩨l:b]v*UثWb]LU]Nثum^n&C:y>#NdZPVoVBE#єbUثWb]m KOu =xҋR.i O0 ]"rH6H^ߊf *#*ƿ)8%àR ZXYZH2?;M Ee{`vҸ:{$PNN2]v*UثWb]v*UثWbw6̡qBB1Wʾenk>],eӯO!ylxeJ.dmA'P⬶&#T㬻z_Wϥ~Xlw~W\kow$, aM|'Bd1WE ^RvT$kP>M|UfoK }{V{u^Kk -$Yֵ{oʞK6kڂZh H*i1W̺?< #epp@=wQO9l\u 4bx⬟xg:9՗f_yf]R˒GB*eۛ ymiZo!S76;#Do+soq WCWŤ:H#9{b^@nb^)/|IJaR7ߚ~~x^yJaK@=09 g4`Ҡ~zZ-݌,/e5/v*h+ኼ<ͯySјAofI'Q7|$1N?^* w 1*49izQo:+01Tzb]v*UB (.ƽY*o2yʶpS(xSп6d1=qVUyDxt˸/>Uyr#Gs67"P⮾<Ϫvw0F85?λ㌊)'GSۏ̭rv~G/#QT66zm>~r>Uchvq :(Ocgjܢ%g?eQN*uy|sEU?)Y`7x튦PkXHr+wRGfa2kK7,m)dcTo.=uy~ߴP>U~]\ .{Gp'e>Q򕟕l7g?i'NWb]d~4X8D Gb1TNmVq U^9jg~r}j+ŦdjU}: ulUH1TF*UثWb]v*UثWb2"XIg-ԴGk jY>q6~x/6eiF*"SJrbçdZ͝ -GSU^[~db(X~qTX`Rzq/7_,D1S)8Dd9%GqV'i_|/[@T _8׿#ySD˚^v*UثWb]v*UثWb [B0_BF*KZVj" +j#_Ic튽/W**]v*UF+(bv 0U[v*UثWb]P &[@eQ@bWb]v*UثWb]v*Uث? -/5+6zqO1Kt!Zb~õ(ZkaNqV5j|ԙd+h[tFa_U)~۩>8" *HiN OTKv !#1UQm U}>EwOH銦 @U*DIE*v*UثWbW7qZwTi/3~ui:R }p犤Bk;Vkխ|u_UyV7Z61W>x4\APߴ1V_(mE<k{kV8R|犥_mz͇tX/bguvC4Mt!TR#]h_ZUs|Ä7LU[Ʋ*F?~\1گ֮> U<[ҟ: yв+$Y$!Tn {42HK)C7E[ {V4ژvӮ5_\:bOZtWX<*|]k &XOMwtft74wa}Wjj%ի!1WbR=w>JWQVw^wiwډ)X!z~bNZFFQAoK ?+Up&WZfNQa? ڻb?,LE+gqv>% =M1V!iwt^C3PN*uO$9']*?/t /#䦣lUGF `1UثT+V$,{^K?[ Z#sX0bt[]y5{1k S9J;{b{PQvg6i[^ù8;v*UثWbXO66qG;bs΋jb xcbK]v*UثWb]v*UثVC 0{}4)<>*1V5uS[9$P튠-'使`@ߊe>U?MR8iDb]LUثWb]v*UثWb]v*Uت]Xߠ*?Ki>_N.1Wb]v*UثWb]v*UثWb]v*UثWb]v*UثVC*\U5(\76lU~jMMbV=Tƹ'Ђ|i㊽v*UثWb]v*Uث* 31HYbgϾ|"Ӟ0:A~^SU×qfJ~lmbpN1Wb]v*UثWb]v*UثWb]ygC/*]&lm"@FE]yBκds*@gQ1ؐm b*UثWb a>C_v*9 -4?ugv8-bA,,*j1ULUثWb]v*UثWb]v*UثWb]o O=,-ISA)|g]ԇmU^ qWb]"RRɖzrI,Β>S-WDխ͝)4Tb. .^^Kou58〽ҲxbѴ{;۟BqT̰x|ͤ<$=}8i~Hoc֧mFMI*/+={Zd]-"*|Uث |f=W~Qy˺]TIcNJpoyyQy<"j S5~B:kX 5?gZcj)~U0]R&CS +>Vy<9m\OlU^O͝R /ׇT`h1UZ)yz0DF;C.Eyn1U/qP<3jܙG*/LKAUQXWb~ri EX变˟'<¦=x}Ef_>y N-mxʸ2'ˍGLn.gjv*UثWb]v*Uث˼pzm7ZxU8Wb]v*UثW@~i{9@U[JQ/P0>),ov*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*U~dNG8J!㊥=Pv?v*ǼhJ2._? >{~*UثWb]v*UlzhUwIv/sr >{2W06㢃֘)?' 8'zf$ׯ*<}"#]e7)>|fWb]v*UثWb]v*UثWb]yg楽ņkyZ[Y=qWA2c]v*ukM7YOB*,yoͻe??'Lx< UX1WbT幊"OJbv_$6'%Zz`'dثWb#WZ[w*jz_>F{;g iWgWb]v*UثWb]v*UثWb]v*ȼj#DeuPt'[i]nZ144Xe2F$ҔS7Xc*LД5E]S 4$uP4]^]qje *:^YOy[GѻUObkҭ$nn4cߖz4k*ݝw⬯v*UثWb]v*UثVyPr=VWbRkvONL*<ͧyR{ 9$:r!#B]o̿4'YY7?|!e鋫I,jwIAލzwcaߚ>YHoj쿻?S=8Q^fA[劳c*H z P:ιi[H*I?yw1oo/ 猓*w#z/|o`ٻqTv*UثWb]v*UثWb]v*UثWb]y}ܖ%@52Uy?U{@cP{ U9]v*Uث˴-ytlqW]32~HG5M+Sc tQLUv*UثWb]v*UثWb]v*UثWb]v*UثWb9`7a㱍jҊ}qcMGsӋ*{N.[z-w'=*JP+x#Bk:ߝtD[ 7I< )gm~.Ռኣ5/XZ )c`3 qVUi'I&V55$bzGΒt# 8̞eM$xb;xn5TNKh}"KqP*{T]v*UثWb]v*UN{3AԓA;mSJ)q,]cZ/'/u# ~U|zL6de\:^fsHN*Pǩyz_*}Y鰤PLqWbeӵԎDZX厧wnyvk/7tY*UثWb]v*UثWb;R UGֿ{/FLIu+ib~W}&Yy'A S7ub徇;glio;s)`*M*2jl(>+ƿ,UyϺ $,ٸqWh#Ra^6Zw|U趖0Y5(W]v*UثWb]v*UثWb]v*UثWb]Sp9-wYO:h XSLKWJ}BP#{U~@"j_gWb]v*UثWb]v*u?>txߘaEgm)fj*[KIi"ĂF*Α(`1T̾bŜX_ UyKyPmFqWy+Wմn(~vE$O1Tv*UJ_J'ʓ U?KNCigeUxWb]v*UثWb] $UN4bv*UثWb]v*U jU#%,ƀ"Ξmϻ-T71WyM}5t|O*Wb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*Uث;]tA斾4y?{:(@vav*UثWb]BjUn8V^/!5֓OBf+^犻v*UثWb]v*UثWb]v*UثWb][,I^52v6o`y=>dUWb]urEkFd,昫.-Gv[5"oEz~'J<$NPܶ܇?Dn,/rjkqViv*UثWb]v*UثWb]v*UثWb]v*UثWb]@z-g&|xb_)V t$&*]*8k1U G(Q)4kDT'E []v*UثWb]v*UثWb^sy7Vѯ|UNξd cXP|:=~kt2jr-mq|U~SKeɾ`y,]Oz-VĊ1U\UثWb:R"x8xWb]v*UثWbSͩ4 lU,I-anW1Ofnث*]v*UثWb]vxG4Z-$ʥh¿f|Xiz|6TK PUTSS\UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*U䟞xm<6|8?iث!f xIisUثWb]v*UثWb,mCOv*UثWb]v*UثWb]v*UثWb]AŮnחARy= $_ne>?,U.e-"X⩆*UثVy v\?YԮO?olUyTצmCӋ_b6k㊽CKҭt5UEQtWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb][$k"pOPqVq(T銯]v*Uث5<ѫͨZ[n"5S)W凕c- fygwc|UK^ew][x%=Q5R;}s5:U蘫Wb]v*UتSyOТ2JF~C`y~i@ϵ~CGwwkdüq^v*UثWb]v*Ԭm%"+SNӴ}bʗP9"{ @E UUثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*+k%wQXWb]v*UثWb]v*UثWb]v*UثWb]S 0DM*|,4/!$T(%|*-ƒӉ{Y_lUb]v*UثWb]v*oT,n*x&+]v*UثWb]v*UثWb]v*UثWb,AyIFN}WYg8P*b]v* ov*UثWbW<ӧy~sL S>`Ry^oc:F*|igcIk볹]0DTPav*UثWb]v*U/ ^=릐.=*ȡv:y2*Ug]v*UثWb]v*UثWb]v*UثWb]v*jbң2LXw} '仔s*BbZy2yւh~?U74BX@PRn~U4]v*UثWb]v*Uث93bʢ. ^_B^&TVF*]v*UثWb]v*UثWb]v*UثWb;ҾG'f~_ ,-McA⩎*UثWbw̡qFR*^k~XzLXu#cVU^mG+Ir_M ژ*|4^eƨܣc֘UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWnk`G[Ww»UhLZ=60 aFHƹ^)l }OmWywOq-qUhqTv*UثWb=WYҢ7,hE<^Q?ކ*|Mk@j=FTb %XE1U|UثWb]v*UثWb]v*]6K5 %R8O6\ƙ9DW劽 xE AAb]v*UثWb]v*UثWb^{hq鯨ߕ#9QeY拯2h^DcaUb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*Uت^kUI6ޒׂ8lTudW<3ZӇ>wYe=O5Hy'@[_gWb]v*UثWb]v*UثWbWwqY $f&WԵ͊hnֺ,rRiȡVt{};4 jSQWb]v*UثWb]v*UثU sqo$"M*K/]{P>]ylqW UثWb]v*UثWb]v*UثWb]v*UJ:+qW_ʾ㻲B4@ٍxbUG[]v*UثW|tXSGr M|Ufge2JUثUlpi{YY0QoMܫ}I#{D[ƃ U~lVfpi⸫5үP>ȯ⨬UثWb]v*UثWb]v*UتI)yOLPoc?Ѽ/Ƒޣqث%27CK֢k;Ӱ>6*́銻v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثT?o8#v*hRd1# zU:佥ϨtMT[?2}OFBŏ*,cbncbCdxWb]v*UثWb]v*UثWb փu3AiƆR{b]}:E (#v*UثWb]v*UثWb]v*Uث󏔴f_T?Gĭ?X__[RKek&*.Ozv*UثWb]v*UثWb]v*UثWb]v*U~hW,Zr .U*'H.oQB4R&mlUثWb]x\-ʦlᣊ1T-ԗvO:𔨪⪡ۨV~eiPVn8Sv' U:ߚ7EڡoUKK򖛦T9[3nN*ioJƛ⪾V[Y2Ep'E+C5k5 IU:|-]Ebk*UثWb]v*UثWb]v*UثWb]v*UثWb]v*Yͦ˽oRbB.bƱmM112ˏbqV-g?Mr!Osy>ӾBFri-Uڸ)b]":u$⬶-fQT2:=s64ׇobh?/5o/YՕ1mXEQLU_v*y[xv튤G+KȄJ*αWb]v*UثWb]v*UثWb]^b՞lh!@++k Kz_7tتe-GR]mi$ܙ6v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]i0UJ+U) RkAb]v*UثWb]v*UثWbTncFcb,TֵO0[![)*n^v*UثWb]v*UثWb]tl\= ኤ_l?a%UPŧr Π)O林'*?<0-4XyHW~Q-Ys۸B(k UثWb]v*UثWb]v*UثWb]v*UثtYSKXmo̐XL>Ob!|_8ΛbaqT#]F:H濆*58XWb]p4銶?PcyTHm*G7b$`Q* UثWb]v*UثWb:ՏahmRj{ U>[R:k|1T᜷Sv*UثhMqVu_yF@f,/ѼqVc旙j1%7߾*??",m%h$QT|1W/_A1U#?ǘQ⇶dSЩDb]v*UثWb]v*UثWb]v*UثWbPZ֤eׯ-*XFԡmF3F}F*P}L[2GljP U~J$zpqWNm?^GD$pzc:qnB+; U{6:XՏ⩮*Uثɱt0T*K'M<8/0p1W~n;n '^]TZEkm(x%GSЂ1TN*UثWb]v*UثWb]v*UEqFO$GiZ>vQrgYG Ⱦ =U*qWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb\M1W#Uo-aѭz[h HbP*]v*UثWb]v*UثTm縍\uc:澟m.w9*;Rˏ˵kyu~w2z1?^i8SbOqFTb_l) Urij ?UP UUثWb]v*UثWb]v*UثWb]v*UثTΖu]FWbG5\z!ea81]6~mizgkzܼ1WX\}̒43~Y{5v(**UثWb]v*U|U$Ե]b^+G1P{}%7⪘Wb]v*UثWb kXS$N**UثWb]:b8ˈC,|F*^E&En*,m $5I[nd6q8FđBqWѺFire xU^{REI4T,kKM#E]v*UثWb]v*̀а^6qv*UثWb]GSW( ~{wGthV;V*z UTaLy^$Fr1T?亪4>;bI]v*խlW̩#cZ枏aEć*qTXԏiԻ Uм߮0 i7U?'m.e@88Ӵ]6cz(}FI./t;ifRԂG8n6ceq,ۅ튬!y7໌x:xbmg(2~gf_SUثWb]v*UثWb]v*Uث|dTխǧ"yG4#xPDW⫱Wb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb3c^dk4DKmV^]Ѣ62I7sՙ8-]v*UثWb]v*UثV=4ZsKONU)Աʏˈ/k47]}B~* 7a&oWb]v*UثWb]v*UثWb]v*UثWb]v*UثN"aU"b9cQѤU_CbGXV}w7:gЫ^IN[ϭuuɤm#k*UثWb]v*UثWb}GNS{+XVycER=|0ܠXt~VnfIbaPA<0"bv*UثWb]x/k֚~»oƆۃZ]v*UثWb]mӊyҡplUk>jhuoiQgY`E}FhN*'Ŝ}cMO8y,zMR"e*F*qy1$L@'*LXImf4?,Us6>aa p;1T԰ov*UثTZ&2@h T;6?H)*/*if IQvoĵ+H4T|T/:_F*mw˘)8⨟(e\J7_$;$zWz-[HGካ$Wov*?3?5lb [)*jKv1V!|]yK@rXTS劫yV7>lԣc96Ƅ⨏?fKoI >dP튲ʫ/y~ٙx*orN*˱Wb^E2隼v3W⩾C񹾹O o劲7NmG^JN@*UثWb]X?+u Қc7cPRLqWb]v*UثWb]v*Uثu -<渽rM9[zp]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]yg&~aXdEqD >DzkO1T~*UثWb]v*UثWb]RyKUx{Y=PzD~W~cx _[ iF*qWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb^wYGM/ bDUB/ {yEQԩTkoSUثWb]v*UثWb],qΞ$C،U$Vmlc$ URGoHc9UVH<„=*:AZoC_f6zOۘO,UݖLWz+qTn*UثWb[6MЮFT$ٻSyJ)׏lU3]v*UثWb]_*?TP4Y[QAqWb]Pq:rXMpKsf_N*u"-܎Q ц*7&d|qT5 rzqVsN:NuS9$X'!Tw;bP[? u_vlU'( ~XT8*t i}~`Cr^ig\~PjiZz!r~bnGWPjTUUتC(dh58~Қux嗗u_$Guy_ؙ11=TͿ>mZCH:}4Ҽ20>?F{&/[uQ;*~MNlzz[[US犱:~T_ j"M9G*K挂t۝:5s1V6>^$^mVLU0 %SUثT^Эu94 x{U.uct.6)uWbXT UثWb]v*UF($ ʝ=ͦIM#EJb!e_"J?6皴1A6Q"wSF*b]v*UثWb]v*U^c|v5"iY?\4DS*-yU']>a`$CՎ*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UWG2V{% U:EY 7%DUƃE]v*UثWb]K|=կo߄K|O*BPpt}>[)^glU s^oZ ?jY7Q14h S/y'M]s*UثWb]v*UثWb]v*UثWb]v*UثWb]v*Uثݴa6}YtvN1Ti 5+qv=|WyZ[BID=B*b]v*UثWb]v*UثWb[Y>ɦ*wgm|8DWLO[I;]/Bv*iߚ>aү]hgnbfѵ=jo4Vh[)*]QS<_jyJ/@`WõqV@cQB*UثWb]v*UثWKkw1v]v*UثWbT.`_N5|W`dk qU'u孩ű?N*ʼ3qzZt! v?6SUثocEyGtfe&XqVgv*UثWb]v*Uت_6պ$p7X?Mskb8DNܲyQ=)Fя{V*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*k_6,Fč*?*-RSΣY bHz'P]v*UثWb]v*=e fSWmUET]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UتW=u 2و;ثcuq>̧劧Wb]v*UyRfe2J"uf8󦤢iٯc<7\UnqT>yŧד8yoM%?.O2yziMoާ"TDx|U +ۏГ z^^l9nm6V@E.*^$ZtQq<*ZA03HPgK9}ѱWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWbZw 1$6?a~_zŵvѬ0@*v*UتV#EK1y~xXreo,q-:'b?8#Tc:EZr+&B󏙝-[ Tf?تm5Բ̀}⬣D򾟢,bOSkv*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWbVȥUXPb ?&Q :^J*4Z]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWbKn.b{su;6fӮ,8ZLTO]v*UثWb]v*UثWb]v* .~aKX1zTsRw~f^ ^Miv*Uت#Y ]_$C (eAW|U6io *(P>CW]]Gk1jY_۹5Keܤ GV>ث,YP[*mfb]v*UثWb]v*UثWb;ɨ5-)GogT%iiAkzƈ>G*ATn*UثWbZf ;Fqo4"Of1Wb7D8HrN*{ ;1PE8*""&…Ap1Vy ) PW]^Lu蚌[ʽS%`h zwm, vYF*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]q *?9m3KD#KSqWb]v*Uثy?|?򇕜R׺qWygy~-:ƴ'⩦*UثUʑ)B$ U:м?tOx~!596%͚S@bM+-.YB»SWQE[]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*64orҊ+!84 Vw?-Tn*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]mъMez튽v*UثWb]v*UثWb]v*Uثο1|*qVy Coхs튲-Cr QΚ@sߊa֬P̄U[^y y}MJQڻFY?<شe8yCg@" CˍM{⪾\]A|(8s(Ё㊳_ˏ%>V0ݛd~Qrኳ\UثWbKiĂ0Vسݏ4RJR )y UvQij Q*v*UثWb]v*UثWb]v*UثWb]v*;}2G bU.0-:u~U;]v*UثWb]Ozݮ.+*ǻB~_Rya)U{u^v*UثTm<Nxw?![4>xRMifIs *bɾK򝘲҄#ݘ*UثV-?V߾m7fcX0h6Koc@jZtK+LqWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*Uت [[)q4l)*$mHGثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UتGƞ㊾^Wb]v*UثWb]v*UثWbR0Ky[~t^u5-zr 'ѽlUOBHB5HxثqWb^y%mYWbOʓȴ{pobNVKoRE #Iǒq04St]v*UثWb]v*UثWb]v*UثUĒIe;wCdتV)qU(3*e _\~-bұAHбbv2=ܱIIQvDmR_Rw^MORl/*}VW)T0X'澙um=m:*-g]z;}Nov;Tv*Uت͔74_+LU~c^Lm.x㞩}fÛh\U*UثWb]v*UثWb]v*UثWb]v*Uث$m~5qx$qyCPK$4{f_GPVЂJXm͟~{YnghbAgZ\:L9zm|Tv*UثY^ Ӂ{?yW?.F9Ԑ’:oኽ t]v*Uث/WGz,kۓbZm~a?\[n{_lUEB8U6UثWbg{}>XcbъO_*b5HyɿbK]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]_[(1W9 ;|Tv*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]Hi~U]v*UثWb]v*UثWb]v*U忙z<_͚4%VrIG*ƭgL{[YUJ+G*#Vխq$2*F*]TտZP7 =)9;1T~5dAұ-LUb]v*UثWb]v*UثWb]v*UثWb]v*UثWbPh%B~*O%y?*^Qkv&'UԞLn5-y۵@iLVƉ(kX%masNxjG*]v*U>[}0DW(fZk6vnL'lU2]v*UثWb]v*UثWb]v*UثWb]K"HCW*)S~{^UYY=I$4UX?04<)PD [¸vsM7.k]#Ҕ8m[kޤSN< $UXڕ5<:b4 :{fcřdz2\U4Rsz~59*+O7\-{i#%Kgߗ67fס0M) g*UثU)!+בc>\+豞Dثc׃CYozb>Z/'6{bv*UثWb_?sb'pbY^*̱Wb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWbg"}B M%9܄4^w*o%ΗTs jتsv*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]Zszwd}:b]v*UثWb]v*UثWb]v*XU(2xՁ$r_wXxbK$0h2w˓9-L*#UVѹC2SqUX6>X.<ɥ_f T&"S_sqWykϾVmHGSM\U]Eu SPqULUثWb]v*UثWb]v*UثWb]v*UثWb]v*UتJ`Ďá` UPM*,Ͷc'KpG-w^z OS5t =}gv*Pڕz*?N*-n˺Ǒ'2*-Oz*UثWb]v*UثWb]v*UثWb]v*U_B\.,**v mK[*)Zycab'y Mlzqi>w8M7]kO?emZGad!P U/). S;^gy:WY.mկ83.|j1T NlzqK1xSTOR7+NeGPGOhMIOY.*U~a/* `}c1TO+5E]q45owIi\U>厍(":?**(av*UثWb_?sb'pbY^*̱Wb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWbaQC|c>DAԠ*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*?JiJ?X^:b]v*UثWb]v*UثWb]v*Uhֺų_ 8qW1Kh8>9bVu#]=4gNJ:đgBαt8#ZUl\ '/%[[8h 5qVw_^K{q$nN#Oբb&E2AW]v*UثWb]v*UثWb]v*UثWb]v*UثWb]5]2RG(X{Uzoɱg8Н'bw]elU-4im.yKmyG `]Puk OUP7&lm6hՔ)"تctٴ!BqW[]EtXdF2UWv*UثWb]v*UثWb]v*UثWb^w-BYnb#S9t4XT$Q(P*]v*U'\\kt2M(@1VWb]e6$/4W~fS'8[pwqWb]v*UثWbR321RR@jƸ1]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]q֛D.('2'S|UثWb]v*UثȚm?XZ/VYR ߘ:K^RUثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*U~h||i^1O^] Ž%P M1Wb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثTXޝ!v*UثWb]v*UثWb]v*UثWbT/aPip7Z40MGSdWb]v*UثWb]v*UثWb]S6f*I@<8zq9܌UxWb]v*UثWbR421ROU6t0(c_"V' +}J_ D82t0Ei,}сqTv*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWbT/#J>|R4bg½VMv*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]zv?^*t]v*UثWb]v*UثWb]v*UثWbSCbBo"aUE]pjHՏ̊⨼UثU;x2F؃y'ԡ4'G:(p=Wiw$U :qTN*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثTPf& G^OM-q۰*UJ]t5[''yv*UثWbS%!ҤN[늼[E f֐o<~*:튽C˟zΜdr2 gK߬xCLUj6Kqj$n*8$(dM^kBykL2#GenF ,I!||j lUS˞Yt>ث<].BZ]y.\=G݊(ſ ƅ@~|_75+clWj>XٱWb]v*UثWb]v*UثWb]Nb?7m'E ٽ1TCSbd~E|/n К qWhzj|b(# 1T~*UثWb]v*UثT̹mT81fXL8?+ITdk+KiiL.  gַQ]ƳqPjUqWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]\GoM3Y1Wߝ.HVZaD>8Siri;7+)[LWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثTXޝ_AWb]v*UثWb]v*UثWb]v*U ϔѦK(bA(Of*(,MF> Uq\G)*qULUتQmC"e=8|?VV?PZOX*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWbX?W͚ΐiTN0*w$ US>oeZ[c@H*8"O^mT*UثWb]v*UثWb]v*Uث65kZ-/IdUV嘌z|A]sثWb]hMA4PIRãw*\:7[qVpo]+F*\7[qWѿWU*64 di ;1TX4(Veı8.]Cj:e [^FUF*"#k\*1VqkZiҬзu==*]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb\}W~hyz)߯ta)J:WqUIs#]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]zv?^*t]v*UثWb]v*UثWb]v*UثWbPm% Ay嶷yjr+Xu{IOF8Wb]q y{KRqS(~cKOVxnI;q};252Q,v#>LWb]v*UثWb]v*UثWb]v*UثWb]v*UثWbTo-cP Ѓ#ͣC>MU>^N~@|*^bl <#}V%_?[ot_NKOֽ}Z]$I`b)zf}JxQӄ!VibfR0kàSlUثWbR;)AwE;0.Tf Vխ b>4d X N*Fmn"g> N* R[e[NcKi኱-WO );s w犾q5 UXECnmbKOasټqWk:8Kiz2*|?Z!B⩡4bjs09g=aSbUثWb]v*UثWb]Ϳ3ˣiW ]7=lN*yq{J3=N*1Wb]v*?oL_B]v*UثWb]v*UثWb';1Lх";?..ڇdy4'LUo̤e͆6*+[g*7v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]PPJYOpqW>Z~OOogS4Z]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb;2׊1Wb]v*UثWb]v*UثWb]v*UثWb<.f\COoQu>Ygt5(zJo~*]/0\xPzb?z ҘA{Z6,U~l]FEu>rA^lFP\t4T]v*׬cccDSUثͿ4=4kzXM'|1V#uYu_>!y+Kf1'QU^걪(xb4<ǣ~qѴ3!t}**UJ+:+Z0*cb46gW!ٗ1VCv*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb^3sO1ٴDR~WJ(b+v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb;2׊1Wb]v*UثWb]v*UثWb]v*UثWbdeR*(A^U嫏_E W犽_v*UثWkcX͡! *U%쇱*ShU9*̱Wb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]?/^Z:ߩVOɯ2.QOI1Vx~?,'3^*|U 6NO߶*M෴"4v[үiLhz⩅IܸD83$$Fbfk Zx,k⩶*O'bꏴvњ+Ai|u/ܿ8n/{b}UX*{Fu4ҮfCӭi:]$ѣ]p\)#zb`JPSqv*UثWb]AR{H\dROR@V~MiALUv*UثWbTⴉqH*ƀ UIKdԝNzWb]v*Uثϼ/㊽v*UثWb]v*UثWb/`hhzLh~XǼ4o E_銦ʿv*_uG݊$AR{.,S ͕5l،Ugb]+V+/?*8Y:EA*v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWbg )}.K@_&:Sxޗ[x`DwU2z uSKob0t>ULUثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]zv?^*t]v*UثWb]v*UثWb]v*UثWb]`R7bc>.A]銣+r}1#ኲO+-7ZK4ނ1Wb}BTI%M~U]hꞩe?P6SWsw!%s^ 嗙_T6W Sm}81]v*UثWb]v*UثWb]5]VJ{1^Ya. j zh KWQWb]v*?oL_A]v*UثWb]v*UتT@)61W9vF+m*]v*iڜF Ċ{PN0Not?N*/'yNT<}N*1Wb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*jNuiEI(7Pu3Y]6*5K"]_ljdՋ`'؂1Tv*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثTXޝ_AWb]v*UثWb]v*UثWb]v*UثWbeeC qWyR[=]Pg^~Xج/.mIe5*UثWhiuX|DdX \u+iu>qV{ uh,2 )#Db]v*UثWb]v*UثWb]v*UثWb]v*UثWb]2y]qq 1ܯٕvaWVe uCVqS\Uy[^CE5rҾ*Jw1B*r]b-.'R9SzbGGo4XZ+o)T>d݌tuω:b/m77SBƛ6*~]u21҃U_󐚇.%ϑ揍$0I><<*<~Cj:׼7$I:xUP1VT6ҴBWlU?~jO#JZ4}=W<ϗtk%#Yg|mKC>%OS|UثWb]v*UثWb]v*>Tu'@wc1W7UWmt[y>+W[m El*v*UثWb^{UXWb]v*UثWb]q|!Z# H^|U:]v*Uثa銥z '66Osy.54['az ]d W]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثW~gyu;aZ/GU>uuB ȧzav*UثWb]v*UثWb]v*UثWb]v*UثWb]v*U#?㷧AWC*UثWb]v*UثWb]v*UثWb]v*UثT_V9P>_5y ξai_y~Y kTߪ⯧t-`Q\Uv*(aB*1V;p}_T\v#b>Uh`pC@d#Sz|ekA{bƝfSNqWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]LUM2gi[T*ǘtM\*qMuO'뿘!#6:x1~'8x?%(X!C`q!k犬6il?lUZ6g;M9,UiWFT՛F+^ zMFԡzUӊz b^?/|}wM%S0}\UثWb]v*UثWb]v*/m F TU=S)*UثWb][]㐞좸 &l.dŤ@*U?u#]> b2ͯjc oF*3~Aث2]v*UثWb]5mVJCb}W~Zٿ5Y|xSXG [v*UثWb\M7=1V%O[=0[*~QCmy^OD[-lULn=YE}*UثWb]v*UثWb]xJE9DIkv*UثWb]7WyjY\.*l~*)+ytYU㊽{CfY?w1LqWb]v*UثWb]v*UثWb]v*UثWb]v*UثWbV*D!Tu$b\ 1 (ڟvPzoq4!_=gEaX%TTP8Կ#,neNWJЃ Jه\U':k;`U2C;~&ُRqTv*UثWb]7ɳq|zZUqVM4/4b8ʝv*UثWb]V/+fOeAz&M=a@ 4=VYa?hU[**2GOcZtCy4{o- Fj:>01TC󞙭!cb*LlUn*UثWb]v*UثWb]v*UتGoN⯠LUثWb]v*UثWb]v*UثWb]v*UثV-?WiӫK,|U 7~媵ԛ3^g./^f'wj_FhbmREtA;bc>=&w\ؿ,UVoG{fHeP⨼UثWb]i(,vyW^mZ? 0QqWb]v*UثWCR] dbFWb]v*UثWb]v*UثW~}Y*[ J>KI̠XWb]v*UثWb@Z J0هz'!6zȃ튽˞g iC~ҟTv*UثWb]v*UثWb]v*UثWb]v*UثT\-*^O~C`K<z6t38|1VQ;Y&'qVQv*UثWbP:։i[5bHt=Ǿ*/M4ϩK%#&xWz>i,Q$Q ^ko~3/R /qVWb]Wእz,5U:lA1TyAnpQHSM7ΚmdoBIxb47_]v*UثWb]v*UثWbR=c;zwd}:b]v*UثWb]v*UثWb]v*UثWbPk%ĥbϬ]yC+!Z(LU:(*a@b`XPI$Mڙ7&⬫7ryc>v寎* UثWb]6J\Ӯ-'{U~Lk{s/qb"{-qWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UP\ULBz1T;h,y#H?]Q4X]7,H% qT=BUaqV+PEyg{e?z{[G{hC+|Uv*UثWb]^C} \(xQ#yyH-Ι!.!~O^8kysKk"h\U]v*iVi\TO^1baɾtXJ~*?*r/X,z{U7]v*UثWb>ۊ $qCb,ǩ_v*UثWb]v*UثWb]Ů:XzW]v*UثWb]v*UrHWn8Gu^XNuO-{άbߜv.zQG?*C ]v*UثWb]v*UثWb]v*UثWb] FNo$XAVf4`2c^ͷE ̂q^;Dg]O\e7T8ov*UثWb]v*UثV@RqLoF*]v*Ur1TU68DtIV@87MËmA(+qVHyC)F**UثWb]v*UثWb]ZY }O}¢Ws#w11Ws#w11Ws#w11Ws#w11Ws#w11Ws#w11Ws#w11V:}ƿ2;4Mf Bn] ^gs’H@vPHzo P#[Ќ1WV4aP~xWb]v*UثWb]p4銡5mWӽND}A}ZKj:?{s<4}|SUثWb]v*UثWb]v*UثWb]a^mε_:tm}{=TȚO-Sd?Uu $ *]v*UثWb]v*UتVL߫xGW YSUثWb]v*b:b]CKԗJƛ~t*?"?lV v&j|~*ɠ;$qVWb]v*UثWb]a_vk(Ud#¸JTWtwjb ]lU᫿M5wWIW6*]&]ثWtwjb ]lU᫿M5wWIW6*]&];61*fPIU<ʟTnBKIؤwm*Ǽbv#}sqTƧv*UثWb!v iNZʟɊ|UثWu^_S͚tMc}J M)q FxV0"v < qTv*UثWb]v*UثWb]FA1T}o/a9;ثуv*UثWb]v*UثWb]v*U*a_1VdHi7ҒY|h+Oڑf>NWb]v*UثWb]v*Uتx^!u#]v*UثWb#;syvmV;i*ב?.uzI8]v*UثW]yGWp=FR-S]MYX藧ԍT#za=5]-SUثWb]v*UثWb]v*UثWb]v*UثW]*85 hsȏ|U6]v*UثWb]v*UثWb]<7moev^m̪!OBlbofWb]v*UثWb]v*k,A]6Ļ UY|-XTSUmAk(Q8Wb]v*UثWb]v*UثWb^gK[Щ.$1ՔuX-. ljWb]v*UثWb]p4bk}ʞc^Q}ʁCVߘa&:Y1 qVZe_Rb]v*Uثc3F*v*UثWb]v*UثWb]v*UثWb]v*UثWbX<|tE ثWb]v*U'Ot4Z58E[JhvG'{5b]v*UثWb]v*UثWb]v*UثWb]x6sqENHqTͅ Wb]v*UثWb]v*UثWbqR]VZNz7IblUYm[+yoKS c_U?%VS\1j7Y( v*UثWb]v*Uث%N]7= Ua~dqw?gثWb]v*UثWb]v*UثWb]s(`AUzΙw6}5ݾ=w>g]ucؕzS|UUثWb]v*UثWb\ 7qU COҾeS7XPIϖ&[jLt=M0⬌ܔSbb]v**v*UثWb]v*UثWb]v*UثWb]v*UثWbX5Z<:UJB=cS)1Tv*UثWoy#Q[k6NOOQ?ioF_o $bQ![IXT21Wb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثNf4sO}C^55;J]v*Uتv40XI8/^VcPw݉AUثWb]v*UثWb]v*UثWb]v*6Ӗ+j8ѴqFXUثWb]v*UثWb]v*Hb=[F#oWjn>GcD| Tw0:eBm*ew튠ubE7ו\U#_kPh£nثct_JulyPA facVVb]v*UثWb]v*UثWb]v*UثWb]v*UثV5:AK%{o%YtKGF%SUثWb]8y ALͪME5j|T^{%^3<+u$+zWeSsfhx}a0SUثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]EK 8³嶲^e(b压>CYƭUثWb]Qk})-c?̫Y&c`(DP@"))VXϐ-&͕ZK,zeثWb]v*UتET_M*cϟpF&7=4 }1Wb]v*UثWb]v*UثWb]v*UثWb]%{`\U/QVb]v*UثWb]v*UثWb]v*UwتM&B˩sˤyM:fKNB&;W{*UثWbV*ĦIUQROA͗rFcM=?Տf>X򕏗 ,R~qTv*UثWb]v*UثWb]v*UثWb]x銳UثWb]/341YŲF4JXVS*-c:׼ IFU |b|3iڕ̑zdWb]v*UثWb]v*UثWb]v*UثWb]v*UثU9cKTu$bv`ޔr!\U'>bהЅe;uΩxCkZ~jh*4%iZY m۟O1Wb]v*Uhzb-`+l mv*UثWb]v*U/PO%rث˄mn:[^}#v*UثWb]v*UثWb]v*UثWb]v*U_vᴈIIcbFԢUUثWb]v*UثWb]v*UثWb]]m_Nqy26{*U }X({0|N*j?z*?eMN*]*FgeKUN?%׭zvc]qV{i6\"55E]v*UثWb]v*UثWb]v*UثWb^!Iלf:I*UثWb]v*UثWb]v*UثWb銰[(a.A 8AVWb]v*UثWb]v*UثWb]v*UثWb]v*UثWbT[YDGኧ7wKLTUX71_L׉U1Wb]~aЭ{J%]m| DSnbyֺ휶7h%Rm_9Ig +aySo#WAڝ_O]v*UثWb]v*UثWb]v*UثWb]v*UتHeuv4Xƫ6I 7uvi)EZ^^<1)lU>Lt*U9U (ov*UثWb]yQ 4MWZ^v*UثWb]v*Uثʿ5|.$^kGyl`]1Whjq^U ObUثWb]v*UثWb]v*UثWb]v*UثVӥ=1XVpntybUثWb]v*UثWb]v*UثWb]hQ0R]R sVO.b̿^ey>k1uPniC}{!oLk{X3;ެ,1W^v-Ci3܊U?8"(UUثWb]v*UثWb]v*UثWb]v*UثWbHT*C%:(xt1VWb]v*UثWb]v*UثWb]c__1VJ?AWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]qU\^c؍4W_zvh.mfnCF%4Ri-PC UWv*և\U^?ur4B7 ⬊teTlU~phk̂<1TY:mrKËאY>*UثWb]v*UثWb]v*UثWb]uF*uQR@\ORdEaCOCIĮz*qTo͆Y| (1V>}]֣--ɢH{b~PZ)ȅY}7IY@Sj]v*UثWb]cw~5?*Ư?8Pi}bs׵?5YŦXQ_IF S\UثWb]v*UثWb]v*UثWb]v*ڱ^fF8T|*?{agv*UثWb]v*UثWb]v*UثWb]v*UثWbw??b?A8v*UثWb]v*UثWb]v*UثV5dkv*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UتK-UCo{"i>Tֿ,&$}JIbRՆGZј4sR튧ֲN1%ZR#/1jNXPV;]C_i#A"ZUOQ-SF Uk>cE-GSFf7 \U$Gmv*UثWb]v*UثWb]v*UتG/9 eNѮObVmy#Vr"Kxg&:J>nEj? UN++FFs_ʖḾ~Oi(&T5⬒:U%a(SHH#PbCKASҚkG_zbt/l 6lU<]v*UثWb]y&ZyCCc9O8ޘ}Ec0ږQɉeqZC *҃T ]v*UثWb]v*Ub8mV5_թz>*UثWb]v*UثWb]v*UثWb]v*Uت [PScoՊ'ɀ-ʽWb]v*UثWb]v*UثWb]v*UثU[_TGWfz*UثWb]v*UثWb]v*UثWb]v*UثWbTO_?y7? *UثWb]v*UثWb]v*UثWbX7r2 UP~UUثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWbW)qUU{&X͹M銽#kCčiĉ`n5*ϼơG6-*b]KhZbNU%571**+C튰(/փů=S?8QBJ?f)]v*UثWb]v*UثWbR1y@Ji \O\#N?7r<@S-~XDK#*B(6Wb]v*UPW^y<[x1W]v*UثWbZw 1GXD=$*\UثWb]v*UثWb]v*U^D{7zX:Wv*UثWb]v*UثWb]v*UثWb]v*UJ\GR>U>ZBCOqWb]v*UثWb]v*UثWb]v*UثWbbȯu??V*UثWb]v*UثWb]v*UثWb]v*UثWb]tՊ~oK8v*UثWb]v*UثWb]v*UثV5dkv*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWbHO4}LUsy[2sp`b[QڰdoNu劦XWbTERUb*@$U3[!o*G,E@[ѐ?#Gm5ef̦7v*UثWb]v*UثWbPzk%ɤq*|yɯEE_#z0b]v*UثWb]_}yU/,HuCdY֓[ӡ#"FSLUثWb]\%m4* %X j=)4+W S  UMev*UثWb]v*UثWbV K Uߖzږ,)UxWb]v*UثWb]v*UثWb]v*UثWb_?i:2$E{*UثWb]v*UثWb]v*UثWb]v*UVU^v*UثWb]v*UثWb]v*UثWb]v*UثT>pM&ȈIWy^\ؖ!]v*UثWb]v*UثWb]v*UثZAaՊv*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UZ4'c:N\ܮn_숅iThm] *o#E](iެUsLzKF /36ҵ"^*Y;UWb]/fc/*qa #uGA#o:aQLU>f9OJb͗b?qn]jZsFK[wjM iZ(IX}GYh,n?ngjv*4]yRCEz\} UfљM-?dU`ȯ7S ΚV;;iU*b]v*I5.抢U1G?)X\= l**UثWb]v*UتɡYqU`AJ-SbbfzN*UثWb^Kja=YG򃊳}i]0yr2u'ax:Dϧ6s]]q4]*̬|5ڒ^f8"]v*UثWb]v*UثWbXw槚?@h2 p}(fG~_x:D6ssSnqVGv*UثWb]v*UثWb]v*UثWb]v*Uh Hh}USv*UثWb]v*UثWb]v*UثWb]T4zUWaWb]v*UثWb]v*UثWb]v*UثWb]v*U,0rV*$m0~Tv*UثWb]v*UثWb]v*UثWbk9k*ɇq?V**UثWb]v*UثWb]v*UثWb]v*UثWb]v*Ur4Y7tnZI>R}cP_Zz;doޕ^˝Ea-zÓ}dEaͽ<\i Knջxb˚_(F>LqWb]v*mlީR>BavfIFLU^I*-v}Hע{N*Ior}0D)Y-thtMî*^~Q?mgV5xM4 U,<$qTv*UثWb]v*UثWlyV-|ӦW_J YYP5U#GPꖶYQ['t[܆*(P# 'lU嗚~y,6JZaзUb>BN#1UandX;nMN*#Ӑ+]v*UثWb]v*UثWb^em/[i,~?kw:yLT;V?yL^ja|ARem:4$׶*";Hn`E")Pv4*]v*UثWb2[pv8?*Un^E{y:㊦R33^?ۙcYF*UثWb]v*UثWbTomU$R^gz7SkUDޘ![EUiB:tkliy4xjS8 cIuw!E=*Idq%qU*oɫRKE56*Dѭ5$}qTv*UثWb]v*UثWb]v*Uت ث41j6rXh@Y9YZEd&(dqV< -(WP<~}ޠ-}D} l48[]Srw'SB;ߎ*+ jFti?8B Fq$2j8#v*UثWb]v*UثWb]v*UثWb,!u+1V;\mUvt=TUثWb]v*UثWb]v*UثWb]v*UNTY%|U:f1VWb]v*UثWb]v*UثWb]v*Ucmd%XXWb]v*UثWb]v*UثWb]v*UثWb]v*UثT:tdY~z_Wz6S=IoOfWb]Vk BS6^5Wi~|u-NDs(&q!|'L߼zS}R~fqWxWbR+yI*\U?-KMִy[Jۄzbm@PQiWb]v*UثWb]v*UثWb]v*UثT_WJaI*-eR_ܱ!~ WgWb]v*UثWb]v*UثWb]v*UثWbSCT[ ImT?'G4(lY#v*UثWbR=yq<ä\X0 CpqV3# >ך{%Snz.*UثNsEU/Ѽa+2#n,TևLqWb]Ee 0H@*ygz bJU7]v*UثWbPݸ S1WyWZW¸!]v*UثWb]v*UثWb]v*UثVتi()m㱖ͣrzbB1(XXWb]v*UثWb]v*UثWb]v*UثWb]v*Uث*>'gѭHo*Pb]v*l<n:aijrdڧ|WΟk?W튧_bҴ;0]|R)4 OlU?37QP9^_UnlU[rfE >U_q`aRWߝZKDz'"wK(<,?)XiGv|Ub]v*UثWb]v*UثWb]v*UثWbc*$CWc< RƛUG[/4ƬU]v*UثWb]v*UثWb]v*UثWbZw@'y}MxJ)iDC7bQ UثWb]v*U忘?3؉'6ڢ~O(d~ΚDw@Ot:bv*?̭OYO]ٶA41TN5/-r'&Շv0X N@aZ#o*[[F{\[۷1 >تlZ,,⪫8YEGG|U''M2}Z.Byߒtik֧d?|?>Uߤ-bO͝qW~g%~X1VIy[]Kޟv*?6rbKg?PڛyQ{)o1iVm##ݼqTN*UثWb]v*UثWb]v*2$!Qza-@4ʐ{bX7|*}U yФatk4U z⨸u3@./e6߲?N*358XWb]v*UثWb]v*UثWb]cM.BQ)baӛFbtu8i, U?1Wb]v*UثWb]v*UثWb]v*UثWb]v*UثWb.#$⨯{y>̅Ry8Op*UثWb]{w/*d)n? y/?0ؼCE'ĩ|qWM82מ\q<\85,=V[% -<IJ" >*\yILזU=R4f L,H<*ӭ>ob)'1W~qyNX5iF5X㧛c6HMlU&*UثWb]v*UثWb]v*UثWb] fNRs$@1yޭw^JG3 FU ?/wG!G*=7NMKKU b Uv*UثWb]v*UثWb]v*UثWb]yǜ ~H1UO6F*=66"BUEv8Pl1Wb]v*UثWb]v*UثWb]v*UثWb]xGui믶M /S#8<1VWb]v*UثWb]v*UثWb]v*گ#LUyS%_J̽xbK-#ӭjbP⨜UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWbkϜ"Hw[(,l᷵PxSFbV*D!Tw;bb]~vW.,y@^kʻu!雀ޚ/*_"(,Ň*/W.ܽҽqW]bdv^_WKUc_P1b ?#?-.? xTl49k录,վʯP>U[Ni\K}5j1>Ui(#cP)1TF*UثWb]v*UثWb]v*UثWb]v*U :⯜mw[,m jǓj;^eqϧ ˾*1Wb]v*UثWb]<~]=Fjz}^moO3Mv9zbG@!R^cqTv*tv*UثWb]v*UثWb]v*UثWb]icS$*R+:Zu94 *6kXvQb6-'׮c9OU`(6u1V/`EyQ +A[ =x# (޸{&ϯ"8!0G`)]v*UثWb]v*UثWb]v*UثWb]v*UثWb]?y\MBT/vc U>M+F^2]1|qTv*UثWb]v*UثWb]v*UثWb4IUyo TeMiN.׍ĮXԌUb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*G#tIBf3U1ъWbf֥:T9E?dvR.kjLM;V[8(rx*#Vխcq$eaqUεk[58PnI1V1_s5RE=:.J \犧Qꖲ[q%CnEyqKMCy#N󥜏4; ~J;U\-mE&D]TgyF Z8W5U=Wb]v*UثWb]v*UثT̾zҼ(cOX̞`kOv6*ukS&mꄀ1T:nZ3P@?,U,`*tov*UثWb]v*UثWb]v*UثWb]v*UثWb^G/*\3T:ra]O bDiikʱZ]½U/-yG,&Jd*>U=Wb]v*UثU+ `U>cGԗXӢcݷZ. 1WXC]Z2*BjlZWS!FU?:=M SO^v*UثWb]v*UثWbSvSW! n\U$'奨Xj/[Vɿ P=WLUثWb]v*UثWb]v*UثWb]v*UثWb]v*UثUH!{i(R>RCq*>8%Yi&{*1U!KꪽI S[i[({yE=Db]v*Uث?m֗l({qT 4wVPGv*UثWb]v*UثWb]v*UثWb]GnkӮ*tO.\_h%fFpz^gHB8tXRGPMQ! $fGٯ1VfLUثWb]zojt3a&A$d20#_v*UثWb]q4늺OISGoy+RROg*Kn qTV*UثWb]v*UثWb]v*UثWb.oW1&^:LUn*UثWb]v*UثWb]v*UثWbR{sa\7؉w$vc=StACqVj1VWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]Htm`h~D֐e[lhUp0ޢb-_A֌mF$hO$'Qՠ**ꑊv*Uثj|1TD {UK(j17݁> > NnT<2R׆*9)i&N5Q@|k:ch/uMBI/w>Yr{t(A{1Wh6hΩ>ޘ=ng2FiOSUثWb]icRhTWr?M[hw9 jb97 jp!^1Cr+)vDT*|O7FV|*fMܑ U'~%5X擳.x^W9I4B3gy&Ir]v*UثWb]v*UثWbR_0Inc^)9Miv/)̗7br]uKen¡E6_IYjvڽze UqWb]v*UثWb]v*UثWb]mM qV敓F=ཛྷW7 jTbxWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]b>Qj$paFa*8tMN>Qџ<}W_mU}EHabC>lVe$Z=QPqW_<4ERH̴I;eqTwg}YdhT>4SUثWb]iQw$ {#_ZUBYdTASث X̚l2\@QJU 5< X[L~a¸9 qmaE{'M1Wb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*Ul *s{bNv^mhyYцHW(3؞8^vQz[M⬫ϭFޡ5.ZhҸ%t&}9UmbS;Z ~XA4vlX㊤SŠ}Gi~M&꺾/[! l[犽Sv*UتYm-wNMI=*?)|=.{/ jOGijqmf_:UثWb]v*UثWb]v*Uثj*/|w%AHtUC㊦;_yeJ²!CK?;ϧ%ҧlUU4 { )^v*UثWb][+h_W|gw=c˷RD;bEsYUqWb]v*ynГ"qW=BƤoWb]\m* eat8/3,j,T\Ww^^u}"S.az{2+}!bd־fKh]?jUib]v*Ul,cF #|a ~v,uB+ Ub<1VWb]v*UثWb]v*UثUH-F!TIRyѼuZ2op9:BɥZI8xνQ⨬UثWb]v*UثVCyFkH_V i+*O=ִ̧fSNhRqU\GpHX:U~*UثWF~jy;B'RRp1_bǩ5V]v*U6ǚu,^JaG8$/|Ѷ9Qc2{B:$bb\`캖!f,ORUثWbQvխ= ]8,F'\62>3(h1Tv*Ur9F 1W^Z[S!{=roኲO5K[\i>jPzYlz]v*UثWb]v*UثWb] qmnx\>>^]#2Rg}Ta1UWb]v*UثWb]v*UثWb]v*UثWb]v*UثWbW$l拊uzDeXaA%[}WE:԰O8qv*UثWb]v*UثT>CIgrc<&k_һ\z bSҬDuLmaO3XjwiRF 9 n(3aSCz#k=V(L#KWcS8ԣe!1UتGyI[[ۅVX<yo鵕1ra=Te;Vg8,]h*5?0^M?MEXUB1WCS+c/9۾*[}{>UBXC:/pqT͞S^eXߘѭ٦kUOZǚ|</\EQ^-̀fR+mVsg^KiFH8ͺU EꥅF*f@Z1W^S5?j+sFå*g#^Z]YqpElU旗_QdMY,RG4k4 7bWb]v*UثWbXe֌YHbxI>Mìaypc\UWb]v*UثWb]qX^}S}evVUX~$zMʮiț3 TqYi sLӐ8T-kw#o*I${:FV꘷Ut+hR^<" SBx/2y~vx զ}YeR;XtQO/=: Mė|1T=yG"KS$j9@1W[Q"*v*UثWb]v*UثWb]v*UثV|1WAy̳r}‘ֆC㊧RcS+ {v?Qu/k^ZMH1TN͒}ZkF(ğlU8Wb]v*UثWb]v*UثWb]{3]o02=b+WȞtmCN̍LUiQsX &_I*⪞F޷|sX,(^#F Sjt*Qv*Uǜ?4s^ ;Ez){z ~$ܜUx"_R晩H8b,@0GQ<UM I=},wUW-h'w зFQኼWs9+Z|ov*UثWb]v*UثWb]v*UثWb]v*Uت6XON Yb^ƨNz9SY. zU2{F Cv*UثWb]v*UثWb]v*5W`_/y$"SSض*JzUثWb]v*UثWb]v*UثWb]v*Uت䍟U|V!*{P{ "fcyR'RC܏ObR$PxW]v*U$6}9qUo)+i_SM)v*UثWb]v*UثWbP:洚5u,z UR~]e%氫%⧢_妉_N+PN~X%."hdU埔p&hVQp(ڞWb]v*UثWb]v*UثWb]v*U~ebmvrk"7R=V;my7k*i\U긫&]JJ1ȯl*F劥t %o:*-QLUz#)'Jw[п'-mݦզɨƃgVYF!E@*UثWb]v*UثWb]v*UثWb^94^]Xk~WVv2Szw_6g>n]VkGD` `1Twt&$? `ߊgE>v挱~`XW\U3-΅>T݆%WѸ?]CTWxTi̱aǥgLUGL,lIn RzQVn1T~ID)WMS Om4مsk?żrѹ$U^ u(HP(SKu?-iu.U4{}kd85>841O=VRX0RfYTWb]v*Uti`G~$ng@LUP~BzɤjҸ5*[_N)m⬃v*UثWb]v*UثWb]v*?4-.Ơq'*mO|U7ybCڵ57PWb7gbWDRh$(ըji y1W͸Wb]v*UثWb]v*UثWb]v*UثWb]zwnvM=1@1WHWؤ`qхF*v*UثWb]v*UثWb]v*U~gi[Դ T#jbv[bWb]v*UثWb]v*UثWb]v*UثV3unzd^qT~M7&,N2!g?M4gnkRVMU1V](G;b]u]R-&կ*Q;4;0߯y}Vl\8XWb]v*UثWb]v*UN(ěqW~[v͚ 6Q)ኽcf󽇗tŦƢqVk$zx4iYϓi嘙a&I5y[1Y*UثWb]v*UثWb]v*Ul,j]UqWMJJ$kM>imN*nJm￫s?ɫ_MjzWOqVkZ"}*Q6PXƼbh*qV"ONU]v*UثWb]v*UثWb]v*UثWb_>ogɚiRƆWn=V%+Vv6Ŧ ɐ Tk>išqi:ҊDv튼+Ț5鲎%TbYb,j]v*UثWb]v*UثWb]v*UثU5؍*BQԒ!9tZa^!Cyn>(](ɁA늬]c71%d5y^S}!-:9>N'v*UثWb]v*UثWb]>p.Ӯ?Ie_P=1WX[Gmp@RO }"yIEaPqW#>xk$UUקքlU~V[>u]^nG^gXWb]v*UثWb]v*UثWb]v*UثWb][,~;r^,|tr#AbahDcm튾BPnv.Tj;b'fl:0*50^OAx6^?quynKW)"v*UثWb]v*UثWb[R_eASb|eYo(czwmwg-(+SD]v*UJ+(N*/l?7ƾ]$E}_{bpg4)iJO[\U5D=40ib@* UUثW?_ l|ߧ(Yc|v*UثWb]v*UثWb]v*UثWb]v*U_IA[e^8曽3!*U?Ɲ}[YtCHXt8*UrrlUyO̖-^P/T=1Vy9Vb]v*UثWb]v*UثWb{Rvpw{Z@JքK>LM-?:4Mzy- & 1}k-6OGaձU?=ytUd(=0(e^0V[0xPGQ8Wb]v*U"gl|jQXV7qP hSdžqo߯8$3ųP*>cדfҾIF[LҙuɧsV!Q-as {,Uj1U]R[Eh1VYcN2z7?N*LUثV'=rzvT*|u # F=2S0]v*UثWb]v*UثWb]v*UثWb]v*UثU+X:C0Pv]ӬAJUBNRc]&g{{RV x3 *^tZmي,|UbIO,\8m&;i⯣,m$KIԒ1B8*UثWb]v*UثWb\2찡R .iZ{g2'|UG#\y|\v۰eu늻P-l%c@[lU(h|C7Z㊧v)s r ]6q:>4h}0;.*1Wb]q48sk~m$cJS*7?*7?*/Bc_Z`'IBpA#s=MMN*]69UhqT*'pUn"UF*2I&UXQF*̯)i]w;_CЭx(R9IPoxWb]c_:|mI3T~k]o+2S،UGv*UثWb]v*UثWb]v*UثWb]v*sD[§blSM U]~m&! O#O W $PF*UثWb]v*UثWb]v*U(no.H|0K&Q,?FKUy-*Tfo䯗l':ȏ1\ͧ *֍<xSOQWb]v*UثWb]v*UثWb]v*+z\܍FC=솄ĜUF4Yx)OYF*ϨF ŬF_JPTc7jLćQ1U;{H8 #_?eҴ6竁ڟAjX-Xۓv*UثWb]v*UثWb]m"W݊1T?ˤi#'#@1T:tLqT͞Sz^]P[!'N:ثo-y~|:]P QcrKgٟGG'_H>ث/!gu& ثT\6Pb 1V ~et(BJGp∿PӼ.m~q$_T9%줰"TEI.Z8$UU<=masSY A"?*@)\ v*UثWb]J|wzgJ?+>]yU]v*UثWb]v*UثWb]v*UثWb]v*UثWb]Q|%u j B2tV=*YDDI b( gUثWb]v*UثWb]KoN*#_5o-ٴoΣ|qVa5bAq{t@|U%=hZz'a+ Uj-q,:w8կca%̰Uft}Rr튰_< ҆ U{U([MΝeYqoWƟ,UI杤Y\\% "[qWZGw*áU]v**)>"|˔QHnOO_y*UثWb]ooͭgWsZ?lU7.je1TvF_)y;-O|U61]FqU`jU1Wb]v*h.M\H&W|IMmB}JE ӹrA\U,]v*UثWb]v*UثWb]v*UثWb]OGEg]McW3r$bToln1TmhfV(eYilUثWb]v*UثWb]v*b{2;[q>Wb"UG?c">̪:㊥zV]8V1TV*Uت6Q8ӿ1d-2yLVUaIn r1T~`; HgqTv*UثWb]mPLU &eQ)\UFqVWbR2jTl+$wbR\>Yӣ5RMlUVJ88]D.Ԡտl.5mrw-n۫Szz}T1ĊW bZƑoڽAB1W:=],17$?,UG(XOĹTIr&`c/7{*UتYyN?'f?F*H@7H4*ꖷIRP:`V*s[OawzC|v*UثWb⯤ /z實XyP⯭M*U{KX\P ?O/k>EBtF7p%j?8/򏛭|kZSSኧWb]C,\ƭxg]v*UثWb]v*UثWb]v*UثWb]t}*]V,W} *+}NF#**aSy9ZVq*/1YxLU /$Kۮ*5U,C[ø4#8<|l/^劲lUثWb]v*UثWb]Hk V:z'U>H|Aƥ*qWb\Ev^=1 fӢI1ևm銵)maP>shvO[YQZ⯣4k8!8|*lU@(1WDڃqoݱTЀjpqVWb]v*UR8ڔR 6Wͺ= [x)Kԑ1WIij`^Ib~*Uǘ|u-(8/K-hk'O+xb=cVE7G;"$bԭZZCQ]v*UJ6yJлGIΚ;pv\U-X1(R4Wb]v*UثWb]v*UثWb]v*U)?ηkz Bøt!|1U[6q :PS_okc˜*UثWb]v*UثWb⏙l8 ?0M4_ڮSoUW:6c-RDP>U0]v*UrmˏPœ+־ثы>+\Uuo) qP7+?m4' ֫rn*LUت],屸P*c㊼'˅9/bbf튧\AH$TpbJ K8I"y)s@H bZPqVRsZM.0- q.䟖*c9~ ⸫)7#aSzF*;Uv; ޝ*8ʢGU*_RYLV5 1^1Wb]v*ΝnU[yk܍An:1Y7"[kv*UثWb]v*UثWb]v*UثWbbq,-;A{nCrCJLUA zmVhsPUqVAv*UثWb]v*UثWb]v*yq ^Dem"ثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*U~g[][_F`*!qqWxU_^[yˈGZGs,?4u_:j3IpP*cϓCէa x`HPW]~jyNŇiX۸aJRկ;i`JOlU긫Wb_Z>q1"!zav*UثWb]v*UثWb]v*UثWb]v*_JMWQRBH<1WКO.BǮ*U9aC†Sb/y˥jfZ9^,e[v*UثWb]v*|O]b|T6}j.qһU~/3gi'o]Y^DV^ݝ7rqVGv*UثWEI!,Mi`GP6\MZ銪]TX [ =IYz1WGg [(劫b]5K0 }Ȼ0qV1VꆻIh>UXycM[ƱAbU$m5.kRFZ(*]*61+U(Ʈx]bRD[mX^AA?ۗ*Lu!5V]v*UثWb4N*6^4="?jtN⩫ycIHRA|1UYA8cwQZGֵHfk8GSa c$wu4F6i㊽:;xT"(P1ULUثWb]|[[OC!~AgFCM1W[G? *]TRP~)PqW]v*UثWb*b]v*UثWb]v*UثW(zi⩐[]v*UثWb]v*UثWb]v*UثWb5C{g{<ِwg/vpu8R76犳7XYʒ3v*UثWb]v*UثWbVO:[JBI=^J hZ|S"_awv*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]i*>o4R[%r}U/e휖PDJثјq48XWbX月Q[CP,%Nڬ<@k8aҭ(!;ָ&Q\HBz5U1WbQӌ2X^ejgz^jz%wEˎq!=*V9z0Wb]v*UثWb]Rn!x_uu #~j~cb9ޟ"j1V7v*UثWbRд0[y Y E=_ZEw6[:Uo̴g'+J#0mخSUm/W75;RUثWb]v*UثWb]v*UثWb]v*Uتm^Zxc/CC튽ɫRd5ӧdWbTbp~]*a"\:=*85`8#]v*UثWb\1V#kti#-zZ lU/n4&[@\8iv*UثWb]v*̿4j7~(*ʗR#*j5&cz/0,jR"Xmt+[N~ُSUثWb]v*UثWb]v*UثWb]iPUP}J6N*Pmtj*K1Wzνj`9(8x1VWb]v*UثWb]v*UثWb]v*UثVՊޯ@|F*I{tilֈM1TiDE{⬃Cnec?`WXj֗%$CЩE]v*UثWb]`XUYt(-.O"AZx*b]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb7ԭGQ\UG^dT/LOS{'ӯ#4"Q*ָWbWEN_LU vMadK{4UK| _^t +f~WhXkኽd J~x*/bkqnoQ>gkR#szKԱ*ǜqͯcT8acϏT$;H:(S]Hs=vzW|Rֽ;]D0Cj=W,j 1VWb]v*UثWb]v*UsY]Wׂ7yycT>&i7lqVi;Zy94x U]v*UثWb]v*UثWb]S:jfTo51N~6QGJ U +7s kv*UثWb]v*UثWb]v*UثWb]v*UثWb]m\C][ޯQPRiNKgU0Z}cT UO9t?v*͚* Ky1J*I^jLs*G*Wb]wT̳h`Ѵ4J1^il kh8PQTbUثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثV| W~P %-Wm|1Wߚwֿ1֥Ҥ5{qŘ-+NX叛F:${bK:in>Z\; U$,|D Yd"M}1T~O+Kۍ>ю犲I58T}7KqTXգ=\qTz620Y@zzb>|c?5J^a޾޽mEZ(9v*UثWb]v*UثVbΏ3\7F4 bv*UثWb]#}s!L늿G*kC' m*qTϒ$z%ِ_LU cjH#=~x)Pb[iP(~X#1zZR>U*]v*UثWb]v*UثWb]v*UثWb_D~W%DnOslUثWb]v*m9^|A$Q^AD>^Şr`qVKk%xf4,\Ivԋ!XV2R:o11$bF*UثWb]v*UثWb]v*UثWb7' IqvvFxBq]:xgMk;[QjDdt^ߩsORT5ZFZYg8@V]LUثWb]v*UثWb]v*UثWb]v*̏ W[YuaO|U-?5u}Dsxv3F9)^vzU&UثWb]v*UثWb]v*UثWbXg4;(VهJb&ڍQSk6ā㊲BMv*UثWb]v*UثWb]v*UثWb]v*UثWb]v*U,r9Iܱ81kdq=^v*Usr\~akCrEql?`bW(T@UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]i0ο4$=Zm.,{T*(ɠ@8Iفk\`Jemb]m\3u&W뤴ѮZV J{M+E'u.Ub]v*UثWb]v* s"?+Z[hG9?i@~XUثWb]v*URߏب~S{aЏqV[O[y E)y:w%1C[b5SlU ޗڟ:b̏2 r&z능Wb]v*UثWb]v*UثVK ^?ʹ{@ ԜU_mNi*U:E.I7x WC*@_EOZne C=wY5]v*UثWuR`OMž;SԜU?48=6MQa@M7SLUثWb]v*UثWb]v*UثWb]v*UثWbw\e(C {̚s~VǬhi7KHJҏ U&e[ޟ* w1Wb]v*UثWb]v*UثWb]G,: - ^{yM*-VqVJѕ[v*UثWb]v*UثWb]v*UثWb]v*UثWbRo1f*~V~Y ľho'u{}8ֱWb]b?Z~[ ^N*SW=Ys.Q&CFyGֿ,3144cVߜ)],~UثWb1W\6bK:bq _QY]5r[:rRTX5b]v*UثWb]v* rgKWo3_ b(]v*UثWb]BKfƧ2p4*X0b|M`VCæ*?)<$j쉩Xث1ռa}s*o/|L+KF lU޵4ڍמ~F~P&'t~[yDEap¡ Cj^HS‡I U1Uyq7}oI,)\Uۡbb]v*UثWb]v*UثWb]v*UثWb]v*U jiq N*/-c̺x1Wb]v*U~s{E9?v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UتSmd(؊b G[JξP$!|Tuԥ}#VMQ_qVdҠVWbPھi[-F5&XWO&]Ct8/_\ySVՖV'c.*UثWb]v*UثWb4<@CᩊO|v*UثWb]_BUB1W_?cؐT qW睵uGl?l>Uƨ.U']Fmxˮ*tɍ. Qes$ͺU}OʚL[{\U:>ANfPShbDhEavј.I#=UWZ\XC鸡UdNs K*|F*lUثWb]v*UثWbVKg^*Ptkv*U銶[**UثWb]u]N &ٯ.#=*7Yqj]-:}#ce k% vV]v*UثWb]v*UثWb]v*UثWb]v*UثW@iGͺjbUW {z<'O%wG)Y*UثWb]v*UثWb]v*UثWb^3=.EXzUثWb]v*UثWb]v*UثWb]v*UثWbP."b>BG]s^PnNDzF;V*UثWb]uJ-6kۊF-$c.-}KqV{v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثT;Mj֚`iU[g<#K[KWUꧡZ]p$cbSkQjzuY1t_cϕ|Ȫ劽v*UثWb]v*U矟DZ/yNc؎b]v*Uت'OӮ56V4 Kh p-8*qrKI__B~Y! it/%aWzV*UثWb]v*qom 7e"㊾ >K1'n~^ñWb]v*UثWbL}$=*2GQG@;bb]v*UثWb]v*{Amnה}@8=^qy6~v:bo]v*UثWb]v*UثWb]v*UثWb]v*UثWb7vP^!D=C UkNiH7PO5,Z?˞ei?Eo+㊽Cv*Up8Tmң _b^6b^8G'(DK^?1=e5Z.<q*)Yn*rAms Yjw_2b]v*gc=hI}m8y[Ũcjoኾ| ҭ=efWb]v*UثWb]o&C-EOfWO{]Fm'RN>qTv*UثWb]{G䮍$6߻|hz5k*UثWb]v*UثWbWG֧YyAOWXWb]v*UثWb]v*UثWb]v*UثWb]l[_jzqAOR,~mh>aoN SvI~~UYk]”+q]LUثѴ^_%EqTGʹS?=|U]v*UثWb]v*UثWb]Yq\F9#=_:_ˍp[I6yXbW2"j62 (h*ɬ`]Z78[*UثWb]v*UثWb]v*UثWb]v*յk}ݰU(O`1TSjү|µ{r6Q٘xY銻v*UثWbKrEsAܖ;Vث~Q}zCާk1VYv*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]5\OA$X^ {wI O#LO1Xk/wCL ]7DTol ߜc-Ҷ'#*v*?:4+5J¡$EO0(qVu\[mT]ǘz+kت<kONKe W)/#wP+Oto.y셨1Tn8j*ďLt/mwʚdNsE*-j,U]4Y׾ʹU1J܃>U34lT1U{+)e[{d2J抪*I^8T)ijS{N8]dN菋A^64+XY*UثWb]v*UثWb]|}9䷵ԭ/zb1Wb]v*Uت<,QNƲ7}8Wb]v*UثWb]lǡ?-n|lЯ7JUF*UثWb]v*UثTX3Dw#I^&PWIkx^ ^>تi Me-F=)6`At]v*UثWb],`u'yo疗v_j1I*_ReLy"˰a8esycJgKŬ}x;mJ?3[$ >$ o*̼'y!&,? t1V1?ݨ"V^"һxWYqy%~fȕS7VP`-QH \UeS N""1TZ5&w{)^v*UثWb]v*UثWb]v*Uتpf\4R;Zˤ}b5ڜlUZkiACHY}*1Wb]v*UثWb]v*UثWb]Xٺ U {Yi^e@;*vn ۖQg[}a+T55iztiՀ諹'G IO1yZڞ1W1Wb]v*U V^ܚGqW CWi*ňF٩qW]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]`=A^sɻMf3~ԗp(1WOu)gmoEF*kvm:n#S} b[N۠YϘi9ԗX)$j ^e8">~I;bP]v*UثWb]v*UثWb]`_.ϧ z9,pVX؃Cb]v*Uh7i0T$ơyUkmB .߉+{~%Y6*UثWb]v*UثWb]bY<8̣ӊBA1VWb]v*UثWb0nu -fPV{aobo$3w$*Nu?[}N.? U`ssNm;z+UGH8xWb]ΞyѼZՇ)_Qw斡2[yͭ)wB|qT^C/{{ t̜U)ˏ35msR6IZ/,UO{˾Y\[?ُ6zb<]~s ԕ }8oĐHGYuH"b@(ካ\TEA^me-ŽHyF)aT-ח8xVڣz\re=*Y hhk#Իl^qc당lfanW?A1Wߔ֨V[ k*`BB6@U1Wb]v*UثWb]v*UثWb]v*UثWb]v*UثWb>Rj tY=⯓u?#Ze̓FhACt_mZlpOmqVm|*>U]y1,.[JbG*^HڍO ޸Ѵ/ŏ(izеqVE~EySGԣ,,+MV`~XfmFY9Hd6銼3oO:ϥdDe";Ql{M*/'z|ц*._ 4:m}r.8S#]sgi%;ҸՌjn$r9O>J|v)qVou[]h-M 0tW\U~Q˷?q_ht^v*UثWb]Bjڵl׮#!VcK^ꫡj>'[Vl) }k%}⭯45SN*y*KyjO:tzWTn\t2iUމ:X.SD~⬽8ȂH:Wb]v*UrͰYMo nqTN[jĐ;U^xl\*Tmu _zf[j,SQqWMV4[]UK9 8Oխu2Yʲ4%MwU/X$QO_3yκ\C0s*oi?wfY;e#cv*UlUmqWro+h% +CB)4'3 ٺN*ys>`J}+}U8 Wb\vOyDf&YFo4y " af D|TLhޭof#rChK13imLӮxتvɹKk d~EIm]xWj/bqVoIvdVcd7H U9]v*UثWb]v*ſ0<o6Rˏ"Iֵ{ݷY*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]gr 7 `wU] 2>}xm7*GDԀ[#UҼ K!{4Hb{0Moi+[+P*NܱVj bb]v*UثWb]Yqn14 UGykI5V;2!WbVO:@YHTQRN*Ư2;42=jmEFբYJƫR8-\23GJb[]v*UثjMF*O՜]BM&?bbyVћ꺵 d/jBu4?Ml|_ eOUmS }ZK2[hvG)$R&z;t}b9_TmY#HqVՊ*VVJ4%|qi_âXQbWb]v*UثWb]c~ݯlyAOvv=1TȞOuT>'đ^v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb=ecd+p*u)T]jR̦ 튾{ycC >(&=F*1Vgc{/N`/ UoqW˫uzԕqVc!:bb]v*UثWb]v*um blUIе#ԡ ;qWb;^bd uoUs$q YMN*A}2 Fz#lU4lU+A ($bmH|WrynWz/eSbG1W3~QLU[v*UثWb]v*UثWb]v*UثWb]v*UثWb]ͦc=ڨ7_&yJ4R_JBȃ¸~+Oq,Qwb UثWbPH,SmFKz r$?L򝿖4 ݛ8{v*UثWb]v*UتQ2[~.d^݀X_|{wxhK e vlUxWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UتJz7*Ul#RQSb﵈u3_vϦOUv*UثWb]v*UثWb=OIMEGcwIЃ^'M;yg]&IoQٽVKһX|>8>;|#bWb;R U^^`0\#zv*UثWb]v*UثWb]v*UثWb]v*UثWb]v*ſ3InMO|A/,$6oGqWb]v*Un&KW]XGW*1"̫:}!]v*UثWb]v*UثWb-ST!"L21N*Ͽ//CjWԮdo.*qWb]v*UثWb]I|.$>7g>bSLuu11G[ڎ_z(]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*U&/G/J&4_/p7ax-LU2[]zb#]q8v*UثWb[^wTk׃ub/U!MF&h@늦vTD8VVǜmw&7{b3̚_ёq6 8%)8Yjv;m]AUITQ}\01T/(/Sht ׾_iY*V;X}Ar+{Wb]v*U48]!.Mz?8UR&E_5t8tփ}C'kOv*D㋢{*yzO[$>T銼SSu-Lj֢ت FӮbGUS-w~7<~. P[tJLU.*UثU+H_SV 85iUثWb]v*UثWb]v*UثWb]v*UثWb]v*UثVP?VMFo%B#{ت+v*UثWb]JZMzkVb]v*UثWb]v*UèPz76,UXWb]v*UثLUyB 2qqm=ŸRy pbh)HYޏY-KkG_*]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWbR5Λq;&?FثϿ<=NJ\5P1qW]Y<m,* $ URjmi#OT"1Wb\R/%qTv*U늲ȝRN.-Ƈ*,3\K UGƷOC6:LZb*UثǦ*Rz0?j v6ZB]v*54)nX$HV#9m*i/<'+|qVyv*UثWb]v*UثWb]v*UثWb]v*UثWb]y~WO.5IG3w}9y Qࣶ*Mw8Wb]v*UثhA2}{]mD1M*]v*UثWb]v*UثQoJmXܱWb]v*UتQ`Ӡ{3ty淬yQo6=i%O*. wywcN*]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]5m-MUe$pnB9Wov*Uث$o.4: m#LxWNG-i6iS_I֬KDUqW]v*UثWb]v*UثWb]v*UثWb]v*UثV?17B5$hx~ثO.[J!}Bc#rqTv*UثWb]v*չ 23;zmQ>gU]v*UثWb]v*UثWb\:USm^劻v*U--;fjWbC>V^d ~@zF;1͊v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb7p3U+C㊫b]v*Uث>X`=qV(А*aWb]v*UثWK:mhʋ֣})9حz'SF*1Wb]v*UتYiMՍV!"mEimdyX*,UثWb]v*UثWb]v*UثWb]v*UثWb]v*}\i_hVc^5iEUqWb]v*UثWbO8ޖqzhi'9|銷v*UثWb]v*UثWb]uF劽v*U+/ld Os=V#6'"Z۷@;;UXWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]^sd>UTVhP{W*<9-m2ZewyI=Ƒx*DжXWb]v*UثWb*MK3U[L"}!Qϡ}tU11Vcv*UثWb_[$Siqىa~VNѣy#WeWb]v*UثWb]v*UثWb]v*UثWb]v*UhvvJk3Mʞþ*(xv*UثWb]ډd{^?1UWb]v*UثWb]v*UثQ4Q;M{*U s[E$򺄄s^x #ScUcEB ov*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثT&ũepJEF~x`y-|itL0OLU]2vZ5[7Bzj>#eJ튵v*UثWb]v*y_ W}U,I5Yf*UثWb&v3@n.渪Qo/˭I=v2dvG5^S>aA2:GK atmnZֳqQGъHv*UثWb]v*UثWb]튠]Mt6zHb4Vs$ܚbIa%CqVGv*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثVVC4/h!5;U0]v*UثWbWv^D$@UA|)[s?5c ⩧ݾUZ--OS\UثWb]Ry8P~U|r$$)F*v*U$؟1j;u>Td-I-kʂqT`?: ],MAgtK[I11VAv*UثWb]zb _Z~u;e'^yjQu %; WSk[oKl*v*UثWb]v*UثUޙR?=cAe֗CjpqTÒ{UUثWb]v*UثU_}¤<.1WЈUP([]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]zb6y^"m񲍹wIyLѤA cLU:ڕSP{UثT=֭Ԓ 2E|®8.*n2i{iZ۲qZWz懓͚$wEbngF2xqTo?.54~ݭ4~0b_YȺcG$TU]/_H ~v*Uث ߯7NkZw%4oHOI(Ncv*UثWb]v*UثWb]v*UثWb]v*UثWb]yԓ>_aV"8#l>X0zXsY=Kby7g枭}~L- S]TTB:y .l-~ E o3^bNI<| G*cUk/HnW}*^jmv4r !^1VWb]v*UثRI(d qVh%F)NU<z 'ȹd׾[{]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*?10t"Rj|+ NݔdI@[|8a@u)X=};9:l.Լ/˘O1YfδI=χ-|٣Cn>%&,v*UثWb]v*Uث?>?05!Y&"xo|cߞŞ F `S߶I/yb]v*UثWb]v*UثWb]v*UثWb]v*U#t7iZbHdJ̧?>@NLSr:S}#z&NX⨸&YGqR=#M)n.6/ʛ3P-=1@#fxWb]5-Sm㘎U P W]bkmys!G⩯Kۑ⸪ov*UثWb]v*UثWb]v*UثWb]v*UثWb]yWo 4Fj`?i?Xcy_ArjJIҧQY=\b>! GBӍ㊧?WvZ6 vCxW_DD>]YiUʑv*UثWb]v*UثWb]9\^l~ĩqWy#̾NH_⏗|U+vZzr_*+kv*UثUрN*k+ehD ӑ8t?- E@ͽ>UYN*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb5f`1[.qrIM˺܋ksvաYyG@p"9YRgEJa !GlC\Nu &o~CM0U_~߳H(7Anm·VR,о4̿?]SWmߙ^_m&?y ;(f5DyCQ WfI8@;24yGŰծRUjwoD7?9)ZKS:lO%Lmj@3F|Eԫo^O|*?rwwjҷ|@|DI|};VJ'SZ|dS^[9^H| \ه1egHP) *I4`d_mսXG1F#tLB n/4ɒ5E1 9i~Vޯ:;DdM7WQ'V'45iۄ'^-bZ|*P U jvitqB1WaWyVMcG$=o`1W]߽is)-# 1O*Wb]v*UثWb]v*UثV/U _(%%5ʝqWWQK/RaWb]\EU&C;yv7&d!tv*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb3_H}2|QI:} F ii5PQI<" E?=FY}i|em"=cM5W"|[/8>}wvJ"׉#=)x4dmBI%9MLWzk{6W-o >;ٍ&Pmr0 }RNr/0UM̺b]ѦJ?&?_4T"qʢM+{io,.o)XDP?^]8V^pM9^A9tBL.tA<긔&^c:lDƲ\&[bq˭y`5Cg$r35aqWNLz{ĞڵrJ5QѿOU.m_ٻYcY.4,?+̣M ˕4ZkMyBȞDOŷrvFi+sEl,O.I=?O0 %OmxP9V3LmOP疂Da-5t m^WퟗUޑ[n:,A6*mv*UثWb]v*UثWb]v*UثWb]v*Ueżw3(xEA|o.~^kI,l|9,Q=*sm<$W=T5Rbgҥ45*Ț}톏o) .8v*UثWb]yji[Qk(;UUYŠ1TV*UثWb]v*UثWb]v*UثWb]v*UثWb]v*Uث̯x'&P{bM]ujDQn&>ث-t mZryr`;z~m`BFT]v*UثWb]v*UثWbR1]\Zd6(-MWοoxʘ$% +*iM\UثWb>j&ot({痴 ]=:xCqTv*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb6׿1+M{ק,ĚgkBַ,зUqPr,)G=XhVOM}(ϘN дgy5^ij9#nWR y@/֝Op{iEdi<;_?v^qԕREM0u”<m̱:eRdy)8R+ XXse#74W |fVoՋ?q,ǃtߡ-k(WH?İR H]&bv#Ag1914@q1Wɮ ?VB\ه3wƳ#/5δGq>9gOdq!c藗w+7-2RDyҷn2)p7gΉF Ëpr@!O?έ ?9Lg)_1G4 o|~e(N;+4/Ο,Iltkndђog_6'=H>-m,v*UثWb]v*UثWb]v*UثWb]v*U%o5YD$=^gz,*ߺ[Lz5dU~uՇ{ƫcAՉS6y:*ZWV$xb]ڧ4.xo.&T*]*B^g/-2.zF!Qj#)=늣tʫ! \j%ˀsmw1Vukkk 5tUqWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]/-2Y{h6ήu|UykR: 4 Ǿ*`~a[yj#.b,7d/ԙ fxWb]v*UثWb]v*UثWb]8yLT\/|&Χ$4wȲ,woNQXSKKo1UJydvQHH{⯦3'q_U_HQCoM-dWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]c7YSB=1V)yhl/V"S&~S_ܳ^s4Ǒzbv*UثWb]v*UثWb]v*UثWbVʥ$AUoҦ}gʕw{B~S`D >(i*~Bh^c'D3*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثV}/\MfYx6*Z|T^aѿ:⺍{C>O+Wͧ¬OAUثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb] 6mxUiO_"y0iqz1bUثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*Ϳ)\ͯ4c6C:N|ǩ\4"xUƟ8ڒjHݙ*-).|ޏ&KY=iث:?JXSboHW=;]jOثm * h F X/;G rO_mJU_%|h+z1yqVSv*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb }]EU%Vo*̴{8eQxWb]v*UثWb]v*UثWb]v*UثWֺ57ԓi~Cfa*_;Akxƻ 1T&64OnobD]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]]EwΡe=8ƞ߸nB>ˊו7[]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWbZtXUH|4hl/ [*˶syջ_ZY}B`1Wb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*4Ԭ` CWi.pҬ8=]v*UثWb]v*UثWb]v*UثWbPzƫoZI{v!IbqW~AyfK͎8[j7ȯPW-mTI/ 늨'yvM>B# +]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*iT-ov8*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]q4|ѡ{Wt_iOwEWt_iOwEWt_iOPo} }`}تEa_ߊ{J}T)ANiEH$N7v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWI'%zv*,58n< "4_L^{R>mѬJNSbB]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*H<* UثWb]v*UثWb]v*UثWb]v*UOoYEc߸ z⬧Lt]6yR5iR1V9;~cG$x'YWg}>=2ib=I8qv*UثWb]v*UثWb]v*UثWb]v*UثWb]v*Ul!M:LSKdŐϽw<n*7SMWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*U-%*hxՊV5YZCɛsV'㊷*ADqWʷ?UdOw}YWʾZb徂MM~8[?ȟ*WzKT[;+Bޫ ɲo;Quff4 y=-.溵'uk֙OΓliRx!}O uEfUثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*6|gm%E{oޣN^'JyCˍ6!рySm*ŵo/:yVg⽵4@W'd{6 ҋኤW׼q.k֘"5_z}U};lp?b_~pLp׮*y쓊t_OtgݟpݟCj^vl1}m.~"#{ϛc^aI *ɱWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb^gm;k3v*UثWb]v*UثWb]v*UثWb]yjyy.7=V 勯?  5Q/;o{Ou5}274Cq]&⬇v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UتVM4]Jم>UѼQjk"^E; UWv*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWbPz/b7o9-gثWb]v*U'劼xUm=qA@XT̩ yרXs~~\\חtMni&GfUثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*_o$i~p*b;y# ]v*UثWb[CC\U4s57_H]v*UثWb*5銻v*UثWb]v*UثWb]v*UثWb]<\yćL:1Tx}F?Ѻ_Tum`Y*UثWb]v*UثWb]v*UثWb]J,kЛ}F%iz*SXTӵ3yPnq>>ثIF[bVDp|)ثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*?I?aoث>]v*UثWb?C^ua-K2׊|u9ŮM}Vdz⃆flȟ og+nGO?G6 ->C%#e#d"ثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*Ud$J=_0DO+y]*N ]1U#v*UثWb]I|زA z+sjЎb|>ZjR&3~NWb]v*oSn+ mn*_1sq4%$"TFxYӧV b\]v*UثWb]v*UثWb]v*UثWbXX-UQVs0WN*Z9z0}8UثWb]v*UثWb]v*UثWb]N[ rѣ,꓊&)VT!}8UثWb]v*UثWb]v*UثWb]a_p*z[#6ثm14w/ޢ}G-W*V󮍯y^f)kN%z*,3=y子'jnwqWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]I<6>4K:вk)4X!lUثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb6|X `JYj?l*8ۧlUUثWb]v*U45P|~"*z?!+Mo`"zbj͚f((M:\y$=4Ex>e|j#R%|‰te3P$tv*UثWLU^i o qW1$P뺰?U4]v*UثWb]v*UثWb]OIQt->mh՞^0qTKHTdʜUثWbV]?Yq-ґ"v'J-thdA U[u@4C̮cbQ{6*?PP.XWԿ)W"sN<]v*UثWb]v*UثWb]v*UتEMNyH>}e^ U~*UثWb]v*UثWb][,$27Exu>PlcV`;Pm}RҤwfcԓWb]p45FXjbNkYe,D|TΝgOV|tٝR<uJr>U:]v*UثWb]v*UثWbT-CP⯛<}??m[(PWj|Wh0EqVWb]v*UثWb]v*UثVF**UثWb]v*Uتۯ9X*UkIbȲb[]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*Uت/^+eX⨜UثWb]v*VWWbv*U$/,nu{3  M<󑖞nh ~ /2F {AN*qW^l5vV9<|GzK.W߅%+Hy`#$KdUثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb_2~dhpiv svP(Mzb]v*UثWb]v*UثWb]v*U0Վur>~eIdF:qUWb]v*UثWb]v*U(zb?7t&mKcv9FY5$_qUWb]v*UlU}9<*|H'FvxfUS(TZy&EN*-? IêC)PpeiuYau*.1z}WXA؟fWb]v*UثWb]y秓.5oɎ 9fHƷAZ*1Tv*UثWb]v*UثWb]K)Q"/0~AyVYhNt,v銾Э$x+?T~*i2JQEI;X֒,bUثWb]B:lZ~ۮ*v0C U5]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثU;SR/D]v*UثWe*W`CykRew#M{1~y+y#A=_*[ޫ]dOTqw'^VXQ+u+VcƿN7/f/D!ҭGmi8'͡v6qTUR)&Q|GWP#rW9!le^l9ޞ%h};XyMVR SN),v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWDn(-LdN*anbK5YF*v*UثWb]v*UثWb]v*UثWb7q^ U~Tmn6v=Wqv*UثWb]v*UثWb]`0[囅P87*dKv5qWb]v*UثWb*Ƽht-~5u^_ph-Mb7Ťe;M/}PSE͹2b'ܺkhomfE~xלҾ>g{Ub]v*UثWb]v*?1., oV`'X?gmO/[s[0z'lUxWb]v*UثWb]v*UتP-JTtm)4qm,8;A\zSG*4*^OIKsn|XUثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*u*[qTN*UثWb]h?,U~U7ث;^g:ӽq rM,1-GGX&l.r ?>mҵ]scIM*bIWOb*1T,=b_>9iZ|[{Y7 8Ss+iLk x2=_LY;v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثTkVri$U*qWiR2$GD]v*UثWb]v*UثWb]v*UثT*` ⯩|îj6ʀb*UثWb]v*UثWb]y_5ܰĊLRJφ*mU"5݊]v*UثWb]R[O PΫ]f.Dm=Tu]%м$1_#Oz*UثWb]v*UثWbk?0b7b )>kb1V+䞩_Gg1흄X^}mp1$HHT]v*UثWb]v*UثWb]cdCZ2¥xvY*UثWb]@kqIl؞2 7R?˽W-%\7S~*Gߊ]]Wm1W|?>U_~*ŷ1VUTAjX;]H<=̱ZSQ_&y ?ʺ-Ц 98K"Ɇ~okڮ˛3%Zd=~Z\^X}K(^4TQLnÓgawWQ(6N[2wN#,W:({ϩ1'іz2)v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb^E|Bi/햬;:y^&hъ<|Uv*UثWb]v*UثWb]v*UثTӧbhwʶMPqUثWb]v*UثWb]v*켫s,xlUrK&e)#DSQWb]v*UثWb-XtGF:ָ|vY_pۊ+yV/B`r5$*UثWbZtYTa5iV13ֵqRQAM>"h]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWbM[NMJ[)Md(OK-]m!+{VWb]v*UثWb]v*UثWb]I~%G_db]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWbfF~A?v*R}A}nTqgr*v*UثWb]v*UثWb]v*Uت] 2MJѷoN`jqTgbfQA?Ö'tLU|z%n$+ɇJڂ,U'urivF >!L󊤗|B]jSn>48kiib+T|UTR_8ksh|^BCśG*!|g3X. WҸWb]B꺌ZmJXI?n$$n%]v*UثWb]Wb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*U0ޘ 9bGŞo[K ՒDE,E`(F :b`ߙ2Z.UA;U~oy}v0N:N* 'O֥u^$>8ʿ EkOQM)$bJK 2+*F**UثWb]|ŤAiZ"p*>{En;buR=iohVVh_2]駈0> ⩈l6xWb]v*UثWb][0vN*?֩jzf5di]v*UثTr\Eܽ#n:mc̞~{o2[HF_^WRiCSaߓߗk)~OWb]v*UثWbP[qW#b1WϾe7^Y-QdavlU:NDUQvӷ*+.jQ[1MïU6*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UتˏqW7dTWb]v*UثOO{s_z>*?5־X?(R!ܻ >'OK+xQ`&+J U%EH Uߞ:t][MmGAxwsy;^Y$,jI|!rb_a8Qq(;Ӿ@8i? <x+6 #3[CC$Zc~#$/gS ثWb]v*UثWb]v*UثWb]v*UثWb]v*UتCo8ZyKMT? GVn|w?2yC\H > V[e*ݛ⪸Wb]v*UثWb]v*UثWb]v*Bzb\]?*EWSKRo/lV^_D uhH\UYMAU,T)2=1WgԿ7Sv*UثT&M{^Ouέ|)# {+Ҹ$⩶*(aC8[N:?/:#H]o]v*UثWb]v*UثU#5S'C3hro4#('}Yv*UثWb * UثV;-5Kq /ъro4GVUwa{*UثWb]A:Ŷi%K31*/K/=%zUwD >U~giWVtҗԽpD`T*?74+Fo!ׁ1Vwv*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]Yq|*sU,UثWb]v*batG_0c1gY@d9s.п"<*Ahu;eŸGILyAj}>^{p%ثWB*kq3SH,Kp2|Q9;5VHN+~Rrlʒ r:Sq:-*eԿZ-R|qxB'b]v*UثWb]v*UثWb]v*UثWb]v*UثVhSo>t_,h\N>G*b[]v*UثWb]v*UثWb]v*UثWV[b/*yNxmF (SOVs|ew-bj~U w6.y.I#z `kL ]v*UثWb]v*е܋K՘ Ud./+K;*7/ўDӲFqT[-%b>C]q`isʏeyN`zgl7~U>*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*Uem8oXWb]v*Uk^'?^ڇEKxq֧8~AW_)8\IN4;Ӿ*/ ǢkNn~>8,[C>۫j/aR1VZ4wVPw[*O\UKj2Ϣ9PgWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*Uت^Yu \I8&Vʎb/]*<@Wʏ?>UkTybʏ?>U}تMfEr^ګqVK9^pźOT"59W*i}8yv*UثWb]v*UثWb]v*UثWb]S/oo㊲ъv*UثWb]v*UثWb]v*UثWb] [e Qz% WrqV{ud[ q6zv41 Ju*VnѠڬE6`qVMv*U_MRU#1Ww*22/pG\Uv*UثWb]v*UR኱8â~a-(5銾UثWb]v*UثWb]v*UثWZoso/#S1V8ǪJ%J9'8ؙUثWSLU)<7ddڽmMxfU1{^*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*U#4BDƘ(/)O]٩*UثWb]v*UثWb]v*UثWb]v*GL) ***UثWb]v*UثWb]v*UثWb[ [*ُ#K/˥iUMs}#So*>^ꗮ5DYyr eoLQvp4=qUW=څt0Y eqi3|U-2<߮+[E;(8&1uV̄o%7:ǕY!dr{fxxWbSC\U#ѵ!:Cq0+kz~ܻb*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثuqWWv*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb\v|jO4I~$'\ƦXWb]v*UثWb]v*UثWb]v*UثU2x.8-xWb]v*UثWb]v*UثWbU-޿F*fKf*ȝFðUUثWb]v*ڊb(590[bâw_KbR>\hr~|W_*\⩎*UثWb]v*Uتث _\U*^ڶѡ4?^G<ɣ#ow=Vmv*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWbZc@O*:>,VM1Tj,U;Sոڟwnxvp]C?[*?WOVWN[{,}V/D#g8Wb]v*UiCp$r=UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb5{}"k HI'劾W_((n*b]v*UثWb]v*UثWb]v*UثWb\ݿ⩗?sYh[]v*UثWb]v*UثWb]Qc''s3~aiFvS/ڵU~kyZA"|U5WH C*UثWb]v*U Gcg-̭*qW9yb=;B: _9Ƕ*UتW櫡kLG.1>F*gːzVOj|Tv*UثWb]v*U ꩥ[gd'*?c}BZ]v*UثWb]v*UتgFG!y?Uh#MCRHkOsM7ys5%ZsTkm{^m>kȎEh{PAS"v\U5-ӧ[h'*˚UUثV):0^ck?]Kf7]ݽَ?9ߢt.TUP#5^I[e$*Wb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثOO~mmK}[Cv*UثWb]}8k(81T4]! 5®][,5.wi^/)!m;OnQq 8g͞i.^jO~h4˘}elx䷞/iXEI^?X(@,!'̟Њ159&/OwO;kI+-@cL}UfUثWb]v*UثWb]v*UثWb]v*UثWb]nǙRP+8 C|Tv*UثWb]v*UثWb]v*UثWb]v*GL) *F**UثWb]v*UثWb]p4Ayt"2t׹Y%-ƩV7~z-clAԎ(Q5=݊6o.]}V,vw_=隵9,WQB8Uc/Tڥp?c*X+vx:dW80F*v*UثWb> [QLTl=d>t?T(=0튦; U`6z-ɻcWw6|WꠞlUv*UثWb]CڄzEm⬿cRy]Ozn$aWM*UثWb]v*UثU;ci`f4b!Կ'3|dWZe!<(O0YOڋMO'J]:4,-׏P|v8Op%ثWb]v*UثWb]v*UثWb]v*UثWb]x [XYb]v*UثWb]v*UثWb]v*UثWb[*hST:u j_3&*UثWb]v*UثWb]v*iy:b_ ZHBZo㊽v*UVz(T"hvQԅPQ\UbQiuh.Gԏ㊼:%u d52(|F*ƭϦ\'e  Uoyot9[aNWbPѶ b/.PMs>d{*07zl6J^icZ-ܷ\Tb@UQb]v*Uث*)(^u SOK\Ti79@}Wۺ}V[XP`1TF*UثWb]v*.ͤFP1W}o%H㊾t_2yZr"݊5P;0iF~!,U=.Mb;{{ x⩕ظ" QCUeVL/YcT&+`z,]m3d**UثWb]/Mc#uy/ol9D犽֘Wb]v*UثWb]v*UثWb]v*UثTY8SK[&GPb]v*UثWb]v*UثWb]v*UثWb]v*U'势7?7?&aWb]v*Uث/DXg\M1V!_-Q{թ!-4'_^M{PemCGyב:Ku0bx `/*dUP9\qx#Af:RM}8on"7*B9 ԁ"M2775/,y4Ft)bn;ȐC D]v*UثWb]v*UثWb]v*UثWb]v*Uثm|ug\w+>F ،U7\UUث|O**UثWb]v*UثWb]v*UثWb]I*Y_;0^o3G `W),G|F*]v*UثWb]v*UR1TT׭ρϩ91y@N!Z^D{ U鿗py>dif5FN*Wb]v*UP o.3>Nju'c^bѯ.e0p5R{TU7IS\[j۝PhG*a{"1U|UثTǬF1t9b*͙.b>^,h$y{4׎`bHUif#NO!G{⩶*O?ͯOu4Y?>Zko.YV8B}D3]j?]j_?]j_?]j_?]j_?]j_?]j_?]j_?]j_?[?`CsO*LC*h~X7v*UثWb]v*hj1TRYmGHoCRffYO|5:vΧ`늳 T܊>U*ZTaw,Q:cE;.-* $aH'_v*UثتM]hZl\1E{ U?S_-iQZYaf*ɱWb]v*UثWb]K–-6_ bUWG݊(W}^?v*]x}ثwQb>UWG݊(V>U/(SU,;n+ԭ嵺Hbu5ԑ*mnOWqUem_uH⮋QG***hU)lUJ["y}8]~: ؝ַ:ގc38ޥh1TU䧙fӊ??Ykx 1VEgFCI4vYևb){R+ɿ*^v%xhΊ05औe*yg'M-Yt#*/tq#@ǥqT"c=V,Lx#cQ-aLzu^? ?/R#SqW=bv*UثWb]v*UثWb_.EsS|Ϥŭ}S¸}v*UثV**Uő>)X"Uy͚{a.~*_󌷗᠂z1ث<+ ]&!Aԁu8wv*UثWb]v*UثWb^{|囋KcI{튼/k6kk"K;/ݻO UBA|qWb]v*UثWb]_U'"h2ט*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWyO/yO厶mq%^]xWb]v*UثWb]v*UثTSƛ0{xe5ߊ./4Dqo-ߊ:?$} j'q[fsuǏ, K8oّ\ӊȍ~YClio6[nBtتW7m.;ŒȎb"k:BN*<} ԭy:O"V*ilty~fxg(6@y_:mp|MuqVk56-F90\}8<ߧj_P~%Ta-F~wS=KaX8Wk0]"4f5:t^amX,Vq0WjY|5h]c_AǰDrG^Uh:Vi,c?R=*jZ|8 6OκNbYג?*.N{)"Y*UثWb]v*UثWb]̨ש#AlrzC<*]v*Ӿ*o|\Ǧ'ӆ{k6娽5ZЎUqVYTГqN]Ds0 nO}UxWb]v*UثWb]v*UثT&ii7Wirj31Tv*UثWb]v*UثU;ج hMN*zYe;F`]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]J|բǬYȡ)+^:UWkX7PoBQQN*ͱWb]v*UثWb]v*UثWb]v*UثW.6Q^eUJOʫr#c@qTCVT{TO$OT UzbU厹kCtImhxbzƧ+;rU{Wz~*UتQ. ,.'c~B/_/ˆ[bgxWb]v*UثWb]v*UثWb|c6[H.$Sđ|ZO^H8[J^{v*UثUBSXnM噿K;({U7֏—RJ qP|1VQO2o>b)jkh_xbB( UUثWb]v*UثWb]v*Uت_NȑR:ĜU~@W[*}+g({z⬛v*UثWb]v*UثV7o ƄԙX(?*TP1-1V]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*Uyȍ|Yќ|@I)/.joU 7ў⬷v*UثWb]v*UثWb]v*UثWb^}O2j@z*UثWbVj81UثWb]/͟.=Շm=iYԁb|ȯ!` uaU>]v*UثWb]v*UثWb]5:SF~qV!۽V-*]v*UثjbC|ӭ>(7*Wr⯷cP:1UثWb]v*UثWb]v*UثWbS,Y^+ɥy[UY#\H馳)H⯤æ*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb^m;6򖦞hBaA҇WZ]Gw \ByG"R;]v*UثWb]v*UثWb]v*UMR>z*UثWb]v*UثVC ^_切|ue a^q/^qWb]v*UثWb]v*UثWUO'~PcҤ촑PS~Vb]v*+R:R4 hUWց h~ԲLOӊ+ 6OOJ$<? Uv*UثWb]v*UثWb]v*Uث#t롦[I@?H|6Z 5HxWb]v*UثU;˯tz"U;6ZdF,G򎘫Wb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*ִK9l2_`zu"~dDžj>U8Wb]v*UثWb]v*UثWb]y%ԾCUWb]v*UثWb]_]yalA7V.$P:b05QzO}VSv*UثWb]v*UثWb]|WOV?0 AUf*U^GRjXtCSf!*ӭztwwM1zUw8*4O׶~ 'S UثXV~JA⬧tӠQ[YL&#M򍠲wsSUثWb]v*UثWb]v*UثWb]v*wue#/Y{v2]=H]Wz!Ku5*zbWb]v*UثVUR.zWz"\UWb]v*UثWb]v*UثWb]v*iX0:vfjL݆Vp|UUثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]_}9G"#犼ľ\՛70^S!^v*UثWb]v*UثWb]v*Uث).b@]v*UثWb]v*UثTg)[R@‡~Ul], gZmQ(gZ!aŜ|ClqTv*UثWb]v*UثWb m4:FN-CpMҢan)V>'D] KII`*o˖Q] } JWexWb]v*UثWb]v*UثWb]v*UثOG|W 8BLU~Ji|yw}gY*UثWb]v*UkqVRjRe*~Bhe'_RDu^v*UثWb]v*UثWb]v*UثWb9ݍͯt]_%)؜U\yn/]VKrvgq[F**UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]Rխ%׀ZHӭ*,ȡثWb]v*UثWb]v*UثWb^Iu/cz*UثWb]v*UثWb]BjPэVۧ/Uoa\U^&i fT@QxWb]v*UثWb]v*UثWb]v*7yY:>0H׊ݱUW֓͞d#}1W]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثT: ִ MlU~Vyky4mE=+2gXWb]v*UثWb]v*UثWb^Iu/cz*UثWb]v*UثWb]v*v+0ynu_S9SWz*UثWb]v*UثWKY+4"K0AYرRƧTWb\qUmO)\ >'y;)jd䔾Ik_ky;_i^5r=qTv*UثWb]v*UثWb]v*UثWb&&/ZbK+/ӊkk1(W~_Sw'8p|?]C/ *)OqWK^U8>Rw'8p|?]C? *`yHRaCOOU7>Sw ϔd[Ib?SVn|'*)~2򟌟8n|'*)\OOU9q1R}ث_7>Sw ϔd]Cs??qWOOU)4v* ϔd]Cs??qWOOU7>Sw ϔd]Cs??qWOOU7>Sw ϔd]Cs??qWOOU7>Sw ϔd]Cs??qWOZɹzbcu}f-B͹A2SqW̗*w)Cd~|ū\2LhNȍ-mhOV}z!Sp[(o$ij2 wA;h QX?݂H!dxލ0i̿16p%ثWb]v*UثNVSyg_(y}J bT]v*UثWb]v*UثWb]y |ɩF*UثWb]v*UثWb]v*UتM-M.}*V(98Ѵ7J4p8T8_0\#Tr-h*δ=k:dQJxe=bWb]v*Uߚߚ,[aN#U?͊NӢf;~x#v*Uت䑓IZ()USo=jZ3,*dب銽\4u K }fXWb]v*UثV7% 1\3FG_@MNLUxsR~xkv*UثWbTo.ⳉ.$QLǠ|K?5-퓊x}8s?2^\\r@o?=9lU %RwP:i_dʤuZ!wtX1gY3)ڹa"v*UثWb]v*Ƽhy aRo[<RyىO`yEcwcWcՏrqTV*UثWb]I5mB]&O ⚋)>!жPQ8 ]v*UثWb]v*UثWb]v*O]u*]$Br= |+svֿ yG;߮*ךZ Ԣ;?J;ڞ{k^HYYNSoO*iOSơpY6].`Hdd4os~xaӯ(%bH܌UmZZ]v*Uh6 [A*MռⷚtB;1{w~ث UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*ioՊ3|k^׊ثWb]v*UثWb]v*ɿ-n#0DIz W~p/d;Ob:?A1Wtl b]11Go K-^C1V:?A1Wtl b]11cdcwG?*-U[  >u=A" >\UUثWb]v*UثWb]v*UثWb]v*UثWb]mzU5$õh;.bхGCJS>] xB]Dd4rV{騦ywSKyV @|r8~o?3 ^~v,9 q7rHN<{1,ķn-ǃ nF>FN1CWb]v*UثWb^o嫋ifDvx WW*=T~*UثWb]v*UثWbXHY*UثWb]v*UثWb]v*UثWb]y5.W~d~aY63U(*qHգUy>6-N# RAܐ/EF8J?0|gq>&cLS|\U y9URRr b>w'z4-oIهc;Ncӣ(jw,{qTN*UثWb]v*\_k{(QKqj<51urO1Wb]v*UثWb]b~USv8Rv;bVE정'*v*UثW~~nMўf?N* -3}cpB~U- Z%WЙh_/ߊB~U&ZK2п_Z 433lC>%VL/h]BeD~*- Z%WЙh_/ߊ t#2w :\?Qw -~*]+[>U&W}MtoWК_q5ҿ]Bk}ߊJw -~*]+[>U&W}MtoWК_q5ҿ]Bm{;b?s0qVK?jK?jK?jK?jK?jK?jK?jK?jK?j_%MU%MU%MU%MUZ*Z*Z*Z*Z*Z*Z*Z*Z*Z*Z*Z*Z*Z*Z*Z*Z*Z*a}WwBl!-!Bъ>ZC}r)S犢5]&U/Y~£B/0R0G٧=mzRcskm6*ziZEbQA@ #˚x&!AvE=Jo)*UثWb]v*UثT.l6eсa3#r[yJjv*UثWb]v*UثWb>GXqWb]v*UثWb]v*UثWb]v*7yV.|f/벏_|Ut7JZH'e[&RzSm8 ]v*Uث,h~dcPގ~R;tZ]v*UثWbToIǭ1W~CougbbF]v*UثWb]v*Wv*UثWb]~i\YddbϦIj5t=v8{v*UثWb]v*08!\ʪi\Ui6"">Uv*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWbV"ƥ܅Qԝ*kݒu Uv*UثWb]v*UlJ^BGRM*kݒ-IŁX$OLUu+a+Ww ܺ?+e'uDbZyȲ/V*v*UثWbV"ƥ܅QԜUJ(xe=bWbHukIҊhA!8/C6`R:~UVeSЃQ$SBCY'ѴC~Uv*UثWb]v*UثWb]v*UثWb95(yY:q,+Tn1Wb$( U g;QM`N*P:#c3UR=Zy5.IT-u;[VTXՊqWb]v*UثWb]v*9J-\9SysFdz֬qV{v*UثWb]v*UثWyR[,U8Wb]v*UثWb]v*UثWbVK2BI*1WA.:=:Yd^L_*iif]7dO_z^l]\G!$0=M<0$p}o3/k]]>b<|S܊]v*UثWb]|[[NЮZI2.܈[d`8dԇmB?hz W{2[{Q:LDholD2r~0Jn&ӏ!ܐ )\DLLK+<|k略feU|+lGG{/47j]][zgVcӭ?$M14~aj:'u،z0єW0La/~gi4jqvK[/cLD?3>X5טϦ=JVH!A'ބFO6CsNmc̃)Sd#,xBSGTZG,jJ֥~eG@_p  Sٿh}9 b #ȥثWb]v*UثWbR?7w>b }C̿ڵ+|l;'*?)HF-*ov?2qVAv*UثWb]<I\N*S7 -B#M1Wb]v*UثT&8ѝo} Ud՝yF-]v*UثWb]v*UثWb]v*U!ז=Γ3!lUv>{м]Yu U^_ʒ b*c rxU:$z}i:j/ԤMҽTv*UثWbʻKկu5X[Ҋ UWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*Uثˏ~qƤ\$R6֡+[ XNLI_ sثWb]v*UتM8 CO ]PNyhKpF+\Г%9"cKph+xxdPez#)'0JX _Jk>-IFov1L?$05{|g\`ۉ [)ok%[$ayjDFV9WK.1v]aCfMv*UثWb''FAG8?$4kMwVt) \J_C4?^_kɟ 7⯗<5IJJeqͲT92sFUG I}rRHdȫN"f'痞Q?# A.L $EFR)wJZHcEٓ 9DWL),?ek]Rܒd5WVPUثWb]v*UثWb]v*UثWb$%*77t X1fj2 A`iᐑDwO?˭KI[5yjrʡL 6 |s^Pj^Aj cdUH7l@i5@}Y5Z[xdoZ3c ycYt :cD.9l^L)m6Ι9sb#'d~jˉVA97o}!p,'={5ڂ[(پؿy&7@ lv*UثWb]v*U,-oՊʹ}M,y(,UثWb]v*UثWb]bA]v*UثWb]v*UثWb]Et9_u1WZNϗxz+Fe4N{P *UثWb]v*UثWͿ^__+D,:qTt튻v*UثWb]}UkYx@Y|@_PN`XDNC@Lg8Wb]v*UثWb]v*UثWb]̫k,0OqxǕ{]jd$ͽN*^y AVv『 Gb+Nih{ԝU7XaPFb]v*Vm'EU̼@wY&_+,u8qWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثW~gYh2j ɥjIC5>r(j~= ..t}tHV#ȅ=H n^9Vǖ,W0sD4rb]v*UثWb"|A?*?1׿su1\︩D ҵ-ysA/T,_9 F3>s?,m6Q,1}™9JͰhR3"ثWb]y)7u_0*ykɐ_yESEDz>d"Ϳ95fo@IB kNS!?SeMD#SVbG٦2e3sMR֦]T?)M0+6hhZ}Ǖ<*]}_鄛ڔ_:Bf44(j#Cψڂ7rO~o|3U'u 7@Խ-?翗-|=֝y|! X t1cV1yB@N74ke; ثWb]v*UثWb]v*UثWb^yތow1 }DxTReǞ5Xu[E!‹#ɬY}?͎̍Ipъ^J>|ѯ'mQQ6)Y~eۤc_KJ$q5Xgߛ\W1Xuuy(5b_n%ܘ,~W/Η4MˎW+5 |O(cj+j,t1IFW0".?юd#S2h+\~i' ˤ i 9srG rIˍW)y}$GpJ<[2ށ'YK6RSz}d9Ȳv*UثWb]v*UثTq&vd15늤 H>;Y*UثWb]v*UثWb^}IlW]v*UثWb]v*UثWbX_濙!ѴyB \~/scFѢ{kHb*UثWb]v*UثV)ǬW0~ <1WΚY,;1Tv*UثWb]~sm/n+qWߒ\M˰F )JWgWb]v*UثWb]v*UثWb]s iU}*_! iG2U>]v*Uث\Uثj*}-t .O[vuA1WP@FF_v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]k&uV{wzc&>Sʗl/i.?䭉Ib]v*UثWb]9GԵd>*pRm+Ol}+[gv^DD⌬*1y*BnF5b,Fwzfieİ | í$hÍ| M|A#G 3jxW%liKWb]v*U%l|٧ky)P:튢|1i+%)qnP<ߗ1kwe_٠<$u\o@-SgqB*0li~Kh\ؕ^ook *5  `~x򿜧=- MJ_h,(wc՘V-u{i,oYYTr$Z^o5y7IVO%Wj?,4-H 0%UثWb]v*UثWb]v*UثWbX?,4oG\O*Wb]v*UثWb]v*UfՔub] \cUq(_ш+\U>м0}Vݺ<|Wk :AcV+H tĂ(UqWb]v*UثWb]v*UثWb]v*UrjMoC=ŹSo U{PJWaGb]cߘ:[K L1UD`֭vBphƃ*V&n*ż8l].لL#T]ۼ>XKOQOSUثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*U*TŦ\<F*)`FGj1Y*UثWb]v*UثWb̖@eaBLU*џ W6 һgS >b-Kr N{U6]v*UN;Xy$h f;*Ӽv>YkZPuSTv*UثWj2,/+ܜUriY((]T^*UثWb]v*UثWb]|: ?&o\F*=qW]*M/VǢ Qz5Bh#~&gG㨸 &xG^@E[ H՗#]v*UثWb]v*UثWb]v*UثWb]1"n?N*w_ɫ|*ygKN,R[J  VSc}oGZ8u8*کnY} *Q~w&X-wQZ H̅1TV򇟵{X-ڂg'zSg~A|);bH]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]f9ۈU8Wb]7X:홒);xxWf[!48SrEI~sMtRH)G\U~jjKCe縙L{Gs,U^OɳZ>E}* +Im5 E]v*UثWb]v*Uy0baycbVך[Wu$h#AOlUh| k F^j{ۡtܒV+*/>yjWh3N1W=uc0q;{(u;hm(eP|AQXWb]v*UثWb]v*UثWb]v*UثWb]v*UتA9s9x|U~*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]x֏B7P=9*!;{.*UثWb]v*UثWb>GXqW~ukxf-ʪEz*ϼ+OcɡP*R1˶ojRAZyM>ԝ9>Jh^AI$^G^%Zu )G]v*UثWb]v*UثWb]v*yie!QEI>˴x5N`}X1UD.+9Vy{Ne3_$ňث殭>'Qek}{{h_6TdWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثW@ ;N?JȅoC":E΋g5*b]v*UثWb]y?%b@jӮ*˒yR}FGXqWb]v*UثWb]v*UثWb]v*UثWb]v*|o32~7UH}*ňV5ZjpƟj-q4e6۾*E>}EIs' бW鈾d|mJLU阫Wb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWbX7ߓ[:gf+F"w+⩧@8L;⬗v*UثWb]v*Uhz*UثWb]v*UثWb]v*UثWb]v*UثWb]v*U/Οa=>x|ݹVkv*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UWcy'4.Iw~(^6Ų^H e87c>Nu4Ya~_yOۛqW+xWb]y%^v*UثWb]v*UثWb]v*UثWb]v*UثWb]b?WiSx⩯h4hxm8Wb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb])T20u?/\^$"2ٳsֵLUhwu]9uDR"`ƅOpF*;/rZ+Mig,>;^/5oc{TEbV1]]NXvܕWb]Huo<:\:1VḵMea@qWb]v*UثWb]v*UثWb]v*Uت@B" UTt]v*UثWb]ZǙ|eMOVHAۘrqWM*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]ELU⟜MKw7,hlUߗnA{F"C8$e ;e'_^yy#N#}*ӿ6kkzd@ {fz_N[7H61UZ%H Sӿ0 3tqV3_ t򾆫62kA}MGUJnicQe-bQ*G`)b]v*UثWb]v*UثWb]v*l4%$;Vb0͞pst].37X*.mBCk:_ |*ӿ45?#j9~*$^osk4,6 USv*UتWlP v${b*i/#Q$ya@p3ݏK)~&Y'|m@,O(-#R{x̟:NjmdDzdz_j_F qݩ1Vav*UثWb]v*UثWb]v*UثV/x>u %rnhzZ~[kZj/nM~@ F[qiD½bUثV7xKݘ*YZ J]Fn]1]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UتYM zm6V9TqVE/DD}*UثWb]v*UثWb]v*UثWb]v*UثW`Y}~C mEQ=?e*<o1l(OTđbgRբmeG4lX*5P( UUثWbI"ƥ@'y^fe F'v*P)]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb5ӯtmդ-e?QգbA֠- bColUv*UثWb]v*UثWb]v*UثWb]v*4C$>%E~Uf?Gl H⩖*UثWb/nuE|T'0}|N*[VQ)=⩎*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]Y4)24RpqWhǘú-k7dc{05銻v*UثWb]v*UثWb]v*UثWb]v*UثWb]$Y8]| qmXs{Xgϫ}7<ǫ1뿆*Wb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb'M:l¨7f`wJ3_b6;o㊽Ov*UثWb]v*UثWb]v*UثWb]v*UثWb}GQN{ jYdͧv9,n20 ze9[';s犲LUثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb8ϲQ@$@צ*XYPHGӊ]v*UثWb]v*UثWb]v*UثWb]v*ssm44@^/'7u3oGa >A1*(#v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثV }FQRe>\%bzS"1Tv*UثWb]v*UثWb]v*UثWb]v*U ve: bh*eٻ;,i?^ii%QUzqWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]a}|a9n~x1a^T#sQ故(^ahpGlj}*UثWb]v*UثWb]v*UثWb]v*Uy'L򺔝TC劰+(ߙ٬Kذ { %,pbWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]x_/-/SZyMqByHaSU<{b>Jbj#E劧6OA~= *q8fKSQZAinĐʂCP|1V+O5F[""R$]*z=׮g8M M 4r Tރzp[E *j@T]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UتWIkpJ=Xu 1pbV5VB/NU'<]tyxP ^iu)q E :qU\UyϚ~='oZ1b.1ngvb8̒ VUmy[% u Jbh;3- MV>8ͺ>/;E|1V{O$XNTF)ʟ'OWb]v*oOs$#3u$uQp h;(UWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]H|7t iZo㊰(yӋ-qsDI>{WP5?_JE=+ELUyON[L nJy1>-]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثW endstream endobj 43 0 obj<> endobj 44 0 obj<> endobj 45 0 obj<> endobj 46 0 obj<> endobj 47 0 obj<> endobj 48 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 49 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 50 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 51 0 obj<>/ProcSet[/PDF/Text]/ExtGState<>>> endobj 52 0 obj<>stream /GS1 gs BT /F1 1 Tf 11.9999 0 0 11.9999 45.3543 708.6046 Tm 0 0 0 1 k 0 Tc 0 Tw (RESULTS)Tj 0 -1.748 TD [(Epidemiological)-307.2(Information)]TJ /F9 1 Tf 9.5 0 0 9.5 45.3543 676.1195 Tm [(Among)-242.5(the)-248.9(206)]TJ /F10 1 Tf 6.4152 0 TD [(P.)-245.4(falciparum)]TJ /F9 1 Tf 5.5619 0 TD [(isolates)-246(collected)-243.8(in)-249.3(this)-243.8(study,)-243.8(202)]TJ -11.9771 -1.2114 TD [(and)-352(177)-347.3(isolates)-353.4(were)-347(successfully)-354(ampli)]TJ /F12 1 Tf 16.3693 0 TD ()Tj /F9 1 Tf 0.5311 0 TD [(ed)-347(and)-352(sequenced)-350.8(for)]TJ -16.9004 -1.2114 TD (the)Tj /F10 1 Tf 1.6292 0 TD (pfdhfr)Tj /F9 1 Tf 2.775 0 TD (and)Tj /F10 1 Tf 1.8798 0 TD (pfdhps)Tj /F9 1 Tf 2.954 0 TD [(genes,)-379.9(respectively;)-387.6(however,)-382.5(only)-381.5(single)]TJ -9.2379 -1.2114 TD [(infections)-399.8(and)-393.8(both)-392.9(of)]TJ /F10 1 Tf 9.59 0 TD (pfdhfr)Tj /F9 1 Tf 2.7869 0 TD (and)Tj /F10 1 Tf 1.8977 0 TD (pfdhps)Tj /F9 1 Tf 2.96 0 TD [(successful)-399.6(amplicons)]TJ -17.2346 -1.2114 TD [(were)-352.9(involved)-350.7(in)-350.8(the)]TJ /F12 1 Tf 8.7307 0 TD ()Tj /F9 1 Tf 0.5311 0 TD [(nal)-353.4(analysis.)-353.1(Therefore,)-357.7(a)-350.7(total)-351.4(of)-348.8(159)-347.3(P)]TJ /F10 1 Tf 16.1723 0 TD (.)Tj -25.4342 -1.2055 TD (falciparum)Tj /F9 1 Tf 4.7025 0 TD [(isolates)-413.1(were)-412.6(successfully)-413.7(detected)-415.8(and)-411.7(analyzed)-415.9(in)]TJ -4.7025 -1.2114 TD [(this)-255.7(study)-252.9(\()]TJ /F14 1 Tf 0 0 0 rg 4.4757 0 TD [(Figure)-254(1)]TJ /F9 1 Tf 0 0 0 1 k 3.4612 0 TD [(\).)-256.6(Their)-255.8(distribution)-260.2(was)-252.6(identi)]TJ /F12 1 Tf 12.2456 0 TD ()Tj /F9 1 Tf 0.5311 0 TD [(ed)-251.6(as)-255.3(2)-255(from)]TJ -20.7137 -1.2114 TD [(North)-291.2(Africa,)-287(23)-289.2(from)-288.8(East)-292.4(Africa,)-287(54)-289.2(from)-288.8(West)-289.3(Africa,)-292.9(and)-292.3(80)]TJ T* [(from)-324.6(Central)-322.2(Africa.)-322.8(Among)-326(them,)-322.9(the)-320.5(Democratic)-325.1(Republic)-323.3(of)]TJ T* [(the)-278.7(Congo)-275.1(\(n)-273.7(=)-275.4(28\),)-277.3(Nigeria)-276.6(\(n)-279.7(=)-275.4(27\),)-277.3(and)-274.4(Angola)-277.9(\(n)-279.7(=)-275.4(16\))-274.5(were)]TJ T* [(co)-9(ns)-8.1(id)-7.7(er)-7.7(ed)-508.2(as)-511.9(th)-8.4(e)-503(t)0(o)-9.6(p)-506.4(th)-8.4(re)-7.7(e)-503(i)0(m)-8.1(por)-12.4(ted)-510.5(so)-7.3(ur)-11.2(ce)-510.7(co)-9(unt)-9.6(ri)-8.6(es)-7.7(.)-504.1(T)-6.6(he)]TJ 0 -1.2055 TD [(average)-451.4(patient)-450.5(age)-449.5(was)-449.6(42)-450.4(years,)-452.3(and)-453.4(154)-448.8(patients)-450.5(\(154/159,)]TJ 0 -1.2114 TD [(96.86%\))-210.4(were)-209.7(male.)-206.3(The)-211.4(numbers)-206.8(of)-211.6(cases)-205.1(reported)-214.4(in)-207.5(2017,)-205.3(2018,)]TJ T* [(and)-304.2(2019)-298(were)-305.2(28,)-298(58,)-304(and)-298.3(73,)-304(respectively.)]TJ /F1 1 Tf 11.9999 0 0 11.9999 45.3543 504.1133 Tm [(Prevalence)-306.7(of)]TJ /F2 1 Tf 6.789 0 TD (pfdhfr)Tj /F1 1 Tf 3.1843 0 TD (Polymorphisms)Tj /F9 1 Tf 9.5 0 0 9.5 45.3543 492.6046 Tm (For)Tj /F10 1 Tf 1.7247 0 TD (pfdhfr)Tj /F9 1 Tf 2.393 0 TD [(,)-343(n)0(o)-337.5(polymorphism)-345.2(was)-342.1(found)-343.3(for)-336.9(codons)-339.8(50)-343(or)-341.5(164.)]TJ -4.1177 -1.2114 TD [(Compared)-280.6(with)-282.9(mutations)-282.6(N51I)-279.5(and)-280.4(C59R,)-275.3(S108N)-280.2(had)-284.4(a)-279.1(higher)]TJ T* [(SNP)-576.3(prev)-8.4(alen)-9(ce,)-579.2(wher)-11.2(eas,)-576.1(the)-577.1(di)-7.7(f)64.2(f)-7.4(erence)-581.9(betw)-8.7(een)-578.4(N51I)-577.9(and)]TJ 0 -1.2055 TD [(C59R)-421.6(was)-419.7(not)-423.4(signi)]TJ /F12 1 Tf 8.1996 0 TD ()Tj /F9 1 Tf 0.5311 0 TD [(cant.)-419.4(Only)-422.9(three)-423.7(isolates)-419.1(were)-424.6(sequenced)]TJ -8.7307 -1.2114 TD [(as)-315(wild-type)-318.9(Asparagine-Cysteine-Serine)-322.3(\(NCS\))-321.5(\(accounting)-314.7(for)]TJ T* 0.031 Tc [(1.89%)5.2(\),)-592.4(wh)7(ere)5.4(a)2.5(s,)-598.4(th)7(e)-597.3(t)-1.2(ri)4.6(ple)5.4(-)3.1(mutan)5.1(t)-598(ge)5.4(no)5.8(ty)5.6(pe)5.4(,)-598.4(I)0(s)7.1(o)-0.1(le)5.4(uci)4.6(n)-0.9(e)5.4(-)]TJ T* 0 Tc (Arginine-Asparagine)Tj /F14 1 Tf 8.7904 0 TD (\()Tj /F9 1 Tf 0.3461 0 TD [(IRN\),)-420.6(comprised)-423.1(80.50%)-416.1(\(n)-422.9(=)-418.6(128\),)-418.9(the)]TJ -9.1365 -1.2114 TD [(others)-435.2(were)-436.5(NCN)-438.1(\(n)-434.9(=)-436.5(3)0(,)-436.9(1.89%\),)-435.6(ICN)-432.3(\(n)-440.8(=)-430.6(10,)-435.3(6.29%\),)-441.5(and)]TJ T* [(NRN)-372.6(\(n)-369.2(=)-370.9(15,)-369.6(9.43%\),)-375.9(respectively)-372.9(\()]TJ /F14 1 Tf 0 0 0 rg 14.9072 0 TD [(Table)-370.4(1)]TJ /F9 1 Tf 0 0 0 1 k 3.1927 0 TD (\).)Tj /F1 1 Tf 11.9999 0 0 11.9999 45.3543 378.085 Tm [(Prevalence)-306.7(of)]TJ /F2 1 Tf 6.789 0 TD (pfdhps)Tj /F1 1 Tf 3.567 0 TD (Polymorphisms)Tj /F9 1 Tf 9.5 0 0 9.5 45.3543 366.633 Tm [(The)-396.4(SNPs)-403.3(of)]TJ /F10 1 Tf 5.6812 0 TD (pfdhps)Tj /F9 1 Tf 2.9719 0 TD [(were)-400.7(relatively)-399.3(scattered,)-404.5(S436A)-397.8(\(27.07%\))]TJ -8.6531 -1.2114 TD [(and)-447.5(K540E)-444.2(\(27.67%\))-446.3(carried)-445.5(a)-446.2(higher)-441.7(allele)-445.7(frequency,)-451.1(which)]TJ T* [(were)-496.2(statistically)-503.4(signi)]TJ /F12 1 Tf 9.1604 0 TD ()Tj /F9 1 Tf 0.5311 0 TD [(cant)-500.1(than)-492.5(others)-500.9(\(the)-496.7(average)-499.1(mutant)]TJ -9.6915 -1.2114 TD [(frequency)-275.2(was)-264.6(6.92%\).)-268.5(The)-271.1(frequencies)-272.1(of)-265.3(the)-272.8(other)-268.1(three)-268.6(alleles,)]TJ T* [(I431V,)-310.8(A437G,)-315.8(and)-310.2(A581G,)-315.8(were)-311.2(lower)-311.4(than)-313.5(those)-315.8(of)-307.1(S436A)-314.3(or)]TJ T* [(K540E,)-232.1(but)-229.6(higher)-232.9(than)-229.9(that)-224.3(of)-229.5(S613A,)-233.5(which)-228.7(was)-234.7(carried)-230.7(by)-229.6(only)]TJ 0 -1.2055 TD [(two)-245.7(isolates.)-254.8(In)-247.9(all,)-247.4(among)-247.8(159)-251.9(P)]TJ /F10 1 Tf 12.8603 0 TD [(.)-248.4(falciparum)]TJ /F9 1 Tf 5.0188 0 TD [(isolates,)-248.8(13)-247.5(kinds)-248.9(of)]TJ -17.8791 -1.2114 TD [(mutants)-451.8(of)]TJ /F10 1 Tf 4.9651 0 TD (pfdhps)Tj /F9 1 Tf 3.0196 0 TD [(were)-454.4(detected.)-448.5(Further)-450.2(sequencing)-457.5(showed)]TJ -7.9847 -1.2114 TD [(th)-8.4(at)-514.2(73)-510(si)-8.6(n)-8(g)0(l)-8.1(e)-509(mu)-10.7(ta)-7(nt)-511.7(is)-8.6(o)-7.3(lat)-13.6(es)-7.7(,)-510.1(inc)-12.3(l)-6.6(udi)-12.9(ng)-510.8(I)-7.2(S)0(A)]TJ ET 0 0 0 rg 228.699 273.487 5.4992 0.22678 re f BT /F14 1 Tf 9.5 0 0 9.5 228.6992 274.6204 Tm 0 0 0 1 k (E)Tj /F9 1 Tf 0.5789 0 TD [(AA)-511.8(\(th)-11.6(e)-509(b)0(o)-8.5(l)-6.6(d)]TJ -19.8783 -1.2114 TD [(residue)-350.6(represents)-349.1(the)-344.4(mutated)-349.2(site;)-343.7(n)-348.2(=)-347(41,)-339.8(25.79%\),)-350.4(I)]TJ ET 0 0 0 rg 256.592 261.978 6.6331 0.28345 re f BT /F14 1 Tf 9.5 0 0 9.5 256.5921 263.1118 Tm 0 0 0 1 k (A)Tj /F9 1 Tf 0.6982 0 TD (AKAA)Tj -22.9337 -1.2114 TD [(\(n)-285.7(=)-281.4(24,)-286.1(15.09%\),)-284.8(IS)]TJ ET 0 0 0 rg 121.493 250.469 6.8598 0.28346 re f BT /F14 1 Tf 9.5 0 0 9.5 121.4929 251.6031 Tm 0 0 0 1 k (G)Tj /F9 1 Tf 0.7221 0 TD [(KAA)-281.4(\(n)-285.7(=)-281.4(6)0(,)-281.7(3.77%\),)-286.4(and)-286.3(ISAK)]TJ ET 0 0 0 rg 247.238 250.469 6.8598 0.28346 re f BT /F14 1 Tf 9.5 0 0 9.5 247.2377 251.6031 Tm 0 0 0 1 k (G)Tj /F9 1 Tf 0.7221 0 TD 0.2798 Tc [(A\()279.8(n)-5.9(=)-1.6(2)279.8(,)]TJ -21.9729 -1.2114 TD 0 Tc [(1.26%\);)-364(13)-366.8(double)-367.4(mutant)-368.2(isolates,)-368.2(including)-363.6(I)]TJ /F14 1 Tf 18.9533 0 TD (AG)Tj /F9 1 Tf 1.4203 0 TD [(KAA)-365(\(n)-363.2(=)-364.9(7)0(,)]TJ -20.3736 -1.2114 TD (4.40%\),)Tj ET 0 0 0 rg 78.18 227.509 13.323 0.22678 re f BT /F14 1 Tf 9.5 0 0 9.5 78.1795 228.5858 Tm 0 0 0 1 k (VA)Tj /F9 1 Tf 1.4024 0 TD [(AKAA)-489.6(\(n)-482.6(=)-484.3(2)0(,)-484.6(1.26%\),)-489.3(ISA)]TJ /F14 1 Tf 11.7622 0 TD (EG)Tj /F9 1 Tf 1.295 0 TD [(A)-482.7(\()0(n)-482.6(=)-490.2(2,)-484.6(1.26%\),)]TJ -17.9149 -1.2055 TD (I)Tj ET 0 0 0 rg 48.529 216 6.6331 0.22678 re f BT /F14 1 Tf 9.5 0 0 9.5 48.5291 217.1338 Tm 0 0 0 1 k (A)Tj /F9 1 Tf 0.6982 0 TD (AKA)Tj ET 0 0 0 rg 74.551 216 4.7622 0.22678 re f BT /F14 1 Tf 9.5 0 0 9.5 74.5512 217.1338 Tm 0 0 0 1 k (S)Tj ET 0 0 0 rg 82.545 216 3.2315 0.22678 re f BT /F9 1 Tf 9.5 0 0 9.5 82.5449 217.1338 Tm 0 0 0 1 k [(\(n)-339.4(=)-341.1(1)0(,)-341.4(0.63%\),)-340.1(and)-346(I)]TJ ET 0 0 0 rg 164.75 216.227 m 171.383 216.227 l 171.383 216 l 164.75 216 l f* BT /F14 1 Tf 9.5 0 0 9.5 164.7496 217.1338 Tm 0 0 0 1 k (A)Tj /F9 1 Tf 0.6982 0 TD (A)Tj ET 0 0 0 rg 177.959 216 5.4425 0.22678 re f BT /F14 1 Tf 9.5 0 0 9.5 177.959 217.1338 Tm 0 0 0 1 k (E)Tj /F9 1 Tf 0.5729 0 TD [(AA)-338.7(\(n)-339.4(=)-341.1(1)0(,)-341.4(0.63%\);)-340.1(9)-344.5(triple)]TJ -14.5312 -1.2114 TD [(mutant)-433.9(genotypes,)-432(comprising)-434.3(8)-428.1(examples)-434.7(of)]TJ ET 0 0 0 rg 227.225 204.491 13.38 0.22676 re f BT /F14 1 Tf 9.5 0 0 9.5 227.2251 205.6252 Tm 0 0 0 1 k (VA)Tj /F9 1 Tf 1.4084 0 TD (AK)Tj ET 0 0 0 rg 253.474 204.491 6.8032 0.22676 re f BT /F14 1 Tf 9.5 0 0 9.5 253.474 205.6252 Tm 0 0 0 1 k (G)Tj /F9 1 Tf 0.7161 0 TD [(A,)-431.8(1)-428.1(o)0(f)]TJ ET 0 0 0 rg 45.354 192.983 6.7465 0.28346 re f BT /F14 1 Tf 9.5 0 0 9.5 45.3543 194.1165 Tm 0 0 0 1 k (V)Tj /F9 1 Tf 0.7102 0 TD (S)Tj ET 0 0 0 rg 56.523 192.983 6.8598 0.28346 re f BT /F14 1 Tf 9.5 0 0 9.5 56.5228 194.1165 Tm 0 0 0 1 k (G)Tj /F9 1 Tf 0.7221 0 TD (K)Tj ET 0 0 0 rg 69.676 192.983 6.8598 0.28346 re f BT /F14 1 Tf 9.5 0 0 9.5 69.6756 194.1165 Tm 0 0 0 1 k (G)Tj /F9 1 Tf 0.7221 0 TD [(A;)-360.1(and)-363.9(only)-357.6(1)-362.4(quadruple)-365.1(mutation,)-363(as)]TJ ET 0 0 0 rg 227.735 192.983 13.323 0.28346 re f BT /F14 1 Tf 9.5 0 0 9.5 227.7354 194.1165 Tm 0 0 0 1 k (VA)Tj /F9 1 Tf 1.4024 0 TD (AK)Tj /F14 1 Tf 1.3547 0 TD (GS,)Tj /F9 1 Tf 1.8321 0 TD (were)Tj -23.7871 -1.2114 TD (identi)Tj /F12 1 Tf 2.3035 0 TD ()Tj /F9 1 Tf 0.5311 0 TD [(ed.)-439.4(There)-445.9(were)-442.5(more)-444.3(wild-type)-444.3(isolates)-442.9(of)]TJ /F10 1 Tf 17.9984 0 TD (pfdhps)Tj /F9 1 Tf 3.0137 0 TD (than)Tj -23.8468 -1.2114 TD (p)Tj /F10 1 Tf 0.5192 0 TD (fdhfr)Tj /F9 1 Tf 2.1782 0 TD (\(63)Tj /F10 1 Tf 1.5635 0 TD (pfdhps)Tj /F9 1 Tf 2.8287 0 TD [(isolates,)-266.7(compared)-264(with)-259(three)-262.6(in)]TJ /F10 1 Tf 13.0095 0 TD (pfdhfr)Tj /F9 1 Tf 2.399 0 TD [(\).)-256.6(Three)]TJ -22.4981 -1.2114 TD [(genotyp)-9.6(es,)-499.9(ISAKA)-11.6(A)-500.6(\(39.62%,)-505.6(63/1)-7.4(59\),)-504(ISA)]TJ ET 0 0 0 rg 216.113 158.513 5.4425 0.22678 re f BT /F14 1 Tf 9.5 0 0 9.5 216.1133 159.5905 Tm 0 0 0 1 k (E)Tj /F9 1 Tf 0.5729 0 TD [(AA)-499.8(\(2)-7.5(5.79%,)-504.1(41/)]TJ -18.5475 -1.2055 TD [(159\),)-347.3(and)-346(I)]TJ ET 0 0 0 rg 88.328 147.005 6.6331 0.22678 re f BT /F14 1 Tf 9.5 0 0 9.5 88.3275 148.1385 Tm 0 0 0 1 k (A)Tj /F9 1 Tf 0.6982 0 TD [(AKAA)-346.4(\(15.09%,)-350.5(24/159\),)-350.4(accounted)-348.1(for)-348.9(80.50%)-344.5(of)]TJ -5.2217 -1.2114 TD (all)Tj /F10 1 Tf 1.2353 0 TD (pfdhps)Tj /F9 1 Tf 2.8764 0 TD [(genotypes)-303.8(\()]TJ /F14 1 Tf 0 0 0 rg 4.619 0 TD [(Table)-304.8(2)]TJ /F9 1 Tf 0 0 0 1 k 3.1271 0 TD (\).)Tj /F1 1 Tf 11.9999 0 0 11.9999 45.3543 114.1228 Tm [(Geographical)-305.7(Genetic)-302.9(Analysis)]TJ /F9 1 Tf 9.5 0 0 9.5 45.3543 102.6141 Tm -0.0189 Tc [(The)-229.5(m)-0.6(utant)-236.1(f)3.6(requency)-235.2(in)-235.8(all)-234.4(t)2.6(a)-5.6(r)4.9(geted)]TJ /F10 1 Tf 14.1792 0 TD -0.0192 Tc (pfdhfr)Tj /F9 1 Tf 2.5124 0 TD -0.017 Tc [(ge)5.1(ne)-227.6(fragme)5.1(nt)4.5(s)-231.9(w)3.6(ere)-227.6(a)2.3(ll)]TJ -16.6915 -1.2114 TD -0.0185 Tc [(above)-372.3(8)1(6)-5(.)2.6(79%,)-373.4(a)0.8(nd)-369.8(there)-378.3(w)2.1(as)-376.6(no)-371.9(signi)]TJ /F12 1 Tf 15.0325 0 TD 0 Tc ()Tj /F9 1 Tf 0.5073 0 TD -0.0174 Tc [(cant)-371.8(di)3.9(f)58.8(f)5.1(eren)4.4(ce)-371.2(\(P)-368.5(>)-377.5(0)2.1(.05\))]TJ -15.5398 -1.2114 TD -0.0185 Tc [(among)-258.7(i)-3.2(solates)-257.2(f)-2(rom)-262.8(W)0.6(est,)-254(East)]TJ 12.0905 0 TD 0.2398 Tc [(,a)259.1(n)261.6(d)-4.1(C)257.3(e)261.9(n)255.6(t)261.3(r)257.7(a)259.1(lA)258.4(f)256.3(r)257.7(i)261.1(c)256(a)259.1(.)-1.7(F)258.5(o)256.4(rt)261.3(h)257.6(e)]TJ /F10 1 Tf 11.0939 0 TD -0.0192 Tc (pfdhps)Tj /F9 1 Tf -23.1843 -1.2114 TD -0.0169 Tc [(ge)5.2(ne,)-425.5(t)-1.3(he)-430.4(mut)4.6(a)2.4(nt)-431(g)5.5(e)-0.7(no)5.7(ty)5.5(pes)-428.7(c)-0.7(arri)4.4(ed)-427.9(a)-433.3(r)1(e)5.2(l)0.4(ati)4.4(v)-0.5(el)6.3(y)-430.2(h)0.9(ig)5.5(h)-428.8(n)-1(umbe)5.2(r)-434.7(o)5.7(f)]TJ 27.4512 26.5919 TD -0.0172 Tc [(pol)6(y)-0.8(mor)6.6(p)-4.5(h)6.5(i)-1.9(sms.)-252.7(The)-251.7(t)4.3(wo)]TJ /F10 1 Tf 9.9063 0 TD -0.0187 Tc [(P.)-255.2(f)-5.3(a)4.8(lciparum)]TJ /F9 1 Tf 5.359 0 TD -0.0183 Tc [(s)5.5(a)-5(mpl)4.9(e)-2.1(s)-257(f)4.2(rom)-256.6(N)4.6(orth)-257.1(Africa)]TJ -15.2653 -1.2055 TD -0.0199 Tc [(were)-409.5(wild-t)-4.4(yp)-7.2(es)-407.8(\()]TJ /F14 1 Tf 0 0 0 rg 6.8747 0 TD -0.0185 Tc [(Table)-403.1(3)]TJ /F9 1 Tf 0 0 0 1 k 3.1151 0 TD -0.0173 Tc [(\).)-408(Two)-406.5(o)-0.7(f)-406.6(s)0.6(i)4(x)-408.6(l)5.9(o)-0.7(ci)-401.8(we)4.8(re)-406.9(det)4.2(ect)4.2(ed)-404.4(as)-405.2(sit)4.2(e)]TJ -9.9899 -1.2114 TD [(mut)4.1(a)-4.1(t)4.1(i)3.9(ons)-363.6(i)-2.1(n)-365.6(s)0.5(ample)4.7(s)-369.5(f)5.1(r)0.5(om)-363.1(Eas)6.4(t)-365.9(Afri)3.9(ca,)-366.3(w)-2.8(i)3.9(t)4.1(h)-369.6(K)4.1(540E)-362.5(repres)6.4(ent)4.1(i)-2.1(n)4.4(g)]TJ T* -0.0186 Tc [(69.57%)-426.3(\(1)-5.1(6/23\))-427.5(of)-425.8(the)-432.1(m)5.7(u)-5.9(t)2.9(ations,)-427.2(w)-4(hich)-424.5(was)-430.4(a)-429(markedly)-425.9(higher)]TJ T* -0.0196 Tc [(frequency)-307.6(t)-4.1(ha)-6.3(n)-308.1(t)-4.1(ha)-6.3(t)-308.4(f)-3.1(or)-312(S436A)-311.3(\(4.)]TJ 13.1348 0 TD -0.0183 Tc [(34%,)-307.6(1)1.2(/23\).)-307.6(E)0.7(ach)-310.8(l)-1(ocus)-310.7(carried)-309.9(a)]TJ -13.1348 -1.2114 TD -0.0178 Tc [(sense)-216.5(m)0.5(utation)-216.8(a)1.5(ssociat)]TJ 8.9037 0 TD -0.018 Tc [(ed)-220.1(with)-215.1(West)-217.3(Africa,)-217.7(t)-2.5(h)5.8(e)-222.6(mutant)-217.3(frequencies)]TJ -8.9037 -1.2114 TD -0.0194 Tc [(were)-373.2(14.81)-5.9(%)-367.4(\()-4.6(8/54,)-374.3(I413)-5.9(V\),)-368.3(5)-5.9(1.85%)-373.4(\(2)-5.9(8/54,)-374.3(S436V\),)-374.3(9.26%)-373.4(\(5/54,)]TJ T* -0.0188 Tc [(A437G\),)-290.2(11.11%)-289.3(\(6/54,)-290.1(K540E\),)-284.2(12.96%)-289.3(\(7/5)-5.3(4,)-284.2(A5)-5.3(81G\),)-284.2(a)-5.5(n)3(d)-286.5(5)-5.3(.56%)]TJ 0 -1.2055 TD -0.019 Tc [(\(3/5)-5.5(4,)-242.6(A613S\).)-242.6(The)-241.5(s)-1.1(ite)-241.5(m)-0.7(utations)-245.8(in)]TJ 14.1016 0 TD -0.0182 Tc [(central)-239.6(A)0.4(frican)-241.1(region)-241.1(were)-240.7(all)]TJ -14.1016 -1.2114 TD -0.0193 Tc [(dif)56.9(f)3.2(erent)-200.7(f)-2.8(or)-198.4(the)-206(S)1.1(436V)-205.5(\(17.5%,)-201.1(1)-5.8(4/80,)-201.1(P)-203.3(<)-200.4(0.00)-5.8(1\))-201.5(and)-203.5(K)-3.8(540E)-203.3(\(27.5%,)]TJ T* -0.0196 Tc [(22/80,)-326.8(P)-328.9(=)-330.8(0.017\))-333(loci,)-326.8(w)1(hich)-330(was)-329.9(s)-1.7(igni)]TJ /F12 1 Tf 15.1758 0 TD 0 Tc ()Tj /F9 1 Tf 0.5132 0 TD -0.0189 Tc [(can)-3.1(t)2.6(ly)-324.8(di)-3.6(f)63.2(f)-2.4(ere)-2.7(n)-3(t)-325.6(c)3.2(o)-2.3(m)-0.6(pare)-2.7(d)]TJ -15.689 -1.2114 TD -0.0183 Tc [(with)-257.1(th)5.4(e)-258.7(W)0.8(estern)-259.1(African)-259.1(R)4.9(egion)-259.1(i)3(sol)4.9(a)1(tes)-263(\()2.4(P)-256(<)-259.1(0.05\).)-259.8(M)1.4(oreover,)-259.8(the)]TJ T* -0.0188 Tc [(muta)-5.5(nt)-343.4(frequency)-342.6(o)3.8(f)-342.5(K)-3.3(540E)-340(varied)-340.2(between)-343.1(W)0.3(estern)-337.1(and)-340.2(E)0.1(astern)]TJ T* [(African)-331.3(R)-1.7(egion)-331.3(i)-3.6(solates)-335.2(\()1.8(P)-334.1(<)-3.1(0.)]TJ 11.6668 0 TD -0.019 Tc [(01)-5.5(\).)-332.1(A613S)-332.8(only)-336.8(occurred)-334.5(i)2.3(n)-337.3(G)2.7(hana)]TJ -11.6668 -1.2055 TD -0.0187 Tc [(\(n)-301.2(=)-300.1(2)0.8(\))-302.3(a)0.6(nd)-298.4(Nigeria)-303.8(\()2(n)-301.2(=)-300.1(1\))-302.3(in)-301.2(West)-295.6(A)-6(f)3.8(rica.)]TJ /F1 1 Tf 11.9999 0 0 11.9999 306.1417 137.2535 Tm 0 Tc [(Linkage)-303.4(Disequilibrium)-302.9(\(LD\))-302.3(Analysis)]TJ /F9 1 Tf 9.5 0 0 9.5 306.1417 125.7448 Tm [(In)-289.7(total,)-282.6(25)-289.2(genotypes)-291.9(of)]TJ /F10 1 Tf 10.0436 0 TD (pfdhfr/pfdhps)Tj /F9 1 Tf 5.5678 0 TD [(were)-293.3(detected)-290.5(among)-289.5(the)]TJ -15.6114 -1.2114 TD [(159)-418.9(P)]TJ /F10 1 Tf 2.4169 0 TD [(.)-421.5(falciparum)]TJ /F9 1 Tf 5.3649 0 TD [(isolates.)-421.9(For)]TJ /F10 1 Tf 5.341 0 TD (pfdhfr)Tj /F9 1 Tf 2.393 0 TD [(,)-420.5(n)0(o)-421.1(SNP)-427.1(was)-419.7(found)-420.9(for)]TJ -15.5159 -1.2114 TD [(codons)-483(16)-480.2(or)-478.7(164.)-481.4(Ultimately,)-483.4(5)-481.8(and)-477.3(13)-480.2(genotypes)-482.9(of)]TJ /F10 1 Tf 23.2619 0 TD (pfdhfr)Tj /F9 1 Tf -23.2619 -1.2114 TD [(\(involving)-239.7(codons)-238.3(51,)-238.3(59,)-232.4(and)-238.6(108\))-237.1(and)]TJ /F10 1 Tf 15.7009 0 TD (pfdhps)Tj /F9 1 Tf 2.8108 0 TD [(\(involving)-239.7(codons)]TJ -18.5117 -1.2114 TD [(431,)-236.8(436,)-236.8(437,)-236.8(540,)-236.8(581,)-242.7(and)-238.6(613\))-237.1(were)-233.6(detected)-242.8(and)-238.6(analyzed.)-239.7(To)]TJ 0 -1.2055 TD -0.0205 Tc [(evalu)4.2(a)-1.2(te)-481.8(the)-475.8(S)-0.1(NP)-479(LD)-479.1(associations)-474.1(of)]TJ /F10 1 Tf 15.2951 0 TD -0.0202 Tc (pfdhfr)Tj /F9 1 Tf 2.7451 0 TD -0.0206 Tc (and)Tj /F10 1 Tf 1.9156 0 TD -0.0202 Tc (pfdhps)Tj /F9 1 Tf 2.4467 0 TD 0.4563 Tc [(,s)474.2(e)478.4(v)478.7(e)472.5(r)480.1(a)475.6(l)]TJ ET 0 0 0 0.7 k 306.142 706.337 m 549.921 706.337 l 549.921 706.053 l 306.142 706.053 l f* 306.142 586.148 243.779 0.28345 re f 306.142 679.181 243.779 0.22681 re f BT /F1 1 Tf 6.9999 0 0 6.9999 306.1417 712.2896 Tm 0 0 0 1 k 0 Tc [(TABLE)-301(1)-428(|)]TJ /F6 1 Tf 5.1349 0 TD -0.0419 Tc [(Prevale)6.4(n)-4.9(c)6.4(e)-244.6(of)]TJ /F5 1 Tf 5.4264 0 TD -0.0462 Tc [(pf)-6.8(dh)-9.3(fr)]TJ /F6 1 Tf 2.4702 0 TD -0.0427 Tc (and)Tj /F5 1 Tf 1.7251 0 TD -0.0375 Tc [(pf)10(dh)7.6(p)8.1(s)]TJ /F6 1 Tf 2.9643 0 TD -0.0397 Tc [(p)5.9(o)2.1(ly)5.2(m)4.8(o)2.1(rp)5.9(h)5.4(i)-0.4(sm)4.8(s)-241(i)7.7(n)-237.6(i)-0.4(m)4.8(p)-2.2(o)10.2(r)-3.1(t)8.3(e)0.6(d)-237.1(A)2.2(fr)5(ic)8.7(an)-237.6(is)10(olat)8.3(es.)]TJ /F1 1 Tf -17.7209 -2.4864 TD 0 Tc [(Gene)-1362(Position)-1903.3(Wild)]TJ 9.5813 -1.3526 TD (type)Tj 4.9648 1.3526 TD (Mutant)Tj 0.6479 -1.3526 TD (type)Tj 4.9162 1.3526 TD [(Mutant)-306.6(isolates)]TJ 3.0615 -1.3526 TD (\(n\))Tj 6.0663 1.3526 TD (Frequency)Tj 1.6927 -1.3526 TD (\(%\))Tj /F5 1 Tf -30.9306 -2.4621 TD (pfdhfr)Tj /F6 1 Tf 5.1996 0 TD [(51)-2224.8(AAT)-3195.2(ATT)-7674.1(138)-5900.5(86.79)]TJ 0 -1.3606 TD [(59)-2224.8(TGT)]TJ ET 0 0 0 rg 400.819 657.524 5.1591 0.28351 re f BT /F1 1 Tf 6.9999 0 0 6.9999 400.8188 658.6581 Tm 0 0 0 1 k (C)Tj /F6 1 Tf 0.737 0 TD [(GT)-7375.1(143)-5900.5(89.94)]TJ -9.3383 -1.3607 TD [(108)-1948.1(AGC)-2936.2(A)]TJ ET 0 0 0 rg 405.184 648.057 4.7622 0.22681 re f BT /F1 1 Tf 6.9999 0 0 6.9999 405.1841 649.1337 Tm 0 0 0 1 k (A)Tj /F6 1 Tf 0.6803 0 TD [(C)-7402.1(156)-5900.5(98.11)]TJ /F5 1 Tf -14.8295 -1.3525 TD (pfdhps)Tj /F6 1 Tf 4.9243 0 TD [(431)-1948.1(ATA)]TJ ET 0 0 0 rg 400.819 638.532 5.2725 0.22681 re f BT /F1 1 Tf 6.9999 0 0 6.9999 400.8188 639.666 Tm 0 0 0 1 k (G)Tj /F6 1 Tf 0.7532 0 TD [(TA)-7748.3(12)-6452.5(7.55)]TJ -9.3545 -1.3607 TD [(436)-1948.1(TCT)]TJ ET 0 0 0 rg 400.819 629.008 5.2725 0.28351 re f BT /F1 1 Tf 6.9999 0 0 6.9999 400.8188 630.1416 Tm 0 0 0 1 k (G)Tj /F6 1 Tf 0.7532 0 TD [(CT)-7676.3(43)-6177.1(27.04)]TJ -9.3545 -1.3526 TD [(437)-1948.1(GCT)-3009.2(G)]TJ ET 0 0 0 rg 405.978 619.54 5.2724 0.22681 re f BT /F1 1 Tf 6.9999 0 0 6.9999 405.9779 620.6738 Tm 0 0 0 1 k (G)Tj /F6 1 Tf 0.7532 0 TD [(T)-7636.2(1)0(5)-6452.5(9.43)]TJ -10.0915 -1.3606 TD [(540)-1948.1(AAA)]TJ ET 0 0 0 rg 400.819 610.016 5.2725 0.28345 re f BT /F1 1 Tf 6.9999 0 0 6.9999 400.8188 611.1495 Tm 0 0 0 1 k (G)Tj /F6 1 Tf 0.7532 0 TD [(AA)-7675.3(44)-6177.1(27.67)]TJ -9.3545 -1.3526 TD [(581)-1948.1(GCG)-2822.2(G)]TJ ET 0 0 0 rg 405.978 600.548 5.2724 0.22681 re f BT /F1 1 Tf 6.9999 0 0 6.9999 405.9779 601.6818 Tm 0 0 0 1 k (G)Tj /F6 1 Tf 0.7532 0 TD [(G)-7449.2(1)0(4)-6452.5(8.81)]TJ -10.0915 -1.3607 TD [(613)-1948.1(GCC)]TJ ET 0 0 0 rg 400.819 591.023 4.252 0.28351 re f BT /F1 1 Tf 6.9999 0 0 6.9999 400.8188 592.1573 Tm 0 0 0 1 k (T)Tj /F6 1 Tf 0.6074 0 TD [(CC)-7952.4(3)-6729.1(1.89)]TJ /F5 1 Tf 6.5001 0 0 6.5001 306.1417 577.1337 Tm [(The)-299.6(bold)-298.7(values)-309.1(stand)-294.6(for)-307.6(mutant)-303.4(nucleic)-298.5(acid)-298(base.)]TJ ET 0 0 0 0.7 k 306.142 544.422 m 549.921 544.422 l 549.921 544.138 l 306.142 544.138 l f* 306.142 348.264 243.779 0.22678 re f 306.142 526.79 243.779 0.22681 re f 306.142 564.718 m 549.921 564.718 l 549.921 564.491 l 306.142 564.491 l 306.142 564.718 l f* BT /F1 1 Tf 6.9999 0 0 6.9999 306.1417 550.4314 Tm 0 0 0 1 k [(TABLE)-301(2)-428(|)]TJ /F6 1 Tf 5.1349 0 TD [(Prevalence)-303.8(of)]TJ /F5 1 Tf 6.0581 0 TD (pfdhfr)Tj /F6 1 Tf 2.7942 0 TD (and)Tj /F5 1 Tf 1.9114 0 TD (pfdhps)Tj /F6 1 Tf 3.2801 0 TD (haplotypes.)Tj /F1 1 Tf -19.1787 -2.4865 TD [(Gene)-3006.2(Genotype)-2516.5(Mutations)-2509.6(Sample)-301.1(size)-2510.6(Frequency)-300.6(\(%\))]TJ /F5 1 Tf 0 -2.4621 TD (pfdhfr)Tj /F6 1 Tf 5.4831 0 TD [(NCS)-7116.9(0)-7166.5(3)-7101.7(1.89%)]TJ 0 -1.3607 TD (NC)Tj ET 0 0 0 rg 354.331 505.134 5.1591 0.22681 re f BT /F1 1 Tf 6.9999 0 0 6.9999 354.3306 506.2676 Tm 0 0 0 1 k (N)Tj /F6 1 Tf 7.7347 0 TD [(1)-7166.5(3)-7101.7(1.89%)]TJ ET 0 0 0 rg 344.523 495.666 2.041 0.22678 re f BT /F1 1 Tf 6.9999 0 0 6.9999 344.5227 496.7432 Tm 0 0 0 1 k (I)Tj /F6 1 Tf 0.2916 0 TD (C)Tj ET 0 0 0 rg 351.496 495.666 5.1591 0.22678 re f BT /F1 1 Tf 6.9999 0 0 6.9999 351.496 496.7432 Tm 0 0 0 1 k (N)Tj /F6 1 Tf 8.1396 0 TD [(2)-6891.1(1)0(0)-6825.1(6.29%)]TJ -9.1358 -1.3526 TD (N)Tj ET 0 0 0 rg 349.455 486.368 m 359.66 486.368 l 359.66 486.142 l 349.455 486.142 l f* BT /F1 1 Tf 6.9999 0 0 6.9999 349.455 487.2755 Tm 0 0 0 1 k (RN)Tj /F6 1 Tf 8.4312 0 TD [(2)-6891.1(1)0(5)-6825.1(9.43%)]TJ ET 0 0 0 rg 344.523 476.617 12.246 0.28345 re f BT /F1 1 Tf 6.9999 0 0 6.9999 344.5227 477.751 Tm 0 0 0 1 k (IRN)Tj /F6 1 Tf 9.1358 0 TD [(3)-6615.7(128)-6273.1(80.50%)]TJ /F5 1 Tf -14.6189 -1.3525 TD (pfdhps)Tj /F6 1 Tf 5.4831 0 TD [(ISAKAA)-5772.9(0)-6891.1(6)0(3)-6549.7(39.62%)]TJ 0 -1.3607 TD (ISA)Tj ET 0 0 0 rg 354.841 457.625 4.4787 0.28345 re f BT /F1 1 Tf 6.9999 0 0 6.9999 354.8409 458.7589 Tm 0 0 0 1 k (E)Tj /F6 1 Tf 0.6398 0 TD [(AA)-5772(1)-6891.1(4)0(1)-6549.7(25.79%)]TJ -2.1139 -1.3526 TD (I)Tj ET 0 0 0 rg 346.053 448.157 4.7622 0.22678 re f BT /F1 1 Tf 6.9999 0 0 6.9999 346.0535 449.2912 Tm 0 0 0 1 k (A)Tj /F6 1 Tf 0.6803 0 TD [(AKAA)-5716.9(1)-6891.1(2)0(4)-6549.7(15.09%)]TJ -0.899 -1.3607 TD (IS)Tj ET 0 0 0 rg 350.476 438.633 5.2157 0.28348 re f BT /F1 1 Tf 6.9999 0 0 6.9999 350.4755 439.7668 Tm 0 0 0 1 k (G)Tj /F6 1 Tf 0.7451 0 TD [(KAA)-5645.3(1)-7166.5(6)-7101.7(3.77%)]TJ -1.5955 -1.3607 TD (ISAK)Tj ET 0 0 0 rg 359.32 429.165 5.2724 0.22678 re f BT /F1 1 Tf 6.9999 0 0 6.9999 359.3196 430.2424 Tm 0 0 0 1 k (G)Tj /F6 1 Tf 0.7532 0 TD [(A)-5643.7(1)-7166.5(2)-7101.7(1.26%)]TJ ET 0 0 0 rg 344.523 419.641 9.1276 0.22678 re f BT /F1 1 Tf 6.9999 0 0 6.9999 344.5227 420.7747 Tm 0 0 0 1 k (VA)Tj /F6 1 Tf 1.304 0 TD [(AKAA)-5311.9(2)-7166.5(2)-7101.7(1.26%)]TJ -1.304 -1.3607 TD (I)Tj ET 0 0 0 rg 346.053 410.116 10.035 0.28345 re f BT /F1 1 Tf 6.9999 0 0 6.9999 346.0535 411.2503 Tm 0 0 0 1 k (AG)Tj /F6 1 Tf 1.4335 0 TD [(KAA)-5588.6(2)-7166.5(7)-7101.7(4.40%)]TJ -1.6522 -1.3526 TD (ISA)Tj ET 0 0 0 rg 354.841 400.649 9.7512 0.22678 re f BT /F1 1 Tf 6.9999 0 0 6.9999 354.8409 401.7826 Tm 0 0 0 1 k (EG)Tj /F6 1 Tf 1.393 0 TD [(A)-5643.7(2)-7166.5(2)-7101.7(1.26%)]TJ -2.8671 -1.3607 TD (I)Tj ET 0 0 0 rg 346.053 391.124 4.7622 0.28348 re f BT /F1 1 Tf 6.9999 0 0 6.9999 346.0535 392.2582 Tm 0 0 0 1 k (A)Tj /F6 1 Tf 0.6803 0 TD (AKA)Tj ET 0 0 0 rg 364.082 391.124 4.5354 0.28348 re f BT /F1 1 Tf 6.9999 0 0 6.9999 364.0818 392.2582 Tm 0 0 0 1 k (S)Tj /F6 1 Tf 6.3416 0 TD [(2)-7166.5(1)-7101.7(0.63%)]TJ -9.1358 -1.3526 TD (I)Tj ET 0 0 0 rg 346.053 381.657 4.7622 0.22678 re f BT /F1 1 Tf 6.9999 0 0 6.9999 346.0535 382.7904 Tm 0 0 0 1 k (A)Tj /F6 1 Tf 0.6803 0 TD (A)Tj ET 0 0 0 rg 355.181 381.883 m 359.716 381.883 l 359.716 381.657 l 355.181 381.657 l f* BT /F1 1 Tf 6.9999 0 0 6.9999 355.181 382.7904 Tm 0 0 0 1 k (E)Tj /F6 1 Tf 0.6479 0 TD [(AA)-5715.3(2)-7166.5(1)-7101.7(0.63%)]TJ ET 0 0 0 rg 344.523 372.132 9.1276 0.28345 re f BT /F1 1 Tf 6.9999 0 0 6.9999 344.5227 373.2661 Tm 0 0 0 1 k (VA)Tj /F6 1 Tf 1.304 0 TD (AK)Tj ET 0 0 0 rg 362.551 372.132 5.2724 0.28345 re f BT /F1 1 Tf 6.9999 0 0 6.9999 362.5511 373.2661 Tm 0 0 0 1 k (G)Tj /F6 1 Tf 0.7532 0 TD [(A)-5182.1(3)-7166.5(8)-7101.7(5.03%)]TJ ET 0 0 0 rg 344.523 362.664 4.4221 0.22678 re f BT /F1 1 Tf 6.9999 0 0 6.9999 344.5227 363.7416 Tm 0 0 0 1 k (V)Tj /F6 1 Tf 0.6317 0 TD (S)Tj ET 0 0 0 rg 353.31 362.664 5.2157 0.22678 re f BT /F1 1 Tf 6.9999 0 0 6.9999 353.3102 363.7416 Tm 0 0 0 1 k (G)Tj /F6 1 Tf 0.7451 0 TD (K)Tj ET 0 0 0 rg 363.061 362.664 5.2724 0.22678 re f BT /F1 1 Tf 6.9999 0 0 6.9999 363.0613 363.7416 Tm 0 0 0 1 k (G)Tj /F6 1 Tf 0.7532 0 TD [(A)-5109.2(3)-7166.5(1)-7101.7(0.63%)]TJ ET 0 0 0 rg 344.523 353.14 9.1276 0.22678 re f BT /F1 1 Tf 6.9999 0 0 6.9999 344.5227 354.2739 Tm 0 0 0 1 k (VA)Tj /F6 1 Tf 1.304 0 TD (AK)Tj ET 0 0 0 rg 362.551 353.14 9.7512 0.22678 re f BT /F1 1 Tf 6.9999 0 0 6.9999 362.5511 354.2739 Tm 0 0 0 1 k (GS)Tj /F6 1 Tf 6.5603 0 TD [(4)-7166.5(1)-7101.7(0.63%)]TJ /F5 1 Tf 6.5001 0 0 6.5001 306.1417 339.2503 Tm [(The)-299.6(bold)-298.7(values)-309.1(stand)-294.6(for)-307.6(mutant)-303.4(nucleic)-298.5(acid)-298(base.)]TJ ET 0 0 0 0.7 k 45.354 737.518 504.567 0.28345 re f BT /F6 1 Tf 6.9999 0 0 6.9999 45.3543 744.2644 Tm [(Yan)-298.8(et)-300.5(al.)]TJ /F5 1 Tf 53.0817 0 TD (pfdhfr)Tj /F6 1 Tf 2.4864 0 TD (/)Tj /F5 1 Tf 0.324 0 TD (pfdhps)Tj /F6 1 Tf 3.2802 0 TD [(Mutations)-303(in)-304.4(Chinese)-298.8(Migrants)]TJ ET 45.354 42.803 504.567 0.22675 re f 45.354 42.803 504.567 0.22675 re f BT 6.9999 0 0 6.9999 45.3543 31.2945 Tm [(Frontiers)-306.1(in)-296.3(Cellular)-302.6(and)-306.5(Infection)-301.5(Microbiology)-499.5(|)-502.8(www.frontiersin.org)-22490(September)-305.7(2021)-505.2(|)-494.7(Volume)-307.7(11)-499.6(|)-494.7(Article)-305.6(673194)]TJ 35.7658 0 TD (4)Tj ET endstream endobj 53 0 obj<> endobj 54 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 55 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 56 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 57 0 obj<>/ProcSet[/PDF/Text]/ExtGState<>>> endobj 58 0 obj<>stream 0 0 0 0.7 k /GS1 gs 45.354 706.053 504.567 0.28345 re f 45.354 688.649 504.567 0.28351 re f 45.354 82.658 504.567 0.22678 re f BT /F1 1 Tf 6.9999 0 0 6.9999 45.3543 712.2896 Tm 0 0 0 1 k 0 Tc 0 Tw [(TABLE)-301(3)-428(|)]TJ /F6 1 Tf 5.1349 0 TD [(Geographical)-309.1(genetic)-296.4(analysis)-307.5(of)]TJ /F5 1 Tf 14.0682 0 TD (pfdhfr/pfdhps)Tj /F6 1 Tf 6.0905 0 TD (genotypes.)Tj /F1 1 Tf -25.2936 -2.4864 TD [(Region)-5618.6(No.)-306.5(samples)-5124.2(Country)-5121.6(No.)-298.4(samples)-3237.1(No.)-306.5(of)-297(mutations)]TJ /F2 1 Tf 49.0079 0 TD (pfdhfr/pfdhps)Tj /F1 1 Tf 6.8438 0 TD [(genotypes)-3241.1(No.)-298.4(of)-305.1(genotypes)]TJ /F6 1 Tf -55.8516 -2.4621 TD [(North)-306(Africa)-6541.3(2)-5894.9(Libya)-11164.2(1)-9547.6(3)-6883(IRN/ISAKAA)-13499.8(1)]TJ 18.0611 -1.3526 TD [(Sudan)-10643.2(1)-9547.6(3)]TJ ET 0 0 0 rg 388.403 667.049 11.112 0.22675 re f BT 6.9999 0 0 6.9999 388.403 668.1825 Tm 0 0 0 1 k [(IRN/ISAKAA)-13499.8(1)]TJ -49.0079 -1.3606 TD [(East)-299.5(Africa)-6792.4(23)-5618.3(Kenya)-10758.2(1)-9547.6(3)]TJ ET 0 0 0 rg 388.403 657.524 11.112 0.28351 re f BT 6.9999 0 0 6.9999 388.403 658.6581 Tm 0 0 0 1 k [(IRN/ISAKAA)-13499.8(1)]TJ -30.9468 -1.3607 TD [(Madagascar)-8125.3(2)-9547.6(2)-6883(N)]TJ ET 0 0 0 rg 393.279 648.057 9.5811 0.22681 re f BT 6.9999 0 0 6.9999 393.2786 649.1337 Tm 0 0 0 1 k [(RN/ISAKAA)-13021.3(2)]TJ -31.6433 -1.3525 TD [(Ethiopia)-10019.3(3)-9547.6(3)]TJ ET 0 0 0 rg 388.403 638.532 11.112 0.22681 re f BT 6.9999 0 0 6.9999 388.403 639.666 Tm 0 0 0 1 k [(IRN/ISAKAA)-13499.8(1)]TJ -7.435 -1.3607 TD (4)Tj ET 0 0 0 rg 388.403 629.008 11.112 0.28351 re f BT 6.9999 0 0 6.9999 388.403 630.1416 Tm 0 0 0 1 k (IRN/I)Tj ET 0 0 0 rg 403.313 629.008 4.3654 0.28351 re f BT 6.9999 0 0 6.9999 403.3133 630.1416 Tm 0 0 0 1 k [(AAKAA)-13490.7(1)]TJ -9.5651 -1.3526 TD (4)Tj ET 0 0 0 rg 388.403 619.54 13.38 0.22681 re f BT 6.9999 0 0 6.9999 388.403 620.6738 Tm 0 0 0 1 k (IRN/ISA)Tj ET 0 0 0 rg 412.044 619.54 4.0819 0.22681 re f BT 6.9999 0 0 6.9999 412.044 620.6738 Tm 0 0 0 1 k [(EAA)-13555.4(1)]TJ -34.3241 -1.3606 TD [(Zambia)-10249.2(4)-9547.6(3)-6883(N)]TJ ET 0 0 0 rg 393.279 610.016 9.5811 0.28345 re f BT 6.9999 0 0 6.9999 393.2786 611.1495 Tm 0 0 0 1 k (RN/ISA)Tj ET 0 0 0 rg 415.389 610.016 4.0819 0.28345 re f BT 6.9999 0 0 6.9999 415.3889 611.1495 Tm 0 0 0 1 k [(EAA)-13077.5(1)]TJ -11.2902 -1.3526 TD (4)Tj ET 0 0 0 rg 388.403 600.548 13.38 0.22681 re f BT 6.9999 0 0 6.9999 388.403 601.6818 Tm 0 0 0 1 k (IRN/ISA)Tj ET 0 0 0 rg 412.044 600.548 4.0819 0.22681 re f BT 6.9999 0 0 6.9999 412.044 601.6818 Tm 0 0 0 1 k [(EAA)-13555.4(3)]TJ -34.3241 -1.3607 TD [(Uganda)-10060.2(6)-9547.6(4)]TJ ET 0 0 0 rg 388.403 591.023 11.112 0.28351 re f BT 6.9999 0 0 6.9999 388.403 592.1573 Tm 0 0 0 1 k (IRN/ISA)Tj ET 0 0 0 rg 412.044 591.023 4.0819 0.28351 re f BT 6.9999 0 0 6.9999 412.044 592.1573 Tm 0 0 0 1 k [(EAA)-13555.4(6)]TJ -34.3241 -1.3607 TD [(Mozambique)-7886.3(7)-9547.6(2)-6883(ICN/ISAKAA)-13468.8(1)]TJ 23.5118 -1.3526 TD (4)Tj ET 0 0 0 rg 388.403 572.031 11.112 0.22675 re f BT 6.9999 0 0 6.9999 388.403 573.1652 Tm 0 0 0 1 k (IRN/ISA)Tj ET 0 0 0 rg 412.044 572.031 4.0819 0.22675 re f BT 6.9999 0 0 6.9999 412.044 573.1652 Tm 0 0 0 1 k [(EAA)-13555.4(6)]TJ -52.3852 -1.3606 TD [(West)-300.5(Africa)-6468.4(54)-5618.3(Mali)-11726.2(1)-9547.6(3)]TJ ET 0 0 0 rg 388.403 562.507 13.38 0.28345 re f BT 6.9999 0 0 6.9999 388.403 563.6408 Tm 0 0 0 1 k [(IRN/ISAKAA)-13499.8(1)]TJ -30.9468 -1.3526 TD [(Sierra)-299.7(Leone)-8032.6(2)-9547.6(2)-6883(NC)]TJ ET 0 0 0 rg 398.211 553.039 4.8756 0.22675 re f BT 6.9999 0 0 6.9999 398.2109 554.1731 Tm 0 0 0 1 k (N/I)Tj ET 0 0 0 rg 406.885 553.039 4.3654 0.22675 re f BT 6.9999 0 0 6.9999 406.8849 554.1731 Tm 0 0 0 1 k [(AAKAA)-12980.5(1)]TJ -10.0753 -1.3607 TD (3)Tj ET 0 0 0 rg 388.403 543.515 13.38 0.28345 re f BT 6.9999 0 0 6.9999 388.403 544.6487 Tm 0 0 0 1 k [(IRN/ISAKAA)-13499.8(1)]TJ -30.9468 -1.3526 TD [(Guinea)-10414.2(2)-9547.6(3)]TJ ET 0 0 0 rg 388.403 534.047 11.112 0.22675 re f BT 6.9999 0 0 6.9999 388.403 535.181 Tm 0 0 0 1 k [(IRN/ISAKAA)-13499.8(1)]TJ -7.435 -1.3607 TD (4)Tj ET 0 0 0 rg 388.403 524.523 11.112 0.28345 re f BT 6.9999 0 0 6.9999 388.403 525.6566 Tm 0 0 0 1 k (IRN/IS)Tj ET 0 0 0 rg 407.679 524.523 5.1591 0.28345 re f BT 6.9999 0 0 6.9999 407.6786 525.6566 Tm 0 0 0 1 k [(GKAA)-13378(1)]TJ -33.7005 -1.3607 TD [(Liberia)-10623.2(3)-9547.6(1)-6883(NC)]TJ ET 0 0 0 rg 398.211 515.055 4.8756 0.22675 re f BT 6.9999 0 0 6.9999 398.2109 516.1321 Tm 0 0 0 1 k [(N/ISAKAA)-12982.7(1)]TJ -8.8362 -1.3526 TD (4)Tj ET 0 0 0 rg 388.403 505.531 11.112 0.22678 re f BT 6.9999 0 0 6.9999 388.403 506.6644 Tm 0 0 0 1 k (IRN/I)Tj ET 0 0 0 rg 403.313 505.531 4.3654 0.22678 re f BT 6.9999 0 0 6.9999 403.3133 506.6644 Tm 0 0 0 1 k [(AAKAA)-13490.7(2)]TJ -33.0769 -1.3607 TD [(Cote)-298.8(d'lvoire)-8035.5(8)-9547.6(0)-6883(NCS/ISAKAA)-13061.8(1)]TJ 23.5118 -1.3525 TD 6.883 Tc (2N)Tj ET 0 0 0 rg 393.279 486.538 9.5811 0.22678 re f BT 6.9999 0 0 6.9999 393.2786 487.6723 Tm 0 0 0 1 k 0 Tc [(RN/ISAKAA)-13021.3(1)]TJ -8.1315 -1.3607 TD (3)Tj ET 0 0 0 rg 388.403 477.014 13.38 0.28348 re f BT 6.9999 0 0 6.9999 388.403 478.1479 Tm 0 0 0 1 k [(IRN/ISAKAA)-13499.8(2)]TJ -7.435 -1.3526 TD (4)Tj ET 0 0 0 rg 388.403 467.546 11.112 0.22678 re f BT 6.9999 0 0 6.9999 388.403 468.6802 Tm 0 0 0 1 k (IRN/I)Tj ET 0 0 0 rg 403.313 467.546 4.3654 0.22678 re f BT 6.9999 0 0 6.9999 403.3133 468.6802 Tm 0 0 0 1 k [(AAKAA)-13490.7(3)]TJ -9.5651 -1.3606 TD (4)Tj ET 0 0 0 rg 388.403 458.022 11.112 0.28345 re f BT 6.9999 0 0 6.9999 388.403 459.1558 Tm 0 0 0 1 k (IRN/ISA)Tj ET 0 0 0 rg 412.044 458.022 4.0819 0.28345 re f BT 6.9999 0 0 6.9999 412.044 459.1558 Tm 0 0 0 1 k [(EAA)-13555.4(1)]TJ -34.3241 -1.3607 TD [(Ghana)-10315.9(16)-9271(1)-6883(NCS/I)]TJ ET 0 0 0 rg 406.375 448.554 4.3654 0.22678 re f BT 6.9999 0 0 6.9999 406.3747 449.6314 Tm 0 0 0 1 k [(AAKAA)-13053.3(1)]TJ -10.0024 -1.3526 TD 6.883 Tc (2N)Tj ET 0 0 0 rg 393.279 439.03 9.5811 0.22678 re f BT 6.9999 0 0 6.9999 393.2786 440.1637 Tm 0 0 0 1 k 0 Tc [(RN/ISAKAA)-13021.3(1)]TJ -8.1315 -1.3607 TD (3)Tj ET 0 0 0 rg 388.403 429.505 11.112 0.28348 re f BT 6.9999 0 0 6.9999 388.403 430.6393 Tm 0 0 0 1 k [(IRN/ISAKAA)-13499.8(3)]TJ -7.435 -1.3526 TD (3)Tj ET 0 0 0 rg 388.403 420.038 1.5307 0.22678 re f BT 6.9999 0 0 6.9999 388.403 421.1715 Tm 0 0 0 1 k (IC)Tj ET 0 0 0 rg 394.809 420.038 7.1433 0.22678 re f BT 6.9999 0 0 6.9999 394.8094 421.1715 Tm 0 0 0 1 k (N/ISA)Tj ET 0 0 0 rg 412.271 420.038 4.0819 0.22678 re f BT 6.9999 0 0 6.9999 412.2708 421.1715 Tm 0 0 0 1 k [(EAA)-13523(1)]TJ -10.8447 -1.3607 TD 6.883 Tc (3N)Tj ET 0 0 0 rg 393.279 410.513 9.5811 0.28345 re f BT 6.9999 0 0 6.9999 393.2786 411.6471 Tm 0 0 0 1 k 0 Tc (RN/I)Tj ET 0 0 0 rg 406.658 410.513 4.3654 0.28345 re f BT 6.9999 0 0 6.9999 406.6582 411.6471 Tm 0 0 0 1 k [(AAKAA)-13012.9(1)]TJ -10.0429 -1.3526 TD (4)Tj ET 0 0 0 rg 388.403 401.046 11.112 0.22675 re f BT 6.9999 0 0 6.9999 388.403 402.1794 Tm 0 0 0 1 k (IRN/I)Tj ET 0 0 0 rg 403.313 401.046 4.3654 0.22675 re f BT 6.9999 0 0 6.9999 403.3133 402.1794 Tm 0 0 0 1 k [(AAKAA)-13490.7(3)]TJ -9.5651 -1.3607 TD (4)Tj ET 0 0 0 rg 388.403 391.521 11.112 0.28348 re f BT 6.9999 0 0 6.9999 388.403 392.655 Tm 0 0 0 1 k (IRN/ISA)Tj ET 0 0 0 rg 412.044 391.521 4.0819 0.28348 re f BT 6.9999 0 0 6.9999 412.044 392.655 Tm 0 0 0 1 k [(EAA)-13555.4(2)]TJ -10.8123 -1.3607 TD (4)Tj ET 0 0 0 rg 388.403 382.053 1.5307 0.22678 re f BT 6.9999 0 0 6.9999 388.403 383.1306 Tm 0 0 0 1 k (IC)Tj ET 0 0 0 rg 394.809 382.053 4.9323 0.22678 re f BT 6.9999 0 0 6.9999 394.8094 383.1306 Tm 0 0 0 1 k (N/I)Tj ET 0 0 0 rg 403.483 382.053 9.5811 0.22678 re f BT 6.9999 0 0 6.9999 403.4834 383.1306 Tm 0 0 0 1 k [(AGKAA)-13352.4(1)]TJ -9.5894 -1.3526 TD 6.883 Tc (4N)Tj ET 0 0 0 rg 393.279 372.529 9.5811 0.22678 re f BT 6.9999 0 0 6.9999 393.2786 373.6629 Tm 0 0 0 1 k 0 Tc (RN/I)Tj ET 0 0 0 rg 406.658 372.529 4.3654 0.22678 re f BT 6.9999 0 0 6.9999 406.6582 373.6629 Tm 0 0 0 1 k (AAKA)Tj ET 0 0 0 rg 424.29 372.529 4.3654 0.22678 re f BT 6.9999 0 0 6.9999 424.2897 373.6629 Tm 0 0 0 1 k 13.0139 Tc (S1)Tj -12.5618 -1.3607 TD 0 Tc (5)Tj ET 0 0 0 rg 388.403 363.005 11.112 0.28345 re f BT 6.9999 0 0 6.9999 388.403 364.1385 Tm 0 0 0 1 k (IRN/I)Tj ET 0 0 0 rg 403.313 363.005 4.3654 0.28345 re f BT 6.9999 0 0 6.9999 403.3133 364.1385 Tm 0 0 0 1 k (AA)Tj ET 0 0 0 rg 412.044 363.005 4.0819 0.28345 re f BT 6.9999 0 0 6.9999 412.044 364.1385 Tm 0 0 0 1 k [(EAA)-13555.4(1)]TJ -10.8123 -1.3526 TD (5)Tj ET 0 0 0 rg 388.403 353.537 11.112 0.22675 re f BT 6.9999 0 0 6.9999 388.403 354.6708 Tm 0 0 0 1 k (IRN/I)Tj ET 0 0 0 rg 403.313 353.537 9.5244 0.22675 re f BT 6.9999 0 0 6.9999 403.3133 354.6708 Tm 0 0 0 1 k [(AGKAA)-13376.7(1)]TJ -33.0769 -1.3607 TD [(Nigeria)-10201.9(22)-9271(2)-6883(N)]TJ ET 0 0 0 rg 393.279 344.013 9.5811 0.28348 re f BT 6.9999 0 0 6.9999 393.2786 345.1464 Tm 0 0 0 1 k [(RN/ISAKAA)-13021.3(1)]TJ -8.1315 -1.3526 TD (3)Tj ET 0 0 0 rg 388.403 334.545 11.112 0.22678 re f BT 6.9999 0 0 6.9999 388.403 335.6786 Tm 0 0 0 1 k [(IRN/ISAKAA)-13499.8(6)]TJ -7.435 -1.3607 TD (4)Tj ET 0 0 0 rg 388.403 325.02 13.38 0.28345 re f BT 6.9999 0 0 6.9999 388.403 326.1542 Tm 0 0 0 1 k (IRN/I)Tj ET 0 0 0 rg 403.313 325.02 4.3654 0.28345 re f BT 6.9999 0 0 6.9999 403.3133 326.1542 Tm 0 0 0 1 k [(AAKAA)-13490.7(5)]TJ -9.5651 -1.3607 TD (4)Tj ET 0 0 0 rg 388.403 315.553 11.112 0.22675 re f BT 6.9999 0 0 6.9999 388.403 316.6298 Tm 0 0 0 1 k (IRN/ISA)Tj ET 0 0 0 rg 412.044 315.553 4.0819 0.22675 re f BT 6.9999 0 0 6.9999 412.044 316.6298 Tm 0 0 0 1 k [(EAA)-13555.4(1)]TJ -10.8123 -1.3526 TD (5)Tj ET 0 0 0 rg 388.403 306.028 11.112 0.22681 re f BT 6.9999 0 0 6.9999 388.403 307.1621 Tm 0 0 0 1 k (IRN/I)Tj ET 0 0 0 rg 403.313 306.028 9.5244 0.22681 re f BT 6.9999 0 0 6.9999 403.3133 307.1621 Tm 0 0 0 1 k [(AGKAA)-13376.7(1)]TJ -9.5651 -1.3607 TD (5)Tj ET 0 0 0 rg 388.403 296.561 11.112 0.22678 re f BT 6.9999 0 0 6.9999 388.403 297.6377 Tm 0 0 0 1 k (IRN/)Tj ET 0 0 0 rg 401.783 296.561 8.4472 0.22678 re f BT 6.9999 0 0 6.9999 401.7826 297.6377 Tm 0 0 0 1 k [(VAAKAA)-13126.4(1)]TJ -9.3464 -1.3526 TD 6.883 Tc (5N)Tj ET 0 0 0 rg 393.279 287.036 9.5811 0.22678 re f BT 6.9999 0 0 6.9999 393.2786 288.17 Tm 0 0 0 1 k 0 Tc (RN/)Tj ET 0 0 0 rg 405.127 287.036 8.4472 0.22678 re f BT 6.9999 0 0 6.9999 405.1275 288.17 Tm 0 0 0 1 k (VAAK)Tj ET 0 0 0 rg 422.475 287.036 9.5244 0.22678 re f BT 6.9999 0 0 6.9999 422.4755 288.17 Tm 0 0 0 1 k [(GS)-12534.1(1)]TJ -12.3026 -1.3607 TD (6)Tj ET 0 0 0 rg 388.403 277.512 11.112 0.28348 re f BT 6.9999 0 0 6.9999 388.403 278.6456 Tm 0 0 0 1 k (IRN/)Tj ET 0 0 0 rg 401.783 277.512 8.4472 0.28348 re f BT 6.9999 0 0 6.9999 401.7826 278.6456 Tm 0 0 0 1 k (VAAK)Tj ET 0 0 0 rg 419.131 277.795 m 424.29 277.795 l 424.29 277.512 l 419.131 277.512 l f* BT 6.9999 0 0 6.9999 419.1306 278.6456 Tm 0 0 0 1 k [(GA)-13012(6)]TJ -53.3976 -1.3526 TD [(Central)-300.8(Africa)-5626.1(80)-5618.3(Chad)-11102.2(1)-9547.6(6)]TJ ET 0 0 0 rg 388.403 268.044 11.112 0.22678 re f BT 6.9999 0 0 6.9999 388.403 269.1779 Tm 0 0 0 1 k (IRN/)Tj ET 0 0 0 rg 401.783 268.044 4.0819 0.22678 re f BT 6.9999 0 0 6.9999 401.7826 269.1779 Tm 0 0 0 1 k (VS)Tj ET 0 0 0 rg 410.23 268.044 5.1591 0.22678 re f BT 6.9999 0 0 6.9999 410.2298 269.1779 Tm 0 0 0 1 k (GK)Tj ET 0 0 0 rg 419.924 268.271 m 425.083 268.271 l 425.083 268.044 l 419.924 268.044 l f* BT 6.9999 0 0 6.9999 419.9243 269.1779 Tm 0 0 0 1 k [(GA)-12898.6(1)]TJ -35.4499 -1.3607 TD [(Central)-300.8(Africa)-7699.5(3)-9547.6(2)-6883(N)]TJ ET 0 0 0 rg 393.279 258.52 9.5811 0.28345 re f BT 6.9999 0 0 6.9999 393.2786 259.6535 Tm 0 0 0 1 k [(RN/ISAKAA)-13021.3(2)]TJ -8.1315 -1.3526 TD (3)Tj ET 0 0 0 rg 388.403 249.052 11.112 0.22676 re f BT 6.9999 0 0 6.9999 388.403 250.1858 Tm 0 0 0 1 k [(IRN/ISAKAA)-13499.8(1)]TJ -30.9468 -1.3607 TD [(Congo)-10528.2(4)-9547.6(2)-6883(N)]TJ ET 0 0 0 rg 393.279 239.527 9.5811 0.22678 re f BT 6.9999 0 0 6.9999 393.2786 240.6614 Tm 0 0 0 1 k [(RN/ISAKAA)-13021.3(2)]TJ -8.1315 -1.3607 TD (3)Tj ET 0 0 0 rg 388.403 230.06 11.112 0.22676 re f BT 6.9999 0 0 6.9999 388.403 231.1369 Tm 0 0 0 1 k [(IRN/ISAKAA)-13499.8(2)]TJ -30.9468 -1.3526 TD [(Equatorial)-304.4(Guinea)-5894.9(6)-9547.6(3)]TJ ET 0 0 0 rg 388.403 220.535 11.112 0.22676 re f BT 6.9999 0 0 6.9999 388.403 221.6693 Tm 0 0 0 1 k [(IRN/ISAKAA)-13499.8(3)]TJ -7.435 -1.3607 TD (4)Tj ET 0 0 0 rg 388.403 211.011 11.112 0.28346 re f BT 6.9999 0 0 6.9999 388.403 212.1448 Tm 0 0 0 1 k (IRN/ISAK)Tj ET 0 0 0 rg 416.579 211.294 m 421.738 211.294 l 421.738 211.011 l 416.579 211.011 l f* BT 6.9999 0 0 6.9999 416.5794 212.1448 Tm 0 0 0 1 k [(GA)-13376.4(1)]TJ -11.4603 -1.3526 TD (5)Tj ET 0 0 0 rg 388.403 201.543 11.112 0.22676 re f BT 6.9999 0 0 6.9999 388.403 202.6771 Tm 0 0 0 1 k (IRN/ISA)Tj ET 0 0 0 rg 412.044 201.77 m 421.285 201.77 l 421.285 201.543 l 412.044 201.543 l f* BT 6.9999 0 0 6.9999 412.044 202.6771 Tm 0 0 0 1 k [(EGA)-13441.4(1)]TJ -10.8123 -1.3606 TD (6)Tj ET 0 0 0 rg 388.403 192.019 11.112 0.28346 re f BT 6.9999 0 0 6.9999 388.403 193.1527 Tm 0 0 0 1 k (IRN/)Tj ET 0 0 0 rg 401.783 192.019 8.4472 0.28346 re f BT 6.9999 0 0 6.9999 401.7826 193.1527 Tm 0 0 0 1 k (VAAK)Tj ET 0 0 0 rg 419.131 192.302 m 424.29 192.302 l 424.29 192.019 l 419.131 192.019 l f* BT 6.9999 0 0 6.9999 419.1306 193.1527 Tm 0 0 0 1 k [(GA)-13012(1)]TJ -35.3365 -1.3526 TD [(Gabon)-10232.9(10)-9271(3)]TJ ET 0 0 0 rg 388.403 182.551 11.112 0.22678 re f BT 6.9999 0 0 6.9999 388.403 183.685 Tm 0 0 0 1 k [(IRN/ISAKAA)-13499.8(7)]TJ -7.435 -1.3607 TD (4)Tj ET 0 0 0 rg 388.403 173.027 11.112 0.28346 re f BT 6.9999 0 0 6.9999 388.403 174.1606 Tm 0 0 0 1 k (IRN/ISA)Tj ET 0 0 0 rg 412.044 173.027 4.0819 0.28346 re f BT 6.9999 0 0 6.9999 412.044 174.1606 Tm 0 0 0 1 k [(EAA)-13555.4(3)]TJ -34.3241 -1.3606 TD [(Angola)-10189.9(14)-9271(2)]TJ ET 0 0 0 rg 388.403 163.559 1.5307 0.22678 re f BT 6.9999 0 0 6.9999 388.403 164.6362 Tm 0 0 0 1 k (IC)Tj ET 0 0 0 rg 394.809 163.559 4.9323 0.22678 re f BT 6.9999 0 0 6.9999 394.8094 164.6362 Tm 0 0 0 1 k [(N/ISAKAA)-13468.6(2)]TJ -8.3502 -1.3526 TD 6.883 Tc [(2N)6883(C)]TJ ET 0 0 0 rg 398.211 154.035 4.8756 0.22678 re f BT 6.9999 0 0 6.9999 398.2109 155.1685 Tm 0 0 0 1 k 0 Tc (N/IS)Tj ET 0 0 0 rg 411.25 154.035 5.1591 0.22678 re f BT 6.9999 0 0 6.9999 411.2503 155.1685 Tm 0 0 0 1 k [(GKAA)-12867.8(1)]TJ -10.699 -1.3607 TD (3)Tj ET 0 0 0 rg 388.403 144.51 11.112 0.28346 re f BT 6.9999 0 0 6.9999 388.403 145.644 Tm 0 0 0 1 k (IRN/)Tj ET 0 0 0 rg 401.783 144.51 1.5307 0.28346 re f BT 6.9999 0 0 6.9999 401.7826 145.644 Tm 0 0 0 1 k [(ISAKAA)-13491.4(4)]TJ -9.3464 -1.3526 TD (4)Tj ET 0 0 0 rg 388.403 135.042 11.112 0.22676 re f BT 6.9999 0 0 6.9999 388.403 136.1763 Tm 0 0 0 1 k (IRN/I)Tj ET 0 0 0 rg 403.313 135.042 4.3654 0.22676 re f BT 6.9999 0 0 6.9999 403.3133 136.1763 Tm 0 0 0 1 k [(AAKAA)-13490.7(2)]TJ -9.5651 -1.3607 TD (4)Tj ET 0 0 0 rg 388.403 125.518 11.112 0.28348 re f BT 6.9999 0 0 6.9999 388.403 126.6519 Tm 0 0 0 1 k (IRN/ISAK)Tj ET 0 0 0 rg 416.579 125.802 m 421.738 125.802 l 421.738 125.518 l 416.579 125.518 l f* BT 6.9999 0 0 6.9999 416.5794 126.6519 Tm 0 0 0 1 k [(GA)-13376.4(1)]TJ -11.4603 -1.3526 TD (4)Tj ET 0 0 0 rg 388.403 116.05 11.112 0.22675 re f BT 6.9999 0 0 6.9999 388.403 117.1842 Tm 0 0 0 1 k (IRN/ISA)Tj ET 0 0 0 rg 412.044 116.05 4.0819 0.22675 re f BT 6.9999 0 0 6.9999 412.044 117.1842 Tm 0 0 0 1 k [(EAA)-13555.4(3)]TJ -10.8123 -1.3607 TD (4)Tj ET 0 0 0 rg 388.403 106.526 11.112 0.28348 re f BT 6.9999 0 0 6.9999 388.403 107.6598 Tm 0 0 0 1 k (IRN/IS)Tj ET 0 0 0 rg 407.679 106.526 5.1591 0.28348 re f BT 6.9999 0 0 6.9999 407.6786 107.6598 Tm 0 0 0 1 k [(GKAA)-13378(1)]TJ -33.7005 -1.3607 TD [(Cameroon)-8650.9(14)-9271(3)]TJ ET 0 0 0 rg 388.403 97.058 11.112 0.22675 re f BT 6.9999 0 0 6.9999 388.403 98.1354 Tm 0 0 0 1 k [(IRN/ISAKAA)-13499.8(5)]TJ -7.435 -1.3526 TD (4)Tj ET 0 0 0 rg 388.403 87.534 11.112 0.22675 re f BT 6.9999 0 0 6.9999 388.403 88.6677 Tm 0 0 0 1 k (IRN/I)Tj ET 0 0 0 rg 403.313 87.534 4.3654 0.22675 re f BT 6.9999 0 0 6.9999 403.3133 88.6677 Tm 0 0 0 1 k [(AAKAA)-13490.7(4)]TJ /F5 1 Tf 16.0444 -2.1463 TD (\(Continued\))Tj ET 0 0 0 0.7 k 45.354 737.518 504.567 0.28345 re f BT /F6 1 Tf 6.9999 0 0 6.9999 45.3543 744.2644 Tm [(Yan)-298.8(et)-300.5(al.)]TJ /F5 1 Tf 53.0817 0 TD (pfdhfr)Tj /F6 1 Tf 2.4864 0 TD (/)Tj /F5 1 Tf 0.324 0 TD (pfdhps)Tj /F6 1 Tf 3.2802 0 TD [(Mutations)-303(in)-304.4(Chinese)-298.8(Migrants)]TJ ET 45.354 42.803 504.567 0.22675 re f 45.354 42.803 504.567 0.22675 re f BT 6.9999 0 0 6.9999 45.3543 31.2945 Tm [(Frontiers)-306.1(in)-296.3(Cellular)-302.6(and)-306.5(Infection)-301.5(Microbiology)-499.5(|)-502.8(www.frontiersin.org)-22490(September)-305.7(2021)-505.2(|)-494.7(Volume)-307.7(11)-499.6(|)-494.7(Article)-305.6(673194)]TJ 35.7658 0 TD (5)Tj ET endstream endobj 59 0 obj<> endobj 60 0 obj<> endobj 61 0 obj<> endobj 62 0 obj<> endobj 63 0 obj<> endobj 64 0 obj<> endobj 65 0 obj<> endobj 66 0 obj<> endobj 67 0 obj<> endobj 68 0 obj<> endobj 69 0 obj<> endobj 70 0 obj<> endobj 71 0 obj<> endobj 72 0 obj<> endobj 73 0 obj<> endobj 74 0 obj<> endobj 75 0 obj<> endobj 76 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 77 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 78 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 79 0 obj<>/Font<>/ProcSet[/PDF/Text/ImageC]/ExtGState<>>> endobj 80 0 obj<>stream /GS1 gs BT /F9 1 Tf 9.5 0 0 9.5 45.3543 522.255 Tm 0 0 0 1 k -0.0218 Tc 0 Tw [(stat)-6.2(istic)-5.6(a)3.4(lly)-453(s)-3.9(igni)]TJ /F12 1 Tf 6.3615 0 TD 0 Tc ()Tj /F9 1 Tf 0.5132 0 TD -0.0215 Tc [(cant)-453.5(assoc)-5.3(i)-0.2(at)-5.9(ions)-451.2(we)-5.3(re)-452.9(f)-5(o)1.1(und)-450.4(a)-2.2(mong)-452.7(the)-452.9(S)-1.1(NPs)]TJ -6.8747 -1.2055 TD -0.0219 Tc [(lo)-5.3(cated)-420.9(i)-0.6(n)-417.8(b)0.7(o)-5.3(t)-0.4(h)-415.9(t)-0.4(h)-4.1(e)]TJ /F10 1 Tf 8.0623 0 TD -0.0192 Tc [(pf)6.1(dhfr)]TJ /F9 1 Tf 2.6854 0 TD -0.0206 Tc (and)Tj /F10 1 Tf 1.8559 0 TD -0.0255 Tc [(pf)-6.1(d)-8.9(h)-4.8(ps)]TJ /F9 1 Tf 2.8645 0 TD -0.022 Tc [(gene)-5.8(s)-415.9(\()]TJ /F14 1 Tf 0 0 0 rg 2.8287 0 TD -0.02 Tc [(Figure)-416.5(2)]TJ /F9 1 Tf 0 0 0 1 k 3.4791 0 TD -0.0217 Tc [(\).)-418.4(For)-421.6(t)-0.2(he)]TJ /F10 1 Tf -21.776 -1.2114 TD -0.0202 Tc (pfdhfr)Tj /F9 1 Tf 2.5124 0 TD -0.021 Tc [(ge)-4.8(ne,)-244.6(N)1.9(51I)-243(was)-241.8(s)2.8(ig)-4.6(ni)]TJ /F12 1 Tf 7.8176 0 TD 0 Tc ()Tj /F9 1 Tf 0.5132 0 TD -0.0204 Tc [(cantly)-242.7(associated)-240.4(with)-241.3(the)-242.9(S)0(NP)4.5(s)-247.2(\()]TJ ET 0 0 0 rg 267.59 498.16 2.6646 0.22678 re f BT 9.5 0 0 9.5 267.5905 499.2944 Tm 0 0 0 1 k -0.023 Tc (t175)Tj ET 0 0 0 rg 283.294 498.16 3.7417 0.22678 re f BT 9.5 0 0 9.5 283.2944 499.2944 Tm 0 0 0 1 k -0.0221 Tc (c,)Tj -25.0462 -1.2114 TD -0.0199 Tc [(C59R;)-249.5(a)5.3(nd)-245.9(g32)5.6(3)]TJ ET 0 0 0 rg 103.124 486.652 3.9685 0.22675 re f BT 9.5 0 0 9.5 103.1244 487.7857 Tm 0 0 0 1 k -0.0197 Tc [(a,)-243.3(S108)5.8(N\))-243.6(with)-246.6(a)-245.1(D)]TJ /F11 1 Tf 7.2686 0 TD 0 Tc ()Tj /F9 1 Tf 0.4416 0 TD -0.0193 Tc [(value)-241.8(o)3.3(f)-247.5(0)6.2(.8)6.2(4)-244.5(\()1.4(P)-245(<)-242.2(0.05\))-243.2(and)-245.3(1)0.2(.0)]TJ -13.7913 -1.2114 TD -0.0189 Tc [(\(P)-268.5(<)-265.6(0)0.6(.05\),)-266.4(r)-1(e)3.2(s)4.9(pe)3.2(ct)2.6(i)2.4(v)3.5(el)4.3(y)3.5(.)-266.4(Si)]TJ 9.8347 0 TD [(m)5.3(i)2.3(la)6.2(rl)4.2(y,)-266.5(t175)6.5(c)-271.4(w)1.6(a)6.2(s)-269.7(signi)]TJ /F12 1 Tf 8.9336 0 TD 0 Tc ()Tj /F9 1 Tf 0.5132 0 TD -0.0213 Tc [(cantly)-267.5(assoc)-5.1(i)0(at)-5.7(ed)]TJ -19.2815 -1.2114 TD -0.0198 Tc [(with)-228.8(the)-230.4(g)2.6(323a)-227.3(\(0.71,)-231.5(P)-227.6(<)-230.7(0.05\).)-231.5(F)4.9(or)-228.7(the)]TJ /F10 1 Tf 14.943 0 TD -0.0255 Tc [(pf)-6.1(d)-8.9(h)-4.8(ps)]TJ /F9 1 Tf 2.6735 0 TD -0.0198 Tc [(gene,)-225.5(t)-4.2(1)5.7(482g,)-231.5(c)2.3(148)5.7(6g,)]TJ -17.6165 -1.2114 TD -0.0204 Tc [(a17)5.1(94g,)-387.2(a)-1.1(nd)-383.6(g2)5.1(013t)-380.8(formed)-383.6(an)-386.5(LD)-389.4(block.)-387.2(The)-386.2(s)3.4(ole)-386.2(S)0(NP)-389.4(\(t148)5.1(2g,)]TJ T* [(S436)5.2(A\))-250.2(was)-247.1(s)-2.4(igni)]TJ /F12 1 Tf 6.5047 0 TD 0 Tc ()Tj /F9 1 Tf 0.5132 0 TD -0.0202 Tc [(cantly)-248.5(a)5(ssociated)-252.1(with)-247.1(the)-248.7(S)0.2(NP)4.7(s)-253(\()0.5(c148)5.3(6g,)-249.8(A)-1.6(43)5.3(7G;)]TJ -7.018 -1.2055 TD [(a17)5.3(94g,)-255.7(K)1.3(540E)4.7(;)-255.7(a)-0.9(nd)-258.1(g2013t,)-255.7(A)4.4(613S\))-256.1(w)0.4(ith)-253.1(D)]TJ /F11 1 Tf 16.5722 0 TD 0 Tc ()Tj /F9 1 Tf 0.4535 0 TD -0.0207 Tc [(values)-259.4(of)-260.8(0)4.8(.)0.4(75,)-256.2(1.0,)-256.2(and)]TJ -17.0257 -1.2114 TD -0.0203 Tc [(0.73)5.2(,)-434.9(r)-2.4(espectively.)-434.9(The)-439.8(S)0.1(NP)-437(\(t15)5.2(2a\))-435.2(o)2.3(f)-433.5(t)1.2(he)]TJ /F10 1 Tf 17.2644 0 TD -0.0202 Tc (pfdhfr)Tj /F9 1 Tf 2.7033 0 TD -0.0217 Tc [(ge)-5.5(ne)-435.2(en)-5.9(coding)]TJ -19.9678 -1.2114 TD -0.0198 Tc [(N51I)-361.1(wa)5.4(s)-366(s)4(igni)]TJ /F12 1 Tf 5.8662 0 TD 0 Tc ()Tj /F9 1 Tf 0.5073 0 TD -0.02 Tc [(ca)5.2(ntly)-361.7(associated)-359.3(with)-360.3(c1486)5.5(g,)-357(with)-360.3(a)-364.8(D)]TJ /F11 1 Tf 15.6174 0 TD 0 Tc ()Tj /F9 1 Tf 0.561 0 TD -0.0209 Tc [(value)-362.8(o)1.7(f)]TJ -22.5518 -1.2114 TD -0.0219 Tc [(0.68.)-257.4(N)-5(o)-250(a)-2.6(sso)-5.3(c)0.2(iation)-6.1(s)-254.7(w)-1.3(ere)-250.4(d)-3.2(et)-6.3(ecte)-5.7(d)-253.8(fo)-5.3(r)-254.7(t)-0.4(he)-256.4(o)-5.3(t)-0.4(her)-260.6(S)-1.5(NPs)-254.7(o)0.7(f)-256.1(e)0.2(i)-6.6(t)-0.4(her)-260.6(t)-0.4(he)]TJ /F10 1 Tf T* -0.0202 Tc (pfdhfr)Tj /F9 1 Tf 2.5721 0 TD -0.0226 Tc (or)Tj /F10 1 Tf 1.1219 0 TD -0.0255 Tc [(pf)-6.1(d)-8.9(h)-4.8(ps)]TJ /F9 1 Tf 2.7451 0 TD -0.0201 Tc [(gen)-4.3(e)2(s.)]TJ /F1 1 Tf 11.9999 0 0 11.9999 306.1417 520.4408 Tm 0 Tc (DISCUSSION)Tj /F9 1 Tf 9.5 0 0 9.5 306.1417 503.7164 Tm [(The)-330.8(emergence)-340.1(and)-334.1(spread)-339(of)-330.9(Sulfadoxine-Pyrimethamine)-345.5(\(SP\))]TJ 0 -1.2114 TD [(resistance)-416.7(has)-416.5(narrowed)-418.1(its)-410.8(usage)-418.8(to)-409.4(IPTp)-417.7(and)-411.7(IPTi)-415.2(in)-416.4(Africa)]TJ 0 -1.2055 TD (\()Tj 0 0 0 0.7 k 0.3461 0 TD [(Rieckmann)-355.6(and)-357.9(Cheng,)-360.8(2002)]TJ 0 0 0 1 k 11.8339 0 TD [(\).)-358(In)-355.3(2019,)-360.5(the)-356.3(WHO)-355.7(covered)-359.3(33)]TJ -12.18 -1.2114 TD [(African)-489.1(countries)-494.4(for)-486.1(IPTp,)-492.2(in)-488(which)-485.3(at)-490.3(least)-486.8(nearly)-488(62%)-488.1(of)]TJ T* [(pregnant)-323.9(women)-324.3(received)-326.5(a)]TJ /F12 1 Tf 11.5235 0 TD ()Tj /F9 1 Tf 0.5311 0 TD [(rst)-318.7(dose)-324.5(of)-319(IPTp)-322.3(\(of)-262.4(four)-324.2(doses)-318.6(of)]TJ -12.0547 -1.2114 TD [(ITPp\)\))-334.5(\()]TJ 0 0 0 0.7 k 3.3956 0 TD [(World)-328.1(Health)-335.6(Organization,)-339.5(2020)]TJ 0 0 0 1 k 13.6898 0 TD [(\).)-334.2(The)-330.8(presents)-335.4(study)]TJ -17.0854 -1.2114 TD [(aimed)-401.6(to)-397.5(determine)-404.9(the)-398.1(prevalence)-402.9(of)-396.6(SP)-402.2(resistance-associated)]TJ /F10 1 Tf T* (pfdhfr)Tj /F9 1 Tf 2.6914 0 TD (and)Tj /F10 1 Tf 1.7903 0 TD (pfdhps)Tj /F9 1 Tf 2.8704 0 TD [(genes)-299.5(in)]TJ /F10 1 Tf 3.5866 0 TD [(P.)-299.2(falciparum)]TJ /F9 1 Tf 5.6633 0 TD [(isolated)-298.9(from)-294.7(returned)]TJ -16.602 -1.2114 TD [(mi)-14.1(gr)-7.5(an)-12.6(t)-509.6(w)-9.3(or)-7.3(ke)-14(rs)-519.2(fr)-7.4(o)-7.3(m)-512.8(Af)-12.6(ri)-8.6(c)-7.7(a)-511.9(re)-13.7(por)-12.4(t)-8.3(e)-7.7(d)-512.4(i)0(n)-511.9(C)-6.4(hi)-14.6(na)-12.6(.)-510.1(T)-6.6(he)-515.1(st)-14.3(ud)-10.3(y)]TJ 0 -1.2055 TD [(showed)-453.3(the)]TJ /F10 1 Tf 5.168 0 TD (pfdhfr)Tj /F9 1 Tf 2.8466 0 TD [(triple)-454.1(haplotype)-458.2(mutation)-455.6(\()]TJ ET 0 0 0 rg 490.904 399.118 16.838 0.22678 re f BT /F14 1 Tf 9.5 0 0 9.5 490.9038 400.2519 Tm 0 0 0 1 k (IRN)Tj /F9 1 Tf 1.7724 0 TD [(,)-450.4(including)]TJ -21.221 -1.2114 TD [(N51I,)-294.2(C59R,)-293.2(S108N\))-295.2(was)-294.4(highly)-292.9(prevalent,)-297.2(which)-294.3(was)-294.4(similar)-296.5(to)]TJ T* [(other)-250.2(publications)-250.3(concerning)-249.5(African)-250.4(isolates)-252(\()]TJ 0 0 0 0.7 k 18.9234 0 TD [(Jiang)-249.7(et)-242.8(al.,)-249.6(2019)]TJ 0 0 0 1 k 6.5167 0 TD (;)Tj 0 0 0 0.7 k -25.4401 -1.2114 TD [(Gikunju)-232.9(et)-236.8(al.,)-231.7(2020)]TJ 0 0 0 1 k 7.752 0 TD (;)Tj 0 0 0 0.7 k 0.4476 0 TD [(Quan)-233.6(et)-236.8(al.,)-231.7(2020)]TJ 0 0 0 1 k 6.6957 0 TD [(\).)-238.7(This)-230.2(high)-237.1(prevalence)-235.8(was)]TJ -14.8953 -1.2114 TD [(also)-376.6(found)-379.1(in)-380.6(the)-374.2(migrant)-382.7(workers)-376.8(returning)-381.5(to)-379.6(Guangxi)-379.6(from)]TJ T* [(Ghana,)-290.9(suggesting)-287(that)-289.9(SP)-282.9(resistant)-290.3(genotype)-291.9(was)-288.4(widespread)-292.1(in)]TJ 0 -1.2055 TD [(Central)-292.4(and)-286.3(West)-289.3(Africa)-290.1(\()]TJ 0 0 0 0.7 k 10.4732 0 TD [(Zhao)-290.3(et)-284.6(al.,)-291.3(2020)]TJ 0 0 0 1 k 6.6838 0 TD [(\).)-286.4(It)-290(was)-288.4(noted)]TJ /F10 1 Tf 6.1109 0 TD (pfdhfr)Tj /F9 1 Tf -23.2679 -1.2114 TD 0.0264 Tc [(I16)4.1(4)-1.8(L,)-531.4(w)5.2(h)-3.6(ich)-528.7(w)5.2(as)-528.6(a)3.9(l)-4.1(so)-523.9(associated)-527.8(with)-522.7(high)-522.7(resista)3.9(n)-5.5(ce)-524.4(to)]TJ T* 0 Tc [(cy)-9.2(clo)-9.6(gua)-11.3(nil)-11.2(,)-504.1(w)0(a)-7.9(s)-507.3(det)-9.2(ec)-9.4(ted)-510.5(in)-511.9(Gh)-8.2(ana)-11.3(ia)-7.2(n)-503.3(i)-8.5(sol)-7.9(at)-7(es)-7.7(,)-504.1(b)-7.3(ut)-508.8(wa)-7.9(s)-507.3(not)]TJ T* [(found)-367.2(in)-368.7(our)-364.5(study)-372.3(\()]TJ 0 0 0 0.7 k 8.5337 0 TD [(Zhao)-367.8(et)-368.1(al.,)-368.9(2020)]TJ 0 0 0 1 k 6.9225 0 TD [(\).)-370(It)-361.6(is)-366.6(worth)-371.1(noting)-363.9(that)]TJ -15.4562 -1.2114 TD [(I164L)-342.7(is)-342.8(common)-345.7(in)-344.8(East)-346.1(Africa)-349.8(and)-346(Asia)-340.7(\()]TJ 0 0 0 0.7 k 17.7776 0 TD [(Basuki)-348.7(et)-338.3(al.,)-345(2018)]TJ 0 0 0 1 k 7.4476 0 TD (,;)Tj 0 0 0 0.7 k -25.2253 -1.2114 TD [(Lynch)-321.8(et)-320.4(al.,)-315.2(2017)]TJ 0 0 0 1 k 7.197 0 TD [(\),)-316.2(but)-319.1(rarely)-324.8(seen)-321.8(in)-320.9(Central)-316.2(and)-322.1(West)-319.2(Africa.)]TJ -7.197 -1.2114 TD [(One)-231.6(of)-223.5(the)-231(explanations)-233.5(was)-228.8(that)-230.2(this)-225.9(mutation)-234.8(site)-227.5(carries)-231.6(a)-231.4(high)]TJ /F12 1 Tf 0 -1.2055 TD ()Tj /F9 1 Tf 0.5311 0 TD [(tness)-215.1(cost)-214.3(to)-212.5(the)-213.1(parasite)-218(and)-208.8(therefore)-219.3(it)-213.8(is)-211.5(unable)-212.4(to)-212.5(survive)-221.4(the)]TJ -0.5311 -1.2114 TD [(immune)-392.7(response)-388(of)-390.6(hosts)-385.7(in)-386.6(West)-390.8(Africa)-391.6(\()]TJ 0 0 0 0.7 k 18.0701 0 TD [(Nzila)-392.5(et)-386(al.,)-392.8(2002)]TJ 0 0 0 1 k 7.0299 0 TD (\).)Tj -25.1 -1.2114 TD [(Further)-223.5(studies)-225.9(are)-221.2(needed)-226.5(to)-224.4(assess)-221.3(the)-225(ef)62.5(fect)-222.1(of)-223.5(this)-219.9(mutation)-222.9(on)]TJ T* [(the)-302.6(phenotype)-301.6(of)-301.1(parasites)-307.6(carrying)-300.5(this)-303.5(haplotype.)]TJ 1.2651 -1.2114 TD [(Mutations)-311.1(in)]TJ /F10 1 Tf 5.532 0 TD (pfdhps)Tj /F9 1 Tf 2.8824 0 TD [(haplotypes)-315(at)-305.3(S436A)-314.3(and)-310.2(K540E,)-309.7(which)]TJ -9.6795 -1.2114 TD [(are)-316.7(associated)-316.5(with)-318.7(decreased)-320.3(parasite)-319.5(sensitivity)-317.7(to)-313.9(Sulfadoxine)]TJ 0 -1.2055 TD [(drugs)-435.6(\()]TJ 0 0 0 0.7 k 3.0077 0 TD [(Berglez)-432.9(et)-433.8(al.,)-440.5(2004)]TJ 0 0 0 1 k 7.9668 0 TD [(\),)-435.6(carried)-433.6(a)-434.3(higher)-435.8(allele)-439.7(frequency,)]TJ -10.9745 -1.2114 TD [(which)-264.5(was)-264.6(also)-263.2(found)-259.7(in)-267.2(Uganda)-261.7(and)-268.4(Tanzania)-261.6(\()]TJ 0 0 0 0.7 k 19.377 0 TD [(Alifrangis)-265.4(et)-260.7(al.,)]TJ -19.377 -1.2114 TD (2009)Tj 0 0 0 1 k 1.9156 0 TD (;)Tj 0 0 0 0.7 k 0.5013 0 TD [(Mbonye)-280.6(et)-284.6(al.,)-279.4(2015)]TJ 0 0 0 1 k 7.9012 0 TD [(\).)-286.4(The)-283(WHO)-278.1(recommended)-288.4(that)-284(IPTp)]TJ -10.3181 -1.2114 TD [(should)-221.3(not)-220.5(implemented)-231.2(in)-219.5(the)-219(regions)-224.1(when)-222.1(K540E)-223.4(exceed)-224.4(50%;)]TJ T* [(in)-291.1(our)-292.9(study,)-297.5(this)-291.5(mutation)-300.5(was)-288.4(present)-299.5(at)-293.4(27.67%,)-293.6(which)-294.3(might)]TJ T* [(favor)-223.7(the)-219(continued)-221.1(ef)]TJ /F12 1 Tf 8.6292 0 TD ()Tj /F9 1 Tf 0.5311 0 TD [(cacy)-218.5(of)-217.5(IPTp)-226.8(treatment)-219.7(in)-219.5(these)-220.8(countries.)]TJ -9.1604 -1.2114 TD [(Another)-347(mutation,)-345.1(A581G,)-351.6(is)-342.8(considered)-349.7(to)-343.8(have)-348.1(an)-346.8(important)]TJ 0 -1.2055 TD [(modulatory)-260.3(role)-260.3(in)-261.2(SP)-259(resistance.)-264.4(IPTp)-262.6(and)-262.5(SP)-259(could)-258.7(not)-262.3(protect)]TJ 0 -1.2114 TD [(pregnant)-288.1(women)-288.5(from)-282.8(delivering)-294.1(low)-279.8(birth)-286.8(weight)-286.1(infants)-289.6(when)]TJ T* [(the)-260.8(frequency)-269.2(of)-259.3(this)-261.7(mutation)-264.7(is)-259.2(above)-267(10%)-261.3(\()]TJ 0 0 0 0.7 k 18.1894 0 TD [(Chico)-262.8(et)-260.7(al.,)-267.5(2015)]TJ 0 0 0 1 k 6.9106 0 TD (\).)Tj -25.1 -1.2114 TD [(In)-271.8(our)-275(study,)-279.6(the)-272.8(frequency)-281.2(of)-271.2(this)-273.6(mutation)-276.6(was)-276.5(8.81%)-274.5(and)-274.4(half)]TJ ET 0 0 0 0.7 k 45.354 547.313 504.567 0.22681 re f 45.354 706.053 504.567 0.28351 re f 45.354 687.798 504.567 0.28351 re f BT /F1 1 Tf 6.9999 0 0 6.9999 45.3543 712.2896 Tm 0 0 0 1 k [(TABLE)-301(3)-428(|)]TJ /F6 1 Tf 5.1349 0 TD (Continued)Tj /F1 1 Tf -5.1349 -2.6079 TD [(Region)-5618.6(No.)-306.5(samples)-5124.2(Country)-5121.6(No.)-298.4(samples)-3237.1(No.)-306.5(of)-297(mutations)]TJ /F2 1 Tf 49.0079 0 TD (pfdhfr/pfdhps)Tj /F1 1 Tf 6.8438 0 TD [(genotypes)-3241.1(No.)-298.4(of)-305.1(genotypes)]TJ /F6 1 Tf -14.2788 -2.4621 TD (4)Tj ET 0 0 0 rg 388.403 675.666 11.112 0.28351 re f BT 6.9999 0 0 6.9999 388.403 676.7998 Tm 0 0 0 1 k (IRN/ISA)Tj ET 0 0 0 rg 412.044 675.666 4.0819 0.28351 re f BT 6.9999 0 0 6.9999 412.044 676.7998 Tm 0 0 0 1 k [(EAA)-13555.4(1)]TJ -10.8123 -1.3526 TD (5)Tj ET 0 0 0 rg 388.403 666.198 11.112 0.22681 re f BT 6.9999 0 0 6.9999 388.403 667.3321 Tm 0 0 0 1 k (IRN/I)Tj ET 0 0 0 rg 403.313 666.198 9.5244 0.22681 re f BT 6.9999 0 0 6.9999 403.3133 667.3321 Tm 0 0 0 1 k [(AGKAA)-13376.7(2)]TJ -9.5651 -1.3607 TD (5)Tj ET 0 0 0 rg 388.403 656.674 11.112 0.28345 re f BT 6.9999 0 0 6.9999 388.403 657.8077 Tm 0 0 0 1 k (IRN/)Tj ET 0 0 0 rg 401.783 656.674 8.4472 0.28345 re f BT 6.9999 0 0 6.9999 401.7826 657.8077 Tm 0 0 0 1 k [(VAAKAA)-13126.4(1)]TJ -9.3464 -1.3606 TD (6)Tj ET 0 0 0 rg 388.403 647.206 11.112 0.22668 re f BT 6.9999 0 0 6.9999 388.403 648.2833 Tm 0 0 0 1 k (IRN/)Tj ET 0 0 0 rg 401.783 647.206 8.4472 0.22668 re f BT 6.9999 0 0 6.9999 401.7826 648.2833 Tm 0 0 0 1 k (VAAK)Tj ET 0 0 0 rg 419.131 647.433 m 424.29 647.433 l 424.29 647.206 l 419.131 647.206 l f* BT 6.9999 0 0 6.9999 419.1306 648.2833 Tm 0 0 0 1 k [(GA)-13012(1)]TJ -35.3365 -1.3526 TD [(DR)-301.1(Congo)-8608.7(28)-9271(2)]TJ ET 0 0 0 rg 388.403 637.682 1.5307 0.22675 re f BT 6.9999 0 0 6.9999 388.403 638.8156 Tm 0 0 0 1 k (IC)Tj ET 0 0 0 rg 394.809 637.682 7.1433 0.22675 re f BT 6.9999 0 0 6.9999 394.8094 638.8156 Tm 0 0 0 1 k [(N/ISAKAA)-13468.6(1)]TJ -8.3502 -1.3606 TD 6.883 Tc (2N)Tj ET 0 0 0 rg 393.279 628.157 11.849 0.28345 re f BT 6.9999 0 0 6.9999 393.2786 629.2912 Tm 0 0 0 1 k 0 Tc [(RN/ISAKAA)-13021.3(1)]TJ -8.1315 -1.3526 TD (3)Tj ET 0 0 0 rg 388.403 618.69 13.38 0.22681 re f BT 6.9999 0 0 6.9999 388.403 619.8235 Tm 0 0 0 1 k [(IRN/ISAKAA)-13499.8(6)]TJ -7.435 -1.3607 TD 6.883 Tc (3N)Tj ET 0 0 0 rg 393.279 609.165 11.849 0.28345 re f BT 6.9999 0 0 6.9999 393.2786 610.2991 Tm 0 0 0 1 k 0 Tc (RN/ISA)Tj ET 0 0 0 rg 415.389 609.165 4.0819 0.28345 re f BT 6.9999 0 0 6.9999 415.3889 610.2991 Tm 0 0 0 1 k [(EAA)-13077.5(1)]TJ -11.2902 -1.3526 TD (3)Tj ET 0 0 0 rg 388.403 599.698 1.5307 0.22675 re f BT 6.9999 0 0 6.9999 388.403 600.8314 Tm 0 0 0 1 k (IC)Tj ET 0 0 0 rg 394.809 599.698 4.9323 0.22675 re f BT 6.9999 0 0 6.9999 394.8094 600.8314 Tm 0 0 0 1 k (N/ISA)Tj ET 0 0 0 rg 412.271 599.698 4.0819 0.22675 re f BT 6.9999 0 0 6.9999 412.2708 600.8314 Tm 0 0 0 1 k [(EAA)-13523(3)]TJ -10.8447 -1.3606 TD (4)Tj ET 0 0 0 rg 388.403 590.173 11.112 0.28345 re f BT 6.9999 0 0 6.9999 388.403 591.3069 Tm 0 0 0 1 k (IRN/I)Tj ET 0 0 0 rg 403.313 590.173 4.3654 0.28345 re f BT 6.9999 0 0 6.9999 403.3133 591.3069 Tm 0 0 0 1 k [(AAKAA)-13490.7(1)]TJ -9.5651 -1.3607 TD (4)Tj ET 0 0 0 rg 388.403 580.705 11.112 0.22681 re f BT 6.9999 0 0 6.9999 388.403 581.7825 Tm 0 0 0 1 k (IRN/)Tj ET 0 0 0 rg 401.783 580.705 1.5307 0.22681 re f BT 6.9999 0 0 6.9999 401.7826 581.7825 Tm 0 0 0 1 k (IS)Tj ET 0 0 0 rg 407.679 580.705 5.1591 0.22681 re f BT 6.9999 0 0 6.9999 407.6786 581.7825 Tm 0 0 0 1 k [(GKAA)-13378(3)]TJ -10.1887 -1.3526 TD (4)Tj ET 0 0 0 rg 388.403 571.181 1.5307 0.22675 re f BT 6.9999 0 0 6.9999 388.403 572.3148 Tm 0 0 0 1 k (IC)Tj ET 0 0 0 rg 394.809 571.181 4.9323 0.22675 re f BT 6.9999 0 0 6.9999 394.8094 572.3148 Tm 0 0 0 1 k (N/ISA)Tj ET 0 0 0 rg 412.271 571.408 m 421.512 571.408 l 421.512 571.181 l 412.271 571.181 l f* BT 6.9999 0 0 6.9999 412.2708 572.3148 Tm 0 0 0 1 k [(EGA)-13409(1)]TJ -10.8447 -1.3607 TD (4)Tj ET 0 0 0 rg 388.403 561.657 11.112 0.28345 re f BT 6.9999 0 0 6.9999 388.403 562.7904 Tm 0 0 0 1 k (IRN/ISA)Tj ET 0 0 0 rg 412.044 561.657 4.0819 0.28345 re f BT 6.9999 0 0 6.9999 412.044 562.7904 Tm 0 0 0 1 k [(EAA)-13555.4(9)]TJ -10.8123 -1.3526 TD (5)Tj ET 0 0 0 rg 388.403 552.189 11.112 0.22675 re f BT 6.9999 0 0 6.9999 388.403 553.3227 Tm 0 0 0 1 k (IRN/I)Tj ET 0 0 0 rg 403.313 552.189 9.5244 0.22675 re f BT 6.9999 0 0 6.9999 403.3133 553.3227 Tm 0 0 0 1 k [(AGKAA)-13376.7(2)]TJ ET 0 0 0 0.7 k 45.354 368.504 m 289.134 368.504 l 288.907 368.277 l 45.581 368.277 l f* 289.134 368.504 m 289.134 67.351 l 288.907 67.578 l 288.907 368.277 l f* 289.134 67.351 m 45.354 67.351 l 45.581 67.578 l 288.907 67.578 l f* 45.354 67.351 m 45.354 368.504 l 45.581 368.277 l 45.581 67.578 l f* q 53.858 350.759 m 280.63 350.759 l 280.63 151.087 l 53.858 151.087 l W n q 226.771591 0 0 199.672424 53.858257 151.086548 cm /Im2 Do Q Q BT /F1 1 Tf 6.9999 0 0 6.9999 50.6268 130.0535 Tm 0 0 0 1 k [(FIGURE)-299.4(2)]TJ /F6 1 Tf 5.0053 0 TD -0.0307 Tc [(|)-460.6(L)-1.8(in)-9.9(kag)-5.1(e)-241.5(di)-7.6(se)-6.6(quil)-7.6(ibri)-7.6(um)-237.3(\(LD)-9.7(\))-237.1(a)-6.7(n)-1.8(al)-7.6(ysi)-7.6(s)-240.1(of)]TJ /F5 1 Tf 15.7609 0 TD -0.0223 Tc [(pf)9(d)7.1(h)6.6(fr)]TJ /F6 1 Tf 2.5593 0 TD -0.0265 Tc (and)Tj /F5 1 Tf 1.7737 0 TD -0.0297 Tc [(pfdh)-8.9(ps)]TJ /F6 1 Tf 3.0453 0 TD -0.0256 Tc [(SN)7.3(Ps.)-233.5(F)3.3(or)]TJ -28.1445 -1.3526 TD -0.0304 Tc (the)Tj /F5 1 Tf 1.4821 0 TD -0.03 Tc [(pf)-6.8(dhfr)]TJ /F6 1 Tf 2.5593 0 TD -0.0285 Tc [(gene,)-236.3(t)-4.8(he)-239.3(single)-239.3(amino)-237.8(a)-4.4(ci)-5.4(d)-242.1(m)-0.2(utat)]TJ 13.3474 0 TD -0.0265 Tc [(i)4.7(o)-0.9(ns)-235.9(were)-237.3(N)6.4(51I)5.2(,)-242.4(C)6.4(59R)7.8(,)-242.4(a)-2.5(nd)-232(S10)7.2(8)-0.9(N,)]TJ -17.3888 -1.3607 TD -0.024 Tc [(r)4.5(e)8.2(sp)5.4(e)8.2(c)0.1(t)7.8(i)-0.9(v)4.7(e)8.2(ly)4.7(.)-231.8(L)4.9(ik)6.2(e)8.2(w)2.3(i)7.2(s)1.5(e,)]TJ /F5 1 Tf 8.9819 0 TD -0.0293 Tc [(pf)-6.1(dhps)]TJ /F6 1 Tf 3.0453 0 TD -0.0259 Tc [(gene)-236.7(a)6.3(r)2.6(e)-236.7(r)2.6(el)5.3(at)5.9(ed)-239.5(t)5.9(o)-235.2(the)-236.7(m)2.4(uta)6.2(t)-2.2(i)5.3(o)-0.3(ns)-235.3(S4)7.8(36)7.8(A,)-241.9(A)7.9(437)7.8(G,)]TJ -12.0272 -1.3526 TD -0.0306 Tc [(K54)-5(0)-5(E)1.7(,)-246.5(a)1.6(nd)-244.2(A)-4.9(6)3.1(1)-5(3)-5(S)3.2(,)-246.5(r)-2.1(es)-5.2(pe)-6.5(ct)-6.9(ive)-6.5(l)0.6(y.)-246.5(The)-241.4(d)-9.3(ark)-243.3(a)1.6(n)-9.8(d)-236.1(l)-7.5(i)0.6(g)-5(h)-1.7(t)-241.7(r)-2.1(ed)-244.2(s)-5.2(q)-1.2(ua)-6.6(res)-240(i)-7.5(ndic)-6.5(at)-6.9(e)-241.4(a)-241.4(l)0.6(i)-7.5(n)-1.7(kag)-5(e)]TJ 0 -1.3607 TD -0.0317 Tc [(tha)-7.6(t)-242.8(w)-5.4(a)0.5(s)-241.1(s)-6.3(ta)-7.6(ti)-8.6(st)-8(ic)-7.6(all)-8.6(y)-237.8(s)-6.3(i)-0.5(g)-6.1(n)-2.8(i)]TJ /F7 1 Tf 9.808 0 TD 0 Tc ()Tj /F6 1 Tf 0.405 0 TD -0.0289 Tc [(cant)-240(\(P)-238.1(<)-245.8(0)-3.3(.)6.2(05\).)-236.7(C)-4.1(amb)-7.6(r)-0.4(idge)-239.7(bl)-5.8(ue)-239.7(sq)-7.6(uares)-238.3(i)2.3(nd)-7.6(icate)-247.8(a)]TJ -10.213 -1.3526 TD -0.0313 Tc [(link)-9.1(a)0.9(g)-5.7(e)-242.1(tha)-7.2(t)-242.4(is)-248.8(pres)-5.9(ent)-250.5(b)-1.9(ut)-242.4(is)-248.8(not)-242.4(s)-5.9(ta)-7.2(ti)-8.2(st)-7.6(ic)-7.2(al)-8.2(ly)-245.5(si)-8.2(gni)]TJ /F7 1 Tf 18.9277 0 TD 0 Tc ()Tj /F6 1 Tf 0.405 0 TD -0.0264 Tc [(ca)5.8(nt)-237.5(\(P)-243.7(>)-235.2(0)-0.8(.0)7.3(5\).)-234.2(A)-243.7(w)8(h)2.5(it)5.4(e)-237.2(s)-1(q)3(u)2.5(are)]TJ -19.3326 -1.3607 TD -0.0314 Tc [(wi)-8.3(th)-245.5(ind)-10.1(i)-0.2(ca)-7.3(te)-7.3(s)-240.8(t)-7.7(hat)-242.5(n)-2.5(o)-248.8(linka)-7.3(g)-5.8(e)-242.2(is)-240.8(p)-10.1(r)-2.9(es)-6(ent)-7.7(.)]TJ ET 0 0 0 0.7 k 45.354 737.518 504.567 0.28345 re f BT 6.9999 0 0 6.9999 45.3543 744.2644 Tm 0 Tc [(Yan)-298.8(et)-300.5(al.)]TJ /F5 1 Tf 53.0817 0 TD (pfdhfr)Tj /F6 1 Tf 2.4864 0 TD (/)Tj /F5 1 Tf 0.324 0 TD (pfdhps)Tj /F6 1 Tf 3.2802 0 TD [(Mutations)-303(in)-304.4(Chinese)-298.8(Migrants)]TJ ET 45.354 42.803 504.567 0.22675 re f 45.354 42.803 504.567 0.22675 re f BT 6.9999 0 0 6.9999 45.3543 31.2945 Tm [(Frontiers)-306.1(in)-296.3(Cellular)-302.6(and)-306.5(Infection)-301.5(Microbiology)-499.5(|)-502.8(www.frontiersin.org)-22490(September)-305.7(2021)-505.2(|)-494.7(Volume)-307.7(11)-499.6(|)-494.7(Article)-305.6(673194)]TJ 35.7658 0 TD (6)Tj ET endstream endobj 81 0 obj<>stream Adobed       @  s!1AQa"q2B#R3b$r%C4Scs5D'6Tdt& EFVU(eufv7GWgw8HXhx)9IYiy*:JZjzm!1AQa"q2#BRbr3$4CS%cs5DT &6E'dtU7()󄔤euFVfvGWgw8HXhx9IYiy*:JZjz ?yK7b]v*HV Ѓim֞MRؽ'c !OZ4CO/hR:;MT[{A$GGMU?KnOa8ۿSX4TGc-U?KnOa8ۿSX4TGc-U?KnOa8ۿSX4TGc-U?KnOa8ۿSX4TGc-U?Ko.'ʹ'IRM#E'M\M=- E~ƓhTGc-U?KnOa8ۿSX4TGc-^HGV*j*[y-7w%V{+cHʨ9c&* qʧ?im,?[m*|qE9M;i4dL!+JzVثWb]v*UثWbXWI2ѯDDŽsRo"/ nX3a@n+8y u~*G]QuF*U1WTb]QuF*U1WTb]QuF*U1WTb]QuF*U1WTb]QuF*U1WTb]QuF*U1WTb]QuF*U1WTbZ'x_+~wvoA?0!5~㊷Q㊺1WTb]QuF*U1WTb]QxL~R\ u/z4 **⮮*⮨Z$m^?e~CZgqZ9UunE1W r:k+dUثWb]v*UثWb.k_:U2],|~"0*:l{/Dq[H=Cq:kLnڍyvoZ4s)nfW L>P%/WYҧK׺덭;%kKG֝?}Կ{\mi/^_=6u/ZwK׺덭5k:5c֘Q[i:|]Ǩ_ b7ĊM4+M"YmЕI0#鍔zoYZӇh)sR޻\mi#kN j_=6#kN j_=6#kN j_=6#kN j_=6#kN j_=6#kN j_=6#kN j_=6#kN j_=6#kN j_=6#kN j_=6#kN j_=6#kN j_=6#kN j_=6#kN j_=6#kN j_=6#kN j_=6#kN j_=6#kN j_=6#kN j_=6#kN j_=6#kN j_=6#kN j_=6#kN j_=6#kN j_=6#kN j_=6#kN7_5/Zo |Կ{\mi`cYw֘{i瘍z D]zvhW(`/fUZiS%kKG֝#kN Rq{GsQ>wټkmm%λ-&wGNZcX/w}{.dMzJ)'Zx ]?|Կ{\mi/^_=6u/Zh:7ej jf?ZH|3F5n&Twa'evzUثWb]v*UثWbR7+1*aaOĿ*QX~\,F=ݡ'{aTn-I;|**UثWb\ 1TYlu`[]xQq zNK0FB?v/O~`pFv*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UT(:1TPbĆ&@J\>M"IG*m%n 䕾)~ރZVּ: 2noooU&uj;nQBhg~`kd-q,muuXbŭ66YAS I~xSv*UثWb]v*UثWb]]YZ(#b{|U"sGyZiqVu'¬B",qHQTtv*UثW(*jްd cG?G *" v*Uî*AOX7Op+Wb]v*UثWb]>nWQUcT9VV\UNOB1TE}KJS-X, z]ٸ'lUb0**UثWb]$v&pqTڶqرES]/VӵhLr|C {N/v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثVr;/v=1Tt^A0/0zz^auYJ1C|TIҭ$ehHE5wL \v'|U*^aL3M$d U6;OZ[BRIN*u{ocg5"vGe˭݁%S UثWb]v*UثWb]Bꚭn&o *YWz#{=4;S~`Wb]v*UꏧXV{p}+hrW®[O<6}?v*Uث\U"& DžS UثWb]v*UثWbO_0mb_Պ`WbF*z}*{ؙG~U2ӵ+MJnmZ$gfFUb1TNv*UثWb[V 튥:⺐^i-Q%Mø8mT|r4f?^sܾWNFkv*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]l#PS)p©ryzy4y(Thy4<9uS= DijRO-U֋.eŵ =(Uw*k*ab0YX(A\*|cc +P"\3$l 4R^o:$ڑ6p|V48R5v*UثWb]v*UثWb]5rJH/u+KK5ܱfQPV8bOjJوvUتrI=p+Wb]v*+%. U ƠU4m5?©$ثWb]uR(?`xU=]v*UثWb]v*Q]GU!S %Xv*Uj1TTn^  p tZT%d_hgUa튣0+Wb]v*UFF%'تH?Lyr67٦=aTP[)Dзq#V]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*U{}8} ?># U,>m2t]=XY>~U_ZRɼ 0?.RzBZCK⩂"Q(&~t ݂"cMHK][y~߶f8p|]:$C`pҨ_8޿n*WEycG{qLHmaS((0+djz[Tf4*_ckj-oIǶT,z&][{XM89lk R ~xv*Uثj>϶*s@?P/*āA`VWb]v*UثWb]mTAsqrFG.oznQViFDdrs!ǭN*]v*UثT+LkDVԙ[e \fKQX'Mo" n]v*UثWb]v*UثWb]v*UثWb]v* 4W/ ^ԋCR6i-`S@4bupИ-t~ڰ_c㊢m/,(>T{E)iۡq$Wb IPzi⑾@aT-rO߷XkU7?N%AXu8$MO\ UثWbg+ ]NRUilVZBzm㊢+Wb]v*UثWb]f!QEY㊱NZhbSP[? vgڋ[Euw;ԱqTFv*UثWb]#]@*iֲuijt:g }~P0 f$VWb]v*Uî*k{0qTv*UثWb]v*UتSEuW&0L,?gbثWb]K5HmH7]VSVhἑz8SSv*UثWb]dhNU!Dt> m:S^cQNc3D?me\`z`Ac]v*UثWb]v*UثWb]v*UثWbAn`G:*^yEp{հ.> n}';;x:;2U~Wwr!ݡk֓;+K;1°FUFX=qVWb]]ZXfbA1ݽf^:\?T[AIhl*Xouy-rdjNUثWbW(gob{Fmbmj@LzQlTI']v*UثWb]v*d6V  Ufӆ\i%,AFO`[{d‚l v*UثWb]b{fgo©Žv[ *>X~*UثWb]p늤p½8y]v*UثWb]v*U)wBʹK**UثWb]@<:G'3o[T]̧O*5d隢}_S?O*A]v*UثWbT6o{2P6 xߥJ?qTh$B3qWb]v*UثWb]v*UثWb]m^R3uMڦzv鑘ҿD$v*UثQ&u1w4*y.ZnPx,XxL4Y̷Z\챟WT kv*UثWbR_3hzsq5۩BZEi@*UثWb]v*UثWbWwy zsKg{'umpkC(_aVBTE *UثWb]v*54oyCws *^nTOjbv*UثWb]p늤P8{]v*UثWb]v*U)wBʹI**UثWb]v*մ]VIxve8UjPG ims/lU:`A]v*UثWbV7%XWlU!Oմ K}1sMVTf2 * ثWb]v*UثWb]v*<[aM`/([4da Ĝt#Գ/@?Ƙ5nqTb3GҴe*~Ux kv*UثWb'~1TR,01#hxJثɮrLoi?ߓ b[{`VWb]v*UثWEL ثWb]v*UثWbR7]GU !S %X[v*UثWb]v*MN-in6enU-.t5'6 Tl,5xG7MF*48UثWb]v*UثW\U }iQ\}7?p©Tfe&ͫ엤GъIkm_F1Ċ* #KFKhEcRf㊦!W_ *UثWb] b-O\4bORsh>U-H5v"vMكbaB!"3I5=qWb]v*UثWSLU!omаTEUtv*UثWb]v*U/ֵXjsև *4I>5=U|۪?`1TMNv*UثWb]v*U( ,ZQ 1iQcnW]v*UثWb\:½8{]v*UثWb]v*UJWV)x|Uz"F"=*v*UثWb]v*UFPIRyOF+)h'k]뇅Ǽ9)miqyr#cXv<+oOeO$;{dR*UثWb]v*g,j>eGLP9cq\!R"~cyGZk iUj׏oliQך]W.hP،USv*UثWb]& Uv{o&}f!(eEdOQ¹.[fZA &Dxr.?F<+oMԬ 4C* W]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*4 əDʊ:qV&ѯ-`Vࣩ48UlWz%̍o{vm 8[]v*UثWbRO=.^TW*޵fdl Ґ^G>i7Bp߶L48(\kWUFuZM=wKh'(KWb]v*UثV'Ϥ_!KC2 xAx2/u%4ZWx)NT'HM)O/ɡ/W"Z\"6up/[SE5H' Yd]v*UثWbWOO_O]p-z̵G5,UyմMG:&-zQqp„%h Guם;= Ɓ[{Kc^}o\[RȔ+Wb]v*Uت_..ieS}qdnS _!_.'|y2JL{.xMԱn2X}/)c%wy RO-Uޅ6* ]67Hҿ0uiuS\v\#̪M9Q xQop BĖwh$N-AUثWb]v*Um뗏\f{ ¯559FzG0 /ƽ'̶k[e5 /셍$bBE״2hUEeÎ+ Y"+Wb]v*UتDV o'sQEI^#Z0Ii}oZwr<ż|@ {¶,IOu$.ď#Ȑv*UثWb]du|0=i3]>۪Bbfۘw{N)-)8G5δ-k-:AO֘ )L a Wb]v*Uثӵ;L\hj3BEA.wE,Ѽ`j~TԚ(~K##PN%@CHj^[^LHI F!Kల 9?U[]v*UثWbX6kڞ_C,wHHfJ%y{_6P-tLqB6a&&_:*iZtHn/<Pg~_|i[]Z7@"R]v*UثWbF{~WEԿ^}& )y5*|r'v*UثWb]shְ* iѿ5'hUNe K14ƊԡZدѿ4gy>9\ <{䷗]Uס)FL4ȫWb]v*Uت18Sb ;Zy]ЗYЮdiU,~&S& z$HsP(pq-'~]c.Sgc3DI$ Je]v*UثWb]EF*ȏ kn-wK&e2FK-?hS%=kAGLq2~[$M"?5i52- d927d{̫5ʫX/A*xWb]v*UyO䬖^uYwe$UE8J(/;|w'.YFdŀ<)LCT^{w噮m<իX.̆)i˒, }3x\06(]v*UثVLU?2~HskGo"moaihy9kSOciL__^y|\hF4]>z(|^xVa|5=&XU1 α7U +Cd]v*UثWbP~b~W k ֩S ^='N:-OsciU/7J!n: a[{/a#ZbT=3v*UثWb]qn yW!u=>ͦsVV@Rn5+yYE!gpxS%‹y>s]|ék-cֺ[aMq{e.Y zhȐ1]v*UثWbz֞^ﭏ+ WY"aV fyzurgXFvj%LmɉMzCJ# FT Í;rŷ-0?u,'H2"C$v*UثWb]ZĮ&6ASj9=k}":{:EX9M2QVMJ'u'Lh"޹st?J4Ͷfӑ!,v*UثWb]hR[VZ'_(In^y&9EC|oeNXZX*!oQk ,cLPrKK H?abE$jARA؎v*UثWb]v*<yY[DthmZo$^o*;~Qj]Cq8x;@n_?~{Vm>]30#䩍tm!rڮ]v*UثWbR6^y*Ahq XciAov; ^A'[V]?2vXOҿszs) UE0HzĪp zdv*UثWb]SPK9AWPwCiǭ~_i %"D6Z)OC-c^zeӭaD1~+QGi3:-rjjw`$xdR]v*UثWbZ+kPqWjqiֿ/R-@sc x\RQ%h?.[>OKH!XAu~//s֑ _MRG .E*ثWb]v*UF3F[VUaӣ:ߑR\-Kklµ ygL;QӴM7w[?MA֞-iŸTh֚R/ȥX Qv*UثWb]54Ni\mb\ۀQ>"v?_}U ǫG?n(C6tdr(G\Z]v*UثWbZ=1W~}>e<4N}E_ֆFMqA`?l_YK S[&0}iHxgg_6J}1Ӊ#&dƙ_\4:1SPÑM=r9"2-QR3(2)Q]v*UثWb]3)4#Dw;\B]`EqWye$0֌7ԍ?H@z&E.]v*UثWb\ [v@Jy?O_.H}Ĩd#ЏSȥثWb]v*UثGLUUUPFث|ȪO-G.GtGWr)[v*UثWb]Gs<aZ.ny!~wYwr1 #$=pDZRv*UثWb]TxÕZ72stPjޥ~`Ou3Shv6-/PE.]v*UثWbUW@jMU C By~g~ciO="%°HwQ]osC5?k\UTl:滴U5 5CJvS'd]KWb]v*UثW;EDʑ9\U޾[M{wD[3ָ>T֣l~_%Xu9.SWb]v*UثWbHD#3ʐ<^mqVe.0H~JMqV/yS\C\H6J^G~C%{!؎2)kv*UثWb]jGėWEq=ww[J+W8O[_-?CI#JNVQA;+,:\]v*UثWbZ#4,0Bjz UmUM~N*3|kb-&]ޥ!4V x2@^̳]*jTqWb]v*UثW98iX`O+>dg$h)%uUj)$WbR|cTDsEcE}{5~J& Y[t9Q]v*UثWb]Mmt4u*|*҂JIb)}YG$ѴR\kSpA!,KWb]v*UثUNjV+tW"V4 P~U埒RL`˚X#>9* Ez풒2)v*UثWb]v*,A\UVŸ\B-m~gѲ$ s <KWb]v*UتK{ n*#xE֮ ^zq,=rJ9:EG֮<7֚_1\tzo]S ]Cq%Νa<7A'+d*UثWb]v*n[`*0Eqůk殶WK6VWt=ԜDuHqdHCl=C kM[i24tG({~_:뗺VA:]v*UثWbGyw楏͍˗ڲ~^lZKdT^TDߛogv-& 1HcPNեr\sQֿ+Bc=-LmctXBToQ ]v*UثWbZXO?zZ%@V+O<5ƈ\! -#jSS({_yg6]>nr91]v*UثWbXǑ|*-A4uIkMMPZR*_?=,ν>ȱU'"DO(ug"^L}r v*UثWb]v*銱8|]LRڭϨ8SDt& ?ޟRW}&ydc=+#q Jc.u0n)CX[ :lT =iݥd)]v*UثV*|0yInnеs:jRUB*:W$ 4qŎT5I4yU6.$EnE/݄GƩvvpTPc JXWb]v*UcvL>V!mlu .* vdAyilյSRKۏQfV0c]<$YPf 6UNB?rJxWb]v*Uت#O4}U[CCYz+KU[7Q;q'E{}}G7*-wSK価܌*UثWb]v*ytucheO/N1{CE յkX\,^;)=ئ^V5O#^JP?!Ҹ]Y_5;}[% UثWb]v*UyOEtn3-d:2/?-Ny3\t?25s :HX?[Rvb:JאGqv}{wZŽSOOJ|9[%UثWb]v*UZK1W_3k+{]{97㻺Fn ^FEڦú6}wS? .睵{tA|AE>yY˰+Wb]v*UتK )^m/ci쭓XWb]v*Uتg<իɧZȱQ Ɗӄ%_2KHue ~ja61)Nn*Ty-T#O\i^a=֏iPP L%\ UثWb]v*5.z̺&ӴtUM+0w~P_y?76qB)TA(k68T[8=i^Ϡi:4KFEAOM?]v*UثWbTm/D5~g *saW~q<ƣqbk+=?JiEJMo*Kf}qzo/^Q|k z{:qAd Wb]v*UثWJccK{^zu|O_1kF"H]!2w$TtXh=]9?6uGJo+|[_:lFh#"P)Wvd Wb]v*UثUH`2Z$UO?&Үuyw~k8 4<^H6OGo%Q`5 +-<2j}Ci4ئ1Z Y?#$MKWb]v*UثVLUqו!G ttgSw^QWF?+t~ܑrTNfj-[-)Il"| 8ثWb]v*U+}2X.襴j؁\!K#常,zlʫNW>[~WilE~d imɚ5vOb,@Iv*UثWb]CKez_\)޸B̿< h%זZ9OFNw>\i+4sxQ\im宧{Vzi0NX%P@ v*UثWb]4U1 Id6(OOaW˭tm j~듦6ܿ>]HL~VX$t9qRVkǢ$c92 UثWb]v*nSg_,\~r~I 4FֿiJ:B͚?7+ KE|ggRMVN~]314KK#j!wxбPFA*UثWb]v*$)hteKJ#tv.e,Ǩ_yƟc*:bk??9GzWٖk& EAblJeiٗ)b]v*UثWb.XbVhge҄^Uƭ_?k2k~]S:&t`'`b殳zӯYR)flJjƫ!( JxWb]v*Uت+N(mWx'O_OW<G7 b뿝>oВA|#̊}i_Dmc8Qg?Wb]v*UثU{7HI%dXA튼K?p愾eJ<6J Tb|[HJ85KZXkUE0ҾҠt]@ԭ;:z ]v*UثWbU-YUݕbR )ž^??6y?ˣìyUX *TLnŊyr7^w˖>P/Hb ؟*i^kMRZEAmUN_F@L+Wb]v*Uت5B\)<5inҠoЪ_[rakϙ8| m !쟗~L -*P+no d UثWb]v*A:ҞͿ /|ѧ^h^huo-[V&XF9WdD~LaR 8ǶEWN ;o1(QwiV ,*]v*UثWbb~y=G 85-+Jn>gH 9-5 =业7OHEBW%H~J2!LnlmȖAUثWb]v*UثG*4NzmL rښLi,G^*(A5l4dR0y~ʫNU#aU-Q0Dׁr Wb]v*UثG*Mz7^NmXKdbjxP^}[L,Nmpxj4ʽ:Xҭ<'P-x^lh+w034u; Wb]v*UثG*GL5^-\_FJjvEZ?r=X9{HA2TM?-h2,M4lrEW4e ,.B)]v*UثWb#͵/lu :JԢ2C< ^Ji2QAy9sr&Ԭ%e:]+[uQBk\"+˽*)K 2#KotWmG֢I;v*UثWb]b?v%WE"$;ES~(KMFuo/!++A0kF%R-3O[&8YT -N'iCԡ[꼅hr +Wb]v*Uثγ%#PϦT@65+ӯ@A5]v*UثWb5$k ŅVud%>!_3:uђK}fSWjd鍲S9q+)%H\im^DʱI+Cbj ;m!O0+Wb]v*Uت"ChZgHU!yVM2yputkv4_;d+o/s,E I)_4Qۍql?FY}r:uS@d.v*UثWb]v*UsEۥޞ aC-@{ ladsyZ[M-#Vo|1O_2im_(Aaw7^"vp똞+CWS= S]v*UثWbU!2Au \ژ 2*5y^?>N@IYկn2t8Oo2~LRCav-'IX|p+G$Ƨ Kv*UثWb]Wf`4)*)e# ⯝52Vd4ʏ'ua eY0N_ert[HǗ[)?1|ou*H%c"im21]+XT *UثWb]v*dqY n**aiQZ˽̋(})FL([_o_.]^ByV9%kD1ةa} op7,ڈ el]v*UثWb@ Ыn |F* m}OMWAi0H=aJ5/:yټ(gHҠB[_6~+-4DaPd/]v*UثWb,$P7^5AeO#yZ+9nXVH}2*!ۗɀz*G--kHwW !k>\u>"+Wb]v*UثjH#Ǧ*_]ZCƞVZmÿ0[&Zr[g-yvzcv{a[| 3̞P&X(P `Wb]v*UثW+4^_&Mz=Gw)[F7N^|2AoRP-YEY.cU7mǶJ-i<]kK]2Ա[(׊,Op+Wb]v*UثFytoARÑ!QY 7'6o"ۘ\[?+y-ibiZIj6 D !dv*UثWb]v*UZ ozm)HEqW˞]M dZ5I~,ي-Gv`ofbGTcpG|h,1"<Q2I2 UثWb]v*ʋ,iH܁hvp<~|o̚]Хy?Eoכ4]R"PcA)Z"YgWb]v*UثTVsn+]*Pw05+rg$ mHdPvө=k b_~eWEfH.kb8f-s!+WnݰH{+2 [v*UثWbZ=1WG^URӤ/PH5_ɭKIME!=9$҆d#*cVvxݤ2A#DOA*XWb]v*Ur2p~] {x0e)@)k қOmeW3iJWl-ۢX'˦ ">f;r oҾ8#5A(]v*UثWb\ b1UswӦثwZ助479 X8UثWb]v*U*oæث_]|Ud1R1UWb]v*UثUq}t(t\o=CY5enDm\UOv*UثWb]v*J#*ٿ=_nf#T*UثWb]v*UY/.Q8+|1U rpVKwq2LUKv*UثWb]v*iኮ7dP!{WR]v*UثWb]wqF=qU^9O{r<1UUثWb]v*UتW3ĥcj\oh\/U=E1UUثWb]v*Uت7C_M^]Ҝ UB)b]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]o87S87S8?wS)]qWp8?UN*wS)]qWp8?wS)]qWp8?UN*wS)]qWp8?UN*wS)]qWp8?Uޛ)]UN*wS8?UN*wS)]qWp8?Uޛ)]qWp8?Uޛ)]Uޛ)]Uޛ)]Uޛ)]UN*]N*MqWp8?UN*wS)]~UN*wqWp8?UN*wS)]qWp8?UN*wS)]Uޛ)]Uޛ)]Uޛ)]Uޛ)]~UN*wS)]qWp?v*|*7[?F_p6 W2\xBۿj7?CU-69W-g?󕟛>gO/DŽ-CU-6ie~nM#/DŽ-sZlgHjDŽ-?F_[w W2\xBۿj7?CU-6ie~nM#/DŽ-sZlLm\<9b}ڸyO.XȔڻ';c"Scjy7`\ /!אݏ/I6ǔ˶'xձ?$Իa"Scj+(O鍫_?$WQxz)1wOvƞLm]EW_G,~^Lm]E)1q?\?6>SASE)1q?\?6>SGK#x~HSE?)1q)(O鍫zyvڵOK?%?6 y'WRO鍫^I~Dձ?$]??6<RO鍫˶x~HrڴGm˖%|=ڼor^XE,. cEiA|SbGp9yiSX?}ysNkcsJ'Q9K_Cեxt}JR1H9Qi*Ml_Ri_- Wb]ݢ[\8@E~UKM?ZxdVv*6[{G;ْI !*U$B;b]k{xZU]i qUP05VF=]u=cAHNMA8#2pҢGq mwW WI b }:9Uwh )Py7OmgY-HBêƕquةTd._-*=Bǭ1UBB;v RqU8.-na[IJ~DbIwc ~nN|UY Z]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb^79gDy(M'ט/I!;o9o9m-m"%Ngn¨O8h\?t;VmQY&k[8^[rTj̕ڠ>Ī5iy/@jKSV`Ԇzmyκwt-=>ZW)?ZjͨǠcnd ZBG\zsڔ‹D~rImy}9KkНd%H$aO>[ΖWuɥ F+lڸ)6:vyeaPl=7iɿ!/#ؙ-l*52Ht!w揕4OmKמ@YtfYdirQ-֧5{7 bCboCN,~Iҽ<ƿ6=M߻z'&YF|K2Ÿ5<0yZK6ApR~+h/"aꚾ[󶚾^Ii &i=!A@yO6ƕ5E7p#'Կ8|VfK9P7Z,^x򇔴+{X[QmZ^r@ PqObkWDMDRWKoTԿ0|{;ktGkn*V"9+E%xjnyt}[hjD*ߵ2P|=+>^59qvПxOa_$~Ik}I-Fi~U+b3\C?Qah[ymP2RiyRHM=sɷ-WP/,o3"Rm)4"6_r.Qy# <{>fϗtrM]O5!#!#n -+͚g֝3˯' @$Bg|1<<]yE+>xء2;"r!%?ZG|e]Vj`!!7]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb{{ɼP_&e_Lo_O!$^QO,+EoegecMI@pMy^2 5Ŷ2ܑ5^'~94e:*8k!8{#J)J\B^a8̏X-"qFCO1Ye@Đ4JWYH*EN} C ]v*UثWb]v*UثWbL_ U^Pֿֿ4ir}e_~_Ѽ} [Ŧ\E73QR#u$_Y󇔮Ktȶ4:U֢?'5 29:Mm!UaWqlMאZczX?.<,.Hj,d: /RR=ij^r2ň SUߛ^`ylƺs]Ķzh$Yƞ8;eq~Z@|vfv^!Y(ME(6 8mirN~[l =$Q? nB:4kIw-=~dh lo/o/dQĈQF{!R$bA#hPlE*XWb]v*UثWb]v*UتxM?/{Mq&'яWyɞ{̋sd1]DTh.ow5ͳr[{9ta߇|E h3}cLHOV Sד(< Ϸ엡8҇O"Z~)%{׷dIpS_ZjO9-KP>Yߘ<K] 22[Z Eqy_R>V.#mGaikgoV! LT T +n Jj2jnrnWljoZO,r^y'A_S6km}cy\qVA_F.ť5ն&bQc :(i?zVnn-n$ lX)Mx%ԐQ* RsOZ[H7ЈֿmP|ytA5En2⅝GVZcu햛i wzzil΍o&!PyĊD~nNA.|&!^zvޯՀ*C3?HHtGBۻ\WWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWZ?=J(/2/gE9 |]v*UثWb]p45qUH\ԍ*v*UثUg1xUf*UثWb]v*UثWb]v*UV{|}.uq&'dg Wb]v*UثWbY3bqWb]^ LUf*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UA1&QA|1}8wyaE>A.]u n{bwoH`xxa}|Qߕp|H<ë$i{,WQOP7BC*]v*UثWbU r |*o̟6yA&zzl9'9v*U+t&Jm5 i}}{Ia`ǗZ:Ax9;6ҝpHyv*UثWb]p85u$O!LE2:\%2c73k6zDZD{֍kCٴ9OvE+qWb]v*UثWu4qV5>iV[-27^kdX4y| K_+@݆mﴘ|G'HP;%n*UثWb]v*Uy?7 #ȰW;qH/7<ɧyzH5i$r UcEb(F"+0FA+qWb]v*UثVVߗVvVuVI(zX?45<M->mY/DT)a;c ֢hn{YaNj v*UثWb]v*73!}oVԉ]:6qM'jKt{6zl^YCbg^I "p޷jz]eQeDۆٸE*ثWb5Ї2QA|1}%8sǚ$X"UM}2 ov*Uto5*/.[c>|&V4hjdA zw7z&E.]v*UثWb]Sۮ*~bii_]JYZ^ $i*w?v X妯a]~bCokeME$s_wTROE.]v*UثWb]W%kOH&Fi#$ N\Νkwkȫ9A'0hNv*d!Q԰_?E$r\|E '^.Ҹ A+qWbW2BmqWyWɃ)/7?,?:&6z(^F/za!W1gxSS]v*UثWb[D>b t5_;m[(_qU|=hC\v^j5.jZRU?ӾVOv*UثWb]v*Υj̳yvE'Iza ^8cw=z7BV[{eC;JVdwbz$9v*UثWb]zbF#s3/ ɥ>*d?;n}q4- tӸ)%S.MvBE٭v+fKUZ>#?FVSv*UثWb]kyG/1y7Jsso3y܁'~w~mkUKk$aq!X|C"P]`PW+, UثW[5nMOȍjUԭ==7R<.FG*/Ub>oGy>ϙO6hP[IE%jdd`Wb]?.m{@Ң;[EP*U;l#kߕ.MrjQ#5msPr*UثWbo^[]v*daTpnp ~uY~b]yW^gzL q|_dBh&^Y֧4>pFh ȔPi]dRUثWIby*UeGn+iA v* 9C:Qb1K$痉Wa4p_=y| ZFFAa *+Hv- WbZ܅%GV~**UثVeo\U_~iʑؼFm&CRU*Oc$D/1?1?342LO-i\QI^CsG +OfNo_O WbW@9R6o0 z*cQ1=y7{BztXBC& ٭㴱Yİ WbZ>¸**UثV';k zjM._}n}>9te<ĴO7>f阵2H1+4ci:QV=>fϦ 8vC4rjv^mo /#ˤe8]^r2b$[p('`1V[imoߚ&%{䀴̟~d\ߣS&IJթ? /tm7I#ѴXODq)BwlND0ߙzƺ?0/gxMfbi M?,44?]6muut^G^r),lzWb]uWg1sWbWG,rCLUi$vjt*v*Uتޔ;"y),NꪁW9e01iXI*֌~W@r)v*UتHcbb< *v*Uت`A(28Iͮ:]"=yZλ^iL2kd B|sͨI30hGOobŷ5iڋ,ZK@en~+fIG i}G.!zs3 ۰+WbI##!(EFE-]ܑWÎ/+2S]v*fe+t8UiZL6qrHGS$ކaf_ݝvE *:d*Uثj̬IVWI< I#85Vb]j:i7ޱ2ivj^iOa_$~edy{Ͷ.ˣҴ{5:;(r`S_BQS_zRUyxT~"M}ryȪ*NϢkvwݎ2OfC,f|ۡCh%*pQddWb]v*Ucbg"Yvt[1$ހ)تżwqw2!% [+1CWb]v* &-MY2VlQO&V1 _~7>џ;?p?.ndi%bHINs&p 8b9, <ɪ{SPe1ʄsC:Wp9qEfa8x}3~hơ ̟'5=tXs,l|CY?7x]$?_xLثWb]EI Uoni_QJ\y2VuNެþH R_<[[S̓k̫zKJPI}eaek%VaiZlViÌQ |Nm#90U…H E",)IGC2LQH4?Z쮚J7sj-jIB e(<~Wgh)d׭~I;zt`ثWb]@ZնmHn?qM˔@yݝN/<uusyrWN^i7>fR26_B`!Q yqm:\[9t5V a2bY~)}g0|2z9<)X띊v*UثWbQ|1e;8- Xa^(y>',[,QG"Fe=*u}"M>OR:B{r)(]v*UثWb0J֔ڞխE?SeeQٹ?KG|5je_P q'eA|+/vGdaay#Rl*[Oo:OSF  1q1a_eM3Su_iuMX2}{{5-l"ɔ fkn]v*Uتki~vQpMm *y$=XSQxPPv [[՚klw1=ǶW()Q"Wb]v*Ut0q2xp.Ҵl!s6Jz2)((qzbk\E!r RPA2 ov*UثWbzEλζ=󸙻*vb2?2[%ޗt(C jԴ:~@y_;j>OBOe^>ly>ϙ?5zkiW2Lp+WbZQv6&r$R6xs7)ثWbwGw2!% ~DZh]v* T¤򭩳+62)@6w+f&V1 _~{9>џ:h]̗W241yerK3$?)lχ 1B1ثT~e|Ǩi]$N9n.(:'Qcx=G<ͥKfP?NGD9a|C{+7g?.3b]UX?s=%n6f PUتrKMm:@XLQH47]WW]*6n JB e`hlcbhY+oۨ#zx(">}p+Wb]ufH$~˔@yݝΆ=?{/45  Sȶv* -nsG dA.(eij\W엱CRfQ1idyS;v*UثU{ 5^x|jK1r+aWbVrȡOB1V#2XIkF? )=VE2KWb]@_FQkl3Z(9 cn}><4O!~^^Vf/,K31I9Díqe'>gѥ`BNuDX|C;+7goI֙W**Ǡ.t)d~%[oZjtG|_<\~\W̟OSQr_n20%UVnuG1sWbU,'ҋ{/`=jK1r+aWb][$qG"Fe=XIa'8kF? u(OcL@RUثT|åykJ}OS5kj3 rrxvoff.W̺%I`kĝa|+ݓtF,Cz)v]v*oq=<4S 7 1q1a_?tVE^Q$4Qr1Ǯozpٙh''*H"u۰+Wb`sQpM`EcLIECWb]ATbވ֬nmTs>#+YKxWbkV۰8UiZT6_fI{$ثWb]sCI_ݝv)r RPAR5#E'uەmWQԱ|5EhȚ*zbTr֞z2`Sm//.urqߙ.җpOEDd7$S=r*UثWb]Pt\Ѯt=no4I"n߲{28U^BQ nRHܽU)u u^YW:,96>!ݟ˼]$?_xLY*z,p7wΗ>lOk3[þH R_=~\\[̷:q!DMGPRUқt̬8xdӴ6J[k T I;sHLpثWb]TUU9#YLsB…H=bAϟֹ0ґ[Fj֬~2h[F\F&m_7.n6:p;u*r),k6EO]?wYC.QvwgOW:cT@yܹy\=ddl0B-Wzr)H qj҆ix]:KXg.mNh Z1ٻ=VE2KTåykJmOTmRgQ{d2(Iͯ1a:]"?5U. _vU,wdvF=&]Wb]v*oq=G"GB0A&8&2=3[7Su]~\,wkQ/|sof?~6dTE31b[ۊLz(8@VaXAǻcLIECWb]v*PzUkz+Zsl ܧ@ *2)o] 3\L@oiZT6|s7>,‡b]v*U|Ukݢ:PJ,IATdNk:iVIҧ I_`tXi>PzzS>0)O_M+J K2] qw$xȓlfjzv*UثWb]P4[Ѯ=n^iwXbuV^UVqΣPf<5uh$]|6}n} 1/nd+Ƥs6yыqBF1襁ثWb]v*U6Ǚu?.Z|d]CXwn. {WkpYFǑxzg#|yQ/t>3x-ԥ=|ec>ɡqLw']\[̷>`%m8jZ#[t8xδv6:v[Z\ k SGF4);v*UثWb]C*%X$RB㒲bA_ƻxԞ*'FPᚌ Mռ7yc,*LnCNb嘀vA-VNP]^ܽrCS\dl o{Z-">M^.fq(e&}iCPUu!pOR3u{=qU' Ut3m:][9xU8A a2bY[j܍"M&<>>˞uc<)ō(Xݒ-u;8- X!^(y=`]b"BU\5vG&\ScO|U_ u0KleJi!54"qTiI׭S\.'TU~B~*δ˝6]ȀlMx7q\U[$i"4r(daFSЃ[HNQ~ԯȦ@zt.rjZz`ʲ8Iϭ1bt|5je_P$~ b(DAuw>yeۻ#00X)6Rv*UثWbWkϕo5+8M nA;s#b;].ۑU-Oc5ߚ٣'l-d馪+(Wb~*b>k>hzC?ȕZ3BGdxWqV-hjI^1+Yʱ@ݍ=Y~Ca 3,`Ĕv;v*ĵk9k:V͡ڰX$E<ƽ*ߔ@_Z)҂S aQQ㊤ZnO7ٝnY: Ѕ!f,늳+kw6 5_]B0%QANTv*㊱5Y\kXv^n[oO_7m 7 +J`OaKOO]/H&E[2]QN?Y49'{VOrY//7y~7|14nR}ugiZ~-vE*|I̜yN)pOBE s<`Wb]v*UثWaTAI#5ɔ¸„P횽Nmkw_Z垶qbH~Rĕvc_ى((,R#yNvDD: BwNja0/{ٽD;9E;Gb;!thuT?b'oP{\}07e&<;_s7$Y w̝o]C>ݶ*W2]&zÕϞaWb;q-w'lF5 Jw9Wxb3'Ю4M яfe2ҙ47v*jZn"h["; |U$QzRlfZܩsi_Cȶlk{L2A^RU򮗨7WP,%*b]/>yL,:] >h㍗3{;68ňX4uOc:m=rr-րe>4]f M/M_'oZsҴqW~S~Rz92*yW뷦GM8rm ܒMI=NE]v*UثWb]v*UتukL^!H{:e;_7XqΫ3NԘc;r̃ɃhQyKͺ45a-zOv#"CwmmCqj3iCJ_ȥb-{ & 1]Z=-[y yZێ"S{ːYK+մorGDcjv;,dn8RQжZK1cSrkq yu k YuWN?1uzPq`O;'?/nd#rNs&p *1ʞjԼ >$CXe}DK:|:'OW|kSʋ~-OKnO*̼x䏋Qy[c癭{b]v*UتM/0å(n>liS^C :,2Y՟S;Yi€D>16Cf.ol4/OLҠ[[ e H4skЧ^7h2ˊ9#TU5}X,/'.Ṕ n]v*UثghM)5zI<56%f0]Z[]Ikuo2)eeaB8UO䞹g/꾃ϔf,jR@:?~BQQnX'D'~GƝ;Պ1.I_9̈́fuPhښ0>PCn1뺴+ūQU ˧s3NdE":HR y/˷]LQ1i2rqp?HpÄܧKv*ӷҤ8m$Ms:^ޡ 7U=v'3ovm'RV!E_{MSʡqFSR@m-.+Rzre͐+e5S#&żUƴ4y>PÃ_֗Wi R) cO|UE^YHDt@Cb MdB咾%&:qLUiU[iJRp5!G*]?׌LA3S..m.dI G\J$/ ˑRUثWb]z?,j$Z=׃=6 j>J]Ce6,Q(vUe*ªv ,zXxCKՖ!LO,0xUXdد]ևev14~E, ZWAyWVCh$AǘpAqT/&Hi^ URWodX֝%4=J܍IwݏqTv*k٩ Pۀ#i,:IF,ƤINm`Ǜ\k2)Ka7vO=WpzW7*cj]O1Kz]R8ALeWqݱT֞jAr5nMXWzHɾeYVm*GiZԻQVC_+zdC=Ԅה*~i:qj)kajB+Ԟ|?o5h:KI4ԍ֘*_]'H*י.#`?f8$Iܞ"]v*UثWb]v*UثUOL5&E-ޙv9#mף=v8Umݧ|dԼ5*SDM}72dO.[.(Kqݿ~|]^b>{?N|y.:Xp?'WW7W\\J,w$I.,P`bϕ|өyoUɹ({v'ӕTqi~ůqdKOxe^k򶝮im*9T۷`UF䏋Q}tyZ}to_zʏmc W:d@^^҆BQ}gU !}NyrLܤM"4uӭ$0JwͬcBeL(v*p~c#rGI=KX <d^C65v*Uثg_Ma_$5zI.nͭ᷅axRaWbWVV[\Ƴ[̥%ee;A_~v~Jz=Cj՘ =ݐA[g) D MCH5E/,O9̈́gv5R"Wb]W|Ro$y"{ TB6AVg'8Omm +KEQOsqKU4RxQbR\He;Lee wdطv*UثV'=i]ӞYd"Usg8s;;krX|ۮ뺖$ExF9eV_bâ1bԞb%sk#Cs hA,A pa1ksoaUK?9Y'ĻE,ؐ5Q>׌<{!?V2[\b&+$l(AkDE\9p7ȩ`lv*UثWbZT-cWQGaN]Ď6ˣ>Uzm1򜻼s+(- XPE6`"1KVUTA銱b q2iRe˚OUMUثWb]j`ps82<1{ F1;sm(skn\ثeM]?=Wp(=ͱY77$aPsUL*UثWb~i:sj)kahIs@I*H8[2܀ח݂?+&ـ$MIr*UثWb]v*UثWb]v*UGS4}sIuuҮ8F·/c_7qiX4uc_NT'IMURn/3&b2$9Pb\HBwmveZvNa_ʹՌB;giώw,O?_;ss#Mq+G5$?)lˇ 1@B1b]>TVR;&䕥ųʝ_K::'AˬOxe^i򶙯io*% cۿV ̼#>.>]GsvGkic5pUثT^aJ| ?3I9O^ohaVYr0uvԵR wzqWΫMچu339YXiV@} )۹9@2;v*Ur;#^ݲ9qG$xJAWE}XKX <d^C65v**4XTO=Wԙ=nY6ЬP^1T®]R%e),N++lA|o+Yg~M26җ$6ڼ DEybMywtV"a]ڞ2^l&{7c0hUثNEiRvu'lHuRQm}?I;oKÄ]ABD()s=\RUثU4RxQRy~q tM"b'{d92U2 ;Wb]/=yM jޛ*)͞8eͭb֗H'k__sB ?4/vgfabyO+s݊v*R[Gui!#9PЂ1c&POUWR<+(-!XZn3ثWb2+VAqV=4wq eҤ5."{C.i7аxUXdتb]Iule4$i'Ͷ kn\ثWb©Ma7v{SGmbͭaf# ڪWbR{]ҴXծOy:L~faTṔ n©}/uO'^Sxc˽16 S v*UثU+[ki-cYR㒲Ug侹e< $q~Xv~QA[g) ߒyӼI$|fg\6h㍗3;./{HQkAjD֫l+/vgfa|OYb]v*R[Gui#Au hq$ (K,Nӫj%#vQn<{.='uW|W)Ht~}FYYCi L>d"1KWb]iYJ8;!M*SYaD_l&\yḅ&&Sv*k٩d.G5KBGGj:n270аdaPFcjR_t "Wծ J'_~ki͖.o2M14mʞ?d}5UￔOޒ73\m݃ꎿ?f7$S9v*UثWb]v*UثWb]v*UثWbZzL&nzM,-e=¯o-8X$}KڋuxߨYPt=`~QoA~q=!}z2&.Dr7b\m>ԠZ)mUOV0_～~}?w,~s]/)Xu}uNA!+))o-d_ƭd NMju339)v:vipj8C ?mc2;v*UثWbW#mOxrbHԒ *k*u,Ye^N] 2/p kLmk黬+5zI.ƹk{xmXa^(cJ]>uǗ< m`Ugfv誫RN*ļ9 i0C7-\+4"kw1W\Co1)yesEUQRI>IO/yH:pnlDA)hU<]]]Kkuo2' ⯍;%Mpɥ@<?Tf2"~ .()ϒ|yMAV՗zO9̈́fv51#H<01s#O):?.'[Eo%3` T.]5mVJ濽ӶK9MqT{癚dҦwh(]dC×\U]g⌧qq\z3J LDS˛!VVPAR*L)<]dW4R9;*)Ϛ8e˭1b:]"6 EާЀ5Ql+/vofby#P9[UF[#@BF j!/|գk262?D£ڹv]4.kO2lwL.!p ;$6h㉔D-;v 7JgE|8%W"Ut2\Gui#Au hAA͆Lp (K,{};MU-eJ_ށ㕓lfĒjMIȫWb]v*UثWb]v*UثWb]v*UKS4sHB-ޑv8 u!|-' ̒\W72V uE;,;ᕐkbrDqBӅ&,䴮ƭ9dD:>l8(@t_7b]v*UثWbGyE }sFF҇)͟gcech/ 1Y>iwon Kz*d/H$bjc΃c\*-Ly}_ccaN#%x1S v*UثWb]I6>ˊ9#RH5kq+Ciu~յ6PTjw1U®]}&+S>VDo2SYC~'IeUVO{/y=[P<EHa\U8WbTmḅC⌧\U/#Xl z}d ktDs'b5]oZmT4S@#jLW1uɷtyo%FhcCn϶tR BHwz+ʄ7 Ss{ޓBk;gb\wGk))#chsP0#DѼeeyN6ڲ (IBw\cNcUg̓rq`?86 T[~&>"3H)v*Uث 'pb\Em4 TQ Nִ$[Z\F[ʨTHہКz * R:Sov*UDt(2)F*.m"M'~eR5d7HfwiXyS^K1T{b]v*UثWbZT֯2i^YN` *~ackP2L4GHM$j隉P;6>ҿ.%tӎrm ܒMI=*UثWb]v*UثWb]v*UثWb]v*UGR4oIunnec_#~c]y^Dfɳ%kʵxn߱g./wU5 kenHGp|sqKՠb1r5ثWb]v*yV\q?oliS^CA!>_zg%%~f럤V-[[ϲ S"'ugH}iCD5(U猣m@=KMs[]WOF2P̓[+Wb]v*UU3iX=Wԙmkrf,&m@|Ab[a}u\ ;RnQ1b;+{bX06ik[Z۲Y Yyu^quYyr^b cDmdR!(]^ 1TW?-9|?6y[[ƛhTC~4I*H5p6(j3&R-_%o߹jA]H/onuk_]]vU|rLƏ~m:H[9H+<\"%~n~Ty^-d $* }YQȽ1W~N~r[]rjza;/wh=(z*Uث^_r@C\ >+햩_#x媛0D4vP U8WbX|gL{Jss(s{73kxX~2Ty.Z ڶʇ;-;׮sS/i=XJ=L>wh(tP׾l{g.( 'f-[yķ1*>PmRG&c&,i?y(Nk̳_1h:Vk}c'JD-i} : _acm;wb<s@0$v@R-kYVn7nG6:M%ˠxi=6Nc{b[B%JP6ͩ/ B!Bmn-Wd FLtɣ$Et`ªácRUثT̺:}w35)"⡽ ?݆qV >m ҼpDjSzm2[B(ʊ USv*U&uԴC'\dxc>eI#,yZͶ %ߤkObUثV#?i~Xr?=6\#>VG5O1o~&ExF*?Yk>yd;#00X)FRZf}^}c3Au ' UǨqP0o6oBZy+wj(t%mj: c7af\>u{"T WŒuq{Q! %q{(slIܜv*UثWb]v*UثWb]v*UثWb]v*UثUSK5BKe%i/c_#d~[&Xy^bԯeרI)d_*`hr2Gx=WO-ݹ#u9e(JZ ~-V!~NVv*U%(=ݧP=34C^khqqC̦zvڞA^L#tpN&|&C9s/4]K4m+JpAUQ<{Wbk/`1J=ՇP|F F Դ16fnUь ` UثWaTG澛b_5zO.nY61/Q@3 UL*Uت٭78Jlotˑj&.B;+5J}CWb]7=1TW6sqSKS&2YY[۬(TQ۹9 )v*UJ[[{iԤ++ `zC?y#"~rĕor?R/@0%ￓ>V[P5::Wr=v*UثV#>~Y丞O}_#*)Ϟ8eͮ1b֗HhF=Q "#Nʠ9g,dvN=(]Wb3S/"% G0괸<CLz6ڍ _9Z%ntJLRGt1\DJ 2fؽe(]]v*Ӻ"cA@'.?-ԦZ֣vl>p&s({d0H@ͩx\xE/UثLQU - iu.0Fz12@Ӊ2hI^6 *:5.]v*U&5ԴS ? 2<1{ G1$RORsm<+[1v*Uۂ؎y< -aZcq/ޠU>290k v*:VO3l䕍+ğ )bachZ,R6zzӽ;5r&`>ҿ.N#)* x??&fjzv*UثWb]v*UثWb]v*UثWb]v*UثWb]zf:&je$n+u={aW?`+,^leׯ2/g4hv9tx8[ Bn-mFsqKOh5XLF~"b7D!~>ٙ潡Dir7L$$m=Qջia3~:8@DP֧S<L'.heZgaj qUhF]v*XuS0J6XFe9Af#3t ` UU3ѴiXW<=j:3lc[mom + **v*UثT=[/$opj\iwCM hkKЏc,b]Zbέrl4h]] L'VVvù9 )v*UثU+[{imcYR2U'/)</FI9TXj/}п24\u=0čJ۱CWbX|cKy+&*~9*)Ϟ8eͮ0֗H [h<Ǫ=%IA<#Nʠk>yd;'00X)FRv*Ujwe734P0x^2P8.=F3 ℅>څi+4I]xTuQe{籞^1d&}2& D#2K 29A DO"RUtE,ƀ`P oˉ)aֵD?P͎I~'OhI鏫< 1DWnjD/ثWbZeWR9+lAH-Ժ4 dd;"HpcM"+FVb]`?h? ydbI'rOsl1)ZܹWb]u* Z6Ҏ5҉J3ɲ PόL)(v*Z>OkKeڊ3=Vc IO>gC B^V´MMa̹x0E~SR?ZOƱAuG1$"]v*UثWb]v*UثWb]v*UثWb]v*UثWbT5]/G4{\[2xSV^aWVvbH?ej0 v'leC[vsˊPڴZC&3q)w< E!|W̍&7.hq`b7yS?ms7^:-[֨2S:8@DPΧQ<L.otMJ}+JKK TbϾIv*UثWbk/`1J=ՇU>##(A`=9fvUQykv*4§|ju&~=sf°¼Qz S v*UثWb{ {fj`"J[ @o% ŗ4w2l\H`:U k-=Y7c@e8X @ωLUWb]v*ukmwm-K5c' ⯑5'OTȺTNdpF {K&?9O} I-lj:y;r‡b>}-.%ګ +q+Ol>x⍗7;367Z]"?4yTMvOWIY}ò;#nj{Y.ثWb]Ei 4n#&`ls>KQ8!zyg=^VkQүVS6PQӽ7ad^M댞D,OCq '`渊ؽLe((D-EK1I_3ìkPhn>׃C6:M%ˠxh6Jc{d0HE)R_Wbu +v*UUu(㒶TBOyt;1$ 8y1%hd# ~*zZ~ݗpdxc>$#bI&yV.bUثWb]{=)Q Nn;2C`BU4HˑiڏHzvDɐD(<3[M 9%+^=YOJf\L}GM~_iD%JR@3lIUثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWbZU΍[-ޙv%z2#aWȿe֞k'7>]b,oihwurpC(cݯH&p+'~f뿤5%׽R7a&]Fyg3r/t=Iд]#IKM:vF(G'=rM(UتVӧ\ƵiȓLU_}.]~Y[ۧ%}L|튣|燳ii5(jk陖LUc.#KuK?"#H늳$$P Sov*[Q6"VxnU3z}EPH+?{zIҘƷf°¡cQ@cJ]SI^ 'e!`o|ҢtK9+*|67dוWS`}n"&NqWbT/l-u{*Oeys\}Big[" 2֭?lO'W6;8- X ^(?sv*q#"c T/ӊƱGV:ӓJtEX(J%M#:~||:*x05kMN-BGUtWENH 7g6SM=3M D $ jQk튫bTm䷸eU)$nVSU/+<-62|W$JPiL zo'&}pWOR}(ޔʳ8s7skx=>hFMQ FRv!#Nʣ9W'ۻ'p0X'Kv*UثWb]Di}Wr700xSBBf&6Ny%Qa~cig DKhr6e9<: ~oBY{ 7;gy?laQL;L|{C814!i06L ݊cj[{To&a@o4eA4/̞[Ե 7hRiQ5k=NL3$HY5?k l&xrSXWXUNT%EM>Sd&:<PpwdEd1;|1C\kr.]v*UثWb­ꚾh>a[->Uo"ٮ8%OF#Ҵ[dRh\BM=YO9&N-om#I2%ϘnT}nǿ f9$RjOSWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*]3Z ރ'Pñ©I4O/Y¶֖h"#ntnI]a{~utnhq[>5wP~*6*ǿ1%3gHϩsmUkͺ}Ǔip]Ao{͉CFNzԀN**UeU,*RN U\I6;[:|}n.@rUӯ䰺eO'4;v*Uث /m=m]Ziʚ )[r͊lUثWb$SN*.%֮dMuWrv\ct=jmb|ke2l]v*jvO4ek zTɤڋwҭ_ʫ8( %g TVЮ(gv 4ND\MR:U --N=9:iUثV9ke%ʹcG؊c$bO9%.=62JiPusiĞoCrd Is_v/r;7͞/Cg>GUALثU/'a[Yި`ծ/ \M:d`S97n|ycym #G2d݋pꪫ(DoDLFfhnXkv*U-\uf;s#.Lq˨0S;wt8 AeKGhHBza҉5Ty8 Ljq?:e*J ΄]-k۴qVvW H7~n /LeI izluiOldm>/Qn|rwg~1ɶ`3I$r*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]hUz~6mr>8'6.Pe#i:2FxUMUUeU,*=*\O>p֖Ħ#W!kbܚv*|[#^$HPR&]q qTXk VvJd \;;{;u ?b핽[μąIn4{fkf\6.Vzoԡ^^{a̛=OP* A#Y%ח׼W4;Jjb%ǖ<ݨڶn!"_IiMvYeV-Xs*ckkVۤ1C]řbqM@Iv pT|3w勶w]_Y'm#G.J[h5tF\F>#4=rU,?{p}饊^Ov'nbc1G&y݊v*UثWbL'lli^hyXi(Ӱ3nGA]L?'gH/뗚ḹOm3Mez^x&i{r#ɓ/I҃[~G?OA6tI$=NE]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]E~}*t=sMI:E!cB}bUثWbZfURhrOLUM>r֖Mq#W!͗$hVT$h(2`1T]>٠l~|F-AJBiz&55IOrhv*UثWb$SH/.5%,~+&rNlഷX Pdb]YynN0jYO\~k[W9kf\b]v*UmnH?P.݋59Ŋ8Ak&bKÒ:!&258 )7זn[^MIw-}d 3fU-]_MdjAz宫jY~cS)QWbv-~.(}Qc;b]v*!y|uf`;<G˸ UlFt@yvWb]Ru-EҮ5rlE-$wrney27ϿmU4VIU{)\W!`))$1_PnFPMIܞv*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثDTbD9otC^' &ثWb3*h䞘}vvzlMߔse=  2tSv*UتQ `"O.t5&]GAi>ɡثWb$S.ȔSK_@e:(2@Sl*UثU +{vu >0j\ dsK[cPw4;v*Uثog~Ip[vbƧ78 qMCWbU"$u e;CfO/&>Z#m˭Oݚ]V v ~M6Q'ڭt!fQػ3饊UZ\Ci=߱3gvUثWyvVI4-,ӛff}K&N]{vo͔_Ϥ?]ouspx6U{ 9;31pCSPSv*Uت'wՆ2169͆`q\d&VDw{/ͮ =ٳΏ wyWثWbR_Ӵ=6]BQ@ٻ*pNqxee0,y>gמ5>Ѱih Bo9G,}gb/]f+;v*UZ+YZX-/SiG@XQPs˵v*jZV\kz閊Y ?i^L! >N|]3KtW22J&YJdom'Jnu f:$S9v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWbQqVC]$E)cB}bUĀ &u'cM5'G쯶C.I60XP*Wb]Cj}A0+ӵ>tMN')&b&Xk )h7C?er.Iե,QOH*UثWb]Y[da{ZWMsKK" lYsOػv*5xֶI![,X!j&ɡثWb]^X~NVm%ߕ咂ܷSNI.A˦25!݊hz嶫l$J$5ƧM,RZ\QcwLݻzgikiμ,٧aјدAM.Dx9to͐} ;Gznn6UQSَCe{7qpCSԔVv*UثUqmqի"5GA .e%M)_faIgG|2eY^q-qKuNٯ[ĵ,zTw'!)rF,ysp,<=P^fBHWŏsTrˠ}gv*SWv*UثWb֗w61]Z YMA dAכ 2@c2A{|i1otV0A(v gj_\٩|ܴ# ~JE f9$SȫWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*U+qVC]5$N2A Ibǧmz[3GitMkk;)WM ~}flX\܏ڧUS&rN,ഁax|@1V®T.!KG J^Gc@ N*:W2fAPqV FOkٖ tiaRh1TB:+O8xU +{vu >qI.4Z\[" sO4C[[i$@<1O&.X!Pj&ɡثWb]v*)xFUbqUe=A'!E Oɻ,IO'6A&ܱihp.Aɦ25 -vU -CΧK,GZv6>:=@hN6GLṶ.Dx9t;dϐgsjNx»A쨣َCefn=>szb7v6R^J!rF>XcM&R4_˚C rtehwfo$zpOKԒ{)Olddo}'IV`:ʃwvG!< `3I5;v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]hU0Rv ٜaBƂ *WbR,WzjHg8I @b֗Z8X8N8h$;eZ @]v*l-m)Uw| UWb; Bum:$1hi#Ko$Ub) i!~@qT7BJ-mo,MA!W}ˎY U_v*UBݠy#`!XIQVa\xnyōNo1Ak&b]v*UثWb tuC +,M%1E ͯ-Oz~`y&0do\Yw's”1~ec.r!q1>FE0z*j xrQsU~OylcL݊aO6|Et{ MPWJвV#;g%rlrhatyNH-2Ys;$R읊r]Oe*۹xO%a#aLb'yk׺'c2X ~n02ii? y7//9k>c\^1X, 4Oûj-& q9s>3݊v*UثWb]M]]J9Z"JY22<.О^ol}瘬45YYB8{mZucgUF_xG,!X`WJCH* >a<MI$NE]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*A*t=oK"ױH!>ɱv*UثO+ڠE,ܱ3SKw'W^֯V&,x Ub]OLU . -P%ɡثThz-ˁX'麘?*"G̰*ȴ]:1'DbUثTP.5 tƥ .ep5DŽRt'(¨wN?fiu<'_Q6EثWb]v* *QgW02>>}Os8ǩwI( Tv hF<(26w5ԾJ&i}2\6x'D&N;ب.I[|T9̈́ٝ L,m!w~)vX_IYѡc09 r̭5QwG!,gZޯo,SJm- ?(O&3py4kQi }ًA5D4@?i:v7?2hUeQɍ@M%kWQ\,fo/e^{{Fp?^aZ (M?Vm@"o+V1=B0XP?e fd>kYf1&X%ywvy-獢&+$l(b9ϐA.,(T3v*UثWb]]\k;YJ249ju8c92X %%kvv*UثWbEe?99{5Y$#T28#PAX@ȂX%RBem g!E ͿK(j'Hi`ְ~ F j4>}.fU<3N󍇚4^ Ey؝sI };NX0e.NK[ĶIn$G&0DҼim[I Hrs)s.>C &Cм(xedCЃ*py--GbIܣ8TEuAɍl^J֮ |QD߷S iOHDWbTn y+t`"3$?bN?eu\> % 3d UثWaZ(G0W0 R1VI+H=; k2.]@I RXb;`O7?)5/''>F X>{\~i}2\.xf'R y׀z7.mISɱv*UĀ+H.5e`l~׊]sggogEHV®]v*tksQ[PR?Pnv;Zܞ<Dؤ4;v*U!.H7C7M&}Nv*UثUH.hf^J~|F-Aa=FJl^UQ_&`WbQ*/O_Ϝx-nVI+H=; k2.]v*9#YbqUe"r3i& 񿑕;L$xχlj4>}.fU<3M?ַ R~%'43ᩅs߱>]VA,h)7u\%DZ cm}/M\g{t`y:׸eh9P)z®]v*HD(v#!?ѶMEǠos_ь>{K-<1;\[m<S$ ؂3 E\Yc"Q7*xQqI#Ccxb:^ۼNm)@>yt,Ov95 mr/tug sK^Bw@do<8$S=r*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثVY~r>8'6.$RhSww:kbU!.in@;7M&~mcn@Q'䀤®]v*Uتݤp43/%=Ke]TNN{,ӽGmP|Gi3a0/giS WP3*X ځl~IR&'n7>ٕqo.O3۽ o{[@#@?Fm<јUثWb][$i"qU;͟XhRG 6YT~{hA>}z xY=Zsyw{i6xv9$/bE uu-45N@שcsv*UF--&#Hu!EqV kX:^i2ⲖeKx8,޻ojP+"L*C)qTv*U cXuS0j Wj67?5_^5Iv\O7Mv^>8{4{u>'$ Nv*UثGIkd/[*OY-喞=:ULU_v*UF 7E,Uҧ|HwB?euTx'(op%UeڟerFs#F=J%iab%+Yv*UثWb]_y#baUe=A$(|Iy>onk}f&MO: j4>o/M) f?S 4vͻŋɚ[zmO$8rg>4{ u%#3<јUثV4\Fyy_tlU3uiW,zT}<1V;ͭ;OXV1E0goZY_.Y]kT+q^1Tv*HЫHxH,װڮ%f^Ќi=?˳[|{,ut&Wmk$ڟy=z],q45X|[~S~R_B}w@BGFdnpI$ȫWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*Uk(e 8 DdmoN%2 b]~?9}EqV-ƽ~/ITOwv_9?geWbXE@Sy&oi|1]rѡ[b'`ɓ]Y4 O+ԻSEN*0گ|ůO_IRMO\U\Ьefƒ8WbR=RnFYuXِcڶqe(YO%#~2y5;v*UثWb] UCH8 nOPFasY8#|g_kb~]eKD 5a=YqK}1ˢ~dh~EmEQ'l{Wb]j$4+{B-b?!**z 6Ro^D߳+*^iΓmnZ&t*UثTf|]kZZZi$r$ QL݀_ deͰizmtzi_A~S~SiXqң'd0$"]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWbZ"⬇C9o ױH!>ɱv*UB;)%$GqFM )*?h6}%aJ"jԕEqVW FLDu%O㊦Wbo̞cKt{h2 }bi[(Oo玻g|v*?._5IlRD v8/ǘffmⷻ @H )ǷZ4-CLuH1_ࡩ {bv*y7[gX[kT.M:*{ UoW9kitR2:@Oo}'Inu£'f9$SȫWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWbZ">dZ̭~R>8'6.]v*Uث'wLD7i>OsW 6^OpfbHd憞# dbmQhpɜyoi>3H#jL3a69;0p'(opɭثWb]*1> C+ɐD7i>OsW 6}#[Ir9!Aч̽.J7Kd UثV!Փda5<Q1VK)GA CϽ˘v*U|r HdeUA$(~e~Y뿗~b]$VZŹ B9ˈ4y6o&9?̍I[mrG8 F]J}ַ\-sR{*`1W_^m󍾛A*41I*wZmʝOlU76n7:ed0$Rzv*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWbZ">dZύR^Hk$ػv*8{h?PLݧ4c=Y^i z)lvO1 ]v*U|3I ҝFȃNO8ߘ."s:# e=,iv*U$)1͑'H an"U|N)IECWb]Qe0j t'*Ò'f2OQ( 5 C&:j p=Je25z(21.JV.bUثWbW P$@VXUYNpJBAxo嶿}/CiVrwnJ6h[9ˈ4y6o&:4̝ elZ[;máJ|%η\hsԞʣ7eLzB 4عOa*J[~A |5+&ـI$ԚUثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثDW⬇C9otC$dر2y-k{v;2 }izM5{l7|1-9sʖhhzZJphp1éu1yoDX[ԡӄ°Ď*Wͩ>k4_4[^ycеHu XU9za([z8@%T/-d`VI\@P7=i$}*+ňC|qV0h4)6yr(|1UM+X5kAwܥձ%DFbTnແy){0 Aa=[C$עQ_0բe0Og+% >p`JV.bUثWb]_C AIaUu;A8 )__r6qui$OGډ٨ˈ4y6oh䏑%>CjV1;#:k Wڙ|_8æiqJ_>vMW_On|rݐ>x(ɶ`3I$Wb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]E~}*W駘MIQOX}=e 1jؔds)z>8cyw=Γ+k~c?X+bpбs"NΗTo(.u?9ϠZ-F V8#:288AbC$^mKONq[ylӭ9kBU^ lגq"~<ϐ.cΎQo W%9VKsBL*v.]wq"1F9&[k hq"ẁvC./F'zdf=$7rr)^;v*k>Y.wߕl̄uLUA klLElGuWǝWfp۟\U}Ost> Q 9—bXg?^S(mi_UĊ]\2aܱJ8?4;w졶iJ&rSpm7!EySzbT6[4 aTL'mm9"5Io]Lfa7X|4YIͶ ͮRsb]v*UثUN#g$UtYTKx2Y{B_qEVcr^æi]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]wjaR.VFXȲhv*UdO)J^FU'xךմC]E-M-G(cVJ͚M޿Y,tU?JPvڄb@t!n{æBM9\lqWiߤ4K➟֡Ixu5 OE];.Mu?S}Wqlu9 X|åd3BFG ^9 ٴy|<~+f׻v*UثWb] [ ?8sRkWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]E~}*ȴ=sivԔmN2A MUR(hRPUv|u#V lM:b-HӮ_N4ONhee#V/9ktZ4BD2 m*4Ӵ[s"ĐnBت+v*͚oɮjI=@ǰd!#ɻK˩0S|*:3<ŢkkZ_c9VYe}lظG$wSnQ/vcSGCyc+ ǐ{'>/ZRjKU6pR?Qӳ/ff8q!f;v*UثWbªAo?j|1>cha5 ]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثDW⬋C=N6MΑk$ػv*UثWb|٦{LQF䞊.Hyשf"Ej3xoUYy>Pd.s߻NW:_?h6KualycU_=ǬOx}k:_մMթ5x_[QIG^ UثWb OD=#g+tCkWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثDW⬋C mnh?}qܚv*U!ot/iL#HsܓTwc+ɒ07itu9F#r<ϓ_=yR^g;jusTrggb/]CɌ+v*Uتw/6jXRṷo,}Շ=VWlv>~ =4mcJCͩ ViQ=$OḁĩX~icU_=Ǩ=^bSWX;\7ۆN?_oifmc(_6+015Z>cha5 ]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*\8]zG!cB}by͚gٯ/&$kRzUey2FrnrrXGy'ʾzާH;b'궵,sj>;VY}RLc1^ثWb]v*yO͚5TjEoJ?Q`,r_0y4mgJġ4o"~?#4_>͡qeA_6VyM15:a3m6-]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثDW:Ku~VP̊\aQm2j2X]^|֥Mv1-,sjYy>`bT=YeKb Wb]v*UثT>lԼGfܣ7X~`,rc1kY9=b{A躖 :=^2[qFWdKϯy} ثWb]v*--d]OUVDn96=g N4s|ϟp +hT$P ($DGRܓ]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]\(z{ Q~h~X}PI5{$02(.np>짵^%i&yww>UثWbY崺˪jpٮ~?iޛ K3ڏj#j|(H A@,Q(6!&R2eثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]V7QGXO[A&[#VAS?5z˹e}9+M>/#5Ov*UZ[KJt3'G=h9c{@8c+h@XQEU3y9>HlF.eثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*9Z3Q;2X6h$bĵԘ[C~˦[\9u+_ZmIG^}}fjCv*--%]OU  a {'7' #(+xX@UF3y9>HlFyv*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*9 e;X6/%I<â ĵu1?iG٧}qdH?_>i_yoz{v{UaOE wDQ"o 5GALOLnGvv*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v* endstream endobj 82 0 obj<> endobj 83 0 obj<> endobj 84 0 obj<> endobj 85 0 obj<> endobj 86 0 obj<> endobj 87 0 obj<> endobj 88 0 obj<> endobj 89 0 obj<> endobj 90 0 obj<> endobj 91 0 obj<> endobj 92 0 obj<> endobj 93 0 obj<> endobj 94 0 obj<> endobj 95 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 96 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 97 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 98 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 99 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 100 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 101 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 102 0 obj<>/ProcSet[/PDF/Text]/ExtGState<>>> endobj 103 0 obj<>stream /GS1 gs BT /F9 1 Tf 9.5 0 0 9.5 45.3543 710.4754 Tm 0 0 0 1 k 0 Tc 0 Tw [(of)-211.6(these)-214.8(mutated)-211.9(isolates)-216.2(were)-209.7(found)-218(in)-207.5(Nigeria.)-219.7(For)-209.4(the)-213.1(mutation)]TJ 0 -1.2114 TD [(A437G,)-345.6(which)-348(was)-342.1(associated)-352.3(with)-342.6(resistance)-351.1(to)-343.8(Sulfadoxine)-353.8(in)]TJ T* [(endemic)-217.5(regions)-218.1(because)-219.2(of)-211.6(the)-213.1(drug)-214.8(pressure)-222.8(selection,)-219.9(showed)-214.6(a)]TJ T* [(frequency)-251.3(of)-247.4(only)-250.2(9.43%)-244.7(in)-249.3(our)-251.1(study,)-249.7(which)-246.6(was)-246.7(lower)-245.7(than)-247.8(that)]TJ T* [(reported)-208.5(in)-201.6(Equatorial)-202.5(Guinea,)-206.1(Pakistan,)-209.3(and)-202.8(Iran)-204.8(\()]TJ 0 0 0 0.7 k 20.0096 0 TD [(Rouhani)-201.5(et)-207(al.,)]TJ -20.0096 -1.2114 TD (2015)Tj 0 0 0 1 k 1.9156 0 TD (;)Tj 0 0 0 0.7 k 0.4416 0 TD [(Yaqoob)-222.2(et)-218.9(al.,)-219.7(2018)]TJ 0 0 0 1 k 7.4894 0 TD (;)Tj 0 0 0 0.7 k 0.4416 0 TD [(Jiang)-225.8(et)-218.9(al.,)-219.7(2019)]TJ 0 0 0 1 k 6.4391 0 TD [(\).)-226.7(The)-217.4(I431V)-224.4(mutation)]TJ -16.7273 -1.2055 TD [(wa)-7.9(s)-507.3(d)0(e)-12.9(tec)-11.8(ted)-516.5(in)-511.9(Ni)-9.5(ge)-9.2(ri)-8.6(a,)-508.7(C)-6.4(a)0(m)-10.2(e)0(r)-7.7(o)0(o)-8.5(n)0(,)-512.1(E)0(q)-8.1(u)0(a)-9.8(tor)-9.6(ia)-7.2(l)-507.9(G)-8.1(ui)-7.7(ne)-9.8(a,)-508.7(an)-12.6(d)]TJ 0 -1.2114 TD [(Chad.)-418.9(The)-414.3(most)-421(frequent)-417.5(haplotype)-422.4(of)-414.5(I431V)-421.4(was)]TJ ET 0 0 0 rg 247.465 628.838 13.38 0.22675 re f BT /F14 1 Tf 9.5 0 0 9.5 247.4645 629.9715 Tm 0 0 0 1 k (VA)Tj /F9 1 Tf 1.4084 0 TD (AK)Tj ET 0 0 0 rg 273.713 628.838 6.8031 0.22675 re f BT /F14 1 Tf 9.5 0 0 9.5 273.7133 629.9715 Tm 0 0 0 1 k (G)Tj /F9 1 Tf 0.7161 0 TD (A,)Tj -24.7538 -1.2114 TD [(similar)-427.8(to)-427.3(that)-427.2(found)-426.8(in)-428.3(isolates)-425(from)-426(Cameroon)-428.8(and)-429.6(Nigeria)]TJ T* (\()Tj 0 0 0 0.7 k 0.3461 0 TD [(Chauvin)-452.1(et)-457.6(al.,)-452.5(2015)]TJ 0 0 0 1 k 8.5218 0 TD (;)Tj 0 0 0 0.7 k 0.6743 0 TD [(Oguike)-453.9(et)-457.6(al.,)-452.5(2016)]TJ 0 0 0 1 k 8.0026 0 TD [(\).)-453.5(These)-457.8(haplotypes)]TJ -17.5449 -1.2114 TD 0.0304 Tc [(occurring)-532.1(in)-532.6(Central)-531.2(a)1.9(nd)-535.7(West)-532.9(Africa)-529.2(su)-4.6(ggested)-529.7(t)-1.8(hat)-532.9(S)-2.9(P)]TJ T* 0 Tc [(conferred)-415(a)-410.4(selective)-413.9(advantage,)-412.9(and)-411.7(ongoing)-412.1(drug)-411.7(pressure)-413.7(is)]TJ 0 -1.2055 TD [(relative)-236(strong)-228.1(because)-237.1(SP)-229.2(was)-234.7(used)-232.9(as)-231.4(IPTp)-232.7(in)-231.4(these)-232.7(regions.)-232.8(It)-230.3(is)]TJ 0 -1.2114 TD [(noted)-305(A437G)-307(was)-306.3(widely)-307.4(spread)-309.1(in)-309(central)-305.6(and)-310.2(western)-303.7(African)]TJ T* [(countries,)-371.9(which)-371.9(indicating)]TJ /F10 1 Tf 11.4281 0 TD [(in)-368.7(vivo)]TJ /F9 1 Tf 3.1509 0 TD [(SP)-366.4(drug)-369.9(resistance)-375(in)-368.7(these)]TJ -14.579 -1.2114 TD [(regions)-301.6(\()]TJ 0 0 0 0.7 k 3.5448 0 TD [(Pearce)-301.2(et)-296.5(al.,)-303.3(2009)]TJ 0 0 0 1 k 7.2686 0 TD [(\).)-298.3(Some)-298.5(other)-297.9(studies)-303.5(combined)-295.9(with)]TJ -10.8134 -1.2114 TD [(the)-219(clinical)-219.5(study)-223.1(indicated)-224.9(the)]TJ /F10 1 Tf 12.2695 0 TD (pfdhfr)Tj /F9 1 Tf 2.6138 0 TD [(triple)-221.4(mutant)-219(genotype)-220.3(was)]TJ -14.8833 -1.2114 TD 0.0134 Tc [(associ)4.9(ate)5.7(d)-510.9(wi)4.9(th)-505.9(SP)-504.7(treat)5.1(m)1.9(ent)-508.1(r)1.4(e)5.7(s)1.4(ist)5.1(a)-3.1(n)5.4(c)-0.3(e)-507.5(\()]TJ 0 0 0 0.7 k 17.9089 0 TD 0.009 Tc [(Ba)-7.5(sco)-517.4(e)1.3(t)-512.5(a)-7.5(l,)-519(2000)]TJ 0 0 0 1 k 7.5312 0 TD 0 Tc (;)Tj 0 0 0 0.7 k -25.4401 -1.2055 TD [(Naidoo)-439.6(et)-433.8(al.,)-440.5(2013)]TJ 0 0 0 1 k 8.0265 0 TD [(\).)-435.6(However,)-440(in)-440.3(this)-434.8(study,)-440.7(the)-433.9(A437G)-438.3(was)]TJ -8.0265 -1.2114 TD [(not)-202.6(widely)-199.9(spread)-207.7(in)-201.6(central)-204.1(and)-202.8(western)-202.2(African)-202.7(region,)-203(even)-204(less)]TJ T* [(than)-271.7(S436A,)-275.3(which)-270.5(was)-276.5(also)-269.1(dif)56.5(ferent)-271.9(with)-270.9(our)-275(previous)-274.1(study)-276.8(in)]TJ T* [(China-Myanmar)-209.5(border)-206.5(\()]TJ 0 0 0 0.7 k 10.139 0 TD [(Zhang)-209(et)-207(al.,)-201.8(2014)]TJ 0 0 0 1 k 6.9404 0 TD [(\),)-202.9(which)-210.8(may)-202.7(partially)]TJ -17.0794 -1.2114 TD [(ascribe)-352.2(as)-350.8(the)-356.3(sample)-351.9(size)-352.2(limitation,)-351.7(the)-356.3(loss)-348.1(of)-354.8(drug)-352(pressure,)]TJ T* [(and)-304.2(time)-298.7(passage)-304.1(may)-304.1(also)-299(the)-302.6(potential)-303.3(reason.)]TJ 1.2651 -1.2114 TD [(In)-331.5(ou)17.4(r)-346.2(s)11.9(tu)22.3(dy)17.2(,)-343(t)0(h)21.4(e)-347.9(fr)22.4(eq)18.9(ue)17(nc)20.1(y)-341.7(o)0(f)-336.9(t)0(h)21.4(e)-347.9(q)14.7(u)0(a)20.1(d)0(r)18.7(u)0(p)19.5(l)0(e)-336.6(m)12.3(ut)16.4(a)13.3(t)0(i)18.9(o)0(n)]TJ ET 0 0 0 rg 269.518 433.361 16.554 0.22678 re f BT /F14 1 Tf 9.5 0 0 9.5 269.5181 434.4377 Tm 0 0 0 1 k [(IR)16.5(N)]TJ /F9 1 Tf 1.7426 0 TD (/)Tj -25.3387 -1.2055 TD [(IS)19.2(A)]TJ ET 0 0 0 rg 59.187 421.852 5.3858 0.22678 re f BT /F14 1 Tf 9.5 0 0 9.5 59.1874 422.9857 Tm 0 0 0 1 k (E)Tj /F9 1 Tf 0.5669 0 TD [(A)12.7(A)-244(wa)15.9(s)-244.7(s)11.9(ig)19.8(ni)]TJ /F12 1 Tf 5.1441 0 TD ()Tj /F9 1 Tf 0.5192 0 TD [(ca)17.5(nt)19.5(ly)-234.9(h)11.8(i)0(g)19.8(h)11.8(er)-234.5(in)-237.4(Ea)20.3(s)11.9(t)-247(Af)17.2(r)11.9(i)0(c)19.6(a)-243.3(\(1)16.4(0)13.5(0)0(%)-239(i)15.3(n)-246.7(U)0(g)17.3(a)13.3(nd)16.7(a)13.3(,)]TJ -7.6863 -1.2114 TD [(85)21.1(.7)22.7(%)-192.9(i)0(n)-183.7(M)13.7(oz)20.8(am)19.7(bi)20(qu)21.5(e\))-183.9(th)21.4(a)13.3(n)-193(we)18.8(s)11.9(t)0(e)19.8(r)11.9(n)-193(a)0(n)17.2(d)-190.2(ce)20.4(nt)19.5(r)11.9(a)0(l)-178.3(A)0(f)17.2(r)11.9(ic)19.6(an)-179.7(co)20.9(un)16.7(tr)21.5(ie)19.6(s)]TJ T* 0.0132 Tc [(\()4.1(P)-457.2(<)-460.3(0)2.9(.)4.4(0)2.9(1\))4.1(,)-461(s)13.2(ugg)5.7(e)5.5(st)4.9(in)5.2(g)-459.8(t)4.9(hat)-454.6(t)4.9(he)-454(cl)6.6(in)5.2(i)4.7(c)-0.5(al)-452.9(im)13.2(pli)4.7(c)-0.5(at)4.9(i)4.7(o)0(n)5.2(s)-458.3(o)5.9(f)-459.7(su)13.2(ch)]TJ T* 0 Tc [(hap)14(lot)13.6(yp)11.2(es)-437.4(req)12.9(uir)10.1(e)-437.4(fur)11.3(the)13.7(r)-441.6(com)15.3(bin)12(ed)-436.6(gen)12.6(oty)12.8(pe)-436.6(an)11.2(d)-440.8(phe)10.9(not)12.2(yp)11.2(e)]TJ T* [(an)17.2(a)13.3(l)0(y)21.7(s)0(i)21.3(s)0(.)-384.8(S)0(P)-384.3(w)0(a)21.9(s)-393.9(li)20.6(m)12.3(i)0(t)18.9(e)0(d)-382.9(f)0(o)21.2(r)-393.9(ma)19.7(la)18.6(r)11.9(i)0(a)-383.1(c)0(o)20.9(n)0(t)19.5(r)11.9(ol)-383.9(am)19.7(on)20.5(g)-389.4(t)0(h)15.4(e)-389.6(ge)20.6(ne)20.1(ra)19.2(l)]TJ T* [(po)-12.4(pu)-16.3(l)-6.6(a)0(t)-12.9(i)0(o)-9.8(n)-467.5(in)-470.1(ma)-10.2(n)-8(y)-461(c)-7.7(o)-7.3(un)-13.2(t)-8.3(r)0(i)-14.5(e)-7.7(s)-459.5(i)-8.5(n)-461.6(A)-11.2(fr)-13.4(ic)-10.3(a)-464.1(b)-7.3(e)-7.7(c)-7.7(a)0(u)-9.8(s)0(e)-473.2(o)-7.3(f)-460.9(t)-8.3(he)-467.3(hi)-14.6(g)-7.5(h)]TJ 0 -1.2055 TD 0.032 Tc [(freque)-5.5(ncy)-482.7(o)0.9(f)-482.6(d)-3(rug)-482.7(r)2.1(esistance)-483(d)-3(evelope)-5.5(d)-480.4(by)]TJ /F10 1 Tf 19.5023 0 TD 0.0299 Tc [(P.)-487.1(fa)-6.3(lc)-6.9(ip)-4.3(ar)-5.9(um)]TJ /F9 1 Tf 5.9378 0 TD 0 Tc (;)Tj -25.4401 -1.2114 TD [(th)21.4(er)22.1(ef)14.8(or)22.6(e,)-362.6(we)-369.1(ex)24.7(pe)17(ct)19.8(ed)-365(to)-361.7(ob)21.3(ta)16.9(i)15.3(n)-378(SP)-366.4(s)11.9(e)0(n)20.1(s)11.9(it)18.9(iv)19.8(e)-371.7(s)0(t)15.5(r)11.9(a)13.3(i)0(n)19.2(s)0(.)-366.9(I)0(n)20.6(d)0(e)17(e)0(d)22.9(,)-372.8(in)]TJ T* [(ou)17.4(r)-202.9(s)11.9(tu)16.4(d)12.7(y)0(,)-195.3(3)0(9)21.1(.)0(6)16.7(2)13.5(%)-204.8(o)0(f)-193.7(t)0(h)15.4(e)-204.6(is)21.3(ol)21.9(at)22.9(es)-198.7(h)11.8(a)0(r)19.2(b)0(o)21.3(r)11.9(ed)-197.9(th)21.4(e)-204.6(n)0(o)20.5(n)0(-)17.7(m)12.3(ut)16.4(a)13.3(t)0(e)19.8(d)]TJ /F10 1 Tf 23.1426 0 TD -0.0158 Tc [(pf)-15.8(dh)-15.8(p)6.4(s)]TJ /F9 1 Tf -23.1426 -1.2114 TD 0 Tc [(ge)20.6(ne)20.1(.)-331(T)0(h)17.1(i)15.3(s)-334.2(m)12.3(ay)-322.4(be)-319.3(s)11.9(i)0(m)15.7(i)0(l)20.6(a)13.3(r)-334.2(t)0(o)-319.9(t)0(h)21.4(e)-330(p)12.8(r)0(o)16.6(c)0(e)20.4(s)11.9(s)-334.2(f)0(o)21.2(r)-328.2(ch)22(lo)16(r)11.9(o)0(q)19.4(u)12.7(in)19.2(e,)-320.8(wh)20.4(ic)19.6(h)]TJ T* [(te)19.8(nd)22.6(s)-334.2(t)0(o)-314(r)0(e)16.1(c)0(o)20.8(v)0(e)20.6(r)-328.2(it)18.9(s)-328.2(e)0(f)80.4(f)0(e)20.7(c)0(t)19.8(i)0(v)19.8(e)0(n)20.1(e)0(s)22.1(s)-334.2(a)13.3(g)0(a)17.8(i)0(n)19.2(s)11.9(t)-330.6(t)0(h)21.4(e)-330(p)12.7(a)0(r)19.2(a)0(s)19.2(i)0(t)18.9(e)-330(a)13.3(f)0(t)20.1(e)0(r)-324(a)-326.9(lo)21.9(ng)]TJ T* [(pe)17(r)11.9(i)0(o)20(d)-148.4(d)12.7(u)0(r)18.7(i)0(n)19.2(g)-150.7(wh)20.4(ic)19.6(h)-149.3(i)0(t)24.9(s)-149.2(us)18.7(e)-150.9(i)0(n)-141.9(m)12.3(al)18.6(a)13.3(r)0(i)21.3(a)-153.8(co)20.8(nt)19.5(r)11.9(o)0(l)-139.2(a)13.3(ct)19.8(iv)19.8(it)18.9(ie)19.6(s)-149.2(i)0(s)-139.9(h)11.8(al)18.6(t)15.6(e)0(d)-144.1(\()]TJ 0 0 0 0.7 k 24.6225 0 TD -0.0118 Tc (Lu)Tj -24.6225 -1.2114 TD 0 Tc [(et)-218.9(al)18.6(.,)-220.4(2)13.5(0)0(1)21.1(7)]TJ 0 0 0 1 k 4.1356 0 TD (\).)Tj /F1 1 Tf 11.9999 0 0 11.9999 45.3543 244.6865 Tm (CONCLUSION)Tj /F9 1 Tf 9.5 0 0 9.5 45.3543 224.674 Tm [(This)-313.7(study)-306.6(showed)-316(a)-309(high)-308.7(frequency)-317(of)-307.1(SP-resistance)-315.8(associated)]TJ 0 -1.2114 TD [(SNPs)-391.3(in)-392.5(the)]TJ /F10 1 Tf 5.353 0 TD (pfdhfr)Tj /F9 1 Tf 2.7869 0 TD (and)Tj /F10 1 Tf 1.8858 0 TD (pfdhps)Tj /F9 1 Tf 2.9659 0 TD [(genes)-389(of)]TJ /F10 1 Tf 3.7656 0 TD [(P.)-388.7(falciparum)]TJ /F9 1 Tf 5.8543 0 TD (isolated)Tj -22.6114 -1.2114 TD [(since)-354.3(2017)-351.7(in)-350.8(returned)-352.4(migrant)-352.9(workers)-352.9(from)-354.4(Africa.)-352.6(The)-354.6(high)]TJ T* [(resistance)-213.8(may)-214.6(be)-205.9(linked)-215.4(to)-212.5(the)-207.1(unsuccessful)-221.8(withdrawal)-211.7(of)-211.6(the)-207.1(SP)]TJ 27.4512 54.7711 TD [(treatment,)-216.6(and)-220.7(thus)-216.5(might)-215(af)59.6(fect)-216.1(the)-219(ef)]TJ /F12 1 Tf 14.9788 0 TD ()Tj /F9 1 Tf 0.5311 0 TD [(cacy)-218.5(of)-211.6(IPTp)-220.8(for)-217.6(pregnant)]TJ -15.5099 -1.2114 TD [(women)-294.4(and)-298.3(IPTi)-295.8(for)-295.1(infants.)-298.4(Mutations)-299.1(such)-293.5(as)-297.1(K540E,)-297.8(and)-298.3(the)]TJ /F10 1 Tf T* 0.0289 Tc (pfdhfr-pfdhps)Tj /F9 1 Tf 6.2064 0 TD 0.0254 Tc [(ha)-9(plo)-5.7(t)-0.8(y)-5.9(p)-3.6(e)]TJ ET 0 0 0 rg 409.946 686.608 m 427.635 686.608 l 427.635 686.324 l 409.946 686.324 l f* BT /F14 1 Tf 9.5 0 0 9.5 409.9464 687.4581 Tm 0 0 0 1 k 0.0306 Tc (IRN)Tj /F9 1 Tf 1.8619 0 TD 0.0257 Tc [(/I)-5.3(SA)]TJ ET 0 0 0 rg 445.89 686.324 5.726 0.28345 re f BT /F14 1 Tf 9.5 0 0 9.5 445.8897 687.4581 Tm 0 0 0 1 k 0 Tc (E)Tj /F9 1 Tf 0.6027 0 TD 0.0292 Tc [(AA,)-528.6(which)-525.9(o)-1.9(ccurred)-530.9(a)0.7(t)]TJ -15.313 -1.2114 TD 0 Tc [(moderate)-464.1(frequencies)-469(in)-464.1(East)-465.5(Africa,)-466(such)-466.6(as)-464.1(in)-464.1(Uganda)-464.6(and)]TJ T* [(Mozambique,)-290.8(the)-278.7(other)-286(regions)-289.7(showed)-286.2(as)-279.2(high)-284.8(frequency)-293.1(triple)]TJ T* [(mutations)-217(of)]TJ /F10 1 Tf 5.2575 0 TD (pfdhfr)Tj /F9 1 Tf 2.399 0 TD [(,)-211.7(but)-211.7(relatively)-214.3(scatter)-215.8(site)-215.6(mutations)-217(in)]TJ /F10 1 Tf 15.4324 0 TD (pfdhps)Tj /F9 1 Tf -23.0889 -1.2055 TD [(gene.)-266.5(The)-259.1(present)-263.7(data)-267.4(could)-258.6(provide)-268.1(the)-260.8(evidence)-262.9(for)-265.3(molecular)]TJ 0 -1.2114 TD [(surveillance)-314.9(in)-309(the)-308.6(post-elimination)-315.5(stage)-308.6(in)-309(China,)-311(focusing)-308.2(on)]TJ T* [(th)-8.4(e)-509(r)0(i)-8.6(s)0(k)-513.6(p)0(o)-12.4(p)0(u)-10.3(lat)-13.6(ion)-513.2(am)-10.2(o)-7.3(n)0(g)-510.8(r)0(e)-13.7(t)0(u)-7.5(r)0(n)-8.1(i)-8.5(ng)-510.8(mi)-8.2(g)-7.5(r)0(a)-10.6(n)0(t)-511.7(w)0(o)-10.6(rke)-14.1(rs)-513.3(fr)-7.4(o)-7.2(m)]TJ T* [(Africa,)-460(and)-465.4(could)-461.6(be)-456.6(used)-459.7(to)-463.1(determine)-464.6(the)-457.8(treatment)-464.4(policy)]TJ T* [(for)-301.1(imported)-304.4(malaria)-303.1(in)-303(China.)]TJ /F1 1 Tf 11.9999 0 0 11.9999 306.1417 557.1778 Tm [(DATA)-298.3(AVAILABILITY)-306.6(STATEMENT)]TJ /F9 1 Tf 9.5 0 0 9.5 306.1417 537.1652 Tm [(The)-360.6(raw)-360(data)-362.8(supporting)-359.5(the)-362.3(conclusions)-364.7(of)-360.8(this)-357.2(article)-359.8(will)-359.3(be)]TJ T* [(made)-303.5(available)-302.7(by)-301.2(the)-296.6(authors,)-308.8(without)-297.6(undue)-305.7(reservation.)]TJ /F1 1 Tf 11.9999 0 0 11.9999 306.1417 487.3889 Tm [(ETHICS)-305.6(STATEMENT)]TJ /F9 1 Tf 9.5 0 0 9.5 306.1417 467.3763 Tm [(The)-450.1(studies)-452.7(involving)-451.4(human)-453.2(participants)-451(were)-454.4(reviewed)-453.4(and)]TJ T* [(approved)-358.8(by)-360.9(the)-356.3(ethical)-359.9(committee)-359.1(of)-360.8(the)-356.3(National)-359.3(Institute)-360(of)]TJ T* [(Parasitic)-357.6(Diseases)-361.9(\(NIPD\),)-355.4(Chinese)-360.8(Centre)-354.5(for)-360.8(Disease)-355.9(Control)]TJ T* [(and)-292.3(Prevention,)-297.6(Chinese)-295.2(Center)-294.8(for)-289.2(Tropical)-297.2(Diseases)-290.3(Research.)]TJ T* 0.0256 Tc [(The)-525.2(p)-3.4(atient)5.3(s/partici)5.1(p)-3.4(ants)-523.5(provided)-522.6(their)-523.5(w)-1.6(ritten)-519.5(i)-0.9(nformed)]TJ 0 -1.2055 TD 0 Tc [(consent)-303.7(to)-302(participate)-301.4(in)-303(this)-303.5(study.)]TJ /F1 1 Tf 11.9999 0 0 11.9999 306.1417 371.5652 Tm [(AUTHOR)-302.7(CONTRIBUTIONS)]TJ /F9 1 Tf 9.5 0 0 9.5 306.1417 351.5527 Tm -0.0174 Tc [(HY)-406.9(co)5.2(nc)4.7(eiv)5(e)-1.2(d)-404.5(t)-1.8(h)6.3(e)-407(study)5(.)-408.1(J)0.2(-hY,)-402.1(FH,)-402.1(X)1(-yF,)-408.1(and)-404.5(J)0.2(F)-404.5(p)1.3(erf)5.1(o)-0.8(rmed)-404.5(t)4.1(h)0.4(e)]TJ 0 -1.2114 TD -0.0186 Tc [(study)-205.1(and)-202.8(a)0.7(nalyzed)-202.8(the)-205.3(d)0.1(ata.)-206.4(JF)-202.8(assist)]TJ 13.8629 0 TD -0.0168 Tc [(ed)-201(w)3.8(i)4.5(th)-201.9(e)5.3(d)1.9(it)4.7(in)5(g)-203.3(t)-1.2(h)6.9(e)-203.5(manusc)5.3(ript)4.7(.)]TJ -13.8629 -1.2114 TD -0.0188 Tc [(J-pC)-490.7(provided)-495.4(s)5(t)-3.3(rategic)-492(a)0.5(dvice)-486(a)]TJ 13.1169 0 TD [(nd)-489.3(revised)-495.3(t)2.8(he)-491.9(manuscript.)-487(A)-0.1(ll)]TJ -13.1169 -1.2055 TD -0.0185 Tc [(auth)5.2(ors)-263.2(a)0.8(ssisted)-262.4(with)-269.3(draft)-265.5(r)-0.6(evisio)]TJ 12.8364 0 TD -0.017 Tc [(ns)6.8(.)-264.5(A)1.6(ll)-262.3(autho)5.6(r)0.9(s)-267.7(c)5.1(on)4.8(tri)4.3(b)-0.4(ut)4.5(ed)-260.9(to)-263(t)4.5(h)0.8(e)]TJ -12.8364 -1.2114 TD -0.02 Tc [(arti)-4.7(c)-3.8(l)3.2(e)-302.2(a)-0.7(n)-4.1(d)-299.7(ap)-7.3(prov)-3.6(ed)-305.6(the)-302.2(s)-2.1(ubmitt)-4.4(e)-3.8(d)-299.7(v)-3.6(e)2.1(rsi)-4.7(on)-4.2(.)]TJ /F1 1 Tf 11.9999 0 0 11.9999 306.1417 267.7606 Tm 0 Tc (FUNDING)Tj /F9 1 Tf 9.5 0 0 9.5 306.1417 247.748 Tm [(The)-229.3(work)-237.7(was)-228.8(supported)-234.9(by)-235.5(the)-231(Key)-232.4(Techniques)-233.9(in)-231.4(Collaborative)]TJ T* [(Prevention)-288.8(and)-280.4(Control)-288.6(of)-283.2(Major)-285.3(Infectious)-288.1(Diseases)-284.3(in)-285.1(the)-284.7(Belt)]TJ 0 -1.2055 TD [(and)-369.9(Road)-375.7(\(Grant)-372.4(No.)-369.1(2018ZX10101002-004\))-374.6(and)-369.9(the)-374.2(National)]TJ 0 -1.2114 TD [(Natural)-215.3(Science)-217.9(Foundation)-210.7(of)-217.5(China)-212.7(\(Grant)-211.3(No.)-214(81602904\).)-214.1(The)]TJ T* [(study)-205.2(had)-200.9(also)-203.5(been)-197.8(supported)-205.1(by)]TJ /F11 1 Tf 13.278 0 TD ()Tj /F9 1 Tf 0.3939 0 TD [(the)-201.1(Fifth)-202.6(Round)-205.3(of)-199.6(Three-Year)]TJ -13.6719 -1.2114 TD [(Public)-249.1(Health)-246.1(Action)-248(Plan)-250.9(of)-247.4(Shanghai)-245.8(\(No.)-252.9(GWV-10.1-XK13\))]TJ /F11 1 Tf 25.0463 0 TD ()Tj /F9 1 Tf 0.3939 0 TD (.)Tj /F1 1 Tf 11.9999 0 0 11.9999 45.3543 156.1889 Tm (REFERENCES)Tj /F9 1 Tf 7.4999 0 0 7.4999 45.3543 141.6755 Tm [(Alifrangis,)-337.4(M.,)-342(Lusingu,)-337.3(J.)-336.9(P.,)-332.4(Mmbando,)-341.7(B.,)-334.1(Dalgaard,)-337.7(M.)-340.8(B.,)-334.1(Vestergaard,)-343.7(L.)-331.9(S.,)]TJ 1.3304 -1.2699 TD [(Ishengoma,)-341.2(D.,)-339.3(et)-332.7(al.)-334.7(\(2009\).)-332.1(Five-Year)-337.7(Surveillance)-344.2(of)-335.3(Molecular)-338.7(Markers)-332(of)]TJ 0 -1.2624 TD [(Plasmodium)-398(Falciparum)-392.5(Antimalarial)-398(Drug)-393.3(Resistance)-397.9(in)-393.3(Korogwe)-387.5(District,)]TJ 0 -1.2699 TD 0.0286 Tc [(Tanzani)-6.2(a)4.5(:)-532(A)5(ccumulation)-526.5(of)-527(the)-530.5(581G)-533.3(Mutation)-534(in)-526.5(the)-530.5(P)1(.)-524.4(F)-3.2(alc)6.2(i)-6.2(parum)]TJ 0 -1.2624 TD 0 Tc [(Dihydropteroate)-433.6(Synthase)-436.4(Gene.)]TJ /F10 1 Tf 13.735 0 TD [(Am.)-427.9(J.)-426.6(Trop.)-429.5(Med.)-427.5(Hyg.)]TJ /F9 1 Tf 10.3031 0 TD [(80,)-426.5(523)]TJ /F11 1 Tf 3.0388 0 TD ()Tj /F9 1 Tf 0.514 0 TD [(527.)-431.3(doi:)]TJ -27.5909 -1.2699 TD (10.4269/ajtmh.2009.80.523)Tj -1.3304 -1.2699 TD [(Basuki,)-387(S.,)-381(F.,)-382(Risamasu,)-388.5(P.)-376.5(M.,)-387.4(Kasmijati,)-385.8(A.)-380(P.,)-377.8(Riyanto,)-389.1(S.,)-381(Hidayat,)-387.5(A.,)-381.3(et)-378.1(al.)]TJ 1.3304 -1.2624 TD 0.0188 Tc [(\(201)6.5(8\).)-519.1(O)1.9(r)4.8(i)-0.9(gins)-516.7(and)-519.5(S)3(pread)-511.9(o)-2.8(f)-514.1(N)1.9(ovel)]TJ 16.8342 0 TD [(Genetic)-517.8(V)-2.4(ariants)-516.8(o)4.7(f)-521.8(S)2.9(ulf)7.3(a)-5.4(doxi)6.6(ne-)]TJ 17.9379 11.3992 TD 0 Tc [(Pyrimethamine)-367.6(Resistance)-360.1(in)-355.5(Plasmodium)-360.2(Falciparum)-362.3(Isolates)-360(In)-358.1(Indonesia.)]TJ /F10 1 Tf 0 -1.2699 TD [(Malaria)-307.5(J.)]TJ /F9 1 Tf 4.3616 0 TD [(17,)-305.6(475.)-295.2(doi:)-301.1(10.1186/s12936-018-2597-6)]TJ -5.692 -1.2624 TD -0.0399 Tc [(Basco,)-215(L.)-215(K.,)-215(T)-0.4(ahar,)-215(R)-0.4(.,)-215(Keundjian)-5.4(,)-215(A.,)-215(a)-3.5(nd)-215.3(Ri)]TJ 16.101 0 TD -0.0404 Tc [(ng)-5.7(wal)5.5(d)-4.2(,)-215.5(P)0(.)-215.5(\()0.2(2)-7.4(000\).)-215.5(Sequen)-5.9(ce)-221.6(Variations)-213.1(in)-217.5(the)]TJ -14.7706 -1.2699 TD -0.044 Tc [(G)-8.8(e)-6(ne)-6(s)-246.9(E)-3.6(n)-9.5(c)-6(od)-7.8(i)-3.2(n)-9.5(g)-243.6(D)-10.4(i)-3.2(h)-4.3(yd)-7.8(r)-5(o)-5.1(pt)-6.6(e)-6(r)-5(oa)-7.6(t)-6.6(e)-247.9(S)-6.9(y)-1.8(n)-9.5(t)1(h)-4.3(a)-7.6(s)-5(e)-247.8(a)-7.6(n)-1.9(d)-249.7(D)-2.9(i)-10.8(h)-4.4(yd)-7.8(ro)-5.1(f)-10(o)2.5(l)-5.7(a)-7.6(t)-6.6(e)-247.8(R)-4.5(e)-6(du)-7.8(c)-6(t)1(a)-7.6(s)-5(e)-247.8(a)-7.6(nd)-257.2(Cl)-5.7(i)-3.2(n)-1.9(i)-10.8(c)1.6(a)-7.6(l)]TJ 0 -1.2624 TD -0.0387 Tc [(Response)-499.6(to)-498.7(Sulfadoxine-)5.4(Pyrimethamin)]TJ 14.9974 0 TD -0.0373 Tc [(e)-498.2(i)3.5(n)-501.7(P)3.1(at)7.7(ie)8.3(nts)-497.2(W)0.9(ith)-496.5(A)-0.4(cu)6.5(te)-498.2(Uncompl)8.6(i)-4.1(ca)6.6(ted)]TJ -14.9974 -1.2699 TD -0.0378 Tc [(Fal)8.1(c)0.2(ipa)6.1(r)1.2(um)-299.2(Ma)6.1(laria)6.1(.)]TJ /F10 1 Tf 7.7179 0 TD -0.0394 Tc [(J.)-294.2(Infect.)-301.7(D)0(is.)]TJ /F9 1 Tf 4.8908 0 TD -0.0406 Tc [(182,)-298.8(62)-7.6(4)]TJ /F11 1 Tf 3.1144 0 TD 0 Tc ()Tj /F9 1 Tf 0.4687 0 TD -0.0406 Tc [(628.)-298.8(doi:)-298.8(1)-7.6(0)0(.10)-7.6(86/3157)-7.6(31)]TJ -17.5221 -1.2624 TD 0 Tc [(Berglez,)-462(J.,)-459(Iliades,)-460(P.,)-460.9(Sirawaraporn,)-460.3(W.,)-463.1(Coloe,)-453.4(P.,)-460.9(and)-459.8(Macreadie,)-461.2(I.)-461.9(\(2004\).)]TJ 1.3304 -1.2699 TD [(A)-8.4(nal)-11.7(ys)-9.5(is)-509.9(in)-514.3(Es)-11.3(che)-12.8(ri)-11(chi)-10(a)-507.9(C)-9.2(oli)-516.9(of)-509.2(Pl)-11.9(asm)-12.2(odi)-12.6(um)-512.4(F)-9.1(a)0(l)-8.4(cip)-13.5(arum)-520.2(Di)-8.8(hy)-8.8(dro)-14.4(pt)-9.5(ero)-12.6(at)-9.3(e)]TJ T* [(Sy)-18.9(nt)-11.2(ha)-14.7(se)-520.2(\(D)-16.5(HPS)-16.6(\))-518.7(All)-14.9(el)-14.3(es)-520.2(Im)-19.1(pl)-8.6(i)-12.1(c)0(a)-8.7(t)-7.9(ed)-522.9(in)-521.9(Re)-13.1(si)-11(st)-14.3(a)-9(n)0(c)-10.6(e)-513.8(t)-7.9(o)-512.9(Su)-17.4(lf)-10.8(a)-9(d)-9.1(ox)-14.7(ine)-15.1(.)]TJ /F10 1 Tf 28.6945 0 TD [(In)-12.9(t)-7.9(.)-511.8(J.)]TJ -28.6945 -1.2624 TD (Parasitol)Tj /F9 1 Tf 3.515 0 TD [(.)-296(34,)-305.6(95)]TJ /F11 1 Tf 2.9556 0 TD ()Tj /F9 1 Tf 0.5065 0 TD [(100.)-302.8(doi:)-301.1(10.1016/j.ijpara.2003.09.009)]TJ ET 0 0 0 0.7 k 45.354 737.518 504.567 0.28345 re f BT /F6 1 Tf 6.9999 0 0 6.9999 45.3543 744.2644 Tm [(Yan)-298.8(et)-300.5(al.)]TJ /F5 1 Tf 53.0817 0 TD (pfdhfr)Tj /F6 1 Tf 2.4864 0 TD (/)Tj /F5 1 Tf 0.324 0 TD (pfdhps)Tj /F6 1 Tf 3.2802 0 TD [(Mutations)-303(in)-304.4(Chinese)-298.8(Migrants)]TJ ET 45.354 42.803 504.567 0.22675 re f 45.354 42.803 504.567 0.22675 re f BT 6.9999 0 0 6.9999 45.3543 31.2945 Tm [(Frontiers)-306.1(in)-296.3(Cellular)-302.6(and)-306.5(Infection)-301.5(Microbiology)-499.5(|)-502.8(www.frontiersin.org)-22490(September)-305.7(2021)-505.2(|)-494.7(Volume)-307.7(11)-499.6(|)-494.7(Article)-305.6(673194)]TJ 35.7658 0 TD (7)Tj ET endstream endobj 104 0 obj<> endobj 105 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 106 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 107 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 108 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 109 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 110 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 111 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 112 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 113 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 114 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 115 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 116 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 117 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 118 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 119 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 120 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 121 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 122 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 123 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 124 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 125 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 126 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 127 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 128 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 129 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 130 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 131 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 132 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 133 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 134 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 135 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 136 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 137 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 138 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 139 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 140 0 obj<>/Border[0 0 0]/Type/Annot>> endobj 141 0 obj<>/ProcSet[/PDF/Text]/ExtGState<>>> endobj 142 0 obj<>stream /GS1 gs BT /F9 1 Tf 7.4999 0 0 7.4999 45.3543 711.9495 Tm 0 0 0 1 k 0 Tc 0 Tw [(Chauvin,)-294.6(P.,)-294.6(Menard,)-300.3(S.,)-297.9(Iriart,)-292.1(X.,)-302.3(Nsango,)-295.8(S.)-289.1(E.,)-302.2(Tchiof)64.6(fo,)-298.7(M.)-295.4(T.,)-295.5(Abate,)-289.8(L.,)-295.4(et)-294.9(al.)]TJ 1.3304 -1.2699 TD 0.0356 Tc [(\(2)-7(015\).)-532.6(Prevalence)-531.1(of)-535.1(Plasmodium)-535.7(Fa)]TJ 17.1215 0 TD 0.0358 Tc [(lciparum)-535.5(Parasites)-537.5(R)-0.3(es)6.7(i)-6.6(s)6.7(tant)-531.5(to)]TJ -17.1215 -1.2624 TD 0 Tc [(Su)-17.4(lfa)-12.2(dox)-16.3(ine)-15.1(/Py)-11.1(ri)-11(me)-11.7(t)-7.9(ham)-11.5(in)-15.4(e)-506.2(i)0(n)-514.3(P)0(r)-11.3(e)0(g)-10.4(n)0(a)-12.2(n)0(t)-510.1(W)0(o)-13.6(m)0(e)-11.7(n)-509.7(in)-514.3(Yao)-10.3(u)-9.1(n)0(d)-12.4(e)0(,)-515(Cam)-15(ero)-12.6(on)-9.7(:)]TJ 0 -1.2699 TD 0.0371 Tc [(E)-5.6(m)2.5(er)8(gence)-529.6(o)0.4(f)-533.6(H)-4.2(ighly)-532.9(R)1(esista)5.4(nt)-530.2(Pfd)5.3(h)1.2(fr/Pfdhp)5.3(s)-536.2(A)-1.6(ll)7.4(eles.)]TJ /F10 1 Tf 24.9376 0 TD 0.0354 Tc [(J.)-536.9(Ant)4.8(i)-4.5(microb)-7.2(.)]TJ -24.9376 -1.2624 TD 0 Tc (Chemother.)Tj /F9 1 Tf 4.8832 0 TD [(70,)-305.6(2566)]TJ /F11 1 Tf 3.3941 0 TD ()Tj /F9 1 Tf 0.514 0 TD [(2571.)-300(doi:)-301.1(10.1093/jac/dkv160)]TJ -10.1217 -1.2699 TD 0.1599 Tc [(C)180.9(h)184.4(i)185.6(c)182.8(o)183.7(,)-0.1(R)184.3(.)-0.1(M)183.2(.)181.4(,C)188.5(a)181.1(n)186.9(o)183.7(,)-0.1(J)179.5(.)181.4(,A)189.3(r)183.7(i)178(t)182.2(i)185.6(,C)188.5(.)181.4(,)-0.1(C)180.9(o)183.7(l)183.1(l)183.1(i)185.6(e)182.8(r)183.7(,T)184.3(.J)187.1(.)181.4(,)-0.1(C)180.9(h)184.4(a)181.1(n)186.9(d)181(r)183.7(a)181.1(m)185.7(o)183.7(h)184.4(a)181.1(n)186.9(,D)185.9(.)181.4(,)-0.1(R)184.3(o)183.7(p)181(e)182.8(r)183.7(,)-0.1(C)188.5(.)181.4(,e)182.8(ta)181.1(l)183.1(.)-0.1(\()185.4(2)185.3(0)185.4(1)177.8(5)185.4(\))185.4(.)]TJ 1.3304 -1.2699 TD -0.0231 Tc (In)Tj /F12 1 Tf 0.8315 0 TD 0 Tc ()Tj /F9 1 Tf 0.5065 0 TD -0.0245 Tc [(uence)-205.7(o)-0.7(f)-209.7(M)-1.2(alaria)-207.3(Trans)-8.2(m)1.4(ission)-209.2(In)-5.1(ten)-5.1(s)-0.7(ity)-201.5(a)-3.3(n)-5.1(d)-207.5(the)-213.2(5)0.9(81G)-208.5(M)-1.2(utation)-209.2(o)-0.7(n)-201.6(t)-2.2(he)-205.7(E)-6.8(f)]TJ /F12 1 Tf 27.674 0 TD 0 Tc ()Tj /F9 1 Tf 0.5065 0 TD -0.0221 Tc [(cac)8.4(y)]TJ -29.5185 -1.2624 TD -0.0237 Tc [(of)-284.5(Intermittent)-281.1(Preventive)-280.5(Treat)6.2(m)-5.4(ent)-281.1(i)2(n)-276.4(P)]TJ 15.9952 0 TD -0.0256 Tc [(regn)-6.2(an)-6.2(cy:)-283.8(S)-3.6(ystema)-4.4(tic)-282.4(R)-1.2(evi)-7.5(e)-2.7(w)-278.4(a)-4.4(nd)-284.2(Meta)-4.4(-)]TJ -15.9952 -1.2699 TD -0.0224 Tc [(Ana)6.4(l)0.8(ysis.)]TJ /F10 1 Tf 3.6435 0 TD -0.0187 Tc [(T)7.4(r)5.1(op)6.8(.)-265.9(M)9.7(ed)5.1(.)-258.4(I)4.4(nt)11.2(.)-265.9(H)2.2(e)5.9(a)1.6(l)8.6(t)3.6(h)-264.6(T)7.4(M)-270(I)4.4(H)]TJ /F9 1 Tf 11.815 0 TD -0.0255 Tc [(20,)-276.2(162)-7.6(1)]TJ /F11 1 Tf 3.1975 0 TD 0 Tc ()Tj /F9 1 Tf 0.4838 0 TD -0.0248 Tc [(163)-6.9(3)0.6(.)-267.9(d)-3.7(oi:)-275.5(10.111)-6.9(1/tm)-6.5(i.12595)]TJ -20.4702 -1.2624 TD -0.0242 Tc [(Chulay)-4.6(,)-335.3(J)-4.6(.)-335.3(D)-5.8(.,)-342.9(Watk)-3.9(in)-4.8(s,)-342.9(W.)-335.3(M.,)-342.9(a)4.6(n)-4.8(d)-335.7(Sixsm)-5.9(i)1.5(th)]TJ 17.3558 0 TD -0.0251 Tc [(,)-336.2(D)-6.7(.)-336.2(G)-5(.)-336.2(\()-7.1(1984)-7.2(\).)-343.8(Sy)-5.5(nerg)-5.5(istic)-342.3(A)-3.3(ntim)-6.8(alarial)]TJ -16.0254 -1.2699 TD -0.0227 Tc [(Activity)-373.5(of)-374.2(Pyrimethamine)-370.2(a)-1.5(nd)-372(Su)6(lfad)6(ox)]TJ 15.7608 0 TD -0.0248 Tc [(in)-5.4(e)-372.3(A)-3(g)-5.2(a)4(i)-6.7(n)2.2(st)-380.4(Plasm)-6.5(o)-1(di)-6.7(um)-376.9(Falciparum)-376.9(in)]TJ -15.7608 -1.2624 TD -0.0234 Tc [(V)-6.7(i)2.3(tro.)]TJ /F10 1 Tf 2.4718 0 TD 0.2472 Tc [(A)268.2(m)272.3(.J)272(.T)273.3(r)271(o)269.2(p)272.7(.)0(M)268(e)271.8(d)271(.)0(H)275.6(y)268.4(g)270.1(.)]TJ /F9 1 Tf 9.0861 0 TD -0.0254 Tc [(33,)-276.1(3)0.1(25)]TJ /F11 1 Tf 2.7364 0 TD 0 Tc ()Tj /F9 1 Tf 0.4913 0 TD -0.025 Tc [(330.)-275.7(d)-3.9(oi:)-268.1(1)-7.1(0.4269/)-5.4(ajtm)-6.7(h.1984.33)-7.1(.)4(3)-7.1(2)0.4(5)]TJ -16.1161 -1.2699 TD 0 Tc [(Feng,)-213(J.,)-209.6(Kong,)-202.2(X.,)-211.6(Xu,)-212(D.,)-203.2(Yan,)-212.4(H.,)-210(Zhou,)-208.1(H.,)-210(Tu,)-205.2(H.,)-210(et)-204.2(al.)-213.7(\(2019\).)-203.6(Investigation)-217.6(and)]TJ 1.3304 -1.2699 TD 0.0296 Tc [(E)-5.6(v)3.8(al)7.5(uat)6.6(i)-5.2(on)-525.5(of)-526(Genet)6.6(i)-5.2(c)-522(D)2.7(i)-5.2(v)3.8(ersity)-525.3(of)-526(Plasmodium)-526.6(Falciparum)-526.6(Kelc)7.2(h)-527.9(1)-5.4(3)]TJ 0 -1.2624 TD 0.0145 Tc [(P)-5.6(o)0.5(lymor)-7(p)5.4(hi)-5.2(sms)-513.5(I)-0.2(m)-5(p)5.4(orted)-516.2(From)-511.5(Southeast)-507.4(A)-1.5(si)-5.2(a)-508.5(a)-2(nd)-508.7(Africa)-516.1(in)-517.9(S)14.5(o)-7.7(uthern)]TJ 0 -1.2699 TD 0 Tc (China.)Tj /F10 1 Tf 2.9481 0 TD [(Front.)-299.7(Public)-305.5(Health)]TJ /F9 1 Tf 8.4436 0 TD [(7,)-300.8(95.)-298(doi:)-301.1(10.3389/fpubh.2019.00095)]TJ -12.7221 -1.2624 TD [(Feng,)-311.3(J.,)-307.8(Li,)-313.8(J.,)-307.8(Yan,)-310.7(H.,)-315.8(Feng,)-311.3(X.,)-309.9(and)-308.6(Xia,)-307.1(Z.)-315.3(\(2015a\).)-310.9(Evaluation)-313.8(of)-305.1(Antimalarial)]TJ 1.3304 -1.2699 TD [(Resistance)-443.2(Marker)-439(Polymorphism)-439.3(in)-431.1(Returned)-441.8(Migrant)-434.3(Workers)-435.5(in)-438.7(China.)]TJ /F10 1 Tf 0 -1.2624 TD [(Antimicrob)-304(Agents)-307.5(Chemother)]TJ /F9 1 Tf 12.3894 0 TD [(59,)-305.6(326)]TJ /F11 1 Tf 2.9178 0 TD ()Tj /F9 1 Tf 0.514 0 TD [(330.)-295.2(doi:)-301.1(10.1128/AAC.04144-14)]TJ -17.1517 -1.2699 TD [(Feng,)-356.6(J.,)-353.2(Xiao,)-351.3(H.,)-353.6(Xia,)-352.5(Z.,)-354.3(Zhang,)-351.5(L.,)-355.8(and)-346.4(Xiao,)-358.9(N.)-350.7(\(2015b\).)-353.7(Analysis)-350.5(of)-358(Malaria)]TJ 1.3304 -1.2699 TD [(Epidemiological)-314.1(Characteristics)-309.4(in)-302.6(the)-300.6(People)]TJ /F11 1 Tf 18.2553 0 TD ()Tj /F9 1 Tf 0.2192 0 TD [(s)-301.2(Republic)-306.2(of)-305.1(China)-303.8(2004-2013.)]TJ /F10 1 Tf -18.4746 -1.2624 TD [(Am.)-306.9(J.)-298.1(Trop.)-301(Med.)-299(Hyg.)]TJ /F9 1 Tf 9.6682 0 TD [(93,)-305.6(293)]TJ /F11 1 Tf 2.9178 0 TD ()Tj /F9 1 Tf 0.5065 0 TD [(299.)-302.8(doi:)-301.1(10.4269/ajtmh.14-0733)]TJ -14.4229 -1.2699 TD [(Feng,)-250.8(J.,)-247.4(Zhang,)-253.2(L.,)-242.5(Huang,)-248.4(F.,)-253.5(Yin,)-245.8(J.)-246.1(H.,)-247.8(Tu,)-250.5(H.,)-247.8(Xia,)-246.6(Z.)-247.3(G.,)-254.4(et)-242(al.)-251.5(\(2018\).)-249(Ready)-246(for)]TJ 1.3304 -1.2624 TD [(Malaria)-278.7(Elimination:)-280.3(Zero)-281.3(Indigenous)-279(Case)-281.3(Reported)-278.7(in)-280(the)-277.9(People)]TJ /F11 1 Tf 26.8123 0 TD ()Tj /F9 1 Tf 0.2192 0 TD [(s)-278.5(Republic)]TJ -27.0315 -1.2699 TD [(of)-305.1(China.)]TJ /F10 1 Tf 4.0441 0 TD [(Malaria)-300(J.)]TJ /F9 1 Tf 4.3541 0 TD [(17,)-305.6(315.)-302.8(doi:)-301.1(10.1186/s12936-018-2444-9)]TJ -9.7286 -1.2624 TD [(Gikunju,)-371.8(S.)-372.3(W.,)-372.4(Agola,)-375.4(E.)-369(L.,)-378.5(Ondondo,)-373.3(R.)-369.9(O.,)-374.6(Kinyua,)-377.2(J.,)-368.3(Kimani,)-373.9(F.,)-374.4(LaBeaud,)]TJ 1.3304 -1.2699 TD [(A.)-236.4(D.,)-233.4(et)-226.9(al.)-236.4(\(2020\).)-226.3(Prevalence)-236.8(of)-237(Pfdhfr)-230.3(and)-233(Pfdhps)-235.6(Mutations)-235.5(in)-227(Plasmodium)]TJ T* [(F)-16.7(a)-9(l)-14.6(c)-14.9(i)-12.1(p)-9.1(a)-9(r)-14(u)-16.7(m)-518.4(A)-16(s)-14(so)-20.4(c)-14.9(i)-12.1(a)-9(t)-15.5(ed)-530.5(W)-14.7(i)-12.1(t)-15.5(h)-519.7(D)-11.8(r)-14(u)-9.1(g)-524.7(R)-13.4(e)-14.9(si)-18.5(s)-14(t)-15.5(a)-9(n)-10.8(c)-14.9(e)-521.3(A)-16(m)-11.9(on)-24.8(g)-517.1(P)-12.5(r)-14(e)-14.9(g)-10.7(n)-10.8(a)-16.5(n)-10.8(t)-521.9(W)-14.7(om)-18.4(e)-14.9(n)]TJ 0 -1.2624 TD [(Receiving)-363.8(IPTp-SP)-366.5(at)-364.6(Msambweni)-361.5(County)-364.1(Referral)-363(Hospital,)-365.1(Kwale)-358.4(County,)]TJ 0 -1.2699 TD (Kenya.)Tj /F10 1 Tf 3.0388 0 TD [(Malaria)-307.5(J.)]TJ /F9 1 Tf 4.3616 0 TD [(19,)-305.6(190.)-302.8(doi:)-301.1(10.1186/s12936-020-03263-z)]TJ -8.7308 -1.2624 TD [(Gosling,)-480.5(R.)-475.7(D.,)-475.3(Cairns,)-486(M.)-476.9(E.,)-476(Chico,)-480.4(R.)-475.7(M.,)-478.1(and)-474.9(Chandramohan,)-482.3(D.)-481.7(\(2010\).)]TJ 1.3304 -1.2699 TD [(Intermittent)-377.7(Preventive)-365.1(Treatment)-376.8(Against)-367.7(Malaria:)-370.6(An)-367(Update.)]TJ /F10 1 Tf 26.5855 0 TD [(Expert)-372.9(Rev.)]TJ -26.5855 -1.2624 TD [(Anti)-304.6(Infect.)-301.4(Ther.)]TJ /F9 1 Tf 7.1963 0 TD [(8,)-300.8(589)]TJ /F11 1 Tf 2.434 0 TD ()Tj /F9 1 Tf 0.5065 0 TD [(606.)-302.8(doi:)-301.1(10.1586/eri.10.36)]TJ -11.4672 -1.2699 TD 0.1897 Tc [(J)216.9(i)215.4(a)218.5(n)209.1(g)216.8(,)-0.5(T)221.6(.)211.2(,C)218.3(h)214.2(e)220.2(n)209.1(,)-0.5(J)216.9(.)218.7(,F)210.8(u)218.4(,)-0.5(H)216.5(.)218.7(,W)212.8(u)218.4(,)-0.5(K)213.2(.)218.7(,Y)210(a)218.5(o)213.5(,Y)217.5(.)218.7(,)-0.5(E)215(y)216.8(i)215.4(,)-0.5(J)216.9(.)-0.5(U)215.7(.)-0.5(M)213(.)218.7(,e)212.6(ta)218.5(l)212.9(.)-0.5(\()215.2(2)222.7(0)215.2(1)215.1(9)215.1(\))215.2(.H)216.5(i)215.4(g)216.8(hP)215(r)213.5(e)220.2(v)209.3(a)218.5(l)220.5(e)212.6(n)216.7(c)212.6(eo)213.5(f)]TJ 1.3304 -1.2699 TD -0.0277 Tc [(Pfd)-6.6(h)4.4(f)-8.8(r)3.7(-)-6.3(P)5.2(fd)-6.6(hps)-276(Q)0.7(ua)-6.5(drupl)-4.5(e)-269.3(M)-4.4(ut)-5.4(at)-5.4(ions)-276(Assoc)-4.8(i)-2(at)-5.4(ed)-271.2(W)-4.6(i)-2(th)-275.3(S)-5.7(u)1(lf)-8.8(adoxine)-4.8(-)1.3(Pyrimet)-5.4(h)-3.2(amine)]TJ 0 -1.2624 TD -0.027 Tc [(Re)-4.1(sista)-5.8(n)0(c)-4.1(e)-503(in)-498.9(Pl)-3.8(asmod)-5.9(i)-1.3(um)-507.6(Fa)-5.8(lc)-4.1(ipa)-5.8(r)-3.2(um)-507.6(I)]TJ 16.0103 0 TD -0.0243 Tc [(solate)6.2(s)-499.4(Fro)7(m)-504.9(Bio)7(k)-4(o)-499.4(I)6.3(sland,)-501.7(Equato)7(rial)]TJ -16.0103 -1.2699 TD -0.0215 Tc [(Gu)7.2(i)4.2(n)5.5(ea)7.3(.)]TJ /F10 1 Tf 3.2202 0 TD -0.0271 Tc [(Mal)-7.3(a)0.8(ria)-301.6(J)-2.3(.)]TJ /F9 1 Tf 4.1197 0 TD -0.0248 Tc [(18,)-298.1(1)0.6(01)8.2(.)-305.7(d)3.9(oi)8.4(:)-305.7(1)8.2(0.11)8.2(86/s1293)8.2(6)0.7(-01)8.2(9)0.7(-2)8.2(734-x)]TJ -8.6703 -1.2624 TD 0 Tc [(Kon)21.3(ate,)-297.6(A.)-304.5(T.)15.6(,)-311.1(Yaro)21.1(,)-311.1(J)0(.)-306.6(B)0(.)14.9(,)-311.1(Oue)19.6(dra)13.3(ogo)21.8(,)-311.1(A)0(.)-304.5(Z.,)-301.4(Dia)20(rra)16(,)-311.1(A.,)-298.1(Gan)15.4(sa)14.9(ne,)-299(A.,)-305.7(So)15.6(ula)20.2(ma,)-301.8(I.)14.3(,)]TJ 1.3304 -1.2699 TD [(et)-234.4(al.)-221.3(\(20)16(11\))16(.)-235.5(Int)19.5(er)16.5(mitt)20.6(ent)-222.6(Pre)19.2(ven)16.6(tiv)22.2(e)-241.6(Tre)18.2(atm)16.5(ent)-222.6(of)-229.5(Ma)14.3(lar)15.4(ia)-225.2(Prov)24.5(ide)16.8(s)-240.7(Sub)21.5(sta)14.5(nt)19.1(ial)]TJ 0 -1.2624 TD [(Prot)19.7(ec)15.6(tio)18.8(n)-381.2(Aga)17.3(in)14.9(st)-377.2(Ma)14.3(lar)15.4(ia)-376.4(in)-370.7(Chi)18.3(ldr)15.3(en)-373.4(Al)14.8(rea)15.1(dy)-375.1(Pro)20(te)15(cte)15.3(d)-379.5(b)0(y)-380(a)0(n)-375.1(Ins)21(ec)15.6(tic)18(ide)16.8(-)]TJ 0 -1.2699 TD [(Tr)-12.2(ea)-8.7(ted)-523.3(Bedn)-18.7(et)-514.1(in)-521.8(Burk)-16.9(ina)-523.3(Faso)-15.9(:)-515.2(A)-507.3(Ra)-14.8(ndo)-11.3(mi)-8.9(sed,)-523(Do)-10.7(uble)-14.8(-Bl)-14.9(ind,)-524.6(Pla)-13.4(ceb)-13.5(o-)]TJ T* [(Con)18.9(tro)17(ll)16.2(ed)-288.6(Tria)19.6(l.)]TJ /F10 1 Tf 6.9469 0 TD [(Plo)19.3(S)-290.4(Med)16.3(.)]TJ /F9 1 Tf 4.2634 0 TD [(8,)-285.7(e10)20.9(004)15.9(08.)-282.9(do)14.6(i:)-285.5(10.)19.5(137)15.9(1/)14.9(jou)15.2(rna)19.2(l.)14.5(pme)17(d.1)15.1(000)23.5(408)]TJ -12.5406 -1.2624 TD [(Lu,)-227.7(F.,)-223.2(Zhang,)-230.5(M.,)-228.6(Culleton,)-224.8(R.)-226.3(L.,)-227.3(Xu,)-227.1(S.,)-229.9(Tang,)-226.5(J.,)-232.2(Zhou,)-223.2(H.,)-232.7(et)-219.3(al.)-228.9(\(2017\).)-226.3(Return)-228.8(of)]TJ 1.3304 -1.2699 TD 0.0201 Tc [(Ch)6.8(lo)6.1(roquine)-516.4(S)-3.2(e)5.2(n)1.7(sit)4.6(i)0.4(vit)4.6(y)-519.7(to)-515.5(A)4.1(f)1.2(ric)5.2(a)-4(?)-512(S)-3.2(urve)5.2(ill)5.5(a)-4(nc)5.2(e)-516.4(o)-1.5(f)-512.8(A)-3.5(fri)8(c)-2.3(an)-519.9(Pl)5.5(as)6.1(modium)]TJ 0 -1.2624 TD 0 Tc [(F)-9.1(alcipar)-14.6(um)-504.9(Chlor)-12.1(oquin)-12.3(e)-506.2(Resist)-15.8(ance)-510.6(Thro)-9.3(ugh)-509.3(Mala)-9.3(ria)-503.7(Imp)-13.1(orted)-513.4(to)-505.7(China.)]TJ /F10 1 Tf 0 -1.2699 TD [(Parasites)-305.4(Vectors)]TJ /F9 1 Tf 7.0376 0 TD [(10,)-305.6(355.)-302.8(doi:)-301.1(10.1186/s13071-017-2298-y)]TJ -8.368 -1.2624 TD [(Lynch,)-222.8(C.)-229.6(A.,)-222.5(Pearce,)-224.9(R.,)-227.5(Pota,)-218.5(H.,)-225.1(Egwang,)-232(C.,)-223.3(Egwang,)-224.4(T.,)-219.9(Bhasin,)-233.2(A.,)-222.5(et)-219.3(al.)-228.9(\(2017\).)]TJ 1.3304 -1.2699 TD [(Travel)-469.5(and)-467.4(the)-466.9(Emergence)-474.6(of)-463.8(High-Level)-471.8(Drug)-468.9(Resistance)-465.9(in)-468.9(Plasmodium)]TJ T* [(Falciparum)-430.3(in)-423.6(Southwest)-425.2(Uganda:)-424.4(Results)-420.4(From)-427(a)-417.2(Population-Based)-432.6(Study.)]TJ /F10 1 Tf 0 -1.2624 TD [(Malaria)-307.5(J.)]TJ /F9 1 Tf 4.3616 0 TD [(16,)-305.6(150.)-295.2(doi:)-308.6(10.1186/s12936-017-1812-1)]TJ -5.692 -1.2699 TD [(Mbonye,)-208.6(A.)-213.7(K.,)-205.7(Birungi,)-212.7(J.,)-209.6(Yanow,)-214.6(S.)-206(K.,)-213.3(Shokoples,)-211.4(S.,)-207.2(Malamba,)-211.7(S.,)-214.7(Alifrangis,)-208.9(M.,)]TJ 1.3304 -1.2624 TD [(et)-423.4(al.)-425.4(\(2015\).)-430.4(Prevalence)-425.7(of)-426(Plasmodium)-428.2(Falciparum)-422.8(Resistance)-428.1(Markers)-430.3(to)]TJ 0 -1.2699 TD [(Sulfadoxine-Pyrimethamine)-286.2(Among)-275.1(Pregnant)-271.9(Women)-278(Receiving)-273.1(Intermittent)]TJ 0 -1.2624 TD [(Preventive)-342.4(Treatment)-339(for)-334.1(Malaria)-339.1(in)-332.9(Uganda.)]TJ /F10 1 Tf 18.7845 0 TD [(Antimicrob)-341.8(Agents)-337.7(Chemother.)]TJ /F9 1 Tf -18.7845 -1.2699 TD [(59,)-305.6(5475)]TJ /F11 1 Tf 3.3941 0 TD ()Tj /F9 1 Tf 7.4999 0 0 7.4999 84.6425 198.9354 Tm [(5482.)-300(doi:)-301.1(10.1128/AAC.00507-15)]TJ -5.2385 -1.2699 TD -0.0241 Tc [(Nai)-6(d)4.6(oo,)-342.8(I.,)-342.8(a)-2.9(nd)-343.2(Roper,)-342.8(C.)-342.8(\(198)-6.2(4)1.3(\).)-342.8(Mappi)-6(n)2.9(g)-344.7(')-1.7(Pa)]TJ 18.0588 0 TD -0.0238 Tc [(rt)6.1(i)-5.7(a)5(lly)-344.4(Resistant',)-342.5(')-1.4(Fully)-344.4(Resistant',)-342.5(a)-2.6(nd)]TJ -16.7284 -1.2624 TD 0.0228 Tc [('Super)-512.7(R)-5.7(esistant')-521.8(M)0.7(a)6.2(l)0.7(aria.)]TJ /F10 1 Tf 11.6033 0 TD 0.0214 Tc [(Tre)-6.9(n)0.6(ds)-514.9(Pa)-3.6(ras)-8.4(i)4.2(tol)-4.2(.)]TJ /F9 1 Tf 7.8388 0 TD 0.0199 Tc [(29)-7.6(,)-518(505)]TJ /F11 1 Tf 3.2656 0 TD 0 Tc ()Tj /F9 1 Tf 0.5291 0 TD 0.0207 Tc [(5)-6.8(15.)-517.2(doi)-6.5(:)-517.2(10.10)-6.8(16/)]TJ -23.2368 -1.2699 TD -0.0244 Tc [(j.pt.2)-6.5(013.08.00)-6.5(2)]TJ -1.3304 -1.2624 TD 0 Tc [(Nzila,)-250.1(A.)-251.5(M.,)-243.7(Mberu,)-249.1(E.)-248(K.,)-251.1(Nduati,)-254.4(E.,)-249.3(Ross,)-245.5(A.,)-252.8(Watkins,)-253.4(W.)-242.7(M.,)-251.3(and)-248.1(Sibley,)-249.5(C.)-252.3(H.)]TJ 1.3304 -1.2699 TD [(\(2002\).)-279.2(Genetic)-274.6(Diversity)-274.4(of)-267.3(Plasmodium)-277(Falciparum)-279.1(Parasites)-273.5(From)-275.8(Kenya)-271.3(is)]TJ 0 -1.2624 TD [(Not)-242.9(Af)63.3(fected)-239.3(by)-243.9(Antifolate)-239.5(Drug)-242.1(Selection.)]TJ /F10 1 Tf 17.0686 0 TD [(Int.)-237.8(J.)-237.6(Parasitol.)]TJ /F9 1 Tf 6.3875 0 TD [(32,)-245.1(1469)]TJ /F11 1 Tf 3.3336 0 TD ()Tj /F9 1 Tf 0.514 0 TD [(1476.)-239.6(doi:)]TJ -27.3036 -1.2699 TD (10.1016/S0020-7519\(02\)00164-9)Tj 33.4417 77.2696 TD 0.2658 Tc [(O)286.7(g)292.9(u)286.9(i)291.5(k)286.1(e)288.7(,)7.6(M)289.1(.C)294.4(.)287.3(,)0(F)294.5(a)287(l)289(a)287(d)294.5(e)288.7(,C)286.8(.)7.6(O)286.7(.)287.3(,)7.6(S)287.8(h)290.3(u)286.9(,)7.6(E)283.5(.)294.8(,E)291.1(n)285.2(a)294.6(t)288.1(o)289.6(,I)288.9(.)7.6(G)285.9(.)294.8(,)0(W)288.9(a)287(t)295.7(i)283.9(l)289(a)294.6(,I)288.9(.)287.3(,)7.6(B)289.4(a)287(b)289.6(a)294.6(,E)291.1(.S)287.8(.)294.8(,)0(e)288.7(t)0.9(a)294.6(l)289(.\()291.3(2)291.2(0)291.2(1)283.7(6)291.3(\))291.3(.)]TJ 1.3304 -1.2699 TD -0.022 Tc [(Molecula)6.8(r)-217.4(D)-3.6(et)7.9(ermina)6.8(nts)-217.4(o)1.8(f)-214.8(S)0(ul)8.8(fad)6.7(o)1.8(xine-P)]TJ 15.7155 0 TD -0.0246 Tc [(yri)-6.5(m)1.3(etham)-6.3(i)1.1(ne)-220.9(R)-7.8(e)-1.7(sistance)-220.9(in)-224.4(Plas)-8.3(modium)]TJ -15.7155 -1.2624 TD -0.0243 Tc [(Falciparum)-263(in)-261.9(Nigeri)-6.2(a)-260.1(a)-3.1(nd)-260.2(the)-258.4(R)-7.5(egion)-4.9(a)4.5(l)-265.6(E)1(merg)-4.7(ence)-258.4(of)-262.4(D)-5.9(h)0.2(ps)-265(431)-6.4(V)-0.1(.)]TJ /F10 1 Tf 25.5424 0 TD -0.0236 Tc [(Int.)-255.7(J.)-263.3(Par)-7.3(a)4.3(sit)6.3(o)-1.6(l)]TJ -25.5424 -1.2699 TD -0.0244 Tc [(Dr)-8.1(ugs)-296.1(D)-0.2(rug)-303.8(R)1.7(e)-7.4(s)-1.3(ist)]TJ /F9 1 Tf 6.8259 0 TD 0.2733 Tc [(.6)291.2(,2)298.8(2)291.2(0)]TJ /F11 1 Tf 2.812 0 TD 0 Tc ()Tj /F9 1 Tf 0.4838 0 TD -0.0245 Tc [(22)-6.6(9.)-297.8(doi:)-305.4(10.1016)-6.6(/j.ijpddr.201)-6.6(6.08.004)]TJ -11.4521 -1.2624 TD 0.3187 Tc [(P)344(a)339.9(t)341(e)341.6(l)341.9(,)7.6(P)344(.)340.2(,B)342.3(h)343.2(a)339.9(r)342.5(t)348.6(i)336.8(,)7.6(P)336.4(.)7.6(K)342.2(.)340.2(,B)342.3(a)347.5(n)338.1(s)342.5(a)339.9(l)341.9(,)7.6(D)344.7(.)340.2(,A)340.5(l)341.9(i)344.4(,)7.6(N)339.6(.A)340.5(.)347.7(,)0(R)343.1(a)339.9(m)344.6(a)339.9(n)345.7(,)0(R)343.1(.)0(K)342.2(.)347.7(,M)342(o)342.5(h)343.2(a)340(p)339.8(a)347.5(t)341(r)342.5(a)339.9(,)7.6(P)336.4(.)7.6(K)342.2(.)340.2(,)0(e)341.6(t)8.4(a)339.9(l)341.9(.)]TJ 1.3304 -1.2699 TD -0.0239 Tc [(\()-6(2)1.6(017\))-5.9(.)-244.3(P)-6.2(revalence)-250.4(o)-0.1(f)-246.9(M)-0.6(utations)-249.5(Linked)-252.3(t)6(o)-249.6(Anti)-5.8(mal)6.9(a)-2.7(rial)-250.1(Resistance)-250.4(in)-253.9(Plas)-7.6(modium)]TJ T* -0.0223 Tc [(Falcipa)6.5(r)1.5(um)-427.3(From)-427.3(Chhat)7.6(t)0(isg)4.8(a)-1.1(rh,)-431.7(C)6.3(ent)7.6(r)1.5(al)]TJ 16.0103 0 TD -0.0198 Tc [(In)7.2(di)5.9(a:)-429.2(A)-421.3(M)3.5(al)3.4(a)9(r)4(ia)-421.9(El)11(im)6(i)5.9(n)-0.4(a)9(t)2.5(io)4(n)-423.7(P)5.5(o)4(i)5.9(nt)-420.8(o)4(f)]TJ -16.0103 -1.2624 TD -0.0246 Tc [(Vi)-6.5(ew.)]TJ /F10 1 Tf 2.4567 0 TD -0.0263 Tc [(Sci)-5.8(.)-303.8(Rep)-8.4(.)]TJ /F9 1 Tf 3.4394 0 TD -0.0253 Tc [(7,)-298.6(16)-7.4(690.)-306.2(doi)-7.2(:)-298.6(10)-7.4(.1)-7.4(038/)-5.7(s4159)-7.4(8-017-1686)-7.4(6-5)]TJ -7.2265 -1.2699 TD 0 Tc [(Pearce,)-308(R.)-301.9(J.,)-307.8(Pota,)-301.6(H.,)-308.3(Evehe,)-301.7(M.)-310.6(S.,)-305.5(Ba)-302.8(el,)-302.8(H.,)-308.3(Mombo-Ngoma,)-299.8(G.,)-307.4(Malisa,)-308.7(A.)-304.5(L.,)]TJ 1.3304 -1.2624 TD [(et)-393.2(al.)-395.2(\(2009\).)-392.6(Multiple)-391.7(Origins)-392.9(and)-391.8(Regional)-394.2(Dispersal)-393(of)-395.8(Resistant)-391.2(Dhps)-395.9(in)]TJ 0 -1.2699 TD [(African)-224.2(Plasmodium)-224.1(Falciparum)-226.2(Malaria.)]TJ /F10 1 Tf 16.7511 0 TD [(PloS)-225.7(Med.)]TJ /F9 1 Tf 4.1575 0 TD [(6,)-225.2(e1000055.)-223.4(doi:)-217.9(10.1371/)]TJ -20.9086 -1.2624 TD (journal.pmed.1000055)Tj -1.3304 -1.2699 TD [(Quan,)-213.4(H.,)-217.5(Igbasi,)-211.7(U.,)-210.8(Oyibo,)-212.6(W.,)-213.6(Omilabu,)-217.4(S.,)-214.8(Chen,)-208.1(S.)-213.5(B.,)-213.1(Shen,)-214.7(H.)-216.3(M.,)-213.5(et)-211.8(al.)-213.7(\(2020\).)]TJ 1.3304 -1.2699 TD [(High)-326.8(Multiple)-331.2(Mutations)-326.2(of)-327.7(Plasmodium)-329.9(Falciparum-Resistant)-331.4(Genotypes)-333.1(to)]TJ 0 -1.2624 TD [(Sulphadoxine-Pyrimethamine)-282.1(in)-272.4(Lagos,)-273.7(Nigeria.)]TJ /F10 1 Tf 19.5177 0 TD [(Infect.)-278.7(Dis.)-270.1(Poverty)]TJ /F9 1 Tf 7.7406 0 TD [(9,)-270.6(91.)-275.3(doi:)]TJ -27.2583 -1.2699 TD (10.1186/s40249-020-00712-4)Tj -1.3304 -1.2624 TD [(Rieckmann,)-305.5(K.,)-304(and)-301.1(Cheng,)-301.9(Q.)-305.4(\(2002\).)-301.9(Pyrimethamine-Sulfadoxine)-308.9(Resistance)-307.2(in)]TJ 1.3304 -1.2699 TD [(Plasmodium)-261.9(Falciparum)-256.5(Must)-257.2(be)-255.7(Delayed)-258.7(in)-249.7(Africa.)]TJ /F10 1 Tf 21.0598 0 TD [(Trends)-254.7(Parasitol)]TJ /F9 1 Tf 6.7352 0 TD [(18,)-252.7(293)]TJ /F11 1 Tf 2.8725 0 TD ()Tj /F9 1 Tf -30.6675 -1.2624 TD [(294.)-302.8(doi:)-301.1(10.1016/S1471-4922\(02\)02287-0)]TJ -1.3304 -1.2699 TD [(Rouhani,)-287(M.,)-281.5(Zakeri,)-292(S.,)-282.8(Pirahmadi,)-293.2(S.,)-282.8(Raeisi,)-288.3(A.,)-283(and)-285.9(Djadid,)-286.2(N.)-282.7(D.)-285.1(\(2015\).)-286.8(High)]TJ 1.3304 -1.2699 TD [(Prevalence)-297.2(of)-297.5(Pfdhfr-Pfdhps)-300.9(Triple)-289.7(Mutations)-295.9(Associated)-299.7(With)-297.4(Anti-Malarial)]TJ 0 -1.2624 TD [(Drugs)-384.5(Resistance)-382.8(in)-385.8(Plasmodium)-382.9(Falciparum)-385(Isolates)-382.7(Seven)-384.5(Years)-379.2(After)-389.1(the)]TJ 0 -1.2699 TD [(Adoption)-289.7(of)-289.9(Sulfadoxine-Pyrimethamine)-301.3(in)-287.5(Combination)-284.7(With)-289.9(Artesunate)-292.3(as)]TJ 0 -1.2624 TD [(First-Line)-381.5(Treatment)-384.4(in)-370.7(Iran.)]TJ /F10 1 Tf 12.329 0 TD [(Infect.)-377(Genet.)-373.7(Evol.)]TJ /F9 1 Tf 8.0203 0 TD [(31,)-373.6(183)]TJ /F11 1 Tf 2.9934 0 TD ()Tj /F9 1 Tf 0.5065 0 TD [(189.)-378.4(doi:)-376.6(10.1016/)]TJ -23.8491 -1.2699 TD (j.meegid.2015.01.020)Tj -1.3304 -1.2624 TD [(Triglia,)-336.5(T.,)-340.9(Menting,)-332.4(J.)-336.9(G.,)-337.6(Wilson,)-338.4(C.,)-336.7(and)-338.9(Cowman,)-331.6(A.)-342.3(F.)-335.4(\(1997\).)-332.1(Mutations)-341.3(in)]TJ 1.3304 -1.2699 TD 0.0142 Tc [(D)-5.2(i)2.1(hydropteroate)-514.7(Synt)6.3(hase)-514.7(are)-514.7(R)0.8(espo)]TJ 15.7382 0 TD 0.0127 Tc [(nsible)-516.2(for)-515.3(S)-3.1(ulfon)-5.7(e)-508.6(a)-3.9(n)1.9(d)-518(S)-3.1(ulf)-6.2(o)12.7(n)-12.1(a)-3.9(mid)-4(e)]TJ -15.7382 -1.2699 TD 0 Tc [(Resistance)-481(in)-476.5(Plasmodium)-481.1(Falciparum.)]TJ /F10 1 Tf 16.6377 0 TD [(Proc.)-483.8(Natl.)-470.5(Acad.)-479.8(Sci.)-474.6(U.)-480(S.)-469.6(A.)]TJ /F9 1 Tf 13.357 0 TD (94,)Tj -29.9947 -1.2624 TD (13944)Tj /F11 1 Tf 2.3963 0 TD ()Tj /F9 1 Tf 0.514 0 TD [(13949.)-297.2(doi:)-301.1(10.1073/pnas.94.25.13944)]TJ -4.2407 -1.2699 TD [(World)-308.2(Health)-305(Organization)-316(\(2020\).)]TJ /F10 1 Tf 14.6118 0 TD [(World)-309.1(Malaria)-307.5(Report)-309.2(2020)]TJ /F9 1 Tf 11.437 0 TD [(\(Geneva:)-310.6(World)]TJ -24.7184 -1.2624 TD [(Health)-305(Organization\).)]TJ -1.3304 -1.2699 TD [(Ya)-11.4(n)-10.8(,)-265.8(H)-11(.)-8.8(,)-265.8(K)-14.3(on)-9.7(g)-10.7(,)-265.8(X)-12.6(.)0(,)-274.6(Z)-11.7(han)-17.9(g)-10.7(,)-265.8(T.)-14.6(,)-273.3(X)0(i)-17.2(ao,)-281.2(H)-11(.)0(,)-274.6(F)-9.1(en)-10.6(g)-10.7(,)-273.3(X.)-13.9(,)-265.8(T)-13.4(u,)-274.9(H)-11(.)0(,)-274.6(e)0(t)-279.8(a)-9(l.)-272.8(\()-12.3(2)0(0)-9.6(2)0(0)-17.1(\))0(.)-278.1(P)0(r)-11.3(e)0(v)-18(a)0(l)-8.4(e)0(n)-18.1(c)0(e)]TJ 1.3304 -1.2624 TD 0.0369 Tc [(of)-526.3(Pla)5.2(s)0.3(modiu)5.1(m)-526.9(Fa)5.2(lcip)5.1(aru)5.1(m)-526.9(Kel)7.2(c)-0.6(h)-528.2(1)]TJ 16.2295 0 TD 0.035 Tc [(3)-529.2(\()0(PfK13\))-529.1(an)-6.1(d)-526(U)0.5(biquitin)-6.1(-Speci)]TJ /F12 1 Tf 13.9617 0 TD 0 Tc ()Tj /F9 1 Tf 0.5669 0 TD (c)Tj -30.7582 -1.2699 TD [(P)-12.5(r)-14(o)-14(t)-7.9(e)-14.9(a)-9(s)-14(e)-513.8(1)-518.8(\()-12.3(Pf)-16.3(u)-16.7(b)0(p)-23.2(1)-12.3(\))-511.2(G)-17.7(en)-18.1(e)-521.3(P)0(o)-19(l)-14.6(y)-10.7(m)-11.9(or)-20.4(p)-9.1(h)-13.3(i)-12.1(s)-14(m)-12(s)-512.9(i)-12.1(n)-517.3(R)-13.4(e)0(t)-22.8(u)-9.1(r)-14(n)-10.8(i)-12.1(n)-10.8(g)-517.1(T)-13.4(ra)-22.9(v)-10.7(e)0(l)-21.9(e)-14.9(rs)-526.8(F)-9.1(r)-14(om)]TJ T* [(A)-8.4(f)-11.4(ri)-11(ca)-447.2(Re)-13.2(p)-9.1(o)0(r)-12.9(t)-7.9(ed)-454.9(in)-446.3(Ea)-13.9(st)-14.3(er)-13.7(n)-441.7(C)-9.2(hi)-10.3(n)-10.8(a)-9(.)]TJ /F10 1 Tf 14.9218 0 TD [(A)-9.2(n)0(t)-13.6(imi)-17(c)-10.5(r)0(o)-14.6(b)0(.)-448.5(A)0(g)-9(e)-13.2(nt)-13.6(s)-438(C)-10(he)-9.7(mo)-13.4(t)-7.9(h)-11.6(er)-12(.)]TJ /F9 1 Tf 13.4326 0 TD [(20)-9.6(,)-447.2(6)0(4)-9.6(.)]TJ -28.3544 -1.2624 TD [(d)-9.1(o)0(i)-11(:)-311.1(10)-9.6(.)-8.8(1)-12.3(12)-9.6(8/)-15.4(A)-8.4(A)-8.4(C)0(.)-10.4(0)0(0)-17.1(9)0(8)-9.6(1)-12.3(-2)-13.6(0)]TJ -1.3304 -1.2699 TD [(Yaqoob,)-232.5(A.,)-230.1(Khattak,)-231.2(A.)-228.9(A.,)-230.1(Nadeem,)-236.7(M.)-227.4(F.,)-230.8(Fatima,)-234.2(H.,)-225.1(Mbambo,)-237.4(G.,)-224.2(Ouattara,)-235.2(A.,)]TJ 1.3304 -1.2624 TD [(et)-287.4(al.)-289.3(\(2018\).)-286.8(Prevalence)-289.7(of)-290(Molecular)-285.8(Markers)-294.2(of)-282.4(Sulfadoxine-Pyrimethamine)]TJ 0 -1.2699 TD [(and)-263.3(Artemisinin)-265.1(Resistance)-261.8(in)-257.3(Plasmodium)-261.9(Falciparum)-271.6(From)-253.2(Pakistan.)]TJ /F10 1 Tf 28.7172 0 TD (Malar)Tj -28.7172 -1.2624 TD (J.)Tj /F9 1 Tf 0.8466 0 TD [(17,)-298(471.)-302.8(doi:)-301.1(10.1186/s12936-018-2620-y)]TJ -2.177 -1.2699 TD -0.0259 Tc [(Zhang,)-231.2(L)6.2(.)-4.4(,)-223.7(F)2.8(eng,)-231.2(J.,)-231.2(X)-0.7(i)7.3(a)-4.7(,)-223.7(Z)0.2(.)-231.2(G)1.8(.,)-223.7(and)-224(Z)0.2(hou,)-223.7(S.)-223.7(S.)]TJ 16.9023 0 TD [(\(2020)7.2(\).)-231.1(Epidemio)5.5(lo)5.5(g)-6.2(i)7.4(cal)-229.4(C)2.8(haracteris)5.6(tics)-228.7(o)5.5(f)]TJ -15.5719 -1.2699 TD -0.0254 Tc [(Malaria)-238.5(a)3.4(nd)-238.6(Progr)6(e)-2.5(ss)-235.9(on)-232.8(It)4.5(s)-243.5(E)-0.1(l)5.4(i)0.3(minatio)5.9(n)-240.3(in)-240.3(China)-238.5(i)0.3(n)-240.3(2)0(0)7.6(1)0.1(9.)]TJ /F10 1 Tf 22.0198 0 TD -0.0271 Tc [(Chi)-6.6(n)5(.)-244.1(J)-2.4(.)-236.5(P)-4.2(arasi)-6.6(t)2.8(o)-5.1(l)-241.6(Parasit)]TJ -22.0198 -1.2624 TD -0.0246 Tc (Dis.)Tj /F9 1 Tf 1.7235 0 TD -0.0255 Tc [(38,)-298.8(133)]TJ /F11 1 Tf 2.7591 0 TD 0 Tc ()Tj /F9 1 Tf 0.4838 0 TD -0.0252 Tc [(138)7.8(.)-306.1(do)6.1(i:)-306.1(1)7.8(0)0.3(.12)7.8(1)0.3(40/j.iss)6.2(n)-5.8(.)3.8(1000)7.8(-74)7.8(2)0.3(3.2)7.8(0)0.2(20.02.0)7.8(01)]TJ -6.2968 -1.2699 TD -0.0409 Tc [(Zhang,)-223.5(Y.,)-216(Y)2(an,)-223.5(H)1(.,)-216(Wei,)-216(G.,)-216(H)-6.6(an)-6.4(,)-216(S)-3.8(.,)-216(H)-6.6(u)2.9(ang)-6.2(,)-216(Y.,)-216(Z)-7.3(h)6.3(a)-4.5(ng)-6.2(,)-216(Q)-4.9(.,)-223.5(et)-222.7(al.)-216(\()-0.3(2)-7.9(014\).)-216(Di)-7.7(stin)-6.4(ctiv)-6.2(e)-214.5(O)-4.9(rigin)]TJ 1.3304 -1.2624 TD -0.0385 Tc [(an)3.6(d)-297.1(S)6.2(prea)5.4(d)-297.1(R)1(ou)5.3(te)-295.3(of)-291.8(Py)3.8(rimethamin)3.6(e-Res)8(i)-5.3(st)6.5(an)3.6(t)-295.9(P)1.9(la)5.4(smodium)-292.3(F)5.3(alc)7.1(i)-5.3(p)5.3(a)-2.1(ru)5.3(m)-292.3(i)-5.3(n)-291.2(S)6.2(outhe)7.1(r)0.5(n)]TJ 0 -1.2699 TD [(Chin)3.7(a.)]TJ /F10 1 Tf 2.7062 0 TD -0.0398 Tc [(Antimicrob.)-294.6(A)-3.7(gents)-304(C)3.1(h)-6(e)-0.1(mother.)]TJ /F9 1 Tf 11.7696 0 TD -0.0406 Tc [(58,)-306.4(237)]TJ /F11 1 Tf 7.4999 0 0 7.4999 444.7558 284.4283 Tm 0 Tc ()Tj /F9 1 Tf 0.4687 0 TD -0.0401 Tc [(246.)-305.9(doi:)-305.9(10.1128/AAC.00972-13)]TJ -18.9508 -1.2624 TD 0 Tc [(Zhao,)-374.2(L.,)-378.5(Pi,)-373.6(L.,)-378.5(Qin,)-373.7(Y.,)-382.8(Lu,)-371.3(Y.,)-375.2(Zeng,)-381.9(W.,)-372.4(Xiang,)-381.5(Z.,)-377(et)-378.1(al.)-372.5(\(2020\).)-377.5(Widespread)]TJ 1.3304 -1.2699 TD [(R)-13.4(e)0(s)-13.7(i)0(s)-18.5(t)-7.9(a)-9(n)0(c)-10.6(e)-521.3(Mu)-16.1(t)-7.9(a)0(t)-9.3(i)-12.1(on)-17.3(s)-512.9(t)-7.9(o)-512.9(S)0(u)-17.4(l)0(f)-18.4(a)-9(d)-9.1(o)0(x)-14.7(i)0(n)-15.4(e)0(-)-16.1(P)0(y)-15.6(r)0(i)-18.5(m)0(e)-11.7(t)-7.9(h)-13.3(a)0(m)-13.4(i)0(n)-15.4(e)-513.8(i)-12.1(n)-517.3(Ma)-16(la)-16(ri)-11(a)-515.5(P)-12.5(a)-9(r)0(a)-15.4(s)0(i)-11(t)-7.9(e)-14.9(s)]TJ T* [(Imported)-314.9(to)-316.7(China)-311.4(From)-313.6(Central)-314.6(and)-316.2(Western)-317.8(Africa.)]TJ /F10 1 Tf 22.2164 0 TD [(Int.)-313.3(J.)-313.2(Parasitol.)-316.7(Drugs)]TJ -22.2164 -1.2624 TD [(Drug)-305.1(Resist.)]TJ /F9 1 Tf 5.0722 0 TD [(12,)-298(1)]TJ /F11 1 Tf 1.9578 0 TD ()Tj /F9 1 Tf 0.5065 0 TD [(6.)-300.8(doi:)-301.1(10.1016/j.ijpddr.2019.11.002)]TJ /F14 1 Tf -8.8669 -2.6003 TD (Con)Tj /F17 1 Tf 1.7462 0 TD ()Tj /F14 1 Tf 0.5745 0 TD [(ict)-305.5(of)-299.4(Interest:)]TJ /F9 1 Tf 6.2665 0 TD [(The)-298.5(authors)-300.4(declare)-302.9(that)-302.7(the)-300.6(research)-297.7(was)-306(conducted)-301.3(in)-302.6(the)]TJ -8.5872 -1.2699 TD [(absence)-273.8(of)-267.3(any)-264.8(commercial)-275.7(or)]TJ /F12 1 Tf 12.2156 0 TD ()Tj /F9 1 Tf 0.5291 0 TD [(nancial)-270.1(relationships)-273.1(that)-272.4(could)-265.8(be)-270.8(construed)-275(as)-264.8(a)]TJ -12.7447 -1.2624 TD [(potential)-304.4(con)]TJ /F12 1 Tf 5.2914 0 TD ()Tj /F9 1 Tf 0.5291 0 TD [(ict)-299.5(of)-305.1(interest.)]TJ /F10 1 Tf -5.8205 -2.5323 TD [(Co)19.6(py)24(ri)21.7(gh)18.9(t)-302.7()-303.2(20)13.8(2)14.5(1)-303(Ya)19.6(n,)-298.3(Fe)23(ng)17.2(,)-300.1(Y)0(i)19.8(n)0(,)-290.7(H)0(u)15.2(a)0(n)22.2(g)0(,)-292.3(K)0(o)16.9(n)0(g)24.8(,)-307.7(Li)22.4(n,)-290.7(Zh)19.6(an)22.2(g,)-299.9(Fe)23(ng)17.2(,)-300.1(Z)0(h)19.6(o)0(u)23.9(,)-307.7(Ca)25.5(o)-310.6(a)0(n)22.2(d)]TJ 0 -1.2699 TD [(Xi)20.6(a.)-483.9(Th)14.5(is)-485.5(is)-485.5(an)-484.3(o)14.5(pen)21.7(-a)20.7(cc)16.8(es)17.4(s)-490.9(art)28.7(ic)17.6(le)-484.7(dis)22(tr)15.9(ib)23.3(ut)16.6(ed)-488.3(un)18.8(de)18.1(r)-490.2(t)0(h)18.3(e)-497(te)24.2(rms)-479.8(of)-486.6(th)18.3(e)-489.4(Cre)23.4(at)20(iv)19.1(e)]TJ 0 -1.2624 TD [(Co)19.6(mm)19.9(o)14.4(n)0(s)-413.5(A)0(t)20.7(t)0(r)23.5(i)0(b)23.3(u)0(t)16.6(i)0(o)19.9(n)-413.9(Li)14.9(ce)21.7(ns)24.9(e)-421.4(\()0(C)20.7(C)-418.2(BY)19.5(\).)-409(Th)22(e)-421.4(u)0(s)17.4(e)0(,)-404(d)0(i)21.7(s)0(t)15.1(r)16.3(ib)15.8(ut)24.2(io)19.9(n)-421.5(o)14.5(r)-422.1(r)0(e)18.2(p)0(r)19.1(o)14.5(du)18.1(ct)19.4(io)19.9(n)-413.9(i)0(n)]TJ 0 -1.2699 TD [(ot)21.7(he)20.6(r)-240.7(f)0(o)19.9(r)0(u)18.1(m)0(s)-231.5(i)0(s)-228.5(p)0(e)19.8(r)0(m)18.7(i)0(t)20.2(t)0(e)24.2(d)0(,)-231(p)0(r)19.1(o)0(v)20.6(i)0(d)21.6(e)0(d)-231.3(t)0(h)18.3(e)-240(o)14.5(r)0(i)14.1(g)15.4(in)14.8(al)-232(au)22.2(th)25.8(or)15.6(\(s)23.5(\))-244.9(a)0(n)22.2(d)-240.8(th)18.3(e)-240(c)0(o)19.1(p)0(y)24(r)0(i)21.7(g)0(h)18.9(t)-242.3(ow)22.8(ne)18.9(r\()16.7(s)15.5(\))]TJ T* [(ar)21.5(e)-308(c)0(r)20.9(e)0(d)18.1(i)0(t)20.2(e)0(d)-299.3(a)0(n)22.2(d)-308.8(th)18.3(at)-297.5(th)25.8(e)-315.6(o)14.5(ri)21.7(gin)30.2(al)-300(pu)19.8(bl)22.6(ic)17.6(at)20(io)19.9(n)-308.1(i)0(n)-302.6(t)0(h)25.8(i)0(s)-296.5(j)0(o)17.4(u)0(r)18.1(n)0(a)22.2(l)-312.8(is)-296.5(ci)25.2(te)16.7(d,)-299(in)-295.1(ac)17.4(co)19.1(r)16.3(dan)30.9(ce)]TJ 0 -1.2624 TD [(wi)21.4(th)-344.5(ac)17.4(ce)21.6(pt)17.5(ed)-344.7(ac)17.4(ad)21.4(em)19.5(ic)-345.2(pr)19.1(ac)24.9(ti)20.2(ce)21.6(.)-360.6(N)0(o)-346.8(u)0(s)17.4(e)0(,)-343.6(d)0(i)21.7(s)0(t)15.1(r)16.3(ib)15.8(ut)24.2(io)19.9(n)-361(o)14.5(r)-361.7(r)0(e)18.2(p)0(r)26.6(o)0(d)15.6(u)0(c)21.6(t)0(i)20.2(o)14.5(n)-361(i)0(s)-349.4(p)0(e)19.8(r)16.3(mi)15.4(tt)21.9(ed)]TJ 0 -1.2699 TD [(wh)19.5(ic)25.2(h)-291.3(d)0(o)15.6(e)0(s)-277.4(n)0(o)23.9(t)-295.2(co)26.6(mp)20.3(ly)-284(wi)21.4(th)-276.5(th)18.3(es)17.4(e)-285.3(t)0(e)16.7(r)0(m)18.7(s)15.5(.)]TJ ET 0 0 0 0.7 k 45.354 737.518 504.567 0.28345 re f BT /F6 1 Tf 6.9999 0 0 6.9999 45.3543 744.2644 Tm [(Yan)-298.8(et)-300.5(al.)]TJ /F5 1 Tf 53.0817 0 TD (pfdhfr)Tj /F6 1 Tf 2.4864 0 TD (/)Tj /F5 1 Tf 0.324 0 TD (pfdhps)Tj /F6 1 Tf 3.2802 0 TD [(Mutations)-303(in)-304.4(Chinese)-298.8(Migrants)]TJ ET 45.354 42.803 504.567 0.22675 re f 45.354 42.803 504.567 0.22675 re f BT 6.9999 0 0 6.9999 45.3543 31.2945 Tm [(Frontiers)-306.1(in)-296.3(Cellular)-302.6(and)-306.5(Infection)-301.5(Microbiology)-499.5(|)-502.8(www.frontiersin.org)-22490(September)-305.7(2021)-505.2(|)-494.7(Volume)-307.7(11)-499.6(|)-494.7(Article)-305.6(673194)]TJ 35.7658 0 TD (8)Tj ET endstream endobj 143 0 obj<>stream Hbd`ab`dd pqvL)I23M4OsNKJa!#O_b`fd((ts20Z`d``"SR+KRs< KRSsr23JRS@zz @y% .z :f&z %E `bԼ̼t=,Ne``lg`bddq5[Kx4MrVn΄,TD܌Z󿷱5e}Z9m۞ϜԿ}9#\,pƜiK׬.*-ݿ%M. Sy endstream endobj 144 0 obj<> endobj 145 0 obj<>stream HTP1n0 2<)ꤻ"Ѯhy+)n> endobj 147 0 obj<> endobj 148 0 obj<>stream HTyPYbѕ r:c AVGAtBdu]utfu_Fkvkyϫ}~cjr͎~!$I^^ .kXla0 0K../p]'...N/Q/T(% ᦌyv<{R,ɄB*QHsg#Ü[X C) (nn^N.e$[J!̔d$J3>s8f\μE[N 8$N-2 =䊸I>欙=癩ԴcS`} Dy a}@s<|x.=Wcamo`yZ?co|O-/^plтEY^ZYY&|!w|r愭m׶F1n~1#SuF{N%vpSR'Mퟞ!nZĤުVىK.\P5)]3`7=37jE˂K4zᯀ<+>ީǐh&6Pm<@@t;H(7d?M+Ϯ"OK!0aE7)1px{VF_5Pd֨dJ"όΣ3MQ$|-vEٗ]zݩ.EkZ";-Ed.̬$Cq${]P1cI"!Q bփϑ7|ъR(*798B=8`+Kf2%sBť<q~/6rw$e$ujժ :\@HӋDP0KMgo>BcRetwKv;@;ȗS̈su}<>fGxM+r{Lĉo[{. F҂6H\mVuU\>Sv]ViTbMޒCżƳ9q7ݾaszr@,C퐃Z“C:b;j{wqgDy}9WH(k0tXmKO}LFn;㻎05*MXS),g):ԟ;(mtwcuo!] `~u7 ]ZuM|ELIBo9! )#iO¼܊ZHژϢހE֪&Q}G7! =qx^[{W2#S._Wkˇl/ |v'II,Uf|E )`3`gwz]F^L Lf2BNާ.v_F'ÿ\:9|yX?jM6%"ފkT|wZʦ2mU:zei1uTm5OZJKR^Qϯ?}C\4"UWtu'z1N>:uJֱ,NfTTinUXyӱMwPj}0A$v0+&a @X C'YQ! ~}AFQ0Hv rmǺ纎ZOQIΈK" ;?F/2n'6W~!,mPԵHXn+vbmƳo nhLlL,WU<9Q'I$;w)47ґ3܁="m:9>TjCM!݆ ̵Ǩ5i@B$q`}*W=!".#%+;͚dwcVNqK3QYe*oRCF ?iֶ3G[dS_ MʉkxPFᩚ7J O^}<:,)QAέh,#{+ktM][U`j3ӳjݑ6=d۞o8dQB #WDkgv6[(xVhd: ,X["X xǁC|xh(4n~ Ɍ#FQJ(+ " "؀53=:GO:r xQ*DAVb}S[ݭꮮz}UzR)iO uejpz>ߔMo}ddj=KKˤe=4p! .p{ihv+op}!m͗FQ8(z`ÉUWe*{E[5Y;wU1"Nn%wڑ*r3؁4I8 ʼn3*5< F\?gmO~BZ;UC9=Eᯁ؄_2#+[E싏d{~D+ycpț^a \R;g: ֛I;R2Ngic6&+8#z,# h)' ʵ"J;X+O@RSlޣEIJ b=ZKL9dJsëq1XE|+: ^O9QT"g9w \aP+Мb쮜ڥJU&nQ[l9:U𴻖965 .:BeFNJCN.cNRP\>b:/lvVHL୉դKج5)/9V4k_PPmz"^jR}g}e˹>P FP4Dsa0܌*ww}!-ƍt73[lnf,dD2W$`)0N `<z 0Ca?h{>)-l g0C%>p6\Cȷo;ѻ(-{uTդ1)Jrݽ]7w/_n6Ěitx<56``P) Ԕbh=r.XYi2@& }3}o4 ͊:!Ncch7c㰄ƝQ$$Zi$Y r1z^R_:*0a;.f(q+yfZ٠ 9z<{ tY|l\]?4 t4RH =`(^v~ }㦭l`v RK]IrH׋rIy bZYN| уu¨h9 Ra (&La/tJ-Wÿ3+e_mD#u[O$#ۑoZ8?* wM8jE_ G.`p#!z݇V > 2iFLTlƢnmhkr<&Qn،Đ[)iEM" a+:C:"/ }}}voK"Ds*$pζ+F+iJE;n0lzH@&ձ91Lx b'v=,lXY%g);tyɩp&]ȧ>ʥ:NCШT5J/>=1uYP\ZVD4VG RSpG@[U>UG~eTY/,!|#)(H=E':^{Vf3wlm~ 8h AsZeY}=rfTlUR&ɑ`D <Ӏ6@ TLSB! P_8cȷ-YeY-ʒbKZ-Yd|`_p4q6IR2SY:'}T禩ZقI8\)PAjOfoK{(j`P;fEASa 㪲}w7\9:7J"<)(4ăBM"soGyYEpԓK ]wϋsw<~U yDo?N (:)|PE37(78[͘b_D?94-J/9ޝ_u,^$>dT^N'1":J,ռ8?fbR }`6CphY;ƭ⛾jZĹnyr8>v؜vn[MME{Is~]>O[xZBW`alTP$3FYݷ$NjX%ܡjWK*sd2LVJkpUsvRy&!&w\M2YCZnuWW-Hػ'L:3}bGxSo8><pˎ&97q#ON<)% GH^dk/ JI8Vo 5l`5H,f] ZGH# @,)/wJݞήn)İ49 y:Ykq. Dї)Sʥ"+RH="j * W$%wqL& TTŚ2: .ʚ;'u/{XFМߢ$IІ?S_*(8m.@V\'f]EQ8G*U*b u|U5~MoeE ELoӕg,&GiVD.?n!&kbB E1 | DK[qx|2LeIeM%$*W+T@,E4&i X-{j@\g>6Q'POHt Cֿ$`rgujF^JUI2%e5ZT kXn#JQb?8C5\ iGBкc#xB{{7pzJS Ƒi;7@y*l < U!Tco]`O@1apc'\?[W;]Þĝqop'lHFt2mb5+tjcڤYTZaE HqBoͭ[ȧ#Vڴh09'ZU 2vSs9nԌb= Y]nmq>߶`=,CgiZ*.|7oWﲞV\M0?)S:퍿ao[3uv];ؐy~4*RLkcɕJwH c,?a-·Уe_JƭFJn ?|p}&-ɚ @,AIU84YνHC`eRTke\[jìsL ) 2 endstream endobj 149 0 obj<> endobj 150 0 obj<> endobj 151 0 obj<> endobj 152 0 obj<> endobj 153 0 obj<>stream HT=o w~ō2`j14U$i:N ŀx+Uz.`zL08o 簐A< ֙E՚IG9!@2svG! OHΏ;ߜo8OЀR`q`pCOrd6:X6Hڏm#T6 5&e0WMy|@b: eeu*qC,sawTk: endstream endobj 154 0 obj<> endobj 155 0 obj<> endobj 156 0 obj<> endobj 157 0 obj<> endobj 158 0 obj<> endobj 159 0 obj<> endobj 160 0 obj<>stream H\kPSgO"9hmz{NU) $[1$bT ! $/ ąlm]VTSӝ=~/χy}1!vj1P޼-Q!N jtgf%[oZ 1ynXhhƍ)(rUrP&&痔 ‚nTM 97M(?M +qBy7<3(1P"%CP J_q ( ʆL#QΘdb̂= T4͊beAF6\/--|hӢ , ܡs"`'v^|Iu t"fFhm:!ܿ-"!Ҧi4#2 &(.'Ŭ=L"ȇu{eE1Z3 _$N[ l* r:S NG`1YgoNc`A IYra!|N?`g|4y -5}ZF8o@s݊:Կ#pBTZBfꐳFgG*a5{kś6ed)*GњZTUTXUGc(ͼdsr*#J?* KH\,gkxPHr?ll ?onH;b35+i`&AJ ~g3Z4_r8PnoɵZs թZTԀ6 w|sfZ, g&`5xC1kRӾ uZ:L:}tnߜXD@ G*Pe >JN4  ϜX'>*C 'z+xgMzT΃6qoJكovC6G@8y_YfP픞caxhvs21r/<&J;yYpykaڞb y4V}yI}%`u:|.<#~n >>Q&*_RBVJ8M8ac/jQy86b }  `5YA)({*MwVj =8_;F|ױ/ǿIlEQJa<ÇU\?YIG3<#텝n7vyO9eԼG~$ZkyQaKҜٴiDcUK#rit/`G q1ǔDȄk{Z棣4{ *.L_|ˊA 9>T+GHo̖ƉeRѨyi%l.永$R(*ShF\%%|#jW5Zlv/9GjJ;Z{@dR[8"vd[U"Fl"Rvov<`<#PJYqD)! s[',zց}ɢVt7u`1G**C`}IbsqҎ" >M qca=v!@e%0g;=yC^+A<~4rшfbMu.ҡLCFq69YX*%5[A0¥z/*?(?"?pKVpd jLFא|/~t;迠kfۃvzX@"rzp13 t$!dq] ߯5^|"pOtoM[cM9mrYnR-MSKޏ~މ*](V0|% ˄[GgI?= #Af<QY}Xߕ/o %yNlr{`Fx3?UU>:ZNgȇg> GqـU N|_)e &)PxӚ[":/j endstream endobj 161 0 obj<> endobj 162 0 obj<>stream Hbd`ab`ddpqvL)1LM375O6NKIe!#s߳102re9B( F: H1%?)U!$5X3/9 ($5EO1'G!(3=X!(8 $TWZ`llcf`_ZP*V(HKKp0 @_101t3XcRvOJ}i-m}͟` ]k On=}ҔN?{zӌ+{Sc+C# 9ZڊJX/"W`)-{˰k*WvlCJ~|doP\T.9<{jtRkjMjNp\elKGsI[~TU {Ȓ KZ ,exe7iNͱs͟p*u* % d7@BR# endstream endobj 163 0 obj<> endobj 164 0 obj<> endobj 165 0 obj<>stream H\TkTSWK F%VIQ-RF1B@@nD7Gt heTꫴchj5'ɬ579?7 a!,kԿ.O*ޘu _=fs'5k,^^q7{{k>gKU̩sknܳޝy7vNLZgrO  7\Xxwp~ˬE8H?`[#1!ʻK!>\^" HƠj+J$;K8\pPSt G0o+oz7&fNB6'Bn79[* @k Ltن* ? SMN^ Q qЍQu`:^{1o>I_,HIMNOv k;g=~^ވ|@{4|C?:X$l8z_<̕ux ^uvFTiTYGT0qMk/H0sz'T&rI[@`^G`O%NT-LJt1$PPC`=M댧*I`*?ܭotmLَ{!p8qy\DKa*^&uv:)u <n>a-.X'JD֪4>\@,DC{![+DG3G*<ȅa(l DՉc9]o}s2Zz/i(f,SD?؅ILw+cHU̻khcbܾH>EjbHHZSyDE5LT'5Lظ8lJ -f쌡k/'-b(79`c.o\&vs=16rۋ7F9+ܡS(8rY:p}S$ń=o3'iW z̵55GbՄa-WML=%* ul2D0j_JpMDyfIEƵz 'Ma\mXqŽ0S p b&VShkhxtES:s5ڕI`TcEI]P`Ba zmhV;A-~DT2=EGպXJKͺ = htv6l̾U߈˰cA\CD9q-DS65oٷwA`% GQ=&3>]Iv:NU*X5\@ bB=%$! ]/ @Z[WNڵ=s~y^G 39x2څeͩx\_QEd*C}ʉ BCoD^˴dTNA"ٻ=cl"jcZE%)]x7;˗9txPef'g>e M>SD\.牼x5mLJ }&y G{={^!`h0zc$+#`Ojg 4\cl|}ZL*|v}ϩSkd-oXI("YРmī> :w1H޶VeV "$-w+츭P+ K։i1 ][q㩘7eY|hzl 'lDI2WzOъFȮ]w=lr8 Xܷˍ1|}P3(77uLK. ![qih9k™0kI4Z74AGKs&1эQyD:>͌ʤaъ_GGS wEVt3dv4^}l:gc^GvV CeTM2?YQBdHOYsU&>uUr1`2}Fj\RjIek }Ѫ8LT:6wb_|E] Io絗Uuk0kUhh-}l`6;gom.'"*# -Z;[͆Wk!:&AqZd稭B/k"@W5y\l*i}I[GWgnn5wG!ue='`J߮=R.mdUv,Ր]6j㗝<8b(a̅;!؜YX\R4b h:c4RZ 2A1БSKYxrZ6Zpc驑+,FJI;wix2"Squ@}vhcw3ݚ~{y3^tF" >zYb,iI?uF'%(ٙ9% 25HJbZJpT_wy7Fġ)\O rX-pV> Pt7nVX6SOSļR/d,)mE6ƺ90#.%ʃ/PҪz{x2G!s `]FUBEcM/E$Z/ٻ8xQ.wak-zd'io]{]i,NN)zLJ5h <>-Mm= ^@beAZ%{]ߊ?녻/}M0 ^>cϱͿLM猭p-fsѫŸ0etɔr\UX~E| o*kjs^Ƥry^5X }> |cvHDi0-JfVE %iV{J$M">}[1pBlêB^j p`N$ut][֜Q Gq_7PM B(d#.=\EKk@Z, PDTdB^] AJ:_&gP;Ë́(\^AՕpCc?&A1X` (۱(_^zIB.˅^O.U}K{\)41 Kt[*]_I–oiޠ6o(vR ?.Ve:&X_'>G6mXFWLvN|*\ I~# ̈6h w)D~b>?k5%Ԡ(멑a]{:9= f6?g_tHB;ћ:tg0)NjCJHZmaMΆ:q[A,OmUZ'pw|0r_Nˀ`5;U-PSnD"`hPJz=7@D0>53,:-N 0*J3ԗjÍ X]|}iO?07ܐsyERح"!3caicѩcGUO7E3Vȸ''ZjR zژ&;4 t+w%)(eBS.,F'JEbt '8VmG;a|h/~$kzB6R@<)Gj͵ank b"N[.zu(=>d[Oݺ#{ endstream endobj 166 0 obj<>stream Hbd`ab`ddpqvL)1LM375O662If!#[WYGO&Ș_R@D)8'*W+x%%)8(eg+C J\Ru LK2R R y)yzNL|rVFF&ڮ;|*/2K~M늲 r'gvITD9~&Ty$JK&6g3'gM[^jˊ{}\EU PU&*~d~<h8@wLj%mEiTr^ITSm$u:.bpekVDM);Q ` endstream endobj 167 0 obj<> endobj 168 0 obj<>stream HWS#7߿b^jyRU;aIAmiJ_|{]6PvZ֧O<3GX2K8o"B'DQ+PjRjf?aJb27_LDLl$UdTrr7x Yư/l<|uC3)sM"ˮXڷgBqD #:D 0r8!gfG_)z9֋hh*pHW,Fr g"y%:)nw,Ƿ@GL0, _)!)7+ (0e& ;z98(Upy ?Nw.3@CRF=FR>pGĖFV vi!啖HIŴ%QF,z&1=8 /ԊhE Bu0V=f=?T{׽ w2|a0ΩH\0'~,CY)SR!0&0F3% UVp32JxZIZn6H؊3dJHAtc* d19o2VyzJضjCk ~hM!_ܦ"հu76gD!iT0 8#jR2i ✉Ւhc-z +PJ>[OАt:)nhbvY-4+%;ыw˼!tZw l=88}+v҂k0 H@~H(Sg~p@%U@*?"ѿ*ISʶ;S~M .t)mF/hю`҅$<[B|!˙Iб t SpT{`(u6'q?@vIz_IW@y*V7}*< +g@<2=SNdwj_Lį>,GgJƜ%!wlRԎ&$_jp&y^g%!bwphNό4=+YϚ|,VDC#j,MчRcNĹEBФ|Pʗ&] 8BQ ?J[{Cd۠,M,ӯjGuB,8086΃nQ)?5L4OaTtdZ. ,~kkg%cpCC1O0avK#Y|G+͡&vXNUn^"TBsq#<5Â] Oa $auW;`P\(;nYӖsS;|'Rv̻-Ω!1g;*}3T0h!?)ۂpZ+>~A0uL.אd!!^o[yR!\IC4]?ZP~p,e"V4a*1w0_p h3`W)$Vriڙշ<6]B?|i;. `3} Ewq%~E&W`x7 endstream endobj 169 0 obj<> endobj 170 0 obj<> endobj 171 0 obj<> endobj 172 0 obj<> endobj 173 0 obj<> endobj 174 0 obj<> endobj 175 0 obj<> endobj 176 0 obj<> endobj 177 0 obj<> endobj 178 0 obj<> endobj 179 0 obj<> endobj 180 0 obj<> endobj 181 0 obj<> endobj 182 0 obj<> endobj 183 0 obj<> endobj 184 0 obj<> endobj 185 0 obj<> endobj 186 0 obj<> endobj 187 0 obj<> endobj 188 0 obj<> endobj 189 0 obj<> endobj 190 0 obj<> endobj 191 0 obj<> endobj 192 0 obj<> endobj 193 0 obj<> endobj 194 0 obj<> endobj 195 0 obj<> endobj 196 0 obj<> endobj 197 0 obj<> endobj 198 0 obj<> endobj 199 0 obj<> endobj 200 0 obj<> endobj 201 0 obj<> endobj 202 0 obj<> endobj 203 0 obj<> endobj 204 0 obj<> endobj 205 0 obj<> endobj 206 0 obj<> endobj 207 0 obj<> endobj 208 0 obj<> endobj 209 0 obj<> endobj 210 0 obj<> endobj 211 0 obj<> endobj 212 0 obj<> endobj 213 0 obj<> endobj 214 0 obj<> endobj 215 0 obj<> endobj 216 0 obj<> endobj 217 0 obj<> endobj 218 0 obj<> endobj 219 0 obj<> endobj 220 0 obj<> endobj 221 0 obj<> endobj 222 0 obj<> endobj 223 0 obj<> endobj 224 0 obj<> endobj 225 0 obj<> endobj 226 0 obj<> endobj 227 0 obj<> endobj 228 0 obj<> endobj 229 0 obj<> endobj 230 0 obj<> endobj 231 0 obj<> endobj 232 0 obj<> endobj 233 0 obj<> endobj 234 0 obj<> endobj 235 0 obj<>/Type/Filespec>> endobj 236 0 obj<>stream Acrobat Distiller 7.0 (Windows) Plasmodium falciparum, sulfadoxine-pyrimethamine, dihydropteroate synthase, dihydrofolate reductase, migrants from Africa 2021-09-08T13:20:01+08:00 2021-09-08T13:20:01+08:00 Arbortext Advanced Print Publisher 10.0.1306/W Unicode application/pdf High Frequency Mutations in pfdhfr and pfdhps of Plasmodium falciparum in Response to Sulfadoxine-Pyrimethamine: A Cross-Sectional Survey in Returning Chinese Migrants From Africa He Yan; Jun Feng; Jian-hai Yin; Fang Huang; Xiang-li Kong; Kang-ming Lin; Tao Zhang; Xin-yu Feng; Shui-sen Zhou; Jian-ping Cao; Zhi-gui Xia Background: Sulfadoxine-pyrimethamine (SP) is recommended for intermittent preventive treatment in Africa against Plasmodium falciparum infection uuid:40a86997-afbc-4bfd-a457-f62b2ade34c9 uuid:50970440-cc27-44da-a2ef-35363d528f4f endstream endobj 237 0 obj<> endobj xref 0 238 0000000000 65535 f 0000211400 00000 n 0000211750 00000 n 0000211857 00000 n 0000211965 00000 n 0000212072 00000 n 0000212182 00000 n 0000212292 00000 n 0000212402 00000 n 0000212512 00000 n 0000212619 00000 n 0000212727 00000 n 0000212837 00000 n 0000212946 00000 n 0000213054 00000 n 0000213162 00000 n 0000213271 00000 n 0000213379 00000 n 0000213489 00000 n 0000213600 00000 n 0000213742 00000 n 0000213884 00000 n 0000214067 00000 n 0000214206 00000 n 0000214399 00000 n 0000214623 00000 n 0000240584 00000 n 0000241911 00000 n 0000242149 00000 n 0000242525 00000 n 0000242716 00000 n 0000243005 00000 n 0000243201 00000 n 0000243371 00000 n 0000243594 00000 n 0000243749 00000 n 0000243903 00000 n 0000244014 00000 n 0000244197 00000 n 0000244336 00000 n 0000244529 00000 n 0000244713 00000 n 0000249475 00000 n 0000494019 00000 n 0000495329 00000 n 0000495437 00000 n 0000495546 00000 n 0000495655 00000 n 0000495764 00000 n 0000495947 00000 n 0000496086 00000 n 0000496279 00000 n 0000496444 00000 n 0000522275 00000 n 0000524453 00000 n 0000524636 00000 n 0000524775 00000 n 0000524968 00000 n 0000525086 00000 n 0000541894 00000 n 0000542640 00000 n 0000542748 00000 n 0000542858 00000 n 0000542967 00000 n 0000543078 00000 n 0000543189 00000 n 0000543300 00000 n 0000543411 00000 n 0000543521 00000 n 0000543629 00000 n 0000543740 00000 n 0000543851 00000 n 0000543958 00000 n 0000544067 00000 n 0000544175 00000 n 0000544286 00000 n 0000544392 00000 n 0000544575 00000 n 0000544714 00000 n 0000544907 00000 n 0000545125 00000 n 0000564910 00000 n 0000662550 00000 n 0000662924 00000 n 0000663034 00000 n 0000663143 00000 n 0000663253 00000 n 0000663364 00000 n 0000663470 00000 n 0000663581 00000 n 0000663690 00000 n 0000663799 00000 n 0000663909 00000 n 0000664020 00000 n 0000664130 00000 n 0000664239 00000 n 0000664391 00000 n 0000664546 00000 n 0000664690 00000 n 0000664846 00000 n 0000665029 00000 n 0000665169 00000 n 0000665363 00000 n 0000665530 00000 n 0000685755 00000 n 0000686219 00000 n 0000686368 00000 n 0000686516 00000 n 0000686672 00000 n 0000686824 00000 n 0000686974 00000 n 0000687125 00000 n 0000687280 00000 n 0000687437 00000 n 0000687585 00000 n 0000687739 00000 n 0000687898 00000 n 0000688054 00000 n 0000688210 00000 n 0000688360 00000 n 0000688515 00000 n 0000688668 00000 n 0000688829 00000 n 0000688987 00000 n 0000689144 00000 n 0000689303 00000 n 0000689461 00000 n 0000689617 00000 n 0000689779 00000 n 0000689938 00000 n 0000690095 00000 n 0000690250 00000 n 0000690401 00000 n 0000690556 00000 n 0000690724 00000 n 0000690875 00000 n 0000691034 00000 n 0000691191 00000 n 0000691349 00000 n 0000691533 00000 n 0000691673 00000 n 0000691867 00000 n 0000692035 00000 n 0000722257 00000 n 0000722672 00000 n 0000722869 00000 n 0000723155 00000 n 0000723213 00000 n 0000723694 00000 n 0000730298 00000 n 0000730891 00000 n 0000731424 00000 n 0000731799 00000 n 0000732002 00000 n 0000732295 00000 n 0000732363 00000 n 0000732540 00000 n 0000732846 00000 n 0000733223 00000 n 0000733384 00000 n 0000733665 00000 n 0000736719 00000 n 0000736872 00000 n 0000737414 00000 n 0000737593 00000 n 0000737831 00000 n 0000743763 00000 n 0000744228 00000 n 0000744401 00000 n 0000746613 00000 n 0000746648 00000 n 0000747737 00000 n 0000747787 00000 n 0000747838 00000 n 0000747889 00000 n 0000747940 00000 n 0000747991 00000 n 0000748042 00000 n 0000748093 00000 n 0000748144 00000 n 0000748195 00000 n 0000748246 00000 n 0000748297 00000 n 0000748347 00000 n 0000748398 00000 n 0000748449 00000 n 0000748500 00000 n 0000748551 00000 n 0000748602 00000 n 0000748653 00000 n 0000748704 00000 n 0000748755 00000 n 0000748806 00000 n 0000748857 00000 n 0000748907 00000 n 0000748958 00000 n 0000749009 00000 n 0000749059 00000 n 0000749110 00000 n 0000749161 00000 n 0000749212 00000 n 0000749263 00000 n 0000749314 00000 n 0000749365 00000 n 0000749416 00000 n 0000749466 00000 n 0000749516 00000 n 0000749566 00000 n 0000749617 00000 n 0000749667 00000 n 0000749717 00000 n 0000749767 00000 n 0000749816 00000 n 0000749865 00000 n 0000749914 00000 n 0000749963 00000 n 0000750012 00000 n 0000750061 00000 n 0000750111 00000 n 0000750161 00000 n 0000750211 00000 n 0000750261 00000 n 0000750311 00000 n 0000750361 00000 n 0000750411 00000 n 0000750461 00000 n 0000750511 00000 n 0000750561 00000 n 0000750611 00000 n 0000750661 00000 n 0000750711 00000 n 0000750748 00000 n 0000750773 00000 n 0000750876 00000 n 0000750911 00000 n 0000751106 00000 n 0000751185 00000 n 0000755570 00000 n trailer <> startxref 116 %%EOF 232 0 obj<> endobj 239 0 obj<> endobj 780 0 obj<> endobj 781 0 obj<> endobj 790 0 obj<> endobj 793 0 obj<> endobj 794 0 obj<> endobj 803 0 obj<> endobj 804 0 obj<>stream Acrobat Distiller 7.0 (Windows) Plasmodium falciparum, sulfadoxine-pyrimethamine, dihydropteroate synthase, dihydrofolate reductase, migrants from Africa 2021-09-08T13:20:01+08:00 2021-09-08T15:11:12+08:00 Arbortext Advanced Print Publisher 10.0.1306/W Unicode 2021-09-08T15:11:12+08:00 application/pdf High Frequency Mutations in pfdhfr and pfdhps of Plasmodium falciparum in Response to Sulfadoxine-Pyrimethamine: A Cross-Sectional Survey in Returning Chinese Migrants From Africa He Yan Jun Feng Jian-hai Yin Fang Huang Xiang-li Kong Kang-ming Lin Tao Zhang Xin-yu Feng Shui-sen Zhou Jian-ping Cao Zhi-gui Xia Background: Sulfadoxine-pyrimethamine (SP) is recommended for intermittent preventive treatment in Africa against Plasmodium falciparum infection Plasmodium falciparum sulfadoxine-pyrimethamine dihydropteroate synthase dihydrofolate reductase migrants from Africa uuid:40a86997-afbc-4bfd-a457-f62b2ade34c9 uuid:9f622371-eecf-45cb-bbb5-74fa2762289e endstream endobj xref 232 1 0000761214 00000 n 239 1 0000761317 00000 n 780 2 0000761490 00000 n 0000761547 00000 n 790 1 0000762032 00000 n 793 2 0000762166 00000 n 0000762328 00000 n 803 2 0000762463 00000 n 0000763154 00000 n trailer <<5296E4C8E77CC84BB5F77CD6004AA1D3>]/Prev 116 >> startxref 768289 %%EOF